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The map label for this gene is ywlC [H]

Identifier: 34498673

GI number: 34498673

Start: 3498679

End: 3499644

Strand: Reverse

Name: ywlC [H]

Synonym: CV_3218

Alternate gene names: 34498673

Gene position: 3499644-3498679 (Counterclockwise)

Preceding gene: 34498674

Following gene: 34498663

Centisome position: 73.66

GC content: 72.77

Gene sequence:

>966_bases
ATGAAGTCGCTTAGCCCCACCCCCGAAGGACTGGACCAGGCCGCCGCGCTGCTGCGCGCCGGCGAGCTGGTCGCCGTGCC
CACCGAAACCGTTTACGGACTAGCGGCCGACGCCACCCAGCCCGACGCCGTGGCCGCCATTTTCCGCGCCAAGAACCGGC
CGGCCGATCACCCGCTGATCGTGCACTTGCCGGGCCTCGAGCAGCTGAACGAGTGGGCGTCGCGGGTCCCGGACTGTGCC
TGGCCGGTGATAGAACGCTTCTGGCCCGGTCCGCTGACCCTGGTGCTGCCGGCAAGCGAAAAGGTGCCGGCCATCGTCAA
CGCCGGACAAGACACGGTGGCGCTGCGCTGGTCCAGCCATCCGCTGCTGCAAGCGTTGTTGGACCGGCTGCAGCGGCCGG
TGGCGGCGCCATCGGCCAACCCGTTCTGCCGCATCAGCCCCACCACCGCCGAGCATGTGCGCGCCAATATGGAAGGCCGC
ATCGCCGCCGTGGTGGACGGCGGGCCGTGCGCGGTGGGCATAGAGTCCACCATTCTCGATCTCAGCGGCGCGCGGCCGGC
CATCCTGCGTCCCGGCGCCGTCACCGCCGCCATGCTGGCGCCTTACCTCGACCTGGCGGAAACCGCCGCGCCCGACGCGC
CGCGCGTGCCGGGCAATCTGGCTTCGCATTACGCGCCGCACCAGCCCTGCTACCGGCTGGAGGCCGCCGAAGCGGAGGAG
AGGGCCGACGACGCCGGCTGGCGGCAGGCCGCGGTGCTGGCCATCGACGCGCCCGCCGCGCGCTGCGGCTGGCTCAAACG
CATGCCGCCGACCCCCGAGGGCTATGCCCAGGCGCTGTACGCCGCGCTGCACCAGGCCGACGCCAGTGGCTGCCCATCGG
TCTGGATCGTGCTGCCGCCCGACGAGCCGGCCTGGCGCGCCGTGCGCGACCGGCTGCAACGCGCCGCGCGCTCGCTAGAC
AGCTAG

Upstream 100 bases:

>100_bases
TGGCAATGCCCGTGCTGCCAGGCCTCGCGCGAACAAACCTTGCAGGCGGCCGCCTCGCCGCAATACTGCGATTACTGCAA
TCCCTGAACCTTGGAAAACC

Downstream 100 bases:

>100_bases
TGTGGCAAAGAAGGATTGGAGAGCTTGTGGTGTGTGGAGGCCATTCAGAGCAATAAAAATACATGCAGCTTGCGGTACGT
ATGGATGCAGGCGCTCTCGA

Product: Sua5 family translation factor

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MKSLSPTPEGLDQAAALLRAGELVAVPTETVYGLAADATQPDAVAAIFRAKNRPADHPLIVHLPGLEQLNEWASRVPDCA
WPVIERFWPGPLTLVLPASEKVPAIVNAGQDTVALRWSSHPLLQALLDRLQRPVAAPSANPFCRISPTTAEHVRANMEGR
IAAVVDGGPCAVGIESTILDLSGARPAILRPGAVTAAMLAPYLDLAETAAPDAPRVPGNLASHYAPHQPCYRLEAAEAEE
RADDAGWRQAAVLAIDAPAARCGWLKRMPPTPEGYAQALYAALHQADASGCPSVWIVLPPDEPAWRAVRDRLQRAARSLD
S

Sequences:

>Translated_321_residues
MKSLSPTPEGLDQAAALLRAGELVAVPTETVYGLAADATQPDAVAAIFRAKNRPADHPLIVHLPGLEQLNEWASRVPDCA
WPVIERFWPGPLTLVLPASEKVPAIVNAGQDTVALRWSSHPLLQALLDRLQRPVAAPSANPFCRISPTTAEHVRANMEGR
IAAVVDGGPCAVGIESTILDLSGARPAILRPGAVTAAMLAPYLDLAETAAPDAPRVPGNLASHYAPHQPCYRLEAAEAEE
RADDAGWRQAAVLAIDAPAARCGWLKRMPPTPEGYAQALYAALHQADASGCPSVWIVLPPDEPAWRAVRDRLQRAARSLD
S
>Mature_321_residues
MKSLSPTPEGLDQAAALLRAGELVAVPTETVYGLAADATQPDAVAAIFRAKNRPADHPLIVHLPGLEQLNEWASRVPDCA
WPVIERFWPGPLTLVLPASEKVPAIVNAGQDTVALRWSSHPLLQALLDRLQRPVAAPSANPFCRISPTTAEHVRANMEGR
IAAVVDGGPCAVGIESTILDLSGARPAILRPGAVTAAMLAPYLDLAETAAPDAPRVPGNLASHYAPHQPCYRLEAAEAEE
RADDAGWRQAAVLAIDAPAARCGWLKRMPPTPEGYAQALYAALHQADASGCPSVWIVLPPDEPAWRAVRDRLQRAARSLD
S

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=192, Percent_Identity=34.375, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI87081864, Length=192, Percent_Identity=25, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI2367210, Length=150, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17537239, Length=195, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321269, Length=372, Percent_Identity=30.6451612903226, Blast_Score=151, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 34151; Mature: 34151

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLSPTPEGLDQAAALLRAGELVAVPTETVYGLAADATQPDAVAAIFRAKNRPADHPLI
CCCCCCCCCHHHHHHHHHHCCCEEEECCHHHHEEECCCCCCHHHHHHHHHCCCCCCCCEE
VHLPGLEQLNEWASRVPDCAWPVIERFWPGPLTLVLPASEKVPAIVNAGQDTVALRWSSH
EEECCHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCHHEECCCCEEEEEECCC
PLLQALLDRLQRPVAAPSANPFCRISPTTAEHVRANMEGRIAAVVDGGPCAVGIESTILD
HHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHCCCCCCEEEEECCCCEEECHHHHEEE
LSGARPAILRPGAVTAAMLAPYLDLAETAAPDAPRVPGNLASHYAPHQPCYRLEAAEAEE
CCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHH
RADDAGWRQAAVLAIDAPAARCGWLKRMPPTPEGYAQALYAALHQADASGCPSVWIVLPP
HHCCCCCCEEEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECC
DEPAWRAVRDRLQRAARSLDS
CCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSLSPTPEGLDQAAALLRAGELVAVPTETVYGLAADATQPDAVAAIFRAKNRPADHPLI
CCCCCCCCCHHHHHHHHHHCCCEEEECCHHHHEEECCCCCCHHHHHHHHHCCCCCCCCEE
VHLPGLEQLNEWASRVPDCAWPVIERFWPGPLTLVLPASEKVPAIVNAGQDTVALRWSSH
EEECCHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCHHEECCCCEEEEEECCC
PLLQALLDRLQRPVAAPSANPFCRISPTTAEHVRANMEGRIAAVVDGGPCAVGIESTILD
HHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHCCCCCCEEEEECCCCEEECHHHHEEE
LSGARPAILRPGAVTAAMLAPYLDLAETAAPDAPRVPGNLASHYAPHQPCYRLEAAEAEE
CCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHH
RADDAGWRQAAVLAIDAPAARCGWLKRMPPTPEGYAQALYAALHQADASGCPSVWIVLPP
HHCCCCCCEEEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECC
DEPAWRAVRDRLQRAARSLDS
CCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]