Click here to switch to the map view.

The map label for this gene is cysM [H]

Identifier: 34499052

GI number: 34499052

Start: 3904146

End: 3904967

Strand: Reverse

Name: cysM [H]

Synonym: CV_3597

Alternate gene names: 34499052

Gene position: 3904967-3904146 (Counterclockwise)

Preceding gene: 34499053

Following gene: 34499051

Centisome position: 82.19

GC content: 72.87

Gene sequence:

>822_bases
ATGACCCCCTTGTTGCAGGCGCCGCGTCTGATGCCCGGCCTGAGCCTGAAGCTCGAATACCTGAATCCCTCGCTGTCGAT
CAAGCACCGTTCGCTGCCGAAGACGCTGCTGGCGCGCGCGGAAGCGGGCCGGATAGGCCGCGGCACGACGCTGGCGATCA
TGACCGCCGGCAGCGCCGGCGTCAGCGTGGCCTGGGCCGCCAGCCAGATAGGCTGCAAGGCGCTGTTGCTGATGCCGGAG
AGCGCGCCGGACAGCGTGGTCAATTACGCGCGCTGGCTGGGCGCCGCGGTGGAGCGCCGCCCGCATCCGCAGTTGCAGGA
GCTGCTGGACGCGCATCGCGGCATGCCGGACAGCCATGTGGTCGAGCAGTTGAGCGACGCGGAGCTGATCGGCCATTACC
GGGCGGTGGGCGAGGAGTTGCTGCGCCAATCGCCCGGGCTGGCGGCGGTGACGGTGCCGGCCGGCACTTGCGCGTCGCTG
ATGGGCATCGCCGAGGCGCTGGCGCCGGCCGGCATCCCGGTCTACGCGGCGGAGCCTGCGGAAGCGGCCGTGCTGTCGGG
CGAGCCGTGGCGTCCGCATGATATTCCCGGCCTGGCGCCGCCGGCGCCGACGAAATTATTCCGGCGCGAGGCCGTGGCCG
GCATCGTGCCGGTGGCGTCGGCGTTGGCCTGGTCGACGGCGCGCGAGGCGCTGGCCGCTTGCGGCGAGCCGGTCGGGCCG
TCGTCAGGCGCCGCCATCGCTGCCGCGCGCGCGCTGCGGCGGCAGGGCGTGGACGGCGACATCGCCGCGGTCTGCTCCTC
TCACATGGCCACCAGCCTGTGA

Upstream 100 bases:

>100_bases
AAGCTGAAGCGCGACAAGATGGCCAGCGGCAACGGCGTCAAGGTGCCGCGCTTCATCGAGCTGCCGCTGCCCGTCCATGC
CTACCTATGAGGGATGCGCG

Downstream 100 bases:

>100_bases
GGCTGCATCAGGCAAGCGCGGGGGGCGTCCGCCTCCCGCCGTTCCTGCCGGACGCGGAACAGGCGCGGCCAGCCATCACG
ATTCCCTGGGAGAAGGCCTG

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MTPLLQAPRLMPGLSLKLEYLNPSLSIKHRSLPKTLLARAEAGRIGRGTTLAIMTAGSAGVSVAWAASQIGCKALLLMPE
SAPDSVVNYARWLGAAVERRPHPQLQELLDAHRGMPDSHVVEQLSDAELIGHYRAVGEELLRQSPGLAAVTVPAGTCASL
MGIAEALAPAGIPVYAAEPAEAAVLSGEPWRPHDIPGLAPPAPTKLFRREAVAGIVPVASALAWSTAREALAACGEPVGP
SSGAAIAAARALRRQGVDGDIAAVCSSHMATSL

Sequences:

>Translated_273_residues
MTPLLQAPRLMPGLSLKLEYLNPSLSIKHRSLPKTLLARAEAGRIGRGTTLAIMTAGSAGVSVAWAASQIGCKALLLMPE
SAPDSVVNYARWLGAAVERRPHPQLQELLDAHRGMPDSHVVEQLSDAELIGHYRAVGEELLRQSPGLAAVTVPAGTCASL
MGIAEALAPAGIPVYAAEPAEAAVLSGEPWRPHDIPGLAPPAPTKLFRREAVAGIVPVASALAWSTAREALAACGEPVGP
SSGAAIAAARALRRQGVDGDIAAVCSSHMATSL
>Mature_272_residues
TPLLQAPRLMPGLSLKLEYLNPSLSIKHRSLPKTLLARAEAGRIGRGTTLAIMTAGSAGVSVAWAASQIGCKALLLMPES
APDSVVNYARWLGAAVERRPHPQLQELLDAHRGMPDSHVVEQLSDAELIGHYRAVGEELLRQSPGLAAVTVPAGTCASLM
GIAEALAPAGIPVYAAEPAEAAVLSGEPWRPHDIPGLAPPAPTKLFRREAVAGIVPVASALAWSTAREALAACGEPVGPS
SGAAIAAARALRRQGVDGDIAAVCSSHMATSL

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=271, Percent_Identity=24.7232472324723, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI295821200, Length=271, Percent_Identity=24.7232472324723, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4557415, Length=271, Percent_Identity=24.7232472324723, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI2367138, Length=279, Percent_Identity=25.4480286738351, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562970, Length=269, Percent_Identity=31.5985130111524, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32566674, Length=269, Percent_Identity=31.5985130111524, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17561720, Length=269, Percent_Identity=30.8550185873606, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17535051, Length=277, Percent_Identity=26.7148014440433, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115535073, Length=265, Percent_Identity=29.0566037735849, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=278, Percent_Identity=25.8992805755396, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24643623, Length=219, Percent_Identity=26.4840182648402, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI20129101, Length=219, Percent_Identity=26.4840182648402, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 28174; Mature: 28043

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLLQAPRLMPGLSLKLEYLNPSLSIKHRSLPKTLLARAEAGRIGRGTTLAIMTAGSAG
CCCCCCCCCCCCCCEEEEEECCCCCEECHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
VSVAWAASQIGCKALLLMPESAPDSVVNYARWLGAAVERRPHPQLQELLDAHRGMPDSHV
CEEEHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHH
VEQLSDAELIGHYRAVGEELLRQSPGLAAVTVPAGTCASLMGIAEALAPAGIPVYAAEPA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCC
EAAVLSGEPWRPHDIPGLAPPAPTKLFRREAVAGIVPVASALAWSTAREALAACGEPVGP
CCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SSGAAIAAARALRRQGVDGDIAAVCSSHMATSL
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPLLQAPRLMPGLSLKLEYLNPSLSIKHRSLPKTLLARAEAGRIGRGTTLAIMTAGSAG
CCCCCCCCCCCCCEEEEEECCCCCEECHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
VSVAWAASQIGCKALLLMPESAPDSVVNYARWLGAAVERRPHPQLQELLDAHRGMPDSHV
CEEEHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHH
VEQLSDAELIGHYRAVGEELLRQSPGLAAVTVPAGTCASLMGIAEALAPAGIPVYAAEPA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCC
EAAVLSGEPWRPHDIPGLAPPAPTKLFRREAVAGIVPVASALAWSTAREALAACGEPVGP
CCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SSGAAIAAARALRRQGVDGDIAAVCSSHMATSL
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9034314; 10688204 [H]