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The map label for this gene is hrcA

Identifier: 33864291

GI number: 33864291

Start: 2137664

End: 2138722

Strand: Direct

Name: hrcA

Synonym: PMT2026

Alternate gene names: 33864291

Gene position: 2137664-2138722 (Clockwise)

Preceding gene: 33864279

Following gene: 33864293

Centisome position: 88.67

GC content: 60.06

Gene sequence:

>1059_bases
GTGACAGAGCACAAAAGAAGGGCAACCCCCCCGTACCATCAAGATCCCGACGTCACCGCTTTGGAGTCGCTACCGGCACG
ACAACAGCAGGTGCTTCAAGCAACGGTGCACCACTACGTGGACACGATTGAGCCTGTTGGCAGCAAAACCCTGGTGCAAC
GCTTTGGCCTCAAAGCCAGCGCCGCAACAGTTCGTTCGGCAATGGGAGCCCTTGAACAGCGTGGCCTGCTCACCCAACCT
CATACCTCGGCGGGAAGAGTGCCGAGCCCGCAGGGCTATCGCCACTATGTGGACTGCTTGCTGCCGCCTCCAGGATCGGC
GGCGCAGCACTTGGAACGGGAACTGACAAACCTCAGTCTGCGCTGGGCAGCTCTCGATGACTTGATGTGGCAATTGGCCC
GTCGCCTCACCGATTTCACCGGCCTGATGAGCTTGATTACCAGGCCCGCACGGCCAAAGCCAACGCTTCAAGCCGTACGC
CTGGTGCGCAGTGGCGACCGGCTGCTGGTGATGCTGGTTGAAAGCTCCAACCAAGCCAGTCATCTCAATCTGCGCCTGCC
CCATGAAGCCAGCAACGAACTCGAAGCCATCGAGGAGTGGACCCGCGATCAACTGGCCACAACGGGCAACGGCAGCCTCG
ACTGGTCGAGCCTGCCACCGCAGCTCAATCTGAGCGGATCTTTACTGCGAGAGGCGATTCACAGCCACAGCCAAGCTCAA
ACACCGGCTGAATCAGATGCAGTGTTCCATGGGATGTCAAGGCTGCTTGCGCAGCCAGAATTCAGCAGTAGCGCCAGCCT
CCAACCCTTACTTGAACTGATGGATACCCAGCCAGCTGCAGTGGTGCCAGTTGGCAGTGAGCAGCTTGGAGGCGTGTGGA
TCGGCGCAGAGCACCCCAAGAGCGCCCTGGAAGCCTGTTCCGTGGTGCAAGCGCCCTATCACAGCTCCGGGGAAGGCATC
GGACAAGTTGCTCTCGTTGGCCCGATGCGCATGGCTTATGCCACAGCCAAGGCAGCCGTGAGCAGCGTGGCGAATCACCT
TGAAAGGTTGCTCTGCTAA

Upstream 100 bases:

>100_bases
AGAAACACAACAGCTGCAATCTGGGAAGAAGCATCGAGACTTGGTGATGCTGGGTTGCAAGCAAGCGCTGCGCCAACACT
GAGACCGGCTTAGTGAGTTC

Downstream 100 bases:

>100_bases
GCGAGACAGCTAGCTATTAGTAGCAACCTTTTTTAATACGACTACCGATGTTCGGCGACTTGGTTATCGGCGAAATAAGC
GGTTCAACAAAAGCTGGAAA

Product: negative regulator of class I heat shock protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTEHKRRATPPYHQDPDVTALESLPARQQQVLQATVHHYVDTIEPVGSKTLVQRFGLKASAATVRSAMGALEQRGLLTQP
HTSAGRVPSPQGYRHYVDCLLPPPGSAAQHLERELTNLSLRWAALDDLMWQLARRLTDFTGLMSLITRPARPKPTLQAVR
LVRSGDRLLVMLVESSNQASHLNLRLPHEASNELEAIEEWTRDQLATTGNGSLDWSSLPPQLNLSGSLLREAIHSHSQAQ
TPAESDAVFHGMSRLLAQPEFSSSASLQPLLELMDTQPAAVVPVGSEQLGGVWIGAEHPKSALEACSVVQAPYHSSGEGI
GQVALVGPMRMAYATAKAAVSSVANHLERLLC

Sequences:

>Translated_352_residues
MTEHKRRATPPYHQDPDVTALESLPARQQQVLQATVHHYVDTIEPVGSKTLVQRFGLKASAATVRSAMGALEQRGLLTQP
HTSAGRVPSPQGYRHYVDCLLPPPGSAAQHLERELTNLSLRWAALDDLMWQLARRLTDFTGLMSLITRPARPKPTLQAVR
LVRSGDRLLVMLVESSNQASHLNLRLPHEASNELEAIEEWTRDQLATTGNGSLDWSSLPPQLNLSGSLLREAIHSHSQAQ
TPAESDAVFHGMSRLLAQPEFSSSASLQPLLELMDTQPAAVVPVGSEQLGGVWIGAEHPKSALEACSVVQAPYHSSGEGI
GQVALVGPMRMAYATAKAAVSSVANHLERLLC
>Mature_351_residues
TEHKRRATPPYHQDPDVTALESLPARQQQVLQATVHHYVDTIEPVGSKTLVQRFGLKASAATVRSAMGALEQRGLLTQPH
TSAGRVPSPQGYRHYVDCLLPPPGSAAQHLERELTNLSLRWAALDDLMWQLARRLTDFTGLMSLITRPARPKPTLQAVRL
VRSGDRLLVMLVESSNQASHLNLRLPHEASNELEAIEEWTRDQLATTGNGSLDWSSLPPQLNLSGSLLREAIHSHSQAQT
PAESDAVFHGMSRLLAQPEFSSSASLQPLLELMDTQPAAVVPVGSEQLGGVWIGAEHPKSALEACSVVQAPYHSSGEGIG
QVALVGPMRMAYATAKAAVSSVANHLERLLC

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_PROMM (Q7V4D3)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895851.1
- ProteinModelPortal:   Q7V4D3
- SMR:   Q7V4D3
- STRING:   Q7V4D3
- GeneID:   1729313
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT2026
- NMPDR:   fig|74547.1.peg.2018
- eggNOG:   COG1420
- HOGENOM:   HBG729878
- OMA:   TVRSAMG
- ProtClustDB:   CLSK826277
- BioCyc:   PMAR74547:PMT2026-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 38206; Mature: 38075

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHKRRATPPYHQDPDVTALESLPARQQQVLQATVHHYVDTIEPVGSKTLVQRFGLKAS
CCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHH
AATVRSAMGALEQRGLLTQPHTSAGRVPSPQGYRHYVDCLLPPPGSAAQHLERELTNLSL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHEECCCCCHHHHHHHHHHHHHHH
RWAALDDLMWQLARRLTDFTGLMSLITRPARPKPTLQAVRLVRSGDRLLVMLVESSNQAS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCC
HLNLRLPHEASNELEAIEEWTRDQLATTGNGSLDWSSLPPQLNLSGSLLREAIHSHSQAQ
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
TPAESDAVFHGMSRLLAQPEFSSSASLQPLLELMDTQPAAVVPVGSEQLGGVWIGAEHPK
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCEEECCCCCH
SALEACSVVQAPYHSSGEGIGQVALVGPMRMAYATAKAAVSSVANHLERLLC
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEHKRRATPPYHQDPDVTALESLPARQQQVLQATVHHYVDTIEPVGSKTLVQRFGLKAS
CCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHH
AATVRSAMGALEQRGLLTQPHTSAGRVPSPQGYRHYVDCLLPPPGSAAQHLERELTNLSL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHEECCCCCHHHHHHHHHHHHHHH
RWAALDDLMWQLARRLTDFTGLMSLITRPARPKPTLQAVRLVRSGDRLLVMLVESSNQAS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCC
HLNLRLPHEASNELEAIEEWTRDQLATTGNGSLDWSSLPPQLNLSGSLLREAIHSHSQAQ
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
TPAESDAVFHGMSRLLAQPEFSSSASLQPLLELMDTQPAAVVPVGSEQLGGVWIGAEHPK
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCEEECCCCCH
SALEACSVVQAPYHSSGEGIGQVALVGPMRMAYATAKAAVSSVANHLERLLC
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642