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The map label for this gene is purM,purG [H]

Identifier: 33863958

GI number: 33863958

Start: 1794007

End: 1795044

Strand: Direct

Name: purM,purG [H]

Synonym: PMT1691

Alternate gene names: 33863958

Gene position: 1794007-1795044 (Clockwise)

Preceding gene: 33863955

Following gene: 33863959

Centisome position: 74.41

GC content: 55.01

Gene sequence:

>1038_bases
ATGGACTACAAGACCGCGGGCGTTGACGTCCAAGCAGGTAGGGCATTCATCGAGCGGATCAGATCTAGCGTCGAAGCCAC
CCACCGCCCAGAGGTCATCGGTGGTCTGGGAGGGTTTGGAGGCTTGATGCGCCTCCCCGCAGGGCTAAACAAGCCTCTGC
TTGTCGCAGGAACTGATGGGGTCGGCACCAAGCTCGAACTAGCGCAGCAACATCAAGCTCACTACGGAGTAGGGCTGGAC
CTGGTTGGAATGTGTGTCAACGACGTCATCACCAGTGGCGCTGAACCCCTCTTTTTCCTCGACTACATCGCCACCGGAGC
CCTCAGTCCAGAGGCCATGGCACAAGTTGTGGAGGGAATTGCAGAGGGATGTCGCCGCAGCGGCTGCGCCCTCCTTGGCG
GAGAAACCGCCGAGATGCCTGGGTTTTACGACCCAGGTTGCTACGACCTAGCCGGCTTTTGCGTAGCAGTGGTAGAAGAA
GACGAGATGATTGACGGTCGCAAGATCAAGCCTGGAGATCAGATTATCGGTGTGGCCAGCAGTGGCGTTCATAGCAACGG
GTTCAGTTTGGTGCGCAAAGTGCTGGCCCTTACTGAGGCCAATAAGAACACTCTCTTCGGATGCGACAACAAACCTCTAA
TCGAGACCCTGCTAACCCCTACCACCCTTTACGGCCAGCTGGTAAAAAACCTCCTAGAAGCAAAAGTTCCACTCCACGGC
ATGGCACATATCACCGGTGGAGGCCTACCAGAGAATCTTCCCAGATGTTGCCCAAAAGACTTAGTTACCGTTATAGATCC
AAGCAGCTGGACCAGACCAGAACTTTTTCAATGGCTCCAAGATGCTGGCCAGATTCCAGAGCATGACCTCTGGCACACAT
TCAATCTTGGAGTGGGTTTCTGCCTAGTGGTCGCAGAGGAAGTAGTAAGTGATGTCCTGCAGGTTTGCAACGAACAAGCT
CTCCAAGCTTGGCCTATTGGTCAAGTCGAAACTGCCTCTCCCTCAACCGGGGAGAGATTACGAGGGCTACCCAGCTAA

Upstream 100 bases:

>100_bases
TGATGCCATCTAGAGGCCCCGCTAATGCAAGACAGGACAATCGTGACATTGGCTGAATAGAGGGCGGCAGGGGAGGATCT
AGAAAGGGCCAGTCGAAACC

Downstream 100 bases:

>100_bases
AGCATTGCATCGCAAGGGCTCTTGAGTCGCAAGATCTCTCTAACTAATTACATCGGACTTGTACGAGCCTATTCTCGAGC
CGATTTTCAGGCACGTCCTC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MDYKTAGVDVQAGRAFIERIRSSVEATHRPEVIGGLGGFGGLMRLPAGLNKPLLVAGTDGVGTKLELAQQHQAHYGVGLD
LVGMCVNDVITSGAEPLFFLDYIATGALSPEAMAQVVEGIAEGCRRSGCALLGGETAEMPGFYDPGCYDLAGFCVAVVEE
DEMIDGRKIKPGDQIIGVASSGVHSNGFSLVRKVLALTEANKNTLFGCDNKPLIETLLTPTTLYGQLVKNLLEAKVPLHG
MAHITGGGLPENLPRCCPKDLVTVIDPSSWTRPELFQWLQDAGQIPEHDLWHTFNLGVGFCLVVAEEVVSDVLQVCNEQA
LQAWPIGQVETASPSTGERLRGLPS

Sequences:

>Translated_345_residues
MDYKTAGVDVQAGRAFIERIRSSVEATHRPEVIGGLGGFGGLMRLPAGLNKPLLVAGTDGVGTKLELAQQHQAHYGVGLD
LVGMCVNDVITSGAEPLFFLDYIATGALSPEAMAQVVEGIAEGCRRSGCALLGGETAEMPGFYDPGCYDLAGFCVAVVEE
DEMIDGRKIKPGDQIIGVASSGVHSNGFSLVRKVLALTEANKNTLFGCDNKPLIETLLTPTTLYGQLVKNLLEAKVPLHG
MAHITGGGLPENLPRCCPKDLVTVIDPSSWTRPELFQWLQDAGQIPEHDLWHTFNLGVGFCLVVAEEVVSDVLQVCNEQA
LQAWPIGQVETASPSTGERLRGLPS
>Mature_345_residues
MDYKTAGVDVQAGRAFIERIRSSVEATHRPEVIGGLGGFGGLMRLPAGLNKPLLVAGTDGVGTKLELAQQHQAHYGVGLD
LVGMCVNDVITSGAEPLFFLDYIATGALSPEAMAQVVEGIAEGCRRSGCALLGGETAEMPGFYDPGCYDLAGFCVAVVEE
DEMIDGRKIKPGDQIIGVASSGVHSNGFSLVRKVLALTEANKNTLFGCDNKPLIETLLTPTTLYGQLVKNLLEAKVPLHG
MAHITGGGLPENLPRCCPKDLVTVIDPSSWTRPELFQWLQDAGQIPEHDLWHTFNLGVGFCLVVAEEVVSDVLQVCNEQA
LQAWPIGQVETASPSTGERLRGLPS

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=333, Percent_Identity=46.5465465465465, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI209869995, Length=333, Percent_Identity=46.5465465465465, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI209869993, Length=333, Percent_Identity=46.5465465465465, Blast_Score=293, Evalue=2e-79,
Organism=Escherichia coli, GI1788845, Length=332, Percent_Identity=51.8072289156626, Blast_Score=345, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17567511, Length=348, Percent_Identity=40.2298850574713, Blast_Score=222, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=45.8579881656805, Blast_Score=273, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24582400, Length=277, Percent_Identity=42.9602888086643, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36691; Mature: 36691

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKTAGVDVQAGRAFIERIRSSVEATHRPEVIGGLGGFGGLMRLPAGLNKPLLVAGTDG
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCCCCCCEEEECCCC
VGTKLELAQQHQAHYGVGLDLVGMCVNDVITSGAEPLFFLDYIATGALSPEAMAQVVEGI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AEGCRRSGCALLGGETAEMPGFYDPGCYDLAGFCVAVVEEDEMIDGRKIKPGDQIIGVAS
HHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEEEC
SGVHSNGFSLVRKVLALTEANKNTLFGCDNKPLIETLLTPTTLYGQLVKNLLEAKVPLHG
CCCCCCHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHCHHHHHHHHHHHHHHHCCCCCC
MAHITGGGLPENLPRCCPKDLVTVIDPSSWTRPELFQWLQDAGQIPEHDLWHTFNLGVGF
CCEECCCCCCCHHHHCCCHHHEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEHHHHHHH
CLVVAEEVVSDVLQVCNEQALQAWPIGQVETASPSTGERLRGLPS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MDYKTAGVDVQAGRAFIERIRSSVEATHRPEVIGGLGGFGGLMRLPAGLNKPLLVAGTDG
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCCCCCCEEEECCCC
VGTKLELAQQHQAHYGVGLDLVGMCVNDVITSGAEPLFFLDYIATGALSPEAMAQVVEGI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AEGCRRSGCALLGGETAEMPGFYDPGCYDLAGFCVAVVEEDEMIDGRKIKPGDQIIGVAS
HHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEEEC
SGVHSNGFSLVRKVLALTEANKNTLFGCDNKPLIETLLTPTTLYGQLVKNLLEAKVPLHG
CCCCCCHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHCHHHHHHHHHHHHHHHCCCCCC
MAHITGGGLPENLPRCCPKDLVTVIDPSSWTRPELFQWLQDAGQIPEHDLWHTFNLGVGF
CCEECCCCCCCHHHHCCCHHHEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEHHHHHHH
CLVVAEEVVSDVLQVCNEQALQAWPIGQVETASPSTGERLRGLPS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA