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The map label for this gene is siaT [H]

Identifier: 34496372

GI number: 34496372

Start: 949647

End: 950975

Strand: Reverse

Name: siaT [H]

Synonym: CV_0917

Alternate gene names: 34496372

Gene position: 950975-949647 (Counterclockwise)

Preceding gene: 34496373

Following gene: 34496371

Centisome position: 20.02

GC content: 64.64

Gene sequence:

>1329_bases
ATGAGCGCCCTGATCATTTTCGGCCTGCTGCTGGCGCTGATGCTGACCGGCATGCCCATTTCCATCTCGCTGGGCCTGAC
CGTCCTCACCTTCCTGTTCACCATGACCGAGGTGCCGATCACCTCGGTCGCCCTCAAGCTGTTCACCGGCATCGAGAAGT
TCGAGATCATGGCGATCCCCTTCTTCATCCTGGCCGGCAACTTCCTGATGCACGGCGGCGTCGCGCGGCGGATGATACGT
TTCGCCACCACCCTGGTCGGCCACTGGTACGGCGGCCTGGGCCTGGCCGGCGTGGTGTCCTGCGCGCTGTTCGCCGCCAT
CACCGGCTCCTCGGTCGCCACCGTCGTCGCCGTGGGCTCCATCATCCTGCCGGCGATGCTGAAACAAGGCTACCCGCAGC
GCTTCGGCGCCGGCGTGATCACCACCTCCGGCGCGCTGGGCATCCTGTTCCCGCCGTCGATCAATCTGGTGATGTACAGC
ATCGCCACCGCCGGCATGGACGTCACCGGCCCCAGCGGCATGAGCGTGTCCACCGCCTCGGTCGGCCAGCTGTTCATGGC
CGGCGTGCTGCCCGGCCTGTGCCTGTCCTTCCTCTTGGGCATGACCACCTGGTTCCGCGCCAAGAAGTTCGACTACCCTA
GGTTGCCTCGCGCCAGCTGGGGCGAGCGCTGGCTCGCGTTCCGCGAATGCGTGTGGGGCCTGCTGCTGATCGTGCTGGTG
ATAGGCGGCATCTACTCCGGCGTGTTCACCCCGACCGAAGCGGCGGCGATGGCCGCGGTGTACGCCTTCGTGATCGCGGT
GTTCGTCTACAAGGACATGGGGCTGAAAGACGTGCCCAAGGTGCTGATCAACGCCGCGTCGATGAGCGCGATGCTGCTCT
ACATCATCACCAACGCGGTGCTGTTCTCCTTCCTGATGGCGTCCGAGCAGATCCCGCAAACCATGGCGGCCTGGATGGCC
AGCCAGGGCTTCGGCATCGTCGCCTTCCTGCTGTTGACCAACATCCTGCTCTTGGCGGCCGGCAACTTCATGGACCCGTC
GGCCATCGTGCTGATCATGGCGCCCATCCTGTACCCGGTGGCGGTGAAGCTGGGCGTCAACCCGGTGCATTTCGGCATCC
TGATCGCGGTCAACATGGAGGTGGGCATGTGCCACCCGCCGGTGGGATTGAACCTTTACGTCGCGTCGGGGATCACCAAG
ATGGGGATCACCGAGTTGACGGTGGCGGTGTGGCCGTGGCTGCTGACCATGCTGGGCTTCCTGCTGGCAGTGACCTTCAT
CCCGGAAATCTCGCTTTGGCTGCCGCGGATGCTGGGCATGATGAACTGA

Upstream 100 bases:

>100_bases
GCGACCTGCCCAAGCATGACCACGGCCACGTGGAAGGCATCGAGGGCAACGAGGCGCTGGACAACCTGCATCCGCACGAC
ATGCATCACGGAGGCCGTCC

Downstream 100 bases:

>100_bases
GTTTCCCGCCCCAAACGACATGCCGCCGCGATGGGCTTTGCCCATCGCGGCTTTTGTCCGACACGGCATAGCCCAGGCCT
GGCATAAGCCTTATAATGCG

Product: C4-dicarboxylate transporter large subunit

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSALIIFGLLLALMLTGMPISISLGLTVLTFLFTMTEVPITSVALKLFTGIEKFEIMAIPFFILAGNFLMHGGVARRMIR
FATTLVGHWYGGLGLAGVVSCALFAAITGSSVATVVAVGSIILPAMLKQGYPQRFGAGVITTSGALGILFPPSINLVMYS
IATAGMDVTGPSGMSVSTASVGQLFMAGVLPGLCLSFLLGMTTWFRAKKFDYPRLPRASWGERWLAFRECVWGLLLIVLV
IGGIYSGVFTPTEAAAMAAVYAFVIAVFVYKDMGLKDVPKVLINAASMSAMLLYIITNAVLFSFLMASEQIPQTMAAWMA
SQGFGIVAFLLLTNILLLAAGNFMDPSAIVLIMAPILYPVAVKLGVNPVHFGILIAVNMEVGMCHPPVGLNLYVASGITK
MGITELTVAVWPWLLTMLGFLLAVTFIPEISLWLPRMLGMMN

Sequences:

>Translated_442_residues
MSALIIFGLLLALMLTGMPISISLGLTVLTFLFTMTEVPITSVALKLFTGIEKFEIMAIPFFILAGNFLMHGGVARRMIR
FATTLVGHWYGGLGLAGVVSCALFAAITGSSVATVVAVGSIILPAMLKQGYPQRFGAGVITTSGALGILFPPSINLVMYS
IATAGMDVTGPSGMSVSTASVGQLFMAGVLPGLCLSFLLGMTTWFRAKKFDYPRLPRASWGERWLAFRECVWGLLLIVLV
IGGIYSGVFTPTEAAAMAAVYAFVIAVFVYKDMGLKDVPKVLINAASMSAMLLYIITNAVLFSFLMASEQIPQTMAAWMA
SQGFGIVAFLLLTNILLLAAGNFMDPSAIVLIMAPILYPVAVKLGVNPVHFGILIAVNMEVGMCHPPVGLNLYVASGITK
MGITELTVAVWPWLLTMLGFLLAVTFIPEISLWLPRMLGMMN
>Mature_441_residues
SALIIFGLLLALMLTGMPISISLGLTVLTFLFTMTEVPITSVALKLFTGIEKFEIMAIPFFILAGNFLMHGGVARRMIRF
ATTLVGHWYGGLGLAGVVSCALFAAITGSSVATVVAVGSIILPAMLKQGYPQRFGAGVITTSGALGILFPPSINLVMYSI
ATAGMDVTGPSGMSVSTASVGQLFMAGVLPGLCLSFLLGMTTWFRAKKFDYPRLPRASWGERWLAFRECVWGLLLIVLVI
GGIYSGVFTPTEAAAMAAVYAFVIAVFVYKDMGLKDVPKVLINAASMSAMLLYIITNAVLFSFLMASEQIPQTMAAWMAS
QGFGIVAFLLLTNILLLAAGNFMDPSAIVLIMAPILYPVAVKLGVNPVHFGILIAVNMEVGMCHPPVGLNLYVASGITKM
GITELTVAVWPWLLTMLGFLLAVTFIPEISLWLPRMLGMMN

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG1593

COG function: function code G; TRAP-type C4-dicarboxylate transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=430, Percent_Identity=32.3255813953488, Blast_Score=218, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 47181; Mature: 47050

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALIIFGLLLALMLTGMPISISLGLTVLTFLFTMTEVPITSVALKLFTGIEKFEIMAIP
CHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHCHHHHHHHHHH
FFILAGNFLMHGGVARRMIRFATTLVGHWYGGLGLAGVVSCALFAAITGSSVATVVAVGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IILPAMLKQGYPQRFGAGVITTSGALGILFPPSINLVMYSIATAGMDVTGPSGMSVSTAS
HHHHHHHHCCCCHHHCCCEEEECCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCHHH
VGQLFMAGVLPGLCLSFLLGMTTWFRAKKFDYPRLPRASWGERWLAFRECVWGLLLIVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IGGIYSGVFTPTEAAAMAAVYAFVIAVFVYKDMGLKDVPKVLINAASMSAMLLYIITNAV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LFSFLMASEQIPQTMAAWMASQGFGIVAFLLLTNILLLAAGNFMDPSAIVLIMAPILYPV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AVKLGVNPVHFGILIAVNMEVGMCHPPVGLNLYVASGITKMGITELTVAVWPWLLTMLGF
HHHCCCCCEEEEEEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LLAVTFIPEISLWLPRMLGMMN
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SALIIFGLLLALMLTGMPISISLGLTVLTFLFTMTEVPITSVALKLFTGIEKFEIMAIP
HHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHCHHHHHHHHHH
FFILAGNFLMHGGVARRMIRFATTLVGHWYGGLGLAGVVSCALFAAITGSSVATVVAVGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IILPAMLKQGYPQRFGAGVITTSGALGILFPPSINLVMYSIATAGMDVTGPSGMSVSTAS
HHHHHHHHCCCCHHHCCCEEEECCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCHHH
VGQLFMAGVLPGLCLSFLLGMTTWFRAKKFDYPRLPRASWGERWLAFRECVWGLLLIVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IGGIYSGVFTPTEAAAMAAVYAFVIAVFVYKDMGLKDVPKVLINAASMSAMLLYIITNAV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LFSFLMASEQIPQTMAAWMASQGFGIVAFLLLTNILLLAAGNFMDPSAIVLIMAPILYPV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AVKLGVNPVHFGILIAVNMEVGMCHPPVGLNLYVASGITKMGITELTVAVWPWLLTMLGF
HHHCCCCCEEEEEEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LLAVTFIPEISLWLPRMLGMMN
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]