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The map label for this gene is siaT [H]

Identifier: 33864427

GI number: 33864427

Start: 2286665

End: 2288035

Strand: Direct

Name: siaT [H]

Synonym: PMT2163

Alternate gene names: 33864427

Gene position: 2286665-2288035 (Clockwise)

Preceding gene: 33864426

Following gene: 33864428

Centisome position: 94.85

GC content: 56.53

Gene sequence:

>1371_bases
TTGATTGAGATTGAACTACTCGACCATGTGATCAGTTTCGATCCCGCCACCACACTTGGGCCTGGGATGTTTATAGCCCT
GGTCTTCGCCCTATTGAGCGGCTATCCAGTTGCCTTCTGCCTCGGTGGCATTGCCGTGATCTTCGCGTTGCTGGGCATGG
CTCTTGGTGTGATCGATCCACTGTTCGTTACCGCTCTGCCGCAGCGAATCCTGGGGATCATGGCCAACTTCACCTTGTTG
GCCATTCCGGCGTTTGTGTTCATGGGCGCCATGCTCGAGACATCAGGTATTGCAGAGCGACTGCTCGAGAGCATGGGACG
TCTACTCGGCAAACTGCGCGGTGGCCTAGCCCTGGCGGTCGTGCTAGTCGGCTCACTGCTCGCTGCCACCACCGGAGTCG
TAGCAGCGACAGTCACCACTATGGGGCTGATCTCTCTACCGGCCATGCTGAGAGCGGGCTACGACCGCTCACTTGCCACG
GGGGTCATTGCTGCCTCAGGAACCCTTGGCCAGATCATCCCACCCAGCATTGTCTTGGTGGTTCTCGGCGACCAGTTGGG
TGTCTCAGTAGGAGATCTGTTCCTTGGCTCACTGATTCCAGGGGTGCTCATGGCTGGTGCATTTGCCACTTATGTGCTCG
TGATCAGCCACCTCAAACCTCATCTCGCCCCCCAACTGAATCCAGCAGACCTGATCCCCATGCAACCTGGCCAACTGCTG
CGTGTGATCATCCCGCCCCTAGGCCTGATCCTCTTAGTGCTAGGCAGCATCTTCTTTGGAATCGCAACACCCACCGAAGC
TGGCGTTCTTGGTGCCACTGGCGCCATGGTCCTAGCAGCGCTCAATGGAGGGTTCAGCCGTAGCAGCCTCTCAAAAGTAT
GCGATGAAACCCTACGAACCACCGCCATGGTGATGGCGATTTTACTGGGCTCAACAGCTTTTAGCCTTGTCTTTCGCGGA
GTAGGCGGCGATCAACTCATTGCCGATCTTTTGCTGAACCTGCCCGGCGGCAAGGTTGGTTTTATGGCCGTGAGCATGCT
CACGATCTTCGGCCTCGGCTTTTTCATCGACTTCTTTGAAATCGCCTTTATTGCCGTTCCGCTCTTACTGCCCGCAGCTC
GCCAAATCCTTGGACCCGAGGCCTTGATCTGGCTAGGTGTGGTCATCGGCGCCAATTTGCAAACCTCCTTCCTCACTCCA
CCTTTCGGCTTCGCACTCTTTTATCTACGCGGAGTAGCCCCTAAAACCATTACCACACAAGAAATCTATAAGGGTGCACT
GCCCTTCGTGGGCCTGCAAATCGCTGTCTTGGTGCTGATCATTGCAGCCCCACCCCTAGTGGATTGGCTGCCCAACCTTG
CCGCCTCCTGA

Upstream 100 bases:

>100_bases
GCCCTACAAGGCGTCGCCGAAGCCATTCGAGCCTGGGCAAAGCTAAAAGCCCAAACATTGATGCCATTCAACCCTGAAGC
GGAACAGGGCGGAGATCGCC

Downstream 100 bases:

>100_bases
AAGAAAGCACAGTTCTCCGAACACCCTCCGTAGAGTTTTGGCATTGGTGTAAAGGGTCCATGAACGTTGCGAGCAAAGAC
ACCACGGTGACAACGGCCAG

Product: TRAP-T family tripartite transporter

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MIEIELLDHVISFDPATTLGPGMFIALVFALLSGYPVAFCLGGIAVIFALLGMALGVIDPLFVTALPQRILGIMANFTLL
AIPAFVFMGAMLETSGIAERLLESMGRLLGKLRGGLALAVVLVGSLLAATTGVVAATVTTMGLISLPAMLRAGYDRSLAT
GVIAASGTLGQIIPPSIVLVVLGDQLGVSVGDLFLGSLIPGVLMAGAFATYVLVISHLKPHLAPQLNPADLIPMQPGQLL
RVIIPPLGLILLVLGSIFFGIATPTEAGVLGATGAMVLAALNGGFSRSSLSKVCDETLRTTAMVMAILLGSTAFSLVFRG
VGGDQLIADLLLNLPGGKVGFMAVSMLTIFGLGFFIDFFEIAFIAVPLLLPAARQILGPEALIWLGVVIGANLQTSFLTP
PFGFALFYLRGVAPKTITTQEIYKGALPFVGLQIAVLVLIIAAPPLVDWLPNLAAS

Sequences:

>Translated_456_residues
MIEIELLDHVISFDPATTLGPGMFIALVFALLSGYPVAFCLGGIAVIFALLGMALGVIDPLFVTALPQRILGIMANFTLL
AIPAFVFMGAMLETSGIAERLLESMGRLLGKLRGGLALAVVLVGSLLAATTGVVAATVTTMGLISLPAMLRAGYDRSLAT
GVIAASGTLGQIIPPSIVLVVLGDQLGVSVGDLFLGSLIPGVLMAGAFATYVLVISHLKPHLAPQLNPADLIPMQPGQLL
RVIIPPLGLILLVLGSIFFGIATPTEAGVLGATGAMVLAALNGGFSRSSLSKVCDETLRTTAMVMAILLGSTAFSLVFRG
VGGDQLIADLLLNLPGGKVGFMAVSMLTIFGLGFFIDFFEIAFIAVPLLLPAARQILGPEALIWLGVVIGANLQTSFLTP
PFGFALFYLRGVAPKTITTQEIYKGALPFVGLQIAVLVLIIAAPPLVDWLPNLAAS
>Mature_456_residues
MIEIELLDHVISFDPATTLGPGMFIALVFALLSGYPVAFCLGGIAVIFALLGMALGVIDPLFVTALPQRILGIMANFTLL
AIPAFVFMGAMLETSGIAERLLESMGRLLGKLRGGLALAVVLVGSLLAATTGVVAATVTTMGLISLPAMLRAGYDRSLAT
GVIAASGTLGQIIPPSIVLVVLGDQLGVSVGDLFLGSLIPGVLMAGAFATYVLVISHLKPHLAPQLNPADLIPMQPGQLL
RVIIPPLGLILLVLGSIFFGIATPTEAGVLGATGAMVLAALNGGFSRSSLSKVCDETLRTTAMVMAILLGSTAFSLVFRG
VGGDQLIADLLLNLPGGKVGFMAVSMLTIFGLGFFIDFFEIAFIAVPLLLPAARQILGPEALIWLGVVIGANLQTSFLTP
PFGFALFYLRGVAPKTITTQEIYKGALPFVGLQIAVLVLIIAAPPLVDWLPNLAAS

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG4664

COG function: function code Q; TRAP-type mannitol/chloroaromatic compound transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=406, Percent_Identity=27.5862068965517, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 47165; Mature: 47165

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEIELLDHVISFDPATTLGPGMFIALVFALLSGYPVAFCLGGIAVIFALLGMALGVIDP
CEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LFVTALPQRILGIMANFTLLAIPAFVFMGAMLETSGIAERLLESMGRLLGKLRGGLALAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLVGSLLAATTGVVAATVTTMGLISLPAMLRAGYDRSLATGVIAASGTLGQIIPPSIVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEE
VLGDQLGVSVGDLFLGSLIPGVLMAGAFATYVLVISHLKPHLAPQLNPADLIPMQPGQLL
EECCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
RVIIPPLGLILLVLGSIFFGIATPTEAGVLGATGAMVLAALNGGFSRSSLSKVCDETLRT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
TAMVMAILLGSTAFSLVFRGVGGDQLIADLLLNLPGGKVGFMAVSMLTIFGLGFFIDFFE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
IAFIAVPLLLPAARQILGPEALIWLGVVIGANLQTSFLTPPFGFALFYLRGVAPKTITTQ
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHH
EIYKGALPFVGLQIAVLVLIIAAPPLVDWLPNLAAS
HHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MIEIELLDHVISFDPATTLGPGMFIALVFALLSGYPVAFCLGGIAVIFALLGMALGVIDP
CEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LFVTALPQRILGIMANFTLLAIPAFVFMGAMLETSGIAERLLESMGRLLGKLRGGLALAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLVGSLLAATTGVVAATVTTMGLISLPAMLRAGYDRSLATGVIAASGTLGQIIPPSIVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEE
VLGDQLGVSVGDLFLGSLIPGVLMAGAFATYVLVISHLKPHLAPQLNPADLIPMQPGQLL
EECCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
RVIIPPLGLILLVLGSIFFGIATPTEAGVLGATGAMVLAALNGGFSRSSLSKVCDETLRT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
TAMVMAILLGSTAFSLVFRGVGGDQLIADLLLNLPGGKVGFMAVSMLTIFGLGFFIDFFE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
IAFIAVPLLLPAARQILGPEALIWLGVVIGANLQTSFLTPPFGFALFYLRGVAPKTITTQ
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHH
EIYKGALPFVGLQIAVLVLIIAAPPLVDWLPNLAAS
HHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]