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The map label for this gene is maeN [H]

Identifier: 34497622

GI number: 34497622

Start: 2339600

End: 2340922

Strand: Reverse

Name: maeN [H]

Synonym: CV_2167

Alternate gene names: 34497622

Gene position: 2340922-2339600 (Counterclockwise)

Preceding gene: 34497623

Following gene: 34497607

Centisome position: 49.27

GC content: 60.17

Gene sequence:

>1323_bases
ATGCATATAGAGGAAACCGTTAGCAAGCCGCCGGCAGGCAATGGGCCATGGAGCAAATTGATGGCCATGCGCGTCGGACC
GCTGCCCTTGCCGCTCTATTTGTCGCTCGCCGCCATTGCAGTCGCCGCCGCCATCGCGCATCGCCTGCCGAACGACCTGA
TCGGCGGCCTGGCCGTCATGATGCTGTCCGGCTTTCTGCTGGGCGAGCTAGGCAAGAGGATTCCCGTGCTCAAGCATATC
GGCGGCTCGGCCATTCTCTGCCTGTTTGTCCCCTCGGCATTGCTGGGATACAAGCTATTCGACCCCGACATGCTGAAAGC
GCTGGCCATGGCGATGAAGACCGCCAATCTGCAATACCTCTACATTGCCTGTCTGGTGGTCGGCAGCATTCTCGGCATGA
ACCACAAGGTTTTGGTGCAGGGCTTTTTGCGGATGTTCATCCCGCTGCTGGTGGGAACGCTGGGCGCCGTCGCCGCCGGC
ATGCTTGTCGGCCTATTGTCCGGCTACACCCCTGGGCACACCTTCTTCTACATCATCATTCCCATTTTGGGCGGTGGCAT
CGGCGAGGGCATTCTGCCGCTCTCCATCGGCTATTCCGAAATGACCCGAATCCCGCAGGCTCAAATTGTCGCCACACTGA
TTCCCGCGGCGCTGATCGGCAATGTCGTCGCCATCCTGCTGGCCGGCCTGCTCAATTTTTATGGCAAGAAGCGCCCGCGA
TTCAGCGGCAATGGCATGCTGGTCAAAACCGGGGAGGATCGGGAATGGCTGGCCGCGCAACATGAAGCGCCGATCAATTT
GAGCTTGATGGGAAGCGGCTTGCTGCTCACCTGTTCTTTTTTCACCCTGGGGTCTTTATTTGCCCCGATTACCGGCATCC
CGGGGCCGATCCTGATGATTATCACCGCCGCCCTGGTCAAGGTGAGCAAGGTGATGCCGGCGCAGATGGAGCTGGGCGCC
TACCAGATGTACCAATTCATGACGAGCAATCTGACATACGCCATCCTGGTTGGGCTGGGCACCCTATTCGTGCCATGGAA
CCAGATGGTGGCTTCCGTCACCCCCGGGTATGTTCTGCTCTGCGCGGCGATCGTGCTGGCCATGGTGGCCAGCGGCTTCG
GCATCGGCCTGTTGCTGAAGATGTATCCGGTGGAATCGGCCATTGTCGCCGCCTGCCATAGCGGCCTGGGCGGCACCGGC
GACGTGGCGATCCTGTCGGCCGCCAACCGGATGGAAATGATGCCCTTCGCGCAAATCTCGACCCGTATCGGCGGGGCGTC
AATGATCGTTCTGGCCACACTGCTGATGAAGCTTCTCCACTAG

Upstream 100 bases:

>100_bases
AAGACATCGCATCCATGACAAAAAACCGTTTGGCGTAAGCGGGCGCCCTGCCGGGCCACCAGCCCGGCGGCGCCGTCACG
CCCTATCAGAGGAGACAAAA

Downstream 100 bases:

>100_bases
CCATCAAGAGACCGTGGCCGCCCTCTTCCAGCAGCGCAGAAAAGCCTCGCTCCCGGTCTCTTGCCGCACGCTCACGACCA
GTCCGGCTTCAACACCATCA

Product: Na+/malate symporter

Products: NA

Alternate protein names: Sodium-dependent malate transporter [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MHIEETVSKPPAGNGPWSKLMAMRVGPLPLPLYLSLAAIAVAAAIAHRLPNDLIGGLAVMMLSGFLLGELGKRIPVLKHI
GGSAILCLFVPSALLGYKLFDPDMLKALAMAMKTANLQYLYIACLVVGSILGMNHKVLVQGFLRMFIPLLVGTLGAVAAG
MLVGLLSGYTPGHTFFYIIIPILGGGIGEGILPLSIGYSEMTRIPQAQIVATLIPAALIGNVVAILLAGLLNFYGKKRPR
FSGNGMLVKTGEDREWLAAQHEAPINLSLMGSGLLLTCSFFTLGSLFAPITGIPGPILMIITAALVKVSKVMPAQMELGA
YQMYQFMTSNLTYAILVGLGTLFVPWNQMVASVTPGYVLLCAAIVLAMVASGFGIGLLLKMYPVESAIVAACHSGLGGTG
DVAILSAANRMEMMPFAQISTRIGGASMIVLATLLMKLLH

Sequences:

>Translated_440_residues
MHIEETVSKPPAGNGPWSKLMAMRVGPLPLPLYLSLAAIAVAAAIAHRLPNDLIGGLAVMMLSGFLLGELGKRIPVLKHI
GGSAILCLFVPSALLGYKLFDPDMLKALAMAMKTANLQYLYIACLVVGSILGMNHKVLVQGFLRMFIPLLVGTLGAVAAG
MLVGLLSGYTPGHTFFYIIIPILGGGIGEGILPLSIGYSEMTRIPQAQIVATLIPAALIGNVVAILLAGLLNFYGKKRPR
FSGNGMLVKTGEDREWLAAQHEAPINLSLMGSGLLLTCSFFTLGSLFAPITGIPGPILMIITAALVKVSKVMPAQMELGA
YQMYQFMTSNLTYAILVGLGTLFVPWNQMVASVTPGYVLLCAAIVLAMVASGFGIGLLLKMYPVESAIVAACHSGLGGTG
DVAILSAANRMEMMPFAQISTRIGGASMIVLATLLMKLLH
>Mature_440_residues
MHIEETVSKPPAGNGPWSKLMAMRVGPLPLPLYLSLAAIAVAAAIAHRLPNDLIGGLAVMMLSGFLLGELGKRIPVLKHI
GGSAILCLFVPSALLGYKLFDPDMLKALAMAMKTANLQYLYIACLVVGSILGMNHKVLVQGFLRMFIPLLVGTLGAVAAG
MLVGLLSGYTPGHTFFYIIIPILGGGIGEGILPLSIGYSEMTRIPQAQIVATLIPAALIGNVVAILLAGLLNFYGKKRPR
FSGNGMLVKTGEDREWLAAQHEAPINLSLMGSGLLLTCSFFTLGSLFAPITGIPGPILMIITAALVKVSKVMPAQMELGA
YQMYQFMTSNLTYAILVGLGTLFVPWNQMVASVTPGYVLLCAAIVLAMVASGFGIGLLLKMYPVESAIVAACHSGLGGTG
DVAILSAANRMEMMPFAQISTRIGGASMIVLATLLMKLLH

Specific function: Acts as a Na(+)-malate symporter, as it catalyzes malate-dependent uptake of Na(+) and Na(+)-dependent uptake of malate [H]

COG id: COG3493

COG function: function code C; Na+/citrate symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:citrate (SCF) symporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004679
- InterPro:   IPR018025 [H]

Pfam domain/function: PF03390 2HCT [H]

EC number: NA

Molecular weight: Translated: 46278; Mature: 46278

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIEETVSKPPAGNGPWSKLMAMRVGPLPLPLYLSLAAIAVAAAIAHRLPNDLIGGLAVM
CCCHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
MLSGFLLGELGKRIPVLKHIGGSAILCLFVPSALLGYKLFDPDMLKALAMAMKTANLQYL
HHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHH
YIACLVVGSILGMNHKVLVQGFLRMFIPLLVGTLGAVAAGMLVGLLSGYTPGHTFFYIII
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHH
PILGGGIGEGILPLSIGYSEMTRIPQAQIVATLIPAALIGNVVAILLAGLLNFYGKKRPR
HHHCCCCCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FSGNGMLVKTGEDREWLAAQHEAPINLSLMGSGLLLTCSFFTLGSLFAPITGIPGPILMI
CCCCCEEEECCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
ITAALVKVSKVMPAQMELGAYQMYQFMTSNLTYAILVGLGTLFVPWNQMVASVTPGYVLL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHCCCHHHHH
CAAIVLAMVASGFGIGLLLKMYPVESAIVAACHSGLGGTGDVAILSAANRMEMMPFAQIS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHCCHHHHHH
TRIGGASMIVLATLLMKLLH
HHCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MHIEETVSKPPAGNGPWSKLMAMRVGPLPLPLYLSLAAIAVAAAIAHRLPNDLIGGLAVM
CCCHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
MLSGFLLGELGKRIPVLKHIGGSAILCLFVPSALLGYKLFDPDMLKALAMAMKTANLQYL
HHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHH
YIACLVVGSILGMNHKVLVQGFLRMFIPLLVGTLGAVAAGMLVGLLSGYTPGHTFFYIII
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHH
PILGGGIGEGILPLSIGYSEMTRIPQAQIVATLIPAALIGNVVAILLAGLLNFYGKKRPR
HHHCCCCCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FSGNGMLVKTGEDREWLAAQHEAPINLSLMGSGLLLTCSFFTLGSLFAPITGIPGPILMI
CCCCCEEEECCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
ITAALVKVSKVMPAQMELGAYQMYQFMTSNLTYAILVGLGTLFVPWNQMVASVTPGYVLL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHCCCHHHHH
CAAIVLAMVASGFGIGLLLKMYPVESAIVAACHSGLGGTGDVAILSAANRMEMMPFAQIS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHCCHHHHHH
TRIGGASMIVLATLLMKLLH
HHCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 10903309; 12949159 [H]