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The map label for this gene is atoB [H]

Identifier: 34497543

GI number: 34497543

Start: 2273901

End: 2275085

Strand: Direct

Name: atoB [H]

Synonym: CV_2088

Alternate gene names: 34497543

Gene position: 2273901-2275085 (Clockwise)

Preceding gene: 34497542

Following gene: 34497544

Centisome position: 47.86

GC content: 68.78

Gene sequence:

>1185_bases
ATGCAACAACAGGAAATCGTGATCGTGGGCATGGCGCGCACCGCCATGGGCGGCTTCCAGGGCGCGCTGTCCGGTCTGAC
CGCCAGCCAGCTGGGCGCGGCCGCGATCCGCGCCGCGGTGGAGCGCGCAGGCGTCTCCGCCGGCGATGTGGACGAAGTGA
TCATGGGCTGCGTGCTGCCGGCCGGCCAGGGCCAGGCCCCGGCGCGCCAGGCGGCCCTGGGCGGTGGCTTGCCGCAGTCC
ACGCCGTGCACCACCATCAACAAGATGTGCGGCTCCGGCATGAAGGCGCTGATGATGGCGCATGACCAATTGCTGGCCGG
CAACGGCGGCGTTGTGGTGGCCGGCGGCATGGAGAGCATGAGCAACGCGCCCTATCTGATGCCCAAGGCCCGCGGCGGCC
TGCGCCTGGGTCATGGCGAAATCAAGGACCACATGTTCCTGGACGGCCTGGAGGATGCTTATCAGAAGGGCACGCTGATG
GGGGTGTTCGCCGAGCAGTGCGCCGAGAAATACGGCTTCAGCCGCCAGGACCAGGATGAGTTCGCCATCGCCTCGCTGAC
CCGCGCCCAGCAGGCGATCAAGGGCGGCCAGTTCAAGGACGAGATCGCCGCTGTCACGGTGCCGGGCCGCGGCGGCGACA
CGGTGGTGGACACCGACGAGCAGCCGCTGAAGGCCAATCTGGACAAGATCCCGACCTTGAAGCCGGCATTCAAGAAGGAC
GGCACCGTGACCCCGGCCAACTCCAGCTCCATCTCCGACGGCGGCGCCGCGCTGGTGTTGATGACGGCGGCCGAGGCGGC
CAAACGCGGCCTGAAGCCCATCGCCCGCGTGGTCGGCCACAGCAGCTTCGCCCACGAGCCGGGCTGGTTCACCACCGCCC
CGGTGCACGCCATTGAAAAGCTGCTGGCCAAGACCGGCTGGAGGGCCGGCGAGGTCGATCTGTACGAGATCAACGAAGCC
TTCGCCGTGGTGACGATGGCGGCGATGCACGACCTGAAGCTGCCGCACGACAAGGTGAACGTGCATGGCGGCGCTTGCGC
GCTGGGCCATCCGATCGGCGCGTCCGGCGCCCGCATCGTGATCTCGCTGCTGTCCGCGCTGAAACAGCGCGGCGGCAAGC
GCGGCGTGGCCAGCCTGTGCATAGGCGGCGGCGAAGCCACCGCGCTGGCGGTCGAGCTGATCTAA

Upstream 100 bases:

>100_bases
ACATCAAGGTGGTGCTGACCGAAATCGGCCAGTTGCGCGGCCAGTGCGAGAAATCGCTGGGCAAGCGCGCCAACGGCCAC
AACCAAGCAAAGGAGCTGTG

Downstream 100 bases:

>100_bases
GCGCTTGCCGCGCCGGCCGACGAGCCGCAGGGCATTCCTGCGGCTCGTTTGTTTTGTAACTTGCCTTGTCGTCGGCGATG
GCGGATTTTGATAGAGTCGC

Product: acetyl-CoA C-acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MQQQEIVIVGMARTAMGGFQGALSGLTASQLGAAAIRAAVERAGVSAGDVDEVIMGCVLPAGQGQAPARQAALGGGLPQS
TPCTTINKMCGSGMKALMMAHDQLLAGNGGVVVAGGMESMSNAPYLMPKARGGLRLGHGEIKDHMFLDGLEDAYQKGTLM
GVFAEQCAEKYGFSRQDQDEFAIASLTRAQQAIKGGQFKDEIAAVTVPGRGGDTVVDTDEQPLKANLDKIPTLKPAFKKD
GTVTPANSSSISDGGAALVLMTAAEAAKRGLKPIARVVGHSSFAHEPGWFTTAPVHAIEKLLAKTGWRAGEVDLYEINEA
FAVVTMAAMHDLKLPHDKVNVHGGACALGHPIGASGARIVISLLSALKQRGGKRGVASLCIGGGEATALAVELI

Sequences:

>Translated_394_residues
MQQQEIVIVGMARTAMGGFQGALSGLTASQLGAAAIRAAVERAGVSAGDVDEVIMGCVLPAGQGQAPARQAALGGGLPQS
TPCTTINKMCGSGMKALMMAHDQLLAGNGGVVVAGGMESMSNAPYLMPKARGGLRLGHGEIKDHMFLDGLEDAYQKGTLM
GVFAEQCAEKYGFSRQDQDEFAIASLTRAQQAIKGGQFKDEIAAVTVPGRGGDTVVDTDEQPLKANLDKIPTLKPAFKKD
GTVTPANSSSISDGGAALVLMTAAEAAKRGLKPIARVVGHSSFAHEPGWFTTAPVHAIEKLLAKTGWRAGEVDLYEINEA
FAVVTMAAMHDLKLPHDKVNVHGGACALGHPIGASGARIVISLLSALKQRGGKRGVASLCIGGGEATALAVELI
>Mature_394_residues
MQQQEIVIVGMARTAMGGFQGALSGLTASQLGAAAIRAAVERAGVSAGDVDEVIMGCVLPAGQGQAPARQAALGGGLPQS
TPCTTINKMCGSGMKALMMAHDQLLAGNGGVVVAGGMESMSNAPYLMPKARGGLRLGHGEIKDHMFLDGLEDAYQKGTLM
GVFAEQCAEKYGFSRQDQDEFAIASLTRAQQAIKGGQFKDEIAAVTVPGRGGDTVVDTDEQPLKANLDKIPTLKPAFKKD
GTVTPANSSSISDGGAALVLMTAAEAAKRGLKPIARVVGHSSFAHEPGWFTTAPVHAIEKLLAKTGWRAGEVDLYEINEA
FAVVTMAAMHDLKLPHDKVNVHGGACALGHPIGASGARIVISLLSALKQRGGKRGVASLCIGGGEATALAVELI

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=391, Percent_Identity=48.5933503836317, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=46.9230769230769, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=37.1794871794872, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI4501853, Length=401, Percent_Identity=35.1620947630923, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=30.4245283018868, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI194353979, Length=396, Percent_Identity=28.7878787878788, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI87082165, Length=390, Percent_Identity=46.1538461538462, Blast_Score=341, Evalue=4e-95,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=47.1938775510204, Blast_Score=311, Evalue=7e-86,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=37.7171215880893, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=35.3960396039604, Blast_Score=201, Evalue=5e-53,
Organism=Escherichia coli, GI1788683, Length=412, Percent_Identity=29.126213592233, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25147385, Length=392, Percent_Identity=40.5612244897959, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=41.1167512690355, Blast_Score=294, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=40.5128205128205, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17535917, Length=407, Percent_Identity=32.1867321867322, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=31.6784869976359, Blast_Score=184, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=46.5994962216625, Blast_Score=338, Evalue=7e-94,
Organism=Saccharomyces cerevisiae, GI6322031, Length=389, Percent_Identity=33.4190231362468, Blast_Score=190, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=48.2051282051282, Blast_Score=354, Evalue=5e-98,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=48.4615384615385, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI17648125, Length=395, Percent_Identity=37.7215189873418, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=29.2740046838407, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40517; Mature: 40517

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQQEIVIVGMARTAMGGFQGALSGLTASQLGAAAIRAAVERAGVSAGDVDEVIMGCVLP
CCCCCEEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
AGQGQAPARQAALGGGLPQSTPCTTINKMCGSGMKALMMAHDQLLAGNGGVVVAGGMESM
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHEECCCCEEEECCHHHH
SNAPYLMPKARGGLRLGHGEIKDHMFLDGLEDAYQKGTLMGVFAEQCAEKYGFSRQDQDE
CCCCEECCCCCCCEEECCCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHH
FAIASLTRAQQAIKGGQFKDEIAAVTVPGRGGDTVVDTDEQPLKANLDKIPTLKPAFKKD
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEECCCCCCHHCCHHHCCCCCCHHCCC
GTVTPANSSSISDGGAALVLMTAAEAAKRGLKPIARVVGHSSFAHEPGWFTTAPVHAIEK
CCCCCCCCCCCCCCCCEEEEEEHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
LLAKTGWRAGEVDLYEINEAFAVVTMAAMHDLKLPHDKVNVHGGACALGHPIGASGARIV
HHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCEECCCCEEECCCCCCCCHHHHH
ISLLSALKQRGGKRGVASLCIGGGEATALAVELI
HHHHHHHHHCCCCCCCHHEEECCCCEEEEEEEEC
>Mature Secondary Structure
MQQQEIVIVGMARTAMGGFQGALSGLTASQLGAAAIRAAVERAGVSAGDVDEVIMGCVLP
CCCCCEEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
AGQGQAPARQAALGGGLPQSTPCTTINKMCGSGMKALMMAHDQLLAGNGGVVVAGGMESM
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHEECCCCEEEECCHHHH
SNAPYLMPKARGGLRLGHGEIKDHMFLDGLEDAYQKGTLMGVFAEQCAEKYGFSRQDQDE
CCCCEECCCCCCCEEECCCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHH
FAIASLTRAQQAIKGGQFKDEIAAVTVPGRGGDTVVDTDEQPLKANLDKIPTLKPAFKKD
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEECCCCCCHHCCHHHCCCCCCHHCCC
GTVTPANSSSISDGGAALVLMTAAEAAKRGLKPIARVVGHSSFAHEPGWFTTAPVHAIEK
CCCCCCCCCCCCCCCCEEEEEEHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
LLAKTGWRAGEVDLYEINEAFAVVTMAAMHDLKLPHDKVNVHGGACALGHPIGASGARIV
HHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCEECCCCEEECCCCCCCCHHHHH
ISLLSALKQRGGKRGVASLCIGGGEATALAVELI
HHHHHHHHHCCCCCCCHHEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]