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The map label for this gene is mutL [H]

Identifier: 34496797

GI number: 34496797

Start: 1412833

End: 1414728

Strand: Reverse

Name: mutL [H]

Synonym: CV_1342

Alternate gene names: 34496797

Gene position: 1414728-1412833 (Counterclockwise)

Preceding gene: 34496798

Following gene: 34496796

Centisome position: 29.78

GC content: 70.09

Gene sequence:

>1896_bases
ATGACACGCATCCAACGCCTGCCCGACCACCTCGTCAACCAGATCGCCGCCGGCGAGGTGGTGGAACGCCCCGCCTCCGC
GCTGAAGGAAATGCTGGAAAACAGCCTGGACGCCGGCGCGACGCGGATCAGCGTGGACCTGGCCCAGGGCGGCATCAAGC
TGATCCGGGTGACGGACAACGGCGCCGGCATCGCCGCCGACGACCTGCCGCTGGCGCTGGACCGCCACGCCACCAGCAAG
ATCGCGTCGCTGGACGACCTGGAATCGGTCTCCACGCTGGGCTTCCGCGGCGAGGGTCTGGCCAGCGTGGCGTCCGTGTC
GCGGCTGACGCTGACGAGCCGCCCGCACGATGCCGACCACGCCCACCAGATCATCGCGATAGACGGCACCCTGCATCCGG
TGGAGCCGGCCGCCCATCCGCACGGCACCAGCGTGGAAGTGGTGGACCTGTATTTCAACACCCCGGCGCGGCGCAAATTC
CTGAAGAGCGAAAACACCGAGTACGCGCACTGCGCGGCCACTTTCGAGCGCATCGCGCTGGCGCATCCGGAGGTGGAGTT
CCTGCTGCGCCACAACGGCAAGGTGGCGTGGCGGCTGCCGTCGCAAAGCGCCGAGGACCGCGTGGCCGCGCTGTTGGGCA
AGGACTTCGTCGCCGCCGCCATCCCGCTGGACAGCCAGGCCGGCCCGCTGGCGCTGAGCGGCTTCGTCGCCTCGCCCACA
TACTCCAAGGCCAGTCGCGACGCCCAGTACTTCTACGTAAACGGCCGCTTCGTGCGCGACAAGACCGCGCAGCACGCGCT
GCGCCAGGCCTATCGCGACGTGCTGCACCACGACCGCCATCCGGCCTACGCGCTGTTCTTCACGCTTGAGCCGTCCGGCG
TGGACGTCAACGTGCACCCGACCAAGATCGAAGTCCGCTTCCGCGAAAGCCAGGCGGTGCACCAGTTCCTGTTCCACAGC
GTGCACAAGGCATTGGCCGGCACCAGCGCCGGCGCCGCGCCGACGGTCCAGGTGGAAGGCGCGGAAACGGCCGCGCCGCA
GCTGCCCCGCGGCGAATCGGCGCCGCTGTTCGCCAGCGCCTCGCCCCAGCCGGCCTCGTCCGGCGCGCCGGCGCCGCAGC
CTTTCCAGTATCAACAGCAGTCCATCCCCCTGAACGTCGCGCGCGAGGCGGTGGGCGTCTACGACAAGCTGTTCGGCGGC
CTGCGCGAGGAAGAGCGGGCGCTGTCGCGCCCCGAGCCGGCGATGCCCTCCCCCGCCGCGCCGCTGCTGCATCCGGCGGT
GCTGGCCATGCCCGCCCACGACGAGAACGGCATCCCGCCGCTGGGCTTCGCGCTGGCGCAGCTGCACGGCGTCTACATCC
TCAGCCAATGCGCAGAAGGCCTGATCCTGGTGGACATGCACGCGGCGCACGAACGCATCGTCTACGAACGGCTGAAAGCC
GCGCTGGAGTCCGACGCCATCCCGCTGCAACCGCTGCTGCTGCCGGTGTCCTTCGCCGCCGACCGCATGGAGGTGGCCAC
CGCGCACGAGCATGGCGAGGAAATGAAGCGGCTGGGCGTGGAGCTGGCGCCGCTGTCCCCAACCCAGATCGCCGTGCGCG
GCGTGCCGGTGTGGCTGAAGGACGGCGACCCGGTGGAGCTGGCCCGCGCGGTGCTGAAGGACGTGCGCGAGTTCGGCCTG
ACCCAGGTGCTGACCGAGCGCCGCAACGAGCTCTTGGCCACCATGGCCTGCCATGGCGCGGTGCGCGCCAACCGCCAGCT
GACCTTGCCGGAAATGAACGCGCTGCTGCGCGACATGGAAGCCACCGAGCGTTCCGGCCAATGCAACCACGGCCGCCCCA
CCTGGACCCGGCTGACCATGCGCGACCTGGACAAGCTGTTCATGCGCGGCCAGTAA

Upstream 100 bases:

>100_bases
GGCGCCACAAGCGCGCGGCCACCCGCGGCTGATCCGTAGTAGAATCGACAAGGCCGCCGCAGCGCGGCCTTTCGTTTTTG
ATATTTCCGCGACGCCGCCC

Downstream 100 bases:

>100_bases
ATCCGTCCCGCCAGATAACAAGAAAGACAAGCATTGTTGCGGATACGGTTAGCCTTCCCCCTCGATACGCCATCCGGTCG
ACATCCGCGCGAAGAAAGCG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 631; Mature: 630

Protein sequence:

>631_residues
MTRIQRLPDHLVNQIAAGEVVERPASALKEMLENSLDAGATRISVDLAQGGIKLIRVTDNGAGIAADDLPLALDRHATSK
IASLDDLESVSTLGFRGEGLASVASVSRLTLTSRPHDADHAHQIIAIDGTLHPVEPAAHPHGTSVEVVDLYFNTPARRKF
LKSENTEYAHCAATFERIALAHPEVEFLLRHNGKVAWRLPSQSAEDRVAALLGKDFVAAAIPLDSQAGPLALSGFVASPT
YSKASRDAQYFYVNGRFVRDKTAQHALRQAYRDVLHHDRHPAYALFFTLEPSGVDVNVHPTKIEVRFRESQAVHQFLFHS
VHKALAGTSAGAAPTVQVEGAETAAPQLPRGESAPLFASASPQPASSGAPAPQPFQYQQQSIPLNVAREAVGVYDKLFGG
LREEERALSRPEPAMPSPAAPLLHPAVLAMPAHDENGIPPLGFALAQLHGVYILSQCAEGLILVDMHAAHERIVYERLKA
ALESDAIPLQPLLLPVSFAADRMEVATAHEHGEEMKRLGVELAPLSPTQIAVRGVPVWLKDGDPVELARAVLKDVREFGL
TQVLTERRNELLATMACHGAVRANRQLTLPEMNALLRDMEATERSGQCNHGRPTWTRLTMRDLDKLFMRGQ

Sequences:

>Translated_631_residues
MTRIQRLPDHLVNQIAAGEVVERPASALKEMLENSLDAGATRISVDLAQGGIKLIRVTDNGAGIAADDLPLALDRHATSK
IASLDDLESVSTLGFRGEGLASVASVSRLTLTSRPHDADHAHQIIAIDGTLHPVEPAAHPHGTSVEVVDLYFNTPARRKF
LKSENTEYAHCAATFERIALAHPEVEFLLRHNGKVAWRLPSQSAEDRVAALLGKDFVAAAIPLDSQAGPLALSGFVASPT
YSKASRDAQYFYVNGRFVRDKTAQHALRQAYRDVLHHDRHPAYALFFTLEPSGVDVNVHPTKIEVRFRESQAVHQFLFHS
VHKALAGTSAGAAPTVQVEGAETAAPQLPRGESAPLFASASPQPASSGAPAPQPFQYQQQSIPLNVAREAVGVYDKLFGG
LREEERALSRPEPAMPSPAAPLLHPAVLAMPAHDENGIPPLGFALAQLHGVYILSQCAEGLILVDMHAAHERIVYERLKA
ALESDAIPLQPLLLPVSFAADRMEVATAHEHGEEMKRLGVELAPLSPTQIAVRGVPVWLKDGDPVELARAVLKDVREFGL
TQVLTERRNELLATMACHGAVRANRQLTLPEMNALLRDMEATERSGQCNHGRPTWTRLTMRDLDKLFMRGQ
>Mature_630_residues
TRIQRLPDHLVNQIAAGEVVERPASALKEMLENSLDAGATRISVDLAQGGIKLIRVTDNGAGIAADDLPLALDRHATSKI
ASLDDLESVSTLGFRGEGLASVASVSRLTLTSRPHDADHAHQIIAIDGTLHPVEPAAHPHGTSVEVVDLYFNTPARRKFL
KSENTEYAHCAATFERIALAHPEVEFLLRHNGKVAWRLPSQSAEDRVAALLGKDFVAAAIPLDSQAGPLALSGFVASPTY
SKASRDAQYFYVNGRFVRDKTAQHALRQAYRDVLHHDRHPAYALFFTLEPSGVDVNVHPTKIEVRFRESQAVHQFLFHSV
HKALAGTSAGAAPTVQVEGAETAAPQLPRGESAPLFASASPQPASSGAPAPQPFQYQQQSIPLNVAREAVGVYDKLFGGL
REEERALSRPEPAMPSPAAPLLHPAVLAMPAHDENGIPPLGFALAQLHGVYILSQCAEGLILVDMHAAHERIVYERLKAA
LESDAIPLQPLLLPVSFAADRMEVATAHEHGEEMKRLGVELAPLSPTQIAVRGVPVWLKDGDPVELARAVLKDVREFGLT
QVLTERRNELLATMACHGAVRANRQLTLPEMNALLRDMEATERSGQCNHGRPTWTRLTMRDLDKLFMRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=333, Percent_Identity=35.4354354354354, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI4505911, Length=399, Percent_Identity=27.0676691729323, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI189458898, Length=399, Percent_Identity=27.0676691729323, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4505913, Length=328, Percent_Identity=27.7439024390244, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI310128478, Length=328, Percent_Identity=27.7439024390244, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI189458896, Length=395, Percent_Identity=25.5696202531646, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI263191589, Length=240, Percent_Identity=27.5, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI310128480, Length=293, Percent_Identity=24.5733788395904, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI91992162, Length=261, Percent_Identity=26.8199233716475, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI91992160, Length=261, Percent_Identity=26.8199233716475, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790612, Length=328, Percent_Identity=53.6585365853659, Blast_Score=335, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=37.8125, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17562796, Length=348, Percent_Identity=27.5862068965517, Blast_Score=134, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323819, Length=353, Percent_Identity=33.9943342776204, Blast_Score=208, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6324247, Length=347, Percent_Identity=26.5129682997118, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=290, Percent_Identity=26.551724137931, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=89, Percent_Identity=40.4494382022472, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17136968, Length=333, Percent_Identity=33.3333333333333, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17136970, Length=348, Percent_Identity=27.0114942528736, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 68552; Mature: 68421

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIQRLPDHLVNQIAAGEVVERPASALKEMLENSLDAGATRISVDLAQGGIKLIRVTDN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECC
GAGIAADDLPLALDRHATSKIASLDDLESVSTLGFRGEGLASVASVSRLTLTSRPHDADH
CCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEECCCCCCCCC
AHQIIAIDGTLHPVEPAAHPHGTSVEVVDLYFNTPARRKFLKSENTEYAHCAATFERIAL
CCEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHH
AHPEVEFLLRHNGKVAWRLPSQSAEDRVAALLGKDFVAAAIPLDSQAGPLALSGFVASPT
CCCCHHHHEECCCEEEEECCCCCHHHHHHHHHCCCHHEEECCCCCCCCCEEEECEECCCC
YSKASRDAQYFYVNGRFVRDKTAQHALRQAYRDVLHHDRHPAYALFFTLEPSGVDVNVHP
CCCCCCCCEEEEECCEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEECC
TKIEVRFRESQAVHQFLFHSVHKALAGTSAGAAPTVQVEGAETAAPQLPRGESAPLFASA
CEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEECC
SPQPASSGAPAPQPFQYQQQSIPLNVAREAVGVYDKLFGGLREEERALSRPEPAMPSPAA
CCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCC
PLLHPAVLAMPAHDENGIPPLGFALAQLHGVYILSQCAEGLILVDMHAAHERIVYERLKA
CHHCCHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHH
ALESDAIPLQPLLLPVSFAADRMEVATAHEHGEEMKRLGVELAPLSPTQIAVRGVPVWLK
HHHCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEECCEEEEC
DGDPVELARAVLKDVREFGLTQVLTERRNELLATMACHGAVRANRQLTLPEMNALLRDME
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHH
ATERSGQCNHGRPTWTRLTMRDLDKLFMRGQ
HHHCCCCCCCCCCCCEEHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRIQRLPDHLVNQIAAGEVVERPASALKEMLENSLDAGATRISVDLAQGGIKLIRVTDN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECC
GAGIAADDLPLALDRHATSKIASLDDLESVSTLGFRGEGLASVASVSRLTLTSRPHDADH
CCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEECCCCCCCCC
AHQIIAIDGTLHPVEPAAHPHGTSVEVVDLYFNTPARRKFLKSENTEYAHCAATFERIAL
CCEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHH
AHPEVEFLLRHNGKVAWRLPSQSAEDRVAALLGKDFVAAAIPLDSQAGPLALSGFVASPT
CCCCHHHHEECCCEEEEECCCCCHHHHHHHHHCCCHHEEECCCCCCCCCEEEECEECCCC
YSKASRDAQYFYVNGRFVRDKTAQHALRQAYRDVLHHDRHPAYALFFTLEPSGVDVNVHP
CCCCCCCCEEEEECCEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEECC
TKIEVRFRESQAVHQFLFHSVHKALAGTSAGAAPTVQVEGAETAAPQLPRGESAPLFASA
CEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEECC
SPQPASSGAPAPQPFQYQQQSIPLNVAREAVGVYDKLFGGLREEERALSRPEPAMPSPAA
CCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCC
PLLHPAVLAMPAHDENGIPPLGFALAQLHGVYILSQCAEGLILVDMHAAHERIVYERLKA
CHHCCHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHH
ALESDAIPLQPLLLPVSFAADRMEVATAHEHGEEMKRLGVELAPLSPTQIAVRGVPVWLK
HHHCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEECCEEEEC
DGDPVELARAVLKDVREFGLTQVLTERRNELLATMACHGAVRANRQLTLPEMNALLRDME
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHH
ATERSGQCNHGRPTWTRLTMRDLDKLFMRGQ
HHHCCCCCCCCCCCCEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA