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The map label for this gene is metR [H]

Identifier: 34499058

GI number: 34499058

Start: 3909114

End: 3910040

Strand: Reverse

Name: metR [H]

Synonym: CV_3603

Alternate gene names: 34499058

Gene position: 3910040-3909114 (Counterclockwise)

Preceding gene: 34499060

Following gene: 34499056

Centisome position: 82.3

GC content: 68.82

Gene sequence:

>927_bases
ATGAGCGTGCTGGAGCTGAGGCATCTGAAAAGCTTGCTGGCATTGGCCGAAACCGGCAGCGTGTCGCTGGCCGCGCAGCG
GGTGTGTCTGACGCAGTCGGCGTTGTCGCATCAGTTGAAACAGCTGGAGACGGCTTATGGTTTGACGCTGTTCGAGCGCA
AGACCCAGCCGCTGCGCTTCACGCCGGCCGGCGAGCGGCTGCTCAGGCTGGCGCGGGAGCTGCCGGCCCAGGTGGCGGCG
GCGGAGCGCGATTTGGCGCGCATCCGCCAGGGCGAGGCCGGCGAGGTCAGGGTGGCGGTGGAATGCCACACCTGTTTCGA
CTGGCTGATGCCGGCGATGGACCGGTTCCGCCAGCATTGGCCGGCGGTGGAGCTGGACATCGTGTCCGGCTTTCATGCCG
ACCCGGTGGGTTTGCTGCTCAGCGACCGCGCCGACCTCGCCATCGTGTCCGAGGCGGAGCCGCAGGCCGGCATCGTCCAC
CTGCCGCTGTTCTCCTACGAAATGGTGGGGATCGCCGCGCGCGAGCATCCGCTGGCGGCGAAAGCGGTGTGGCGGGCCGA
GGATTTCGCCGCCGAGACGCTGATCCACTACCCGGTGGCGGACGAGATGCTGGATTTGCTGCGCAAGCTGCTGCTGCCGG
CCGGCGTCAATCCGGCGCGGCGCACCGCCGAGCTGACCATCGCCATCATCCAGCTGGTGGCCAGCCGGCGCGGCGTGGCG
GTGCTGCCGTACTGGGCGGTGCAACCCTATCTGGAGCGCGGCTACGTCGCGGCCAGCCAGGTCGGGGAGGACAAGCTGCG
CAGCGAGCTGTACGCGGCCTTGCGCGCGGACGATGCCGAACGCGCCTATATGCAGGATTTCGTGCAGACGGTGCGGGACA
GCAGCTTCGCGACGCTGCCGGGCTTATCCCCGTTGGCGGGGGCTTGA

Upstream 100 bases:

>100_bases
TGGGTGCGTTCCTGTTCTTGTCGGGATGGAACAAGCATCTGTCATTGCGGTGTATGATTCAAACTCATTATTTTGTTGTT
CAACATGAATGGAATCGATG

Downstream 100 bases:

>100_bases
GCGCAGCGCCGGCAGCAGCGCGTCCAGCCGTTGCCGGCATTGCGGACGCAGCCGCCGGCTGTTGGCCGCCATCGCGGCCG
CCCCGCCGGCGTCCCGGACC

Product: transcriptional activator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSVLELRHLKSLLALAETGSVSLAAQRVCLTQSALSHQLKQLETAYGLTLFERKTQPLRFTPAGERLLRLARELPAQVAA
AERDLARIRQGEAGEVRVAVECHTCFDWLMPAMDRFRQHWPAVELDIVSGFHADPVGLLLSDRADLAIVSEAEPQAGIVH
LPLFSYEMVGIAAREHPLAAKAVWRAEDFAAETLIHYPVADEMLDLLRKLLLPAGVNPARRTAELTIAIIQLVASRRGVA
VLPYWAVQPYLERGYVAASQVGEDKLRSELYAALRADDAERAYMQDFVQTVRDSSFATLPGLSPLAGA

Sequences:

>Translated_308_residues
MSVLELRHLKSLLALAETGSVSLAAQRVCLTQSALSHQLKQLETAYGLTLFERKTQPLRFTPAGERLLRLARELPAQVAA
AERDLARIRQGEAGEVRVAVECHTCFDWLMPAMDRFRQHWPAVELDIVSGFHADPVGLLLSDRADLAIVSEAEPQAGIVH
LPLFSYEMVGIAAREHPLAAKAVWRAEDFAAETLIHYPVADEMLDLLRKLLLPAGVNPARRTAELTIAIIQLVASRRGVA
VLPYWAVQPYLERGYVAASQVGEDKLRSELYAALRADDAERAYMQDFVQTVRDSSFATLPGLSPLAGA
>Mature_307_residues
SVLELRHLKSLLALAETGSVSLAAQRVCLTQSALSHQLKQLETAYGLTLFERKTQPLRFTPAGERLLRLARELPAQVAAA
ERDLARIRQGEAGEVRVAVECHTCFDWLMPAMDRFRQHWPAVELDIVSGFHADPVGLLLSDRADLAIVSEAEPQAGIVHL
PLFSYEMVGIAAREHPLAAKAVWRAEDFAAETLIHYPVADEMLDLLRKLLLPAGVNPARRTAELTIAIIQLVASRRGVAV
LPYWAVQPYLERGYVAASQVGEDKLRSELYAALRADDAERAYMQDFVQTVRDSSFATLPGLSPLAGA

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=298, Percent_Identity=41.6107382550336, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI145693105, Length=194, Percent_Identity=29.3814432989691, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082132, Length=306, Percent_Identity=28.1045751633987, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787879, Length=254, Percent_Identity=27.9527559055118, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786401, Length=154, Percent_Identity=29.8701298701299, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI157672245, Length=173, Percent_Identity=28.9017341040462, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787530, Length=292, Percent_Identity=26.027397260274, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790208, Length=156, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786713, Length=181, Percent_Identity=29.8342541436464, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789204, Length=217, Percent_Identity=30.4147465437788, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI2367136, Length=219, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082024, Length=172, Percent_Identity=29.0697674418605, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790399, Length=255, Percent_Identity=24.3137254901961, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789173, Length=191, Percent_Identity=27.2251308900524, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI145693193, Length=189, Percent_Identity=23.8095238095238, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1788748, Length=94, Percent_Identity=37.2340425531915, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33939; Mature: 33807

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLELRHLKSLLALAETGSVSLAAQRVCLTQSALSHQLKQLETAYGLTLFERKTQPLRF
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCEEE
TPAGERLLRLARELPAQVAAAERDLARIRQGEAGEVRVAVECHTCFDWLMPAMDRFRQHW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHC
PAVELDIVSGFHADPVGLLLSDRADLAIVSEAEPQAGIVHLPLFSYEMVGIAAREHPLAA
CCEEEEECCCCCCCCHHHEECCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHCCCCCHH
KAVWRAEDFAAETLIHYPVADEMLDLLRKLLLPAGVNPARRTAELTIAIIQLVASRRGVA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
VLPYWAVQPYLERGYVAASQVGEDKLRSELYAALRADDAERAYMQDFVQTVRDSSFATLP
EEEHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECC
GLSPLAGA
CCCCCCCC
>Mature Secondary Structure 
SVLELRHLKSLLALAETGSVSLAAQRVCLTQSALSHQLKQLETAYGLTLFERKTQPLRF
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCEEE
TPAGERLLRLARELPAQVAAAERDLARIRQGEAGEVRVAVECHTCFDWLMPAMDRFRQHW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHC
PAVELDIVSGFHADPVGLLLSDRADLAIVSEAEPQAGIVHLPLFSYEMVGIAAREHPLAA
CCEEEEECCCCCCCCHHHEECCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHCCCCCHH
KAVWRAEDFAAETLIHYPVADEMLDLLRKLLLPAGVNPARRTAELTIAIIQLVASRRGVA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
VLPYWAVQPYLERGYVAASQVGEDKLRSELYAALRADDAERAYMQDFVQTVRDSSFATLP
EEEHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECC
GLSPLAGA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]