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The map label for this gene is trpE [H]

Identifier: 33863978

GI number: 33863978

Start: 1810672

End: 1812192

Strand: Direct

Name: trpE [H]

Synonym: PMT1711

Alternate gene names: 33863978

Gene position: 1810672-1812192 (Clockwise)

Preceding gene: 33863977

Following gene: 33863979

Centisome position: 75.1

GC content: 54.31

Gene sequence:

>1521_bases
ATGCTCAGCTCTGATCGTGACCATTTCTTTGAGATGGCTGCTAGTGGTGCCAATTTCATTCCTTTGGCCCGCAGTTGGCC
AGCGGATCTGGAGACTCCTCTAACAACTTGGTTAAAAGTTGGGGCAGATCATCCCCCTGGGGTCTTACTCGAATCGGTCG
AAGGGGGTGAAACTCTTGGGCGCTGGAGTGTGGTGGCCTGCAATCCACTTTGGACAGCCACCTGCCGAGGGAAACACCTC
ACACGTCGTTGGCGAGAAGGACGAACCGATGAAGCCATCGGCAACCCTTTTGAAGGCCTCAGGCAATGGCTTGCTCCTTA
TCGCACCGCAACCCTGCCAGGCCTACCCCCCCTTGGCCAGCTCTATGGAATGTGGGGTTTTGAACTGATCAAGTGGGTTG
AACCCACAGTGCCCGTTCACTTAAGGGACAACAACGATCCGCCTGATGGCATCTGGATGCTGATGGACAGCATCTTGATC
ATTGATCAAGTTAAACGCCTCATCACTGCCGTGGCATACGCAGACCTGAGTGTCGAGCAAACGGCTAACGAAGCTTGGGA
CAAGGCACAAGCACGCATTCAAGACCTAGAAAAGTGCATGGCGGAACCACTTGCGCCGATTCAGCCACTGCAATGGCAAC
CAAAAAGTCAATCTCCACCTTCCACCATCAGTAACTACAGCCAACAAGGCTTTGAGGAGGCAGTTCAAACCGCCAAGCAA
CACATCGCCGCAGGTGATGTGTTCCAGCTTGTAATCAGTCAACGGCTGGAGACCAGAGTTCCTCAACAGCCACTTGAGCT
CTACAGAAGTCTGCGGATGGTGAATCCTTCTCCATATATGGCTTTCTTTGACTTCGGCGACTGGCAGCTGATTGGCTCAA
GCCCGGAGGTCATGGTCAAGGCGGAGCCTGTCGCCGATGGCATTAAGGCCAGCCTTCGGCCTATTGCCGGCACGCGTCAG
CGTGGCGGCAACGAACTTGAGGACCACAATCTTGAAGCAGAGTTGATGGCAGATCCCAAGGAACGTGCCGAGCATGTGAT
GTTGGTTGATCTTGGCCGCAATGACCTTGGACGCGTTTGCAGGCCGGGCAGTGTGATGGTGAAAGAGCTGATGGTGATCG
AGAAATATTCCCACGTCATGCACATCGTCAGTGCAGTGGAAGGTGTGCTTGCCAAAGGCAAGGATGTTTGGGATCTACTC
ATGGCCTCATTCCCAGCAGGCACGGTCAGTGGCGCCCCAAAAATCAGAGCCATGCAGCTCATTCATGAGCTCGAACCCGA
CTCAAGAGGACCTTATTCAGGTGTGTATGGGTCCATCGATCTCAACGGTGCTCTGAATACAGCTATAACCATTCGCACAA
TGATTGTGCGGCCCCATCCTGAAGGCGGCTGGCAAGTCAAGGTTCAAGCAGGCGCTGGTGTGGTGGCCGATTCCATCCCC
ACCAAGGAATACGAAGAGACCCTCAACAAGGCAAGGGGAATGCTCACAGCCCTGGCCTGCCTCGAGTCCCACAAGTCATG
A

Upstream 100 bases:

>100_bases
TTAAAATTCAGCGGGCGCAACACCTACGACGCCTGAGTCCCTTTCGCCTGAAGGGTACGGGGATCTTCAACCACTCGGCA
CCAGCTGCGAAGATTCCCTC

Downstream 100 bases:

>100_bases
GTACCCGGCTGCTACTTAAGGGGTTCGAAGTGGAGCTGTTCACAGGACGCTTCAGCGGTGAGCACGTCGGCGTAGCTACT
GCCGTAGCAAGCGATCTTGC

Product: anthranilate synthase component I/chorismate-binding protein

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MLSSDRDHFFEMAASGANFIPLARSWPADLETPLTTWLKVGADHPPGVLLESVEGGETLGRWSVVACNPLWTATCRGKHL
TRRWREGRTDEAIGNPFEGLRQWLAPYRTATLPGLPPLGQLYGMWGFELIKWVEPTVPVHLRDNNDPPDGIWMLMDSILI
IDQVKRLITAVAYADLSVEQTANEAWDKAQARIQDLEKCMAEPLAPIQPLQWQPKSQSPPSTISNYSQQGFEEAVQTAKQ
HIAAGDVFQLVISQRLETRVPQQPLELYRSLRMVNPSPYMAFFDFGDWQLIGSSPEVMVKAEPVADGIKASLRPIAGTRQ
RGGNELEDHNLEAELMADPKERAEHVMLVDLGRNDLGRVCRPGSVMVKELMVIEKYSHVMHIVSAVEGVLAKGKDVWDLL
MASFPAGTVSGAPKIRAMQLIHELEPDSRGPYSGVYGSIDLNGALNTAITIRTMIVRPHPEGGWQVKVQAGAGVVADSIP
TKEYEETLNKARGMLTALACLESHKS

Sequences:

>Translated_506_residues
MLSSDRDHFFEMAASGANFIPLARSWPADLETPLTTWLKVGADHPPGVLLESVEGGETLGRWSVVACNPLWTATCRGKHL
TRRWREGRTDEAIGNPFEGLRQWLAPYRTATLPGLPPLGQLYGMWGFELIKWVEPTVPVHLRDNNDPPDGIWMLMDSILI
IDQVKRLITAVAYADLSVEQTANEAWDKAQARIQDLEKCMAEPLAPIQPLQWQPKSQSPPSTISNYSQQGFEEAVQTAKQ
HIAAGDVFQLVISQRLETRVPQQPLELYRSLRMVNPSPYMAFFDFGDWQLIGSSPEVMVKAEPVADGIKASLRPIAGTRQ
RGGNELEDHNLEAELMADPKERAEHVMLVDLGRNDLGRVCRPGSVMVKELMVIEKYSHVMHIVSAVEGVLAKGKDVWDLL
MASFPAGTVSGAPKIRAMQLIHELEPDSRGPYSGVYGSIDLNGALNTAITIRTMIVRPHPEGGWQVKVQAGAGVVADSIP
TKEYEETLNKARGMLTALACLESHKS
>Mature_506_residues
MLSSDRDHFFEMAASGANFIPLARSWPADLETPLTTWLKVGADHPPGVLLESVEGGETLGRWSVVACNPLWTATCRGKHL
TRRWREGRTDEAIGNPFEGLRQWLAPYRTATLPGLPPLGQLYGMWGFELIKWVEPTVPVHLRDNNDPPDGIWMLMDSILI
IDQVKRLITAVAYADLSVEQTANEAWDKAQARIQDLEKCMAEPLAPIQPLQWQPKSQSPPSTISNYSQQGFEEAVQTAKQ
HIAAGDVFQLVISQRLETRVPQQPLELYRSLRMVNPSPYMAFFDFGDWQLIGSSPEVMVKAEPVADGIKASLRPIAGTRQ
RGGNELEDHNLEAELMADPKERAEHVMLVDLGRNDLGRVCRPGSVMVKELMVIEKYSHVMHIVSAVEGVLAKGKDVWDLL
MASFPAGTVSGAPKIRAMQLIHELEPDSRGPYSGVYGSIDLNGALNTAITIRTMIVRPHPEGGWQVKVQAGAGVVADSIP
TKEYEETLNKARGMLTALACLESHKS

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=383, Percent_Identity=38.9033942558747, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1788114, Length=458, Percent_Identity=30.1310043668122, Blast_Score=199, Evalue=5e-52,
Organism=Escherichia coli, GI1786809, Length=274, Percent_Identity=28.4671532846715, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082077, Length=272, Percent_Identity=26.8382352941176, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320935, Length=483, Percent_Identity=36.231884057971, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6324361, Length=419, Percent_Identity=24.1050119331742, Blast_Score=106, Evalue=8e-24,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 55959; Mature: 55959

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSSDRDHFFEMAASGANFIPLARSWPADLETPLTTWLKVGADHPPGVLLESVEGGETLG
CCCCCHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCCC
RWSVVACNPLWTATCRGKHLTRRWREGRTDEAIGNPFEGLRQWLAPYRTATLPGLPPLGQ
CEEEEEECCCEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHH
LYGMWGFELIKWVEPTVPVHLRDNNDPPDGIWMLMDSILIIDQVKRLITAVAYADLSVEQ
HHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
TANEAWDKAQARIQDLEKCMAEPLAPIQPLQWQPKSQSPPSTISNYSQQGFEEAVQTAKQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HIAAGDVFQLVISQRLETRVPQQPLELYRSLRMVNPSPYMAFFDFGDWQLIGSSPEVMVK
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCEEEE
AEPVADGIKASLRPIAGTRQRGGNELEDHNLEAELMADPKERAEHVMLVDLGRNDLGRVC
ECCHHHHHHHHHHCCCCHHHCCCCCCHHCCCCHHEECCHHHHCCEEEEEECCCCCHHHHC
RPGSVMVKELMVIEKYSHVMHIVSAVEGVLAKGKDVWDLLMASFPAGTVSGAPKIRAMQL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
IHELEPDSRGPYSGVYGSIDLNGALNTAITIRTMIVRPHPEGGWQVKVQAGAGVVADSIP
HHHCCCCCCCCCCCCEECEECCCCCCCEEEEEEEEEECCCCCCEEEEEECCCCEEECCCC
TKEYEETLNKARGMLTALACLESHKS
CHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLSSDRDHFFEMAASGANFIPLARSWPADLETPLTTWLKVGADHPPGVLLESVEGGETLG
CCCCCHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCCC
RWSVVACNPLWTATCRGKHLTRRWREGRTDEAIGNPFEGLRQWLAPYRTATLPGLPPLGQ
CEEEEEECCCEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHH
LYGMWGFELIKWVEPTVPVHLRDNNDPPDGIWMLMDSILIIDQVKRLITAVAYADLSVEQ
HHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
TANEAWDKAQARIQDLEKCMAEPLAPIQPLQWQPKSQSPPSTISNYSQQGFEEAVQTAKQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HIAAGDVFQLVISQRLETRVPQQPLELYRSLRMVNPSPYMAFFDFGDWQLIGSSPEVMVK
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCEEEE
AEPVADGIKASLRPIAGTRQRGGNELEDHNLEAELMADPKERAEHVMLVDLGRNDLGRVC
ECCHHHHHHHHHHCCCCHHHCCCCCCHHCCCCHHEECCHHHHCCEEEEEECCCCCHHHHC
RPGSVMVKELMVIEKYSHVMHIVSAVEGVLAKGKDVWDLLMASFPAGTVSGAPKIRAMQL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
IHELEPDSRGPYSGVYGSIDLNGALNTAITIRTMIVRPHPEGGWQVKVQAGAGVVADSIP
HHHCCCCCCCCCCCCEECEECCCCCCCEEEEEEEEEECCCCCCEEEEEECCCCEEECCCC
TKEYEETLNKARGMLTALACLESHKS
CHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 3141423 [H]