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The map label for this gene is strD [H]

Identifier: 33864277

GI number: 33864277

Start: 2127021

End: 2128199

Strand: Direct

Name: strD [H]

Synonym: PMT2012

Alternate gene names: 33864277

Gene position: 2127021-2128199 (Clockwise)

Preceding gene: 33864276

Following gene: 33864279

Centisome position: 88.23

GC content: 52.67

Gene sequence:

>1179_bases
ATGAAGGCGATGATTTTGGCGGCCGGCAAAGGGACGCGCGTCCAGCCGATCACCCACGTGATCCCCAAGCCGATGATTCC
CATCCTTCAGAAACCCGTGATGGAGTTTCTGCTCGAACTGCTGAAGGAGCACGGATTCAAAGAAGTAATGGTGAATGTGT
CTCACCTAGCTGAGGAAATTGAAAACTACTTCCGCGATGGCCAGCGCTTTGGCGTAGAAATCGCCTACAGCTTCGAGGGA
CGCATCGAAGAGGGAGAACTGATTGGTGATGCCCTTGGTTCCGCTGGCGGCCTCAAAAAAATCCAGGATTTTCAACAATT
CTTTGATGACACCTTTGTGGTGCTCTGTGGCGACGCCCTCATTGATCTCGACCTCTCAGAAGCCGTAAAACGCCATCGAG
CCAAAGGCGCTCTGGCGAGCTTGGTGACCAAACGAGTCCCCAAAGATCAAGTCAGCAGCTATGGCGTGGTGGTCACAGAC
GAGAATGATTGTGTTCAGGCATTCCAAGAGAAACCCTCCACTGATGCAGCGCTGAGCGACACAATCAACACAGGCATCTA
TCTCTTTGAACCAGAGATTTTCGAGCACATTCCTTCCGACCAACCCTTCGATATCGGCTCTGACCTATTCCCCAAGCTGG
TGGAGATGGGCTTACCATTCTTTGCCCTACCCATGGATTTTGAATGGGTGGACATTGGCAAGGTTCCTGATTATTGGAGA
GCCATTCGCAGCGTGCTGCAAGGAGAGGTTCGCCAAGTAGGCATTCCTGGTAAGGAAGTGCGTCCTGGGATCTACACAGG
CTTGAACGTTGCCGCGAACTGGGACAAGATCAATGTGCAAGGGCCAATTTATGTGGGTGGCATGACCCGCATCGAAGATG
GAGCAACAATTATTGGGCCATCAATGATCGGCCCTAGCTGTTGCATCTGCGAAGGGGCAACCGTGGACAACTCGATCATC
TTTGACTATTCCCGTATTGGAGCTGGTGTGCAGCTGGTGGAAAAGCTGGTGTTTGGCCGTTACTGCGTTGGCAAAAACGG
CGATCACTTTGACCTTCAAGAAGCAGCCCTTGATTGGCTGATCACCGATGCAAGGCGCCAAGACCTGGTTGAACCATCTC
CTCAGCAGAAGGCCATGGCCGAACTCCTTGGCACAGACCTCACACCGGCACCAAGCTGA

Upstream 100 bases:

>100_bases
TACCAGCCTTAACGTGCCAGCTGCCACTCCGGCCGAGGTCGTGAATGCCGCTTGAATGGAGGTCTATGTTGTTTAATCGA
GCTGAGGCCTAACAACGCCA

Downstream 100 bases:

>100_bases
TTCCAGCCTGATCAAGAATCTCGGGGATGCGCTCTTCTGCTTTCACGGCCATCAGATGGACGCCCTGGGTAAGAGACAAG
TAACTCCTGACCTGCTCAGC

Product: sugar-phosphate nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKAMILAAGKGTRVQPITHVIPKPMIPILQKPVMEFLLELLKEHGFKEVMVNVSHLAEEIENYFRDGQRFGVEIAYSFEG
RIEEGELIGDALGSAGGLKKIQDFQQFFDDTFVVLCGDALIDLDLSEAVKRHRAKGALASLVTKRVPKDQVSSYGVVVTD
ENDCVQAFQEKPSTDAALSDTINTGIYLFEPEIFEHIPSDQPFDIGSDLFPKLVEMGLPFFALPMDFEWVDIGKVPDYWR
AIRSVLQGEVRQVGIPGKEVRPGIYTGLNVAANWDKINVQGPIYVGGMTRIEDGATIIGPSMIGPSCCICEGATVDNSII
FDYSRIGAGVQLVEKLVFGRYCVGKNGDHFDLQEAALDWLITDARRQDLVEPSPQQKAMAELLGTDLTPAPS

Sequences:

>Translated_392_residues
MKAMILAAGKGTRVQPITHVIPKPMIPILQKPVMEFLLELLKEHGFKEVMVNVSHLAEEIENYFRDGQRFGVEIAYSFEG
RIEEGELIGDALGSAGGLKKIQDFQQFFDDTFVVLCGDALIDLDLSEAVKRHRAKGALASLVTKRVPKDQVSSYGVVVTD
ENDCVQAFQEKPSTDAALSDTINTGIYLFEPEIFEHIPSDQPFDIGSDLFPKLVEMGLPFFALPMDFEWVDIGKVPDYWR
AIRSVLQGEVRQVGIPGKEVRPGIYTGLNVAANWDKINVQGPIYVGGMTRIEDGATIIGPSMIGPSCCICEGATVDNSII
FDYSRIGAGVQLVEKLVFGRYCVGKNGDHFDLQEAALDWLITDARRQDLVEPSPQQKAMAELLGTDLTPAPS
>Mature_392_residues
MKAMILAAGKGTRVQPITHVIPKPMIPILQKPVMEFLLELLKEHGFKEVMVNVSHLAEEIENYFRDGQRFGVEIAYSFEG
RIEEGELIGDALGSAGGLKKIQDFQQFFDDTFVVLCGDALIDLDLSEAVKRHRAKGALASLVTKRVPKDQVSSYGVVVTD
ENDCVQAFQEKPSTDAALSDTINTGIYLFEPEIFEHIPSDQPFDIGSDLFPKLVEMGLPFFALPMDFEWVDIGKVPDYWR
AIRSVLQGEVRQVGIPGKEVRPGIYTGLNVAANWDKINVQGPIYVGGMTRIEDGATIIGPSMIGPSCCICEGATVDNSII
FDYSRIGAGVQLVEKLVFGRYCVGKNGDHFDLQEAALDWLITDARRQDLVEPSPQQKAMAELLGTDLTPAPS

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=348, Percent_Identity=28.735632183908, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI11761621, Length=348, Percent_Identity=28.735632183908, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI31881779, Length=373, Percent_Identity=23.8605898123324, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI45447090, Length=373, Percent_Identity=23.8605898123324, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1789837, Length=265, Percent_Identity=27.1698113207547, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788351, Length=260, Percent_Identity=23.4615384615385, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=345, Percent_Identity=28.9855072463768, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17509979, Length=361, Percent_Identity=26.0387811634349, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=329, Percent_Identity=27.355623100304, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21355443, Length=346, Percent_Identity=29.7687861271676, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24644084, Length=346, Percent_Identity=29.7687861271676, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24653912, Length=205, Percent_Identity=28.780487804878, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 43153; Mature: 43153

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGKGTRVQPITHVIPKPMIPILQKPVMEFLLELLKEHGFKEVMVNVSHLAEEI
CCEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ENYFRDGQRFGVEIAYSFEGRIEEGELIGDALGSAGGLKKIQDFQQFFDDTFVVLCGDAL
HHHHHCCHHCCEEEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCEEEEEECCHH
IDLDLSEAVKRHRAKGALASLVTKRVPKDQVSSYGVVVTDENDCVQAFQEKPSTDAALSD
EECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEECCHHHHHHHHCCCCCCHHHHH
TINTGIYLFEPEIFEHIPSDQPFDIGSDLFPKLVEMGLPFFALPMDFEWVDIGKVPDYWR
HHHCCEEEECCHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCEEEECCCCCHHHH
AIRSVLQGEVRQVGIPGKEVRPGIYTGLNVAANWDKINVQGPIYVGGMTRIEDGATIIGP
HHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEECCCEEECCCCEEECCCEEECCCCEEECC
SMIGPSCCICEGATVDNSIIFDYSRIGAGVQLVEKLVFGRYCVGKNGDHFDLQEAALDWL
CCCCCCEEEECCCCCCCCEEEEHHHHCHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHH
ITDARRQDLVEPSPQQKAMAELLGTDLTPAPS
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKAMILAAGKGTRVQPITHVIPKPMIPILQKPVMEFLLELLKEHGFKEVMVNVSHLAEEI
CCEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ENYFRDGQRFGVEIAYSFEGRIEEGELIGDALGSAGGLKKIQDFQQFFDDTFVVLCGDAL
HHHHHCCHHCCEEEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCEEEEEECCHH
IDLDLSEAVKRHRAKGALASLVTKRVPKDQVSSYGVVVTDENDCVQAFQEKPSTDAALSD
EECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEECCHHHHHHHHCCCCCCHHHHH
TINTGIYLFEPEIFEHIPSDQPFDIGSDLFPKLVEMGLPFFALPMDFEWVDIGKVPDYWR
HHHCCEEEECCHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCEEEECCCCCHHHH
AIRSVLQGEVRQVGIPGKEVRPGIYTGLNVAANWDKINVQGPIYVGGMTRIEDGATIIGP
HHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEECCCEEECCCCEEECCCEEECCCCEEECC
SMIGPSCCICEGATVDNSIIFDYSRIGAGVQLVEKLVFGRYCVGKNGDHFDLQEAALDWL
CCCCCCEEEECCCCCCCCEEEEHHHHCHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHH
ITDARRQDLVEPSPQQKAMAELLGTDLTPAPS
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]