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The map label for this gene is moeA [H]

Identifier: 34497806

GI number: 34497806

Start: 2536835

End: 2538049

Strand: Direct

Name: moeA [H]

Synonym: CV_2351

Alternate gene names: 34497806

Gene position: 2536835-2538049 (Clockwise)

Preceding gene: 34497805

Following gene: 34497809

Centisome position: 53.39

GC content: 70.7

Gene sequence:

>1215_bases
ATGGGTCCGGCCCATCGCAAGACAGGATTGGAATACCGCATGCTGAGCTATCAACAGGCGCGGGACTGGCTGCTGGAGCG
CGCCAAACCGCTGAACACCCATCAAGAATTGCCGCTGATGCAAGCGTTGGGCCGCGTGTTGGCCCAGCCGGTGGCGGCCG
GCATGGACGTGCCGCCGCACGACAACAGCGCGATGGACGGTTACGCGCTGCGTTGCGCCGACCTGGCGCCGGCGATGGCG
GTGACGCAGCGGGTGCCTGCCGGCAGCGTGCCGGCGCCGCTCCAGGCCGGCACCGCGGCGCGGATCTTCACCGGCGCGCC
GATTCCGCCGGGCGCGGACGCGGTGATCATGCAGGAGCAGGCGGATCTGGACGGCGAGGGTCGTGTGACTTTCAGCGCGG
AGCCCAGCCCCGGGCAGAACATCCGCCGCCGCGGCGAGGACATCGCTGCCGGCCAGCGCATTCTGGAAGCCGGGCGCAAG
CTGTCCGCCGCCGATCTGGGGCTGGCGGCCTCCATCGGCCTGGCGCGGCTGCCGGTGCTGCCGCGGTTGCGGGTGGCTGC
CTTCTTCACCGGCGACGAGCTGGTGGAGCCGGGCCAGCCGCTGGCCGAAGGCCAGATCTACAACTCCAACCGCTACTGGC
TGCTGCCGGCTTTGCAGCAGCTGGGCTGCGAGGTGATCGACCTCGGCCATGTCGGCGACGCGCTGGAGCCCACCCGGCAG
CTGCTGCGCGACGCGGCGATGGTGGCCGACGTGGTGATCACCTGCGGCGGCGTGTCGGTCGGCGAGGAGGACCACGTCAA
GGCCGCGGTGGAGGCGGAGGGCGAGCTCACGCTGTGGAAGGTGGCGATCAAGCCGGGCAAGCCGCTGGCCTATGGCAAGG
TGGGCAGCGCGGATTTCATCGGCCTGCCCGGCAATCCGGTGTCCGGCTACGTGACGCTGCAGACGCTGATCAAGCCTTTC
CTGCAGAAGCGGATGGGCCTGGAGGTGCCGCCGCCGGAGACGCAGCGGTTGCCGGCCGCCTTCGCCTGGGACAAGCCGGA
CACGCGCCGCAGCGAGTTCCTGCGCGTGCGCAAACTGGCGGGCCAGCTGCAGCTGTATCCGCAGCAGGGCTCCGGCGTGC
TGATGTCCTGCGCCTGGGCGGACGGCCTGGTCTGGCTGCAGCCGGGCCAGCAGGTGAAGCCGGGCGACGAACTGGCTTAC
CTGGAGCTGACGTGA

Upstream 100 bases:

>100_bases
AAGTCGCGCTGATACGTTTTCCGCTTTTTCCAAGCCCGCCCGCTCAACGCCGGCGGGCTTTTTGCATGGCCGCGCGTGCT
ATGATGGGGGCTTGTGAAGG

Downstream 100 bases:

>100_bases
CGCGAATACGTTTCGTCAGCGAGAGCGGGGCCTTGCTGAACGAGTCGGATGCGATGCCGGGCGACAATCTGCTGGACGTC
GCCCGCCTGGCCGACGTGCC

Product: molybdopterin biosynthesis moeA protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MGPAHRKTGLEYRMLSYQQARDWLLERAKPLNTHQELPLMQALGRVLAQPVAAGMDVPPHDNSAMDGYALRCADLAPAMA
VTQRVPAGSVPAPLQAGTAARIFTGAPIPPGADAVIMQEQADLDGEGRVTFSAEPSPGQNIRRRGEDIAAGQRILEAGRK
LSAADLGLAASIGLARLPVLPRLRVAAFFTGDELVEPGQPLAEGQIYNSNRYWLLPALQQLGCEVIDLGHVGDALEPTRQ
LLRDAAMVADVVITCGGVSVGEEDHVKAAVEAEGELTLWKVAIKPGKPLAYGKVGSADFIGLPGNPVSGYVTLQTLIKPF
LQKRMGLEVPPPETQRLPAAFAWDKPDTRRSEFLRVRKLAGQLQLYPQQGSGVLMSCAWADGLVWLQPGQQVKPGDELAY
LELT

Sequences:

>Translated_404_residues
MGPAHRKTGLEYRMLSYQQARDWLLERAKPLNTHQELPLMQALGRVLAQPVAAGMDVPPHDNSAMDGYALRCADLAPAMA
VTQRVPAGSVPAPLQAGTAARIFTGAPIPPGADAVIMQEQADLDGEGRVTFSAEPSPGQNIRRRGEDIAAGQRILEAGRK
LSAADLGLAASIGLARLPVLPRLRVAAFFTGDELVEPGQPLAEGQIYNSNRYWLLPALQQLGCEVIDLGHVGDALEPTRQ
LLRDAAMVADVVITCGGVSVGEEDHVKAAVEAEGELTLWKVAIKPGKPLAYGKVGSADFIGLPGNPVSGYVTLQTLIKPF
LQKRMGLEVPPPETQRLPAAFAWDKPDTRRSEFLRVRKLAGQLQLYPQQGSGVLMSCAWADGLVWLQPGQQVKPGDELAY
LELT
>Mature_403_residues
GPAHRKTGLEYRMLSYQQARDWLLERAKPLNTHQELPLMQALGRVLAQPVAAGMDVPPHDNSAMDGYALRCADLAPAMAV
TQRVPAGSVPAPLQAGTAARIFTGAPIPPGADAVIMQEQADLDGEGRVTFSAEPSPGQNIRRRGEDIAAGQRILEAGRKL
SAADLGLAASIGLARLPVLPRLRVAAFFTGDELVEPGQPLAEGQIYNSNRYWLLPALQQLGCEVIDLGHVGDALEPTRQL
LRDAAMVADVVITCGGVSVGEEDHVKAAVEAEGELTLWKVAIKPGKPLAYGKVGSADFIGLPGNPVSGYVTLQTLIKPFL
QKRMGLEVPPPETQRLPAAFAWDKPDTRRSEFLRVRKLAGQLQLYPQQGSGVLMSCAWADGLVWLQPGQQVKPGDELAYL
ELT

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=400, Percent_Identity=34.25, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI66932975, Length=400, Percent_Identity=34.25, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=45.1697127937337, Blast_Score=293, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI25147659, Length=331, Percent_Identity=31.1178247734139, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562606, Length=320, Percent_Identity=25.3125, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136978, Length=357, Percent_Identity=31.9327731092437, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24638841, Length=357, Percent_Identity=31.9327731092437, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43341; Mature: 43210

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPAHRKTGLEYRMLSYQQARDWLLERAKPLNTHQELPLMQALGRVLAQPVAAGMDVPPH
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCC
DNSAMDGYALRCADLAPAMAVTQRVPAGSVPAPLQAGTAARIFTGAPIPPGADAVIMQEQ
CCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECC
ADLDGEGRVTFSAEPSPGQNIRRRGEDIAAGQRILEAGRKLSAADLGLAASIGLARLPVL
CCCCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHHCCCCCHHHCCHHHHCCHHHCCCC
PRLRVAAFFTGDELVEPGQPLAEGQIYNSNRYWLLPALQQLGCEVIDLGHVGDALEPTRQ
CCEEEEEEECCCHHCCCCCCCCCCEEECCCCEEEEHHHHHCCCEEEEECCCCCHHHHHHH
LLRDAAMVADVVITCGGVSVGEEDHVKAAVEAEGELTLWKVAIKPGKPLAYGKVGSADFI
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCCEECCCCCCCCEE
GLPGNPVSGYVTLQTLIKPFLQKRMGLEVPPPETQRLPAAFAWDKPDTRRSEFLRVRKLA
CCCCCCCCHHEEHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
GQLQLYPQQGSGVLMSCAWADGLVWLQPGQQVKPGDELAYLELT
CCEEEEECCCCCEEEEEECCCCEEEECCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
GPAHRKTGLEYRMLSYQQARDWLLERAKPLNTHQELPLMQALGRVLAQPVAAGMDVPPH
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCC
DNSAMDGYALRCADLAPAMAVTQRVPAGSVPAPLQAGTAARIFTGAPIPPGADAVIMQEQ
CCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECC
ADLDGEGRVTFSAEPSPGQNIRRRGEDIAAGQRILEAGRKLSAADLGLAASIGLARLPVL
CCCCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHHCCCCCHHHCCHHHHCCHHHCCCC
PRLRVAAFFTGDELVEPGQPLAEGQIYNSNRYWLLPALQQLGCEVIDLGHVGDALEPTRQ
CCEEEEEEECCCHHCCCCCCCCCCEEECCCCEEEEHHHHHCCCEEEEECCCCCHHHHHHH
LLRDAAMVADVVITCGGVSVGEEDHVKAAVEAEGELTLWKVAIKPGKPLAYGKVGSADFI
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCCEECCCCCCCCEE
GLPGNPVSGYVTLQTLIKPFLQKRMGLEVPPPETQRLPAAFAWDKPDTRRSEFLRVRKLA
CCCCCCCCHHEEHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
GQLQLYPQQGSGVLMSCAWADGLVWLQPGQQVKPGDELAYLELT
CCEEEEECCCCCEEEEEECCCCEEEECCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]