Click here to switch to the map view.

The map label for this gene is napA [H]

Identifier: 33864209

GI number: 33864209

Start: 2054117

End: 2055490

Strand: Reverse

Name: napA [H]

Synonym: PMT1944

Alternate gene names: 33864209

Gene position: 2055490-2054117 (Counterclockwise)

Preceding gene: 33864210

Following gene: 33864208

Centisome position: 85.26

GC content: 53.13

Gene sequence:

>1374_bases
ATGGTTTTGCATTCAGTGTTGTCCGTGCTGAGCAGCCACGACGTGGAGGTGGCTGAAACTTTGATCGGTGTGCTGAATTT
CCTGCTGATTTTTGTTGCAGCACGCACTCTGGCTGAGCTTTTGGTGCGTTTGCATCTACCTACGATCGTCGGCGAACTGC
TGGCAGGGGTTCTGATCGGGGCCTCAGGTTTGCATCTATTGGTGCCGCCGAGTACTCATTCTCATTTGAATGAGGGTTTG
GTCAGCCTGATCAGCGCTTTGGCCTCGATTCCTCCTGAGGCAGTACCAGACCTCTATTACGAAACCTTCCCCTCTCTGCA
AGCGGTTGCCACGCTCGGCTTGTATGCCCTGCTTTTCCTCACCGGGTTGGAAAGTGAGTTGGAAGAGTTGGTCGCTGTAG
GAGTCCAGGCCTTCACAGTGGCCATGGCTGGCGTGGTGCTGCCTTTTGCCTTAGGCACCTTTGGTTTGATGGCTCTCTTC
CAGGTGGAATTGATCCCGGCGATTTTTGCTGGTGCTTCGATGACTGCTACCAGCATCGGCATCACTGCCAGTGTGTTTGG
CGAACTCGGTTATCTCAAAACGCGAGAGGGCCAGATCGTGATTGGTGCGGCTGTGCTTGATGACATCCTTGGCATTGTGA
TCCTGGCTGTTGTTGTGGCCTTGGCCACAGGAGGCAACCTCGAGATTGCCCCGATTGTGAAACTTGTCGTAGCAGCGACA
GTGTTTGTGGTCTTAGCAATCGTGCTTAGCCGTACTGCGGCTCCAGCCTTTGATTGGGTGATCGACCGACTTAAAGCGCC
TGGAGCGGTTGTTGTGGCCTCGTTTGTGATTCTTGTGCTGTGTTGCTTTATCGCTACGGCGATTGGTTTGGAAGCCGCTT
TGGGGGCCTTTGCCGCTGGATTGATCCTCAGCAGCTCGAAGAACAATCACGCGATTCAGCAGTCGGTTTTGCCGATCGTG
ACCCTCTTCGCCACGATTTTCTTTGTTTTGGTTGGCGCTGGCATGGATCTTTCAGTGATCAATCCTCTGGATCCTGCGAG
CCGCTCTGCACTCGTTGTGGCTGGATTCCTGGTTGTTGTAGCGATTGTGGGCAAGATTGCTGCTGGTTGGGCTTTCTGGA
TTGACAAACCCACCAATCGTTTGGTTGTTGGTCTTGGAATGATGCCTCGCGGTGAAGTTGGTTTGATTTTTCTTGGGCTG
GGTACAAGCGCCGGACTGCTTTCTCCTTCTTTAGAAGCTGCCGTTCTATTGATGGTGATTAGCACCACCTTCCTTGCACC
GTTGCTTTTGCGTTTGGTGCTTAAAGACAAAACGCCTGGAGGCGGCAACTCCATCCCTGATGACGTTGCTGCCAATCCTG
TTGGCCTGGTTTAG

Upstream 100 bases:

>100_bases
CATCAACACCTGCAGGTTCTCCTCACGCTTCGTTTTGAGCCCACCAAAGCAGGATTTGCCTTTCCTTTAATCTCGCTCAC
AAAGACTGAAATCCGGCTCC

Downstream 100 bases:

>100_bases
TGCAGCTTTTTTGATTGCATAGCCCTGATAAGTAAAAGAATTGCCTACCATCAACTTTCGCCACCGTCGCCGTTGTGACG
TCAGCTCCATCTGCCGTTCT

Product: CPA2 family Na+/H+ antiporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MVLHSVLSVLSSHDVEVAETLIGVLNFLLIFVAARTLAELLVRLHLPTIVGELLAGVLIGASGLHLLVPPSTHSHLNEGL
VSLISALASIPPEAVPDLYYETFPSLQAVATLGLYALLFLTGLESELEELVAVGVQAFTVAMAGVVLPFALGTFGLMALF
QVELIPAIFAGASMTATSIGITASVFGELGYLKTREGQIVIGAAVLDDILGIVILAVVVALATGGNLEIAPIVKLVVAAT
VFVVLAIVLSRTAAPAFDWVIDRLKAPGAVVVASFVILVLCCFIATAIGLEAALGAFAAGLILSSSKNNHAIQQSVLPIV
TLFATIFFVLVGAGMDLSVINPLDPASRSALVVAGFLVVVAIVGKIAAGWAFWIDKPTNRLVVGLGMMPRGEVGLIFLGL
GTSAGLLSPSLEAAVLLMVISTTFLAPLLLRLVLKDKTPGGGNSIPDDVAANPVGLV

Sequences:

>Translated_457_residues
MVLHSVLSVLSSHDVEVAETLIGVLNFLLIFVAARTLAELLVRLHLPTIVGELLAGVLIGASGLHLLVPPSTHSHLNEGL
VSLISALASIPPEAVPDLYYETFPSLQAVATLGLYALLFLTGLESELEELVAVGVQAFTVAMAGVVLPFALGTFGLMALF
QVELIPAIFAGASMTATSIGITASVFGELGYLKTREGQIVIGAAVLDDILGIVILAVVVALATGGNLEIAPIVKLVVAAT
VFVVLAIVLSRTAAPAFDWVIDRLKAPGAVVVASFVILVLCCFIATAIGLEAALGAFAAGLILSSSKNNHAIQQSVLPIV
TLFATIFFVLVGAGMDLSVINPLDPASRSALVVAGFLVVVAIVGKIAAGWAFWIDKPTNRLVVGLGMMPRGEVGLIFLGL
GTSAGLLSPSLEAAVLLMVISTTFLAPLLLRLVLKDKTPGGGNSIPDDVAANPVGLV
>Mature_457_residues
MVLHSVLSVLSSHDVEVAETLIGVLNFLLIFVAARTLAELLVRLHLPTIVGELLAGVLIGASGLHLLVPPSTHSHLNEGL
VSLISALASIPPEAVPDLYYETFPSLQAVATLGLYALLFLTGLESELEELVAVGVQAFTVAMAGVVLPFALGTFGLMALF
QVELIPAIFAGASMTATSIGITASVFGELGYLKTREGQIVIGAAVLDDILGIVILAVVVALATGGNLEIAPIVKLVVAAT
VFVVLAIVLSRTAAPAFDWVIDRLKAPGAVVVASFVILVLCCFIATAIGLEAALGAFAAGLILSSSKNNHAIQQSVLPIV
TLFATIFFVLVGAGMDLSVINPLDPASRSALVVAGFLVVVAIVGKIAAGWAFWIDKPTNRLVVGLGMMPRGEVGLIFLGL
GTSAGLLSPSLEAAVLLMVISTTFLAPLLLRLVLKDKTPGGGNSIPDDVAANPVGLV

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=404, Percent_Identity=25.2475247524752, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322367, Length=370, Percent_Identity=23.5135135135135, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 46987; Mature: 46987

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLHSVLSVLSSHDVEVAETLIGVLNFLLIFVAARTLAELLVRLHLPTIVGELLAGVLIG
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ASGLHLLVPPSTHSHLNEGLVSLISALASIPPEAVPDLYYETFPSLQAVATLGLYALLFL
CCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TGLESELEELVAVGVQAFTVAMAGVVLPFALGTFGLMALFQVELIPAIFAGASMTATSIG
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ITASVFGELGYLKTREGQIVIGAAVLDDILGIVILAVVVALATGGNLEIAPIVKLVVAAT
HHHHHHHHHCCCEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VFVVLAIVLSRTAAPAFDWVIDRLKAPGAVVVASFVILVLCCFIATAIGLEAALGAFAAG
HHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILSSSKNNHAIQQSVLPIVTLFATIFFVLVGAGMDLSVINPLDPASRSALVVAGFLVVV
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHH
AIVGKIAAGWAFWIDKPTNRLVVGLGMMPRGEVGLIFLGLGTSAGLLSPSLEAAVLLMVI
HHHHHHHHCHHEEECCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
STTFLAPLLLRLVLKDKTPGGGNSIPDDVAANPVGLV
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCC
>Mature Secondary Structure
MVLHSVLSVLSSHDVEVAETLIGVLNFLLIFVAARTLAELLVRLHLPTIVGELLAGVLIG
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ASGLHLLVPPSTHSHLNEGLVSLISALASIPPEAVPDLYYETFPSLQAVATLGLYALLFL
CCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TGLESELEELVAVGVQAFTVAMAGVVLPFALGTFGLMALFQVELIPAIFAGASMTATSIG
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ITASVFGELGYLKTREGQIVIGAAVLDDILGIVILAVVVALATGGNLEIAPIVKLVVAAT
HHHHHHHHHCCCEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VFVVLAIVLSRTAAPAFDWVIDRLKAPGAVVVASFVILVLCCFIATAIGLEAALGAFAAG
HHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILSSSKNNHAIQQSVLPIVTLFATIFFVLVGAGMDLSVINPLDPASRSALVVAGFLVVV
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHH
AIVGKIAAGWAFWIDKPTNRLVVGLGMMPRGEVGLIFLGLGTSAGLLSPSLEAAVLLMVI
HHHHHHHHCHHEEECCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
STTFLAPLLLRLVLKDKTPGGGNSIPDDVAANPVGLV
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]