Click here to switch to the map view.

The map label for this gene is appC [H]

Identifier: 34497435

GI number: 34497435

Start: 2155778

End: 2156836

Strand: Direct

Name: appC [H]

Synonym: CV_1980

Alternate gene names: 34497435

Gene position: 2155778-2156836 (Clockwise)

Preceding gene: 34497434

Following gene: 34497436

Centisome position: 45.37

GC content: 65.44

Gene sequence:

>1059_bases
ATGACGACATTGCAGAATACCGCCGGCGCCGCGCCGGCCGCGCCGTCCCGCAGCCTGTGGGGCCTGGGATGGCAGCGCCT
GAAGCGCAATAAGGTGGGTTTTATTTCGATGTGGATCGTGCTGGCCTATCTGCTGGTCTCGATCGGCGGCTGGTTCAATC
TGGTGGGGGCGCACTGGACGGACGAGGTGGGTGTCCCTTATGCGCCGCCAAGCTGGGTCAATGAGTCCCCGGACGATGTG
TTGCCGCCGGAGCCGACGGCTAAGGCCGCTGCCGCGCCCACTGTCGAACTGAGCCGCGCCGAGGATCCGATCGGCAAGCA
GCTGTCCGAGGCGGAGAAGCATGTCGGCGAATACGCCGACCACACGCCGCCGCGGCAGGAGCGACTGCCGTTCGGCGGCG
ATCTGCAGGGCCGGGACGTGATCCAGAAAGCGTTGAAGGGCACGTCCACGTCCATCTTCGTCGGTGTGTTCGGCGCGGTG
TTTTCTCTGCTGATCGGCTGCGCGCTGGGCGCGGTGTCCGGCTATTTCGGCGGCAAGACCGACGATTTCCTCAACTGGTT
CTACAGCGTGTTCACTTCGGTGCCTGACATGCTGCTGCTGCTGTCCTTCGCCGCGGTGTCCGGCCGCGGCATCACCACCA
TCATTTCGGTGATGGCGCTGACCAGCTGGACCGGCACCTACCGCCTGGTGCGCGCCGAGTACCTGAAGCTGAAAGGCCGC
GAGTACGTGCAGGCGGCGGACGCCATCGGCGCCGGCAGCAGCCGGAAAATGTTTGTCCATATCCTGCCCAACCTCTCCCA
CCTGCTGCTGGTGCAGTTCTCCTTGCTGACGGTGGCGCTGATCAAGTACGAGGCCATTCTGTCCTTCCTCGGCTTCGGCG
TCGGCGTGCGCGAAGTGAGCCTGGGTTCGATGCTGGCCGAAGCGCCGACCGAGCTGATCCAGGGCTACTGGTGGCAGATG
CTGGCGGTGACCATCGCCATGTCGGTGCTGGTGACGGCGTTCAGCCTGCTGGTGGATGCTTTGCGCGACGCGCTGGACCC
GCGCGCGGCGGCCAAGTGA

Upstream 100 bases:

>100_bases
TATATCGCCATCGCCACCATGGTGTTCAACCTGTTGGGCGACCTGGTCTACAAGTGGATCGATCCGCGCGTGCAACTGAA
GTAAGCGGAGGAGAACAATC

Downstream 100 bases:

>100_bases
GCGGGATGAGGAGAAATGGATATGAGCGATAACAAAACCCTGCTTTCGGTCCGCAACCTGCGGGTGCGTTTCCGCCAGGA
GGACGGCGGCCGCTTCGAGG

Product: ABC transporter permease

Products: ADP; phosphate; oligopeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTTLQNTAGAAPAAPSRSLWGLGWQRLKRNKVGFISMWIVLAYLLVSIGGWFNLVGAHWTDEVGVPYAPPSWVNESPDDV
LPPEPTAKAAAAPTVELSRAEDPIGKQLSEAEKHVGEYADHTPPRQERLPFGGDLQGRDVIQKALKGTSTSIFVGVFGAV
FSLLIGCALGAVSGYFGGKTDDFLNWFYSVFTSVPDMLLLLSFAAVSGRGITTIISVMALTSWTGTYRLVRAEYLKLKGR
EYVQAADAIGAGSSRKMFVHILPNLSHLLLVQFSLLTVALIKYEAILSFLGFGVGVREVSLGSMLAEAPTELIQGYWWQM
LAVTIAMSVLVTAFSLLVDALRDALDPRAAAK

Sequences:

>Translated_352_residues
MTTLQNTAGAAPAAPSRSLWGLGWQRLKRNKVGFISMWIVLAYLLVSIGGWFNLVGAHWTDEVGVPYAPPSWVNESPDDV
LPPEPTAKAAAAPTVELSRAEDPIGKQLSEAEKHVGEYADHTPPRQERLPFGGDLQGRDVIQKALKGTSTSIFVGVFGAV
FSLLIGCALGAVSGYFGGKTDDFLNWFYSVFTSVPDMLLLLSFAAVSGRGITTIISVMALTSWTGTYRLVRAEYLKLKGR
EYVQAADAIGAGSSRKMFVHILPNLSHLLLVQFSLLTVALIKYEAILSFLGFGVGVREVSLGSMLAEAPTELIQGYWWQM
LAVTIAMSVLVTAFSLLVDALRDALDPRAAAK
>Mature_351_residues
TTLQNTAGAAPAAPSRSLWGLGWQRLKRNKVGFISMWIVLAYLLVSIGGWFNLVGAHWTDEVGVPYAPPSWVNESPDDVL
PPEPTAKAAAAPTVELSRAEDPIGKQLSEAEKHVGEYADHTPPRQERLPFGGDLQGRDVIQKALKGTSTSIFVGVFGAVF
SLLIGCALGAVSGYFGGKTDDFLNWFYSVFTSVPDMLLLLSFAAVSGRGITTIISVMALTSWTGTYRLVRAEYLKLKGRE
YVQAADAIGAGSSRKMFVHILPNLSHLLLVQFSLLTVALIKYEAILSFLGFGVGVREVSLGSMLAEAPTELIQGYWWQML
AVTIAMSVLVTAFSLLVDALRDALDPRAAAK

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788505, Length=339, Percent_Identity=26.8436578171091, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787054, Length=220, Percent_Identity=35.4545454545455, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1787760, Length=224, Percent_Identity=31.25, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789964, Length=218, Percent_Identity=35.7798165137615, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1787498, Length=226, Percent_Identity=31.4159292035398, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1789889, Length=231, Percent_Identity=31.1688311688312, Blast_Score=88, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 37994; Mature: 37863

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLQNTAGAAPAAPSRSLWGLGWQRLKRNKVGFISMWIVLAYLLVSIGGWFNLVGAHWT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DEVGVPYAPPSWVNESPDDVLPPEPTAKAAAAPTVELSRAEDPIGKQLSEAEKHVGEYAD
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHC
HTPPRQERLPFGGDLQGRDVIQKALKGTSTSIFVGVFGAVFSLLIGCALGAVSGYFGGKT
CCCCHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DDFLNWFYSVFTSVPDMLLLLSFAAVSGRGITTIISVMALTSWTGTYRLVRAEYLKLKGR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCH
EYVQAADAIGAGSSRKMFVHILPNLSHLLLVQFSLLTVALIKYEAILSFLGFGVGVREVS
HHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LGSMLAEAPTELIQGYWWQMLAVTIAMSVLVTAFSLLVDALRDALDPRAAAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TTLQNTAGAAPAAPSRSLWGLGWQRLKRNKVGFISMWIVLAYLLVSIGGWFNLVGAHWT
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DEVGVPYAPPSWVNESPDDVLPPEPTAKAAAAPTVELSRAEDPIGKQLSEAEKHVGEYAD
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHC
HTPPRQERLPFGGDLQGRDVIQKALKGTSTSIFVGVFGAVFSLLIGCALGAVSGYFGGKT
CCCCHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DDFLNWFYSVFTSVPDMLLLLSFAAVSGRGITTIISVMALTSWTGTYRLVRAEYLKLKGR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCH
EYVQAADAIGAGSSRKMFVHILPNLSHLLLVQFSLLTVALIKYEAILSFLGFGVGVREVS
HHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LGSMLAEAPTELIQGYWWQMLAVTIAMSVLVTAFSLLVDALRDALDPRAAAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; oligopeptides [Periplasm]; H2O [C]

Specific reaction: ATP + oligopeptides [Periplasm] + H2O = ADP + phosphate + oligopeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]