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The map label for this gene is yopH [H]

Identifier: 34496429

GI number: 34496429

Start: 1008392

End: 1009861

Strand: Reverse

Name: yopH [H]

Synonym: CV_0974

Alternate gene names: 34496429

Gene position: 1009861-1008392 (Counterclockwise)

Preceding gene: 34496430

Following gene: 34496428

Centisome position: 21.26

GC content: 69.25

Gene sequence:

>1470_bases
ATGAGCACCATCCAAACCGGCATCCAACTGGGCGGACGCCAGCTCGACCTGTCCCGTCTGGACAGCCTGAGCGGCGTGAA
CGCCGACAAGGCCCGCATCGGCATCCGCAAGGACGGCACCCTGGTGGTCTACACCGGCCGCTCCTACCTGCTGCACCCTG
ATCAGACGCGCCGCGCTGACCAGTTCCTGCTCAAGCACGATCTGCTGATTCCAGGACAAAAGCCGCGCGAATTCCGCCTG
GCGCAATTGTTCGACCGGCCGATGGACGCGCTTACCCAGCGCAACACCCAAGCCAACGAAACCATCGCCAAACCCACCCA
GCAAGATGTGGACACGGTTACCCGCGGCGGCAAGCCGAAACTGCGCTGGGCGGATCAAGCCGCCGCCCGCCCATCCGGCG
AGCCGTCCCGCGGCGAGCGCGCGTCGTTGAAGCAGCGCCGCGGCGCCGAGCACCTGAAGCTGGCCCAGCCGCGCGCCGAG
GCCCGTCCCGAGAAGCACGACGCGATCAAGACGGAATTGGCCAGCCGGCTCGGCAGCAGCGATCAGCCAAGCGGCCTGCT
GCTGCAGCTCAAGGCCCAGGTCGGCTCCAGCGCGGAAGGCGCGCGCTTCCTCAACGATGTCGGCCAAGCCCGCTTCCGCG
ACATCCCCACCGCCGCCGCCACCCAGGTCCGCGCGCCGGATGGCGCGCCGCTGCCGGCCAACCGCGTCCAGGTCGGCGGC
GTCAACGTCGCCATCGCCAGCCAATATCCGAAAGCCGCCCAACTGGAAAGCTACTTCGGCATGCTGGCCGCCAACCGCAC
GCCGGTGCTGGTGGTGCTGGCCTCCGACGCCGACATGGCCAAGCAAGGCCGGGACGGCAAGGCAGACCTGCCCGACTATT
TCTCCCAGAGCGGCCGCTACGGCCGGGTCGAGGTCGAGTCCAAGAGCAAGGGGAGCACCACGCTGGAAGGCGGGCTGGAG
GTACGCGCCTACCATCTGAACGTCAGGGGCGCCGACCACAAGAGCGTCTCCATCCCGGTGCTGCACGTGCCCAACTGGGC
CGACTTCGGCGCCCAGGGCGCGACCGCGCTGAAAGCGCTGGCCCAGCACGTCGATGCGGTGGCGGACAAGAAAACCGCGT
TCTACCGCGACAACAACAGCAGCGCGCTGAACGACCCGGACAAGCTGCTGCCGGTCATCCACTGCCGCGCCGGCGTCGGC
CGCACCGGCCAGTTGATCGCCGCGCGCGAGCTGCTGAAGCCGGGCGCGTCCAGCCTGGAATCCATCGTCGCCGACATGCG
CGGCAGCCGCAACCATCTGATGGTGCAGACCAGCGGCCAGCTCTCCACGCTGGTGGACCTGGCTCAACAGCAGGGCCGAG
CCATCCTGCAGCCCGAAACCGCCGCCGAGCCGATCTACGCGAACCAGGCGCAAGCGGAGCCGATCTACGCCAACGACGCG
CCGCCGCCGCCGCCCCGCCGCCCGCGCTGA

Upstream 100 bases:

>100_bases
CAAGCCGAAGCCGCCCTTCCTCGCTGACCCATCCGGCGCGCCGCAGCCGCGCGGCCGCTCTACAAGCCCATCCGGGCAAC
CCGCTAAGAAAGAAGTGAAG

Downstream 100 bases:

>100_bases
GCATGGCAGCCGTGAAAAAAGCACGCCCAGGCGTGCTTTTTTCATTTCAGCCATGCGCGCGATGACGACCATCGTCAAAT
TGACAAAGACATAAGGGATG

Product: tyrosine phosphatase

Products: NA

Alternate protein names: Virulence protein [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MSTIQTGIQLGGRQLDLSRLDSLSGVNADKARIGIRKDGTLVVYTGRSYLLHPDQTRRADQFLLKHDLLIPGQKPREFRL
AQLFDRPMDALTQRNTQANETIAKPTQQDVDTVTRGGKPKLRWADQAAARPSGEPSRGERASLKQRRGAEHLKLAQPRAE
ARPEKHDAIKTELASRLGSSDQPSGLLLQLKAQVGSSAEGARFLNDVGQARFRDIPTAAATQVRAPDGAPLPANRVQVGG
VNVAIASQYPKAAQLESYFGMLAANRTPVLVVLASDADMAKQGRDGKADLPDYFSQSGRYGRVEVESKSKGSTTLEGGLE
VRAYHLNVRGADHKSVSIPVLHVPNWADFGAQGATALKALAQHVDAVADKKTAFYRDNNSSALNDPDKLLPVIHCRAGVG
RTGQLIAARELLKPGASSLESIVADMRGSRNHLMVQTSGQLSTLVDLAQQQGRAILQPETAAEPIYANQAQAEPIYANDA
PPPPPRRPR

Sequences:

>Translated_489_residues
MSTIQTGIQLGGRQLDLSRLDSLSGVNADKARIGIRKDGTLVVYTGRSYLLHPDQTRRADQFLLKHDLLIPGQKPREFRL
AQLFDRPMDALTQRNTQANETIAKPTQQDVDTVTRGGKPKLRWADQAAARPSGEPSRGERASLKQRRGAEHLKLAQPRAE
ARPEKHDAIKTELASRLGSSDQPSGLLLQLKAQVGSSAEGARFLNDVGQARFRDIPTAAATQVRAPDGAPLPANRVQVGG
VNVAIASQYPKAAQLESYFGMLAANRTPVLVVLASDADMAKQGRDGKADLPDYFSQSGRYGRVEVESKSKGSTTLEGGLE
VRAYHLNVRGADHKSVSIPVLHVPNWADFGAQGATALKALAQHVDAVADKKTAFYRDNNSSALNDPDKLLPVIHCRAGVG
RTGQLIAARELLKPGASSLESIVADMRGSRNHLMVQTSGQLSTLVDLAQQQGRAILQPETAAEPIYANQAQAEPIYANDA
PPPPPRRPR
>Mature_488_residues
STIQTGIQLGGRQLDLSRLDSLSGVNADKARIGIRKDGTLVVYTGRSYLLHPDQTRRADQFLLKHDLLIPGQKPREFRLA
QLFDRPMDALTQRNTQANETIAKPTQQDVDTVTRGGKPKLRWADQAAARPSGEPSRGERASLKQRRGAEHLKLAQPRAEA
RPEKHDAIKTELASRLGSSDQPSGLLLQLKAQVGSSAEGARFLNDVGQARFRDIPTAAATQVRAPDGAPLPANRVQVGGV
NVAIASQYPKAAQLESYFGMLAANRTPVLVVLASDADMAKQGRDGKADLPDYFSQSGRYGRVEVESKSKGSTTLEGGLEV
RAYHLNVRGADHKSVSIPVLHVPNWADFGAQGATALKALAQHVDAVADKKTAFYRDNNSSALNDPDKLLPVIHCRAGVGR
TGQLIAARELLKPGASSLESIVADMRGSRNHLMVQTSGQLSTLVDLAQQQGRAILQPETAAEPIYANQAQAEPIYANDAP
PPPPRRPR

Specific function: Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of yopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Secreted via type III secretion system [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 tyrosine-protein phosphatase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000387
- InterPro:   IPR015103
- InterPro:   IPR016130
- InterPro:   IPR003546
- InterPro:   IPR000242 [H]

Pfam domain/function: PF00102 Y_phosphatase; PF09013 YopH_N [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 52786; Mature: 52655

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS00383 TYR_PHOSPHATASE_1 ; PS50056 TYR_PHOSPHATASE_2 ; PS50055 TYR_PHOSPHATASE_PTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIQTGIQLGGRQLDLSRLDSLSGVNADKARIGIRKDGTLVVYTGRSYLLHPDQTRRAD
CCCHHHHHHCCCCEECHHHHHHHCCCCCCHHEEEEECCCEEEEECCCEEEECCCHHHHHH
QFLLKHDLLIPGQKPREFRLAQLFDRPMDALTQRNTQANETIAKPTQQDVDTVTRGGKPK
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHCCCCCC
LRWADQAAARPSGEPSRGERASLKQRRGAEHLKLAQPRAEARPEKHDAIKTELASRLGSS
EEECHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHCCCHHHCCCCHHHHHHHHHHHHCCCC
DQPSGLLLQLKAQVGSSAEGARFLNDVGQARFRDIPTAAATQVRAPDGAPLPANRVQVGG
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEECCCCCCCCCCCEEECC
VNVAIASQYPKAAQLESYFGMLAANRTPVLVVLASDADMAKQGRDGKADLPDYFSQSGRY
EEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCCCCCCCCHHHHCCCCC
GRVEVESKSKGSTTLEGGLEVRAYHLNVRGADHKSVSIPVLHVPNWADFGAQGATALKAL
EEEEECCCCCCCCEECCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHH
AQHVDAVADKKTAFYRDNNSSALNDPDKLLPVIHCRAGVGRTGQLIAARELLKPGASSLE
HHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHH
SIVADMRGSRNHLMVQTSGQLSTLVDLAQQQGRAILQPETAAEPIYANQAQAEPIYANDA
HHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCEECCCC
PPPPPRRPR
CCCCCCCCC
>Mature Secondary Structure 
STIQTGIQLGGRQLDLSRLDSLSGVNADKARIGIRKDGTLVVYTGRSYLLHPDQTRRAD
CCHHHHHHCCCCEECHHHHHHHCCCCCCHHEEEEECCCEEEEECCCEEEECCCHHHHHH
QFLLKHDLLIPGQKPREFRLAQLFDRPMDALTQRNTQANETIAKPTQQDVDTVTRGGKPK
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHCCCCCC
LRWADQAAARPSGEPSRGERASLKQRRGAEHLKLAQPRAEARPEKHDAIKTELASRLGSS
EEECHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHCCCHHHCCCCHHHHHHHHHHHHCCCC
DQPSGLLLQLKAQVGSSAEGARFLNDVGQARFRDIPTAAATQVRAPDGAPLPANRVQVGG
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEECCCCCCCCCCCEEECC
VNVAIASQYPKAAQLESYFGMLAANRTPVLVVLASDADMAKQGRDGKADLPDYFSQSGRY
EEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCCCCCCCCHHHHCCCCC
GRVEVESKSKGSTTLEGGLEVRAYHLNVRGADHKSVSIPVLHVPNWADFGAQGATALKAL
EEEEECCCCCCCCEECCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHH
AQHVDAVADKKTAFYRDNNSSALNDPDKLLPVIHCRAGVGRTGQLIAARELLKPGASSLE
HHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHH
SIVADMRGSRNHLMVQTSGQLSTLVDLAQQQGRAILQPETAAEPIYANQAQAEPIYANDA
HHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCEECCCC
PPPPPRRPR
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3244311; 2166336; 1429715; 8052312; 8702535 [H]