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The map label for this gene is dfp [H]

Identifier: 33864069

GI number: 33864069

Start: 1903581

End: 1904867

Strand: Reverse

Name: dfp [H]

Synonym: PMT1802

Alternate gene names: 33864069

Gene position: 1904867-1903581 (Counterclockwise)

Preceding gene: 33864070

Following gene: 33864067

Centisome position: 79.01

GC content: 55.79

Gene sequence:

>1287_bases
ATGAAGATTGAGGCGGCACGCCCTCTTATGGGTCGCCGTCTGCTTGTAGCAGTCACTGGCAGTATCGCGGCTGTTAAAAC
ACCATTGCTGGTGAGTGCTCTGATCAAGGCCGGCGCTGAGGTGCGCTGTCTTGTGACGCCTAGTGCTGCTCGTCTAGTCA
GCCCTGTTGCTCTTGCCAGTCTTAGTAGGCATCGCTGCTACCAGGATGAGGATCAATGGAATTCGAGCGAGCCTCGTCCT
TTACATGTGGCCCTGGCTGAATGGGCTGAGCTTGTCATTGTCGCTCCTTTAAGTGCAACGAGTCTTGCCCGTTGGTCACA
TGGGCTTGCAGAGGGGCTTCTGGCAAGTTTGTTGCTGGCCTGTGAACGGCCGGTGCTTGCAGCGGCAGCAATGAACACTG
CCATGTGGTCCAACCCTGCCGTGAGGAGGAACTGGCAAGAGTTGCAGACTGATCGAAGAGTGCTGCCATTGGCCCCTGAA
TCTGGGCTGCTGGCCTGTGATCGGATCGGGGATGGCCGCATGGTCGATCCGAAGTTGATTGAGCTGGCTGTTGTTAGTGG
GCTTTTGCAGGCTGATGAGACAGGCAGGCTGCAACGCGATTGGCAAGGGCGAAGGTTGTTGGTGACCGCTGGATCGACAG
TGGAGGTTTTGGATCCAGCCAGGCTGTTGATCAATCGCAGCAGCGGCCGCATGGGGGTGTTGCTGGCGCAGGCAGCTCGG
CTACGCGGAGCACAGGTTGATTTGGTGCATGGTCCTTTGAAATTACCTGTTGCTTGGTTGGAGGGGTTGGCGGCCTATCC
AGTGACCAGCGCAGATGAGATGCAGAACATGCTGGCGCAGCTGCAGTCCAAAGCAGATGCAGTGGCGATGGCGGCGGCGG
TTGCGGACGTTCGTCGGGTTAACCCTGCTCAGACTGAGAAACTTTCGAAGGATTGCTTGCTTCAGTCTTTTTCTCAGGGC
TGGGAGCAAGTCCCTGACCTTCTCGCTGAGCTCGTTTTAAGGCGACCAGTTGGTCAGGTTCTGCTTGGTTTTGCTGCACT
AACTGGTAATGAAGCTCAGATTCAGCAGCTTGGTGAGGAAAAGCGTCTTCGCAAAGGCTGTGATCTGCTGATGGCGAATC
CGATTGATCGCCCAGGTCAGGGTTTTGAGGAGGATTTCAATGGTGGTTGGTTGCTTGCTGCCGATGGCAGCATCCGTTCT
TTACCTGTTACGTCCAAGCTGGCATTGGCGCATCAGTTGCTTGATGCCATTTTGGAGGTTCAGGTCGTGATTTCGGCGCC
ATCTTGA

Upstream 100 bases:

>100_bases
TTTGCCGGGTTGGGCGATTGGCATCTATTGCGGGCTTTGGCGATTCATCGCCCTGAGCTGACAGCTCCATACGTGCATCT
GATCGATCAGGAACCCTTCG

Downstream 100 bases:

>100_bases
CCAAGTAGATCGATGAAAGTGCGCAGTTGCAGCCTTGGGATATATGGCCAGCCTCCGCTTTTCTTCATGGTCTGAAGCAG
GGTGTAAAGGTCTTGAAGAT

Product: p-pantothenate cysteine ligase and p-pantothenenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKIEAARPLMGRRLLVAVTGSIAAVKTPLLVSALIKAGAEVRCLVTPSAARLVSPVALASLSRHRCYQDEDQWNSSEPRP
LHVALAEWAELVIVAPLSATSLARWSHGLAEGLLASLLLACERPVLAAAAMNTAMWSNPAVRRNWQELQTDRRVLPLAPE
SGLLACDRIGDGRMVDPKLIELAVVSGLLQADETGRLQRDWQGRRLLVTAGSTVEVLDPARLLINRSSGRMGVLLAQAAR
LRGAQVDLVHGPLKLPVAWLEGLAAYPVTSADEMQNMLAQLQSKADAVAMAAAVADVRRVNPAQTEKLSKDCLLQSFSQG
WEQVPDLLAELVLRRPVGQVLLGFAALTGNEAQIQQLGEEKRLRKGCDLLMANPIDRPGQGFEEDFNGGWLLAADGSIRS
LPVTSKLALAHQLLDAILEVQVVISAPS

Sequences:

>Translated_428_residues
MKIEAARPLMGRRLLVAVTGSIAAVKTPLLVSALIKAGAEVRCLVTPSAARLVSPVALASLSRHRCYQDEDQWNSSEPRP
LHVALAEWAELVIVAPLSATSLARWSHGLAEGLLASLLLACERPVLAAAAMNTAMWSNPAVRRNWQELQTDRRVLPLAPE
SGLLACDRIGDGRMVDPKLIELAVVSGLLQADETGRLQRDWQGRRLLVTAGSTVEVLDPARLLINRSSGRMGVLLAQAAR
LRGAQVDLVHGPLKLPVAWLEGLAAYPVTSADEMQNMLAQLQSKADAVAMAAAVADVRRVNPAQTEKLSKDCLLQSFSQG
WEQVPDLLAELVLRRPVGQVLLGFAALTGNEAQIQQLGEEKRLRKGCDLLMANPIDRPGQGFEEDFNGGWLLAADGSIRS
LPVTSKLALAHQLLDAILEVQVVISAPS
>Mature_428_residues
MKIEAARPLMGRRLLVAVTGSIAAVKTPLLVSALIKAGAEVRCLVTPSAARLVSPVALASLSRHRCYQDEDQWNSSEPRP
LHVALAEWAELVIVAPLSATSLARWSHGLAEGLLASLLLACERPVLAAAAMNTAMWSNPAVRRNWQELQTDRRVLPLAPE
SGLLACDRIGDGRMVDPKLIELAVVSGLLQADETGRLQRDWQGRRLLVTAGSTVEVLDPARLLINRSSGRMGVLLAQAAR
LRGAQVDLVHGPLKLPVAWLEGLAAYPVTSADEMQNMLAQLQSKADAVAMAAAVADVRRVNPAQTEKLSKDCLLQSFSQG
WEQVPDLLAELVLRRPVGQVLLGFAALTGNEAQIQQLGEEKRLRKGCDLLMANPIDRPGQGFEEDFNGGWLLAADGSIRS
LPVTSKLALAHQLLDAILEVQVVISAPS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=195, Percent_Identity=36.9230769230769, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI87082301, Length=416, Percent_Identity=35.0961538461538, Blast_Score=185, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17560194, Length=196, Percent_Identity=30.6122448979592, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322762, Length=180, Percent_Identity=31.6666666666667, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24657262, Length=188, Percent_Identity=29.2553191489362, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 46032; Mature: 46032

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEAARPLMGRRLLVAVTGSIAAVKTPLLVSALIKAGAEVRCLVTPSAARLVSPVALAS
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHH
LSRHRCYQDEDQWNSSEPRPLHVALAEWAELVIVAPLSATSLARWSHGLAEGLLASLLLA
HHHHCCCCCCCCCCCCCCCEEEEEHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
CERPVLAAAAMNTAMWSNPAVRRNWQELQTDRRVLPLAPESGLLACDRIGDGRMVDPKLI
HCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCEEEEECCCCCCCCHHHH
ELAVVSGLLQADETGRLQRDWQGRRLLVTAGSTVEVLDPARLLINRSSGRMGVLLAQAAR
HHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCEEECCCHHHHHEECCCCCCHHHHHHHHH
LRGAQVDLVHGPLKLPVAWLEGLAAYPVTSADEMQNMLAQLQSKADAVAMAAAVADVRRV
HCCCEEEEEECCHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NPAQTEKLSKDCLLQSFSQGWEQVPDLLAELVLRRPVGQVLLGFAALTGNEAQIQQLGEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHH
KRLRKGCDLLMANPIDRPGQGFEEDFNGGWLLAADGSIRSLPVTSKLALAHQLLDAILEV
HHHHHCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHE
QVVISAPS
EEEEECCC
>Mature Secondary Structure
MKIEAARPLMGRRLLVAVTGSIAAVKTPLLVSALIKAGAEVRCLVTPSAARLVSPVALAS
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHH
LSRHRCYQDEDQWNSSEPRPLHVALAEWAELVIVAPLSATSLARWSHGLAEGLLASLLLA
HHHHCCCCCCCCCCCCCCCEEEEEHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
CERPVLAAAAMNTAMWSNPAVRRNWQELQTDRRVLPLAPESGLLACDRIGDGRMVDPKLI
HCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCEEEEECCCCCCCCHHHH
ELAVVSGLLQADETGRLQRDWQGRRLLVTAGSTVEVLDPARLLINRSSGRMGVLLAQAAR
HHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCEEECCCHHHHHEECCCCCCHHHHHHHHH
LRGAQVDLVHGPLKLPVAWLEGLAAYPVTSADEMQNMLAQLQSKADAVAMAAAVADVRRV
HCCCEEEEEECCHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NPAQTEKLSKDCLLQSFSQGWEQVPDLLAELVLRRPVGQVLLGFAALTGNEAQIQQLGEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHH
KRLRKGCDLLMANPIDRPGQGFEEDFNGGWLLAADGSIRSLPVTSKLALAHQLLDAILEV
HHHHHCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHE
QVVISAPS
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]