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The map label for this gene is mtnP [H]

Identifier: 34496855

GI number: 34496855

Start: 1474831

End: 1475739

Strand: Reverse

Name: mtnP [H]

Synonym: CV_1400

Alternate gene names: 34496855

Gene position: 1475739-1474831 (Counterclockwise)

Preceding gene: 34496856

Following gene: 34496854

Centisome position: 31.06

GC content: 68.43

Gene sequence:

>909_bases
ATGACTGAATCCCATCCGGCCCGCATCGGCATCATAGGCGGCAGCGGTTTCCAGCGCCTGCTGGGCCTGACCGACTCCCG
CGTCCACCATTGCGCCACCGCCTTCGGCGCGCCGTCGTCGCCGGTGACCACCGGCTATCTCGGCGGCGTGCCGGTCGCTT
TCCTGCAGCGGCACGGCCCCGGCCATACCATCCCGCCCGCCTCCATCAACGCCAGGGCCAACATCGCCGCGCTGCGCCGC
GTCGGCTGCACCCAGATCCTGTCGCTGAGCGCGGTGGGCAGCCTGCGCGAGGATGTGCCCCCCGGCCGCTTCGTGTTGGT
CGACCAGTTCATCGACCGCACGCTGATGCGGGACAAGACCTTCTTCGGTCCCGGCCTGGTCGGCCACGTGCCTTTCGGCG
ACCCGGTCTGCGGACGGATGCGCGAAACGCTGGCCGACAGCGTCGGCGCAACGGGCGTGCCGGCCCGCGACGGCGGCACC
TACGTGGTGATGGAAGGTCCGCAATTCTCCACCCGCGCCGAATCCCTGCTCTATCGCCAGTGGGGAGGCACCGTGATAGG
CATGACCGCAATGCCGGAAGCCAAGCTCGCCCGCGAAGCCGAGCTGTGCTACGCGCTGGTGGCCATCCCCACCGATTACG
ACTGCTGGTTCGAATCGCAGGAACCGGTCAATGCCGCGCTGGTGGCGGAGCGGATGGCCGAAGTCGGCGACAGCGCGCGC
CGCCTGGTGGAAGAAGCGGTGCAACGCCTGGGACGCCACGCCGGCGCCTGCCGCTGCGGCTGCGACCGCGCGCTGGACAC
CGCGATCATGACCGCGCCGGAACAACGCGATCCGGCCATGCTCGCGAAACTGTTGACCGTGGCGCCAAACGCCAACCGAT
TGATGAACAAGCAAAAGGAAAATTCATGA

Upstream 100 bases:

>100_bases
CTGTTCCGCCGCGGCAACGCGCCGTCGGCGCTGTCCGAGCTGCGCGAGCGGCTGGTCGCACAGCCCTTGTCCGGCCGCCT
CTCCACCCAAGGAAGCCACC

Downstream 100 bases:

>100_bases
GCGATGTCGCCGCCACTCGGGAACGGGTGCGCATCCAGAAAGTGGAAGTGTTGTCCGATGACTGGTACGTGCTGCGCAAG
ACCACTTTCGACTACCGGCG

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTESHPARIGIIGGSGFQRLLGLTDSRVHHCATAFGAPSSPVTTGYLGGVPVAFLQRHGPGHTIPPASINARANIAALRR
VGCTQILSLSAVGSLREDVPPGRFVLVDQFIDRTLMRDKTFFGPGLVGHVPFGDPVCGRMRETLADSVGATGVPARDGGT
YVVMEGPQFSTRAESLLYRQWGGTVIGMTAMPEAKLAREAELCYALVAIPTDYDCWFESQEPVNAALVAERMAEVGDSAR
RLVEEAVQRLGRHAGACRCGCDRALDTAIMTAPEQRDPAMLAKLLTVAPNANRLMNKQKENS

Sequences:

>Translated_302_residues
MTESHPARIGIIGGSGFQRLLGLTDSRVHHCATAFGAPSSPVTTGYLGGVPVAFLQRHGPGHTIPPASINARANIAALRR
VGCTQILSLSAVGSLREDVPPGRFVLVDQFIDRTLMRDKTFFGPGLVGHVPFGDPVCGRMRETLADSVGATGVPARDGGT
YVVMEGPQFSTRAESLLYRQWGGTVIGMTAMPEAKLAREAELCYALVAIPTDYDCWFESQEPVNAALVAERMAEVGDSAR
RLVEEAVQRLGRHAGACRCGCDRALDTAIMTAPEQRDPAMLAKLLTVAPNANRLMNKQKENS
>Mature_301_residues
TESHPARIGIIGGSGFQRLLGLTDSRVHHCATAFGAPSSPVTTGYLGGVPVAFLQRHGPGHTIPPASINARANIAALRRV
GCTQILSLSAVGSLREDVPPGRFVLVDQFIDRTLMRDKTFFGPGLVGHVPFGDPVCGRMRETLADSVGATGVPARDGGTY
VVMEGPQFSTRAESLLYRQWGGTVIGMTAMPEAKLAREAELCYALVAIPTDYDCWFESQEPVNAALVAERMAEVGDSARR
LVEEAVQRLGRHAGACRCGCDRALDTAIMTAPEQRDPAMLAKLLTVAPNANRLMNKQKENS

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=258, Percent_Identity=41.4728682170543, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71980569, Length=252, Percent_Identity=37.6984126984127, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323045, Length=304, Percent_Identity=38.4868421052632, Blast_Score=185, Evalue=9e-48,
Organism=Drosophila melanogaster, GI20130079, Length=275, Percent_Identity=40.3636363636364, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI221459247, Length=223, Percent_Identity=37.6681614349776, Blast_Score=164, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 32297; Mature: 32166

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESHPARIGIIGGSGFQRLLGLTDSRVHHCATAFGAPSSPVTTGYLGGVPVAFLQRHGP
CCCCCCCEEEEECCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCC
GHTIPPASINARANIAALRRVGCTQILSLSAVGSLREDVPPGRFVLVDQFIDRTLMRDKT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCC
FFGPGLVGHVPFGDPVCGRMRETLADSVGATGVPARDGGTYVVMEGPQFSTRAESLLYRQ
CCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
WGGTVIGMTAMPEAKLAREAELCYALVAIPTDYDCWFESQEPVNAALVAERMAEVGDSAR
CCCEEEEECCCCHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHH
RLVEEAVQRLGRHAGACRCGCDRALDTAIMTAPEQRDPAMLAKLLTVAPNANRLMNKQKE
HHHHHHHHHHHHHCCCCHHCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHC
NS
CC
>Mature Secondary Structure 
TESHPARIGIIGGSGFQRLLGLTDSRVHHCATAFGAPSSPVTTGYLGGVPVAFLQRHGP
CCCCCCEEEEECCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCC
GHTIPPASINARANIAALRRVGCTQILSLSAVGSLREDVPPGRFVLVDQFIDRTLMRDKT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCC
FFGPGLVGHVPFGDPVCGRMRETLADSVGATGVPARDGGTYVVMEGPQFSTRAESLLYRQ
CCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
WGGTVIGMTAMPEAKLAREAELCYALVAIPTDYDCWFESQEPVNAALVAERMAEVGDSAR
CCCEEEEECCCCHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHH
RLVEEAVQRLGRHAGACRCGCDRALDTAIMTAPEQRDPAMLAKLLTVAPNANRLMNKQKE
HHHHHHHHHHHHHCCCCHHCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHC
NS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA