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The map label for this gene is urtC [H]

Identifier: 33864491

GI number: 33864491

Start: 2353773

End: 2354900

Strand: Reverse

Name: urtC [H]

Synonym: PMT2227

Alternate gene names: 33864491

Gene position: 2354900-2353773 (Counterclockwise)

Preceding gene: 33864492

Following gene: 33864490

Centisome position: 97.68

GC content: 54.08

Gene sequence:

>1128_bases
ATGTTGCAAGCGTTTCAACAACGCCGTTGGCCCCTGGTGATTGTCTGGGTCTTGATCATTGCTGCGATTGTGGCGGCGCC
TGCAGTGGTGTCGGTATTTGGGCTCAACCTGCTCGGTCGTTTTCTCTCTCTCTCAATCGTGGCCCTCGGCATCGATTTGA
TTTGGGGTTTTACAGGCTTATTGAGCCTGGGTCAGGGCATCTTCTTTGCGCTCGGTGGTTACGCAGCCGCAATGTACCTT
CAGCTCAACAGCTCGAGCGAACAACCCAACGGGATTCCAGAGTTCTTTGGCCTTTATGGGGTGGATCAACTGCCTGGATT
TTGGCAGCCGTTTCATTCGCCTTGGTTCACGCTGATTGCCATCTGGTTGATCCCTGCACTGCTTGCCGCGCTGTTAGGCA
ACTTGGTGTTCCGCAACCGGATCAAGGGAGTTTATTTTTCGATTCTTACCCAGGCCGCCTTGCTGGTTTTCTTTAATTTC
TTCAACGGACAGCAGAAACTGATCAATGGCACCAACGGTCTTAAGACCGATGTCACAGAGCTTTTTGGCCAGCAGGTGGG
CTCTGCATTCATGCAGCGAGGCTTCTTCTGGTTAACGGCCGTGATGGTGATCCTGGCCTGGTTGGCTGTGCGCTGGGTGG
TGCGTGGCCGTTTTGGGGAAGTGTTGATCGCCATTCGCGATGATGAGCCGCGTTTGCGTTTTGCTGGTTACAACCCCACC
TTGTTTAAAACCATCGTGTTTGCGATGGCTGGTGGCTTGGCCGGCATCGGTGGTGCTCTTTACACCGTGCAGTCCGGCAT
CGTCTCGCCTCAATACATGACTGTTCCCTTCTCAATCGACATGGTGATTTGGGTGGCAGTGGGTGGACGCGGAACTTTGA
TTGGTGCCATTCTTGGCGCTCTAGTCATTAATTTGGCGAGGAGCCAAATCAGCACGGTTTGGCCAGAAGGCTGGCTATTT
ATCCTGGGAGGCTTGTTTATTCTCGTCGTTACGGCACTACCAGAAGGTGTTGTGGGCTGGTGGCAGGCGGGTGGGCCACG
AAACCTGCTTACTCGCTTGGGTGTCGCGCGCAGGATCGGCACCTATCCACGCTTGGAAATGGATGGCAAGGAGGAGGTGA
AGTCATGA

Upstream 100 bases:

>100_bases
ATGGCCCAGGTAATGGTGTTTGCGCTGATTGTGGTGTTCCTGCAGTTCCGACCTGCTGGTCTGTTTCCCCAGAGGGGACG
CATGGTGGAGGCTTAAATCG

Downstream 100 bases:

>100_bases
CAACCGCTTTGCTTGAGTTGAGTCAAATCAGTGTCAGCTTTGATGGCTTTATGGCACTGCGTGATCTCAATCTCAGCCTG
CAGCCAGGAGAACTGCGTGC

Product: membrane protein of ABC transport system

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MLQAFQQRRWPLVIVWVLIIAAIVAAPAVVSVFGLNLLGRFLSLSIVALGIDLIWGFTGLLSLGQGIFFALGGYAAAMYL
QLNSSSEQPNGIPEFFGLYGVDQLPGFWQPFHSPWFTLIAIWLIPALLAALLGNLVFRNRIKGVYFSILTQAALLVFFNF
FNGQQKLINGTNGLKTDVTELFGQQVGSAFMQRGFFWLTAVMVILAWLAVRWVVRGRFGEVLIAIRDDEPRLRFAGYNPT
LFKTIVFAMAGGLAGIGGALYTVQSGIVSPQYMTVPFSIDMVIWVAVGGRGTLIGAILGALVINLARSQISTVWPEGWLF
ILGGLFILVVTALPEGVVGWWQAGGPRNLLTRLGVARRIGTYPRLEMDGKEEVKS

Sequences:

>Translated_375_residues
MLQAFQQRRWPLVIVWVLIIAAIVAAPAVVSVFGLNLLGRFLSLSIVALGIDLIWGFTGLLSLGQGIFFALGGYAAAMYL
QLNSSSEQPNGIPEFFGLYGVDQLPGFWQPFHSPWFTLIAIWLIPALLAALLGNLVFRNRIKGVYFSILTQAALLVFFNF
FNGQQKLINGTNGLKTDVTELFGQQVGSAFMQRGFFWLTAVMVILAWLAVRWVVRGRFGEVLIAIRDDEPRLRFAGYNPT
LFKTIVFAMAGGLAGIGGALYTVQSGIVSPQYMTVPFSIDMVIWVAVGGRGTLIGAILGALVINLARSQISTVWPEGWLF
ILGGLFILVVTALPEGVVGWWQAGGPRNLLTRLGVARRIGTYPRLEMDGKEEVKS
>Mature_375_residues
MLQAFQQRRWPLVIVWVLIIAAIVAAPAVVSVFGLNLLGRFLSLSIVALGIDLIWGFTGLLSLGQGIFFALGGYAAAMYL
QLNSSSEQPNGIPEFFGLYGVDQLPGFWQPFHSPWFTLIAIWLIPALLAALLGNLVFRNRIKGVYFSILTQAALLVFFNF
FNGQQKLINGTNGLKTDVTELFGQQVGSAFMQRGFFWLTAVMVILAWLAVRWVVRGRFGEVLIAIRDDEPRLRFAGYNPT
LFKTIVFAMAGGLAGIGGALYTVQSGIVSPQYMTVPFSIDMVIWVAVGGRGTLIGAILGALVINLARSQISTVWPEGWLF
ILGGLFILVVTALPEGVVGWWQAGGPRNLLTRLGVARRIGTYPRLEMDGKEEVKS

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=314, Percent_Identity=25.796178343949, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 41045; Mature: 41045

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQAFQQRRWPLVIVWVLIIAAIVAAPAVVSVFGLNLLGRFLSLSIVALGIDLIWGFTGL
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLGQGIFFALGGYAAAMYLQLNSSSEQPNGIPEFFGLYGVDQLPGFWQPFHSPWFTLIA
HHHCCHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCHHCCHHHHHHH
IWLIPALLAALLGNLVFRNRIKGVYFSILTQAALLVFFNFFNGQQKLINGTNGLKTDVTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHH
LFGQQVGSAFMQRGFFWLTAVMVILAWLAVRWVVRGRFGEVLIAIRDDEPRLRFAGYNPT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCHH
LFKTIVFAMAGGLAGIGGALYTVQSGIVSPQYMTVPFSIDMVIWVAVGGRGTLIGAILGA
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEECEEEEEEEEEEECCCHHHHHHHHHH
LVINLARSQISTVWPEGWLFILGGLFILVVTALPEGVVGWWQAGGPRNLLTRLGVARRIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHC
TYPRLEMDGKEEVKS
CCCCCCCCCHHHHCC
>Mature Secondary Structure
MLQAFQQRRWPLVIVWVLIIAAIVAAPAVVSVFGLNLLGRFLSLSIVALGIDLIWGFTGL
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLGQGIFFALGGYAAAMYLQLNSSSEQPNGIPEFFGLYGVDQLPGFWQPFHSPWFTLIA
HHHCCHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCHHCCHHHHHHH
IWLIPALLAALLGNLVFRNRIKGVYFSILTQAALLVFFNFFNGQQKLINGTNGLKTDVTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHH
LFGQQVGSAFMQRGFFWLTAVMVILAWLAVRWVVRGRFGEVLIAIRDDEPRLRFAGYNPT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCHH
LFKTIVFAMAGGLAGIGGALYTVQSGIVSPQYMTVPFSIDMVIWVAVGGRGTLIGAILGA
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEECEEEEEEEEEEECCCHHHHHHHHHH
LVINLARSQISTVWPEGWLFILGGLFILVVTALPEGVVGWWQAGGPRNLLTRLGVARRIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHC
TYPRLEMDGKEEVKS
CCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]