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The map label for this gene is dsbH

Identifier: 34498648

GI number: 34498648

Start: 3477332

End: 3477832

Strand: Reverse

Name: dsbH

Synonym: CV_3193

Alternate gene names: 34498648

Gene position: 3477832-3477332 (Counterclockwise)

Preceding gene: 34498649

Following gene: 34498645

Centisome position: 73.2

GC content: 67.86

Gene sequence:

>501_bases
ATGGGTTTGAATATCACGAACCGTCAGGGGTTCTTGCTGGTGGCGGCGGCTTGCGCCGGCGCCATCGGCTTTGCGCTGTT
CGCGCAATACCAGCTGGGGGAGGAGCCATGCCCGCTGTGCATTCTGCAGCGCATCGGCGTGATGGCGGTCGGCGCGCTGG
CCTTGCTGGCCGCGTTGCACAATCCCGGCAAGACTGGCGCGAAGGTATGGGGCGGGCTGATGACGCTGGCCGCGCTTTCC
GGCGCGGGCGTGTCGCTGCGCCAGCTGTGGCTGCAGAGCCTGCCGGCCGACCAGGTGCCGCAGTGCGGGCCGGGCCTGGA
GTTCCTGATGGAGTCCTTCCCATTGTGGGAGGTGTTGTCCAAGGTGCTGAAGGGCAGCGGCGAGTGCGCGGCCATCCAGG
GGCGTTTCCTCGGCATGACCATGCCGTTCTGGGTGGCGGTGTTCTTTGCCGGCGTGATCGTCTGGACCTTGTGGCTGGTT
GGGCGCCGCCGCCGCGGCTGA

Upstream 100 bases:

>100_bases
GCAGGCTCCCCGCTCCGGAACTTTGCCGGGCCGCCCCAATCTCAGCTTTTCCGTTTACACTGCGTTCACTCACAAGACAT
AACAGGAAAGGTCAAGGGGG

Downstream 100 bases:

>100_bases
ACCGTTTCCCGGATGTTCAATCCTGCCGCGCGGACGTTATGTCCGCGCTTTTTTTTGCGCCGTTCCCGGGTGGGCCTTGG
TAAAGGCTGGCGCGGTTGCG

Product: protein-disulfide reductase

Products: glutathione disulfide; Protein dithiol

Alternate protein names: Disulfide oxidoreductase

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MGLNITNRQGFLLVAAACAGAIGFALFAQYQLGEEPCPLCILQRIGVMAVGALALLAALHNPGKTGAKVWGGLMTLAALS
GAGVSLRQLWLQSLPADQVPQCGPGLEFLMESFPLWEVLSKVLKGSGECAAIQGRFLGMTMPFWVAVFFAGVIVWTLWLV
GRRRRG

Sequences:

>Translated_166_residues
MGLNITNRQGFLLVAAACAGAIGFALFAQYQLGEEPCPLCILQRIGVMAVGALALLAALHNPGKTGAKVWGGLMTLAALS
GAGVSLRQLWLQSLPADQVPQCGPGLEFLMESFPLWEVLSKVLKGSGECAAIQGRFLGMTMPFWVAVFFAGVIVWTLWLV
GRRRRG
>Mature_165_residues
GLNITNRQGFLLVAAACAGAIGFALFAQYQLGEEPCPLCILQRIGVMAVGALALLAALHNPGKTGAKVWGGLMTLAALSG
AGVSLRQLWLQSLPADQVPQCGPGLEFLMESFPLWEVLSKVLKGSGECAAIQGRFLGMTMPFWVAVFFAGVIVWTLWLVG
RRRRG

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein

COG id: COG1495

COG function: function code O; Disulfide bond formation protein DsbB

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DsbB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DSBB_CHRVO (Q7NT68)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902863.1
- ProteinModelPortal:   Q7NT68
- SMR:   Q7NT68
- GeneID:   2547167
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3193
- NMPDR:   fig|243365.1.peg.3193
- HOGENOM:   HBG637909
- OMA:   WAWARAK
- ProtClustDB:   CLSK2485581
- BioCyc:   CVIO243365:CV_3193-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_00286
- InterPro:   IPR003752
- InterPro:   IPR022920

Pfam domain/function: PF02600 DsbB

EC number: 1.8.4.2

Molecular weight: Translated: 17673; Mature: 17542

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1220236c)-; HASH(0x11f2e5ac)-; HASH(0x12589f8c)-; HASH(0x1234ac2c)-;

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLNITNRQGFLLVAAACAGAIGFALFAQYQLGEEPCPLCILQRIGVMAVGALALLAALH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
NPGKTGAKVWGGLMTLAALSGAGVSLRQLWLQSLPADQVPQCGPGLEFLMESFPLWEVLS
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCHHHHHH
KVLKGSGECAAIQGRFLGMTMPFWVAVFFAGVIVWTLWLVGRRRRG
HHHCCCCCEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
GLNITNRQGFLLVAAACAGAIGFALFAQYQLGEEPCPLCILQRIGVMAVGALALLAALH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
NPGKTGAKVWGGLMTLAALSGAGVSLRQLWLQSLPADQVPQCGPGLEFLMESFPLWEVLS
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCHHHHHH
KVLKGSGECAAIQGRFLGMTMPFWVAVFFAGVIVWTLWLVGRRRRG
HHHCCCCCEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutathione; Protein disulfide

Specific reaction: 2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782