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The map label for this gene is pepP [H]

Identifier: 34498577

GI number: 34498577

Start: 3409067

End: 3410362

Strand: Reverse

Name: pepP [H]

Synonym: CV_3122

Alternate gene names: 34498577

Gene position: 3410362-3409067 (Counterclockwise)

Preceding gene: 34498578

Following gene: 34498576

Centisome position: 71.78

GC content: 69.21

Gene sequence:

>1296_bases
ATGCACCAGCCGCATGCCGAACGCCGCAAGCGCCTGTTGGCCCAGATAGGCGACGGCGTCGCCTTGTTGTCCACCGCCCC
CGTGGCGGTGCGCAACGCCGACAATCACTATCCCTACCGCGCCGACAGCCATTTCCTGTACCTGACCGGTTTCGAAGAGC
CGGAGGCTGTGTTGCTGCTCGACGGCCGCAGCGGCCATTCTGTGCTGTTCTGCCGCGATCGCAATCCCGAGATGGAAATC
TGGGACGGCTTCCGCTACGGGCCGGACGGCGCGAAGGAGATGTTCGGCTTCGACGAGTCCTATCCCTTGTCCGAGATGGC
CGAACGGGTTCCCGACCTGTTGGCCGACCGCAGCCAGCTGTGGTGGCCGCTGGGCCACGACGAGGCCTTCGACCGCCGCG
TCAACCGCTGGCTGGACGCGGTGCGCGGCCGTTCGCGCGCCGGCGCCCGGCCGCCCGCGCATTACGGAGACCTGCGCGCG
CTGCTGGACGAAATGCGCATGGTCAAGGACGAGGCCGAGATCGCGCTGCTGCGCCGCGCCGGCGAGATCTCCGCCGCCGG
CCACGTGCAGGCGATGCGTACCGCGCGTCCCGGCATGCGCGAATACCAGCTGGAAGCGGAGCTGCTGCACGTTTTCGTCG
GCCACGGCGCCCGCCAGCCAGCGTACGAAAGCATCGTCGCCGCCGGCGCCAACGCCTGCACGCTGCACTACGTGGCCAAC
AACGCGCGGATCAACGACGGCGAGCTGCTGCTGATCGACGCCGGCTGCGAATACCGCGGCTACGCCGGGGACATCACCCG
CACCTTTCCGGCCAACGGCCGCTTCAGCGGGCCGCAGCGCGACGTGTACGAGATCGTGCTGGCGGCGCAGCAGGCCGGAA
TCGACGCGGTGAAGCCGGGCGCGGTCTGGCACGCGCCGTCCGACGCGGCGCTCGAAGTCCTGGCGCAGGGCATGGTGGAT
CTGGGACTGTTGGCTGGCAGCGCGGATGGCGTGATCGAATCCGGCGCCTACCGCCAGTTTTACATGCACGGCATCGGCCA
CCTGATCGGCCTGGACGTCCACGATGTCGGCCAGCGCAAGCACGACGGGCAATGGCGCCGCTACCAGCCGGGCATGTGCA
CCACGATAGAGCCGGGCCTGTACATCCGGCCGGCGCCCGGGGTGCCTGAGGCGTTCCACGGCATCGGCGTGCGCATCGAG
GACAATGTGCTGGTGACCGCGGACGGCAACGAGGTGTATACCGCGGCGGCGCCCAAGACGGTGGCCGGGATCGAGGCGCT
GATGCGCGGGGAGTAA

Upstream 100 bases:

>100_bases
CCGGGTTTTTTCATGCCCGCGCCGCTTGGGCCGCGCGCCGGCCCGGTGTAAACTGGCGTTTTGCCCCGCACGACCCGTTC
CCGCAAGGATTTCATTGCCC

Downstream 100 bases:

>100_bases
GGACGATGGATTCTACGATGAGTGAACATGCCGATGTGCTGATCGTCGGCGGCGGCCCGGTGGGCGCGCTGGCCGCCTTG
AGGCTGGCGCGGCAGGGCCG

Product: xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MHQPHAERRKRLLAQIGDGVALLSTAPVAVRNADNHYPYRADSHFLYLTGFEEPEAVLLLDGRSGHSVLFCRDRNPEMEI
WDGFRYGPDGAKEMFGFDESYPLSEMAERVPDLLADRSQLWWPLGHDEAFDRRVNRWLDAVRGRSRAGARPPAHYGDLRA
LLDEMRMVKDEAEIALLRRAGEISAAGHVQAMRTARPGMREYQLEAELLHVFVGHGARQPAYESIVAAGANACTLHYVAN
NARINDGELLLIDAGCEYRGYAGDITRTFPANGRFSGPQRDVYEIVLAAQQAGIDAVKPGAVWHAPSDAALEVLAQGMVD
LGLLAGSADGVIESGAYRQFYMHGIGHLIGLDVHDVGQRKHDGQWRRYQPGMCTTIEPGLYIRPAPGVPEAFHGIGVRIE
DNVLVTADGNEVYTAAAPKTVAGIEALMRGE

Sequences:

>Translated_431_residues
MHQPHAERRKRLLAQIGDGVALLSTAPVAVRNADNHYPYRADSHFLYLTGFEEPEAVLLLDGRSGHSVLFCRDRNPEMEI
WDGFRYGPDGAKEMFGFDESYPLSEMAERVPDLLADRSQLWWPLGHDEAFDRRVNRWLDAVRGRSRAGARPPAHYGDLRA
LLDEMRMVKDEAEIALLRRAGEISAAGHVQAMRTARPGMREYQLEAELLHVFVGHGARQPAYESIVAAGANACTLHYVAN
NARINDGELLLIDAGCEYRGYAGDITRTFPANGRFSGPQRDVYEIVLAAQQAGIDAVKPGAVWHAPSDAALEVLAQGMVD
LGLLAGSADGVIESGAYRQFYMHGIGHLIGLDVHDVGQRKHDGQWRRYQPGMCTTIEPGLYIRPAPGVPEAFHGIGVRIE
DNVLVTADGNEVYTAAAPKTVAGIEALMRGE
>Mature_431_residues
MHQPHAERRKRLLAQIGDGVALLSTAPVAVRNADNHYPYRADSHFLYLTGFEEPEAVLLLDGRSGHSVLFCRDRNPEMEI
WDGFRYGPDGAKEMFGFDESYPLSEMAERVPDLLADRSQLWWPLGHDEAFDRRVNRWLDAVRGRSRAGARPPAHYGDLRA
LLDEMRMVKDEAEIALLRRAGEISAAGHVQAMRTARPGMREYQLEAELLHVFVGHGARQPAYESIVAAGANACTLHYVAN
NARINDGELLLIDAGCEYRGYAGDITRTFPANGRFSGPQRDVYEIVLAAQQAGIDAVKPGAVWHAPSDAALEVLAQGMVD
LGLLAGSADGVIESGAYRQFYMHGIGHLIGLDVHDVGQRKHDGQWRRYQPGMCTTIEPGLYIRPAPGVPEAFHGIGVRIE
DNVLVTADGNEVYTAAAPKTVAGIEALMRGE

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=442, Percent_Identity=33.710407239819, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI149589008, Length=458, Percent_Identity=31.2227074235808, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI260593665, Length=301, Percent_Identity=35.8803986710963, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI260593663, Length=277, Percent_Identity=33.9350180505415, Blast_Score=142, Evalue=6e-34,
Organism=Escherichia coli, GI1789275, Length=430, Percent_Identity=46.5116279069767, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1788728, Length=306, Percent_Identity=33.0065359477124, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790282, Length=286, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17508215, Length=437, Percent_Identity=34.324942791762, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI71989583, Length=373, Percent_Identity=27.0777479892761, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320922, Length=442, Percent_Identity=28.9592760180996, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321118, Length=450, Percent_Identity=30.2222222222222, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI19920384, Length=409, Percent_Identity=35.4523227383863, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI21357079, Length=448, Percent_Identity=33.0357142857143, Blast_Score=201, Evalue=8e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 47396; Mature: 47396

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQPHAERRKRLLAQIGDGVALLSTAPVAVRNADNHYPYRADSHFLYLTGFEEPEAVLLL
CCCCHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEE
DGRSGHSVLFCRDRNPEMEIWDGFRYGPDGAKEMFGFDESYPLSEMAERVPDLLADRSQL
ECCCCCEEEEEECCCCCCEEECCEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHCHHHH
WWPLGHDEAFDRRVNRWLDAVRGRSRAGARPPAHYGDLRALLDEMRMVKDEAEIALLRRA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GEISAAGHVQAMRTARPGMREYQLEAELLHVFVGHGARQPAYESIVAAGANACTLHYVAN
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEEC
NARINDGELLLIDAGCEYRGYAGDITRTFPANGRFSGPQRDVYEIVLAAQQAGIDAVKPG
CCEECCCCEEEEECCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
AVWHAPSDAALEVLAQGMVDLGLLAGSADGVIESGAYRQFYMHGIGHLIGLDVHDVGQRK
CEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEECCHHHHCCCC
HDGQWRRYQPGMCTTIEPGLYIRPAPGVPEAFHGIGVRIEDNVLVTADGNEVYTAAAPKT
CCCCCCEECCCCCEEECCCEEEECCCCCCHHHHCCCEEEECCEEEEECCCEEEEECCCCH
VAGIEALMRGE
HHHHHHHHCCC
>Mature Secondary Structure
MHQPHAERRKRLLAQIGDGVALLSTAPVAVRNADNHYPYRADSHFLYLTGFEEPEAVLLL
CCCCHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEE
DGRSGHSVLFCRDRNPEMEIWDGFRYGPDGAKEMFGFDESYPLSEMAERVPDLLADRSQL
ECCCCCEEEEEECCCCCCEEECCEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHCHHHH
WWPLGHDEAFDRRVNRWLDAVRGRSRAGARPPAHYGDLRALLDEMRMVKDEAEIALLRRA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GEISAAGHVQAMRTARPGMREYQLEAELLHVFVGHGARQPAYESIVAAGANACTLHYVAN
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEEC
NARINDGELLLIDAGCEYRGYAGDITRTFPANGRFSGPQRDVYEIVLAAQQAGIDAVKPG
CCEECCCCEEEEECCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
AVWHAPSDAALEVLAQGMVDLGLLAGSADGVIESGAYRQFYMHGIGHLIGLDVHDVGQRK
CEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEECCHHHHCCCC
HDGQWRRYQPGMCTTIEPGLYIRPAPGVPEAFHGIGVRIEDNVLVTADGNEVYTAAAPKT
CCCCCCEECCCCCEEECCCEEEECCCCCCHHHHCCCEEEECCEEEEECCCEEEEECCCCH
VAGIEALMRGE
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]