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The map label for this gene is rnc [H]

Identifier: 33864214

GI number: 33864214

Start: 2059896

End: 2060741

Strand: Direct

Name: rnc [H]

Synonym: PMT1949

Alternate gene names: 33864214

Gene position: 2059896-2060741 (Clockwise)

Preceding gene: 33864211

Following gene: 33864216

Centisome position: 85.44

GC content: 55.32

Gene sequence:

>846_bases
ATGACTCATCGATCGAAGACGAAAACATCCCGAACAACCCCAAAAAACCTCTCTAACGAACGGGTCCAGCAACTACAAAA
CCTGCTGCAGAAACTCGCGCTGGTGGATCCTGCACGATCAAAAAGCTGCCCTGGAACTGAACCGAGAGGTCTAGCCGTTA
TCGATGAAGCACTGACGCACACCTCAGCTCAAGAAATCATCAACCACGAGCGCCTGGAATTCCTTGGCGACGCAGTTCTG
CGGCTAGCCGCCTCGGAATATATCGATCGCCACTTCCCGCGCATGAATGTAGGCGAGCGCTCGGCATTAAGAGCTCACCT
TGTGAGTGATCGCTGGCTAGCCGAAGTCGGTCAACGTATCGGCATCGAATCAGTACTCATCATCGGACCCATGGCTGCAG
GGGATGCCTCTGCTAAACCCACCCTGCAGGCTGAAGCAACCGAAGCGTTGATTGGAGCGCTCTATGAGTGCTGGCAAAGC
CTTGAGCCAATCCACCGCTGGCTCACACCTCACTGGCAAGAGGCAAGCAGTGCGGTGCTAACCGATCCTCATCGACTGAA
CAGCAAATCCGCGCTGCAGGAATGGAGCCAGGCAAGGGGGCTCGGGCTACCCCGCTACGAATGTGCAGAACGCAGCAAGC
AACATGGAGATCCTCAACGTTATGTTTGCCAAGTTCATCTCGATGATCGGCCAATTGGAGAGGGTTGGGGAGGCTCCCGC
CGCAATGCCGAGCAAGAGGCAGCTCGCCGCTCACTACAGGCACTCACCCAATCAGCCAACGACAACTCAAGCCGAACTGA
ACAGAAAGCCATGCTCCTGAAAGATGGAGATCAATCTCCTTGCTGA

Upstream 100 bases:

>100_bases
TGAGCAGTGAACAGAACCCGGCTTACGAACTGCTTTCACCCTCTTCCCTAACGCTGTTGATCAATCTGCAGAGAAGACCA
GACAATCCATCCTTAGCGTG

Downstream 100 bases:

>100_bases
CTAGAGAAAATCAGTGGCAGCAGTGAAGGGACTGCCAAAAACCTCAAGCCAGCAAAAGATGTTTCAGAGGGATCGTGACC
AACTTGTCCCAGTTCCCCCC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III 2; RNase III 2 [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTHRSKTKTSRTTPKNLSNERVQQLQNLLQKLALVDPARSKSCPGTEPRGLAVIDEALTHTSAQEIINHERLEFLGDAVL
RLAASEYIDRHFPRMNVGERSALRAHLVSDRWLAEVGQRIGIESVLIIGPMAAGDASAKPTLQAEATEALIGALYECWQS
LEPIHRWLTPHWQEASSAVLTDPHRLNSKSALQEWSQARGLGLPRYECAERSKQHGDPQRYVCQVHLDDRPIGEGWGGSR
RNAEQEAARRSLQALTQSANDNSSRTEQKAMLLKDGDQSPC

Sequences:

>Translated_281_residues
MTHRSKTKTSRTTPKNLSNERVQQLQNLLQKLALVDPARSKSCPGTEPRGLAVIDEALTHTSAQEIINHERLEFLGDAVL
RLAASEYIDRHFPRMNVGERSALRAHLVSDRWLAEVGQRIGIESVLIIGPMAAGDASAKPTLQAEATEALIGALYECWQS
LEPIHRWLTPHWQEASSAVLTDPHRLNSKSALQEWSQARGLGLPRYECAERSKQHGDPQRYVCQVHLDDRPIGEGWGGSR
RNAEQEAARRSLQALTQSANDNSSRTEQKAMLLKDGDQSPC
>Mature_280_residues
THRSKTKTSRTTPKNLSNERVQQLQNLLQKLALVDPARSKSCPGTEPRGLAVIDEALTHTSAQEIINHERLEFLGDAVLR
LAASEYIDRHFPRMNVGERSALRAHLVSDRWLAEVGQRIGIESVLIIGPMAAGDASAKPTLQAEATEALIGALYECWQSL
EPIHRWLTPHWQEASSAVLTDPHRLNSKSALQEWSQARGLGLPRYECAERSKQHGDPQRYVCQVHLDDRPIGEGWGGSRR
NAEQEAARRSLQALTQSANDNSSRTEQKAMLLKDGDQSPC

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=192, Percent_Identity=26.5625, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI155030236, Length=192, Percent_Identity=26.5625, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1788920, Length=206, Percent_Identity=32.5242718446602, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 31289; Mature: 31158

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHRSKTKTSRTTPKNLSNERVQQLQNLLQKLALVDPARSKSCPGTEPRGLAVIDEALTH
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
TSAQEIINHERLEFLGDAVLRLAASEYIDRHFPRMNVGERSALRAHLVSDRWLAEVGQRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GIESVLIIGPMAAGDASAKPTLQAEATEALIGALYECWQSLEPIHRWLTPHWQEASSAVL
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
TDPHRLNSKSALQEWSQARGLGLPRYECAERSKQHGDPQRYVCQVHLDDRPIGEGWGGSR
CCCHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCC
RNAEQEAARRSLQALTQSANDNSSRTEQKAMLLKDGDQSPC
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
THRSKTKTSRTTPKNLSNERVQQLQNLLQKLALVDPARSKSCPGTEPRGLAVIDEALTH
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
TSAQEIINHERLEFLGDAVLRLAASEYIDRHFPRMNVGERSALRAHLVSDRWLAEVGQRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GIESVLIIGPMAAGDASAKPTLQAEATEALIGALYECWQSLEPIHRWLTPHWQEASSAVL
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
TDPHRLNSKSALQEWSQARGLGLPRYECAERSKQHGDPQRYVCQVHLDDRPIGEGWGGSR
CCCHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCC
RNAEQEAARRSLQALTQSANDNSSRTEQKAMLLKDGDQSPC
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]