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The map label for this gene is mtrA [H]

Identifier: 34497816

GI number: 34497816

Start: 2548084

End: 2548782

Strand: Direct

Name: mtrA [H]

Synonym: CV_2361

Alternate gene names: 34497816

Gene position: 2548084-2548782 (Clockwise)

Preceding gene: 34497815

Following gene: 34497817

Centisome position: 53.63

GC content: 58.94

Gene sequence:

>699_bases
ATGAGCAAAATCGACAAGCAGGACCAGCAGGAAGCGATATCGCAGCGCATCCGTTACCGGTTGCAGGCGGCGGGGGCGCG
CTTCCATGCCAACGACAATATATCGGCCTTTATCGAGGACGGAGAGCTGGATGCATTGCAGGAAGAGGTGCAGGCCAAGC
TCAAGGGCGTGCTGGAAAGCTTGGTGATCGATACCGCGAACGACCACAACACGCAGGAGACCGCGAAGCGGGTGGCGAAG
ATGTTCGTCCGCGAAGTATTTCGGGGGCGCTACGTGTCGATGCCTCCCTGCACCGAATTCCCGAATGTCGAGCATCTGAA
CGAGCTGATGATCATCGGGCCGATCACGGTGCGCAGCGCCTGCTCCCATCATCTTTGCCCCATCATCGGCCGGGTGTGGG
TGGGCGTGCTGCCGAACGAGGCTTCGAACCTGATCGGGCTGTCCAAATACGCCCGCCTGATAGATTGGGTGATGACCCGT
CCGCAGATACAGGAAGAGGCGGTATCGCAGATAGCGGATTTGCTGATGCAGAAGCTGCAGCCTGACGGTCTGGCCATCGT
GATGGAGGCGGATCACTTCTGCATGCACTGGCGCGGCGTGAAGGACAGCAACAGCAAGATGACCAATAGCGTGATGCGCG
GCTCCTTCCTGACCAATCCGGACCTGCGCAAGGAATTTCTGTCCTTGATGCGGAAGTGA

Upstream 100 bases:

>100_bases
CGCGGCCATGCGCTTGCGTGCATGGACCGCTCGAACCCGTGCCGTAAGTTGCTGTATATTTCGAAATGATTTCCATTTTC
TTGCGAACAAGTAATCAACA

Downstream 100 bases:

>100_bases
GCGGGCGGCATAGGGCCGGACGCGCAGCATTTACTTGAATGAAAGAGCCTATGTTTTCCACACGAATGATTTCCGCCCTG
GCCCTGCTGGCCTGCGCGAG

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MSKIDKQDQQEAISQRIRYRLQAAGARFHANDNISAFIEDGELDALQEEVQAKLKGVLESLVIDTANDHNTQETAKRVAK
MFVREVFRGRYVSMPPCTEFPNVEHLNELMIIGPITVRSACSHHLCPIIGRVWVGVLPNEASNLIGLSKYARLIDWVMTR
PQIQEEAVSQIADLLMQKLQPDGLAIVMEADHFCMHWRGVKDSNSKMTNSVMRGSFLTNPDLRKEFLSLMRK

Sequences:

>Translated_232_residues
MSKIDKQDQQEAISQRIRYRLQAAGARFHANDNISAFIEDGELDALQEEVQAKLKGVLESLVIDTANDHNTQETAKRVAK
MFVREVFRGRYVSMPPCTEFPNVEHLNELMIIGPITVRSACSHHLCPIIGRVWVGVLPNEASNLIGLSKYARLIDWVMTR
PQIQEEAVSQIADLLMQKLQPDGLAIVMEADHFCMHWRGVKDSNSKMTNSVMRGSFLTNPDLRKEFLSLMRK
>Mature_231_residues
SKIDKQDQQEAISQRIRYRLQAAGARFHANDNISAFIEDGELDALQEEVQAKLKGVLESLVIDTANDHNTQETAKRVAKM
FVREVFRGRYVSMPPCTEFPNVEHLNELMIIGPITVRSACSHHLCPIIGRVWVGVLPNEASNLIGLSKYARLIDWVMTRP
QIQEEAVSQIADLLMQKLQPDGLAIVMEADHFCMHWRGVKDSNSKMTNSVMRGSFLTNPDLRKEFLSLMRK

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=128, Percent_Identity=42.96875, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI4503949, Length=128, Percent_Identity=42.96875, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI66932970, Length=97, Percent_Identity=37.1134020618557, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI66932972, Length=87, Percent_Identity=40.2298850574713, Blast_Score=71, Evalue=8e-13,
Organism=Escherichia coli, GI1788476, Length=183, Percent_Identity=32.7868852459016, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17560486, Length=129, Percent_Identity=42.6356589147287, Blast_Score=116, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6321706, Length=124, Percent_Identity=42.741935483871, Blast_Score=102, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24656782, Length=127, Percent_Identity=41.7322834645669, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24656796, Length=127, Percent_Identity=41.7322834645669, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24656791, Length=127, Percent_Identity=41.7322834645669, Blast_Score=95, Evalue=4e-20,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 26348; Mature: 26217

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIDKQDQQEAISQRIRYRLQAAGARFHANDNISAFIEDGELDALQEEVQAKLKGVLES
CCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
LVIDTANDHNTQETAKRVAKMFVREVFRGRYVSMPPCTEFPNVEHLNELMIIGPITVRSA
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHEHEECCHHHHHH
CSHHLCPIIGRVWVGVLPNEASNLIGLSKYARLIDWVMTRPQIQEEAVSQIADLLMQKLQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
PDGLAIVMEADHFCMHWRGVKDSNSKMTNSVMRGSFLTNPDLRKEFLSLMRK
CCCEEEEEECCHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SKIDKQDQQEAISQRIRYRLQAAGARFHANDNISAFIEDGELDALQEEVQAKLKGVLES
CCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
LVIDTANDHNTQETAKRVAKMFVREVFRGRYVSMPPCTEFPNVEHLNELMIIGPITVRSA
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHEHEECCHHHHHH
CSHHLCPIIGRVWVGVLPNEASNLIGLSKYARLIDWVMTRPQIQEEAVSQIADLLMQKLQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
PDGLAIVMEADHFCMHWRGVKDSNSKMTNSVMRGSFLTNPDLRKEFLSLMRK
CCCEEEEEECCHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA