Click here to switch to the map view.

The map label for this gene is ndk

Identifier: 34498997

GI number: 34498997

Start: 3850603

End: 3851028

Strand: Reverse

Name: ndk

Synonym: CV_3542

Alternate gene names: 34498997

Gene position: 3851028-3850603 (Counterclockwise)

Preceding gene: 34498999

Following gene: 34498996

Centisome position: 81.06

GC content: 58.92

Gene sequence:

>426_bases
ATGGCAATCGAACGTACCTTGTCCATCGTTAAGCCGGACGCTGTAGCCAAAAACGTGATCGGCAAAATCTACGACCGCTT
CGAGTCCGCGGGCCTGAAGATCGTCGCCGCCAAGATGAAGCAACTGTCCCGCGCCGAAGCCGAAGGCTTCTACGCCGTGC
ACAAAGAGCGTCCTTTCTTCAAGGACCTGGTCGACTTCATGGTTTCCGGCCCGGTGATGATCCAGGCGCTGGAAGGCGAA
AACGCCGTACTGAAGAACCGCGAGCTGATGGGCGCCACCGATCCGAAGAAAGCTGAAGCCGGCACCATCCGCGCCGACTT
CGCCGAATCGATCGACGCCAACGCCGTTCACGGTTCCGACAGCGTGGAAAACGCTGCCATCGAAGTGGCCTATTTCTTCG
CCGCTTCCGAAATCAGCTCCCGCTGA

Upstream 100 bases:

>100_bases
AAAACGCTGCTAAAATAGCGGGTTCGTCAGAATTGGGTAACCCGAGTGGCGTCATAATACTCAAGTTTAGCCACTTGTCT
TGTCGTTAGGGAGAATTTAT

Downstream 100 bases:

>100_bases
TTCAAAAGTAGTCGAATGACCGGAGGTCGCCGCTGCCGGCGGCCTCTTTTGCCTGTTGAGGATTGCATGAAAACCAACCT
GCTCGACTTCAATCTGGACC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAIERTLSIVKPDAVAKNVIGKIYDRFESAGLKIVAAKMKQLSRAEAEGFYAVHKERPFFKDLVDFMVSGPVMIQALEGE
NAVLKNRELMGATDPKKAEAGTIRADFAESIDANAVHGSDSVENAAIEVAYFFAASEISSR

Sequences:

>Translated_141_residues
MAIERTLSIVKPDAVAKNVIGKIYDRFESAGLKIVAAKMKQLSRAEAEGFYAVHKERPFFKDLVDFMVSGPVMIQALEGE
NAVLKNRELMGATDPKKAEAGTIRADFAESIDANAVHGSDSVENAAIEVAYFFAASEISSR
>Mature_140_residues
AIERTLSIVKPDAVAKNVIGKIYDRFESAGLKIVAAKMKQLSRAEAEGFYAVHKERPFFKDLVDFMVSGPVMIQALEGEN
AVLKNRELMGATDPKKAEAGTIRADFAESIDANAVHGSDSVENAAIEVAYFFAASEISSR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=45.985401459854, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=41.1764705882353, Blast_Score=116, Evalue=5e-27,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=41.1764705882353, Blast_Score=116, Evalue=6e-27,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=40.4411764705882, Blast_Score=116, Evalue=6e-27,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=40.4411764705882, Blast_Score=116, Evalue=6e-27,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=40.4411764705882, Blast_Score=116, Evalue=6e-27,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=40.4411764705882, Blast_Score=116, Evalue=6e-27,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=40.4411764705882, Blast_Score=116, Evalue=6e-27,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=40.8759124087591, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI37574614, Length=141, Percent_Identity=37.5886524822695, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI7019465, Length=141, Percent_Identity=37.5886524822695, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=35.2941176470588, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI30023828, Length=143, Percent_Identity=32.8671328671329, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=31.8840579710145, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=60.2836879432624, Blast_Score=184, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=41.9117647058824, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=40.7407407407407, Blast_Score=115, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=44.5255474452555, Blast_Score=125, Evalue=6e-30,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=32.089552238806, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_CHRVO (Q7NS84)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903212.1
- ProteinModelPortal:   Q7NS84
- SMR:   Q7NS84
- GeneID:   2547357
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3542
- NMPDR:   fig|243365.1.peg.3542
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q7NS84
- ProtClustDB:   PRK00668
- BioCyc:   CVIO243365:CV_3542-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15312; Mature: 15180

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTLSIVKPDAVAKNVIGKIYDRFESAGLKIVAAKMKQLSRAEAEGFYAVHKERPFF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHH
KDLVDFMVSGPVMIQALEGENAVLKNRELMGATDPKKAEAGTIRADFAESIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCC
SVENAAIEVAYFFAASEISSR
CCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIERTLSIVKPDAVAKNVIGKIYDRFESAGLKIVAAKMKQLSRAEAEGFYAVHKERPFF
CCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHH
KDLVDFMVSGPVMIQALEGENAVLKNRELMGATDPKKAEAGTIRADFAESIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCC
SVENAAIEVAYFFAASEISSR
CCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782