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The map label for this gene is hhoA [H]

Identifier: 33863903

GI number: 33863903

Start: 1737678

End: 1738865

Strand: Reverse

Name: hhoA [H]

Synonym: PMT1636

Alternate gene names: 33863903

Gene position: 1738865-1737678 (Counterclockwise)

Preceding gene: 33863911

Following gene: 33863901

Centisome position: 72.13

GC content: 57.15

Gene sequence:

>1188_bases
ATGTCTGCGTTAGTTGAGGAATCCTCCGCAGAGCTGCGGTTATCCAGCCAATCTTCTGGTTTGAGCAGGGTTTTCCGTGG
TGGTCTTCTGCTTGGCACTGGATTGGTTTGTCTGCCTGTGTTGTCGGGTCTTTCCCCTCAACCGCTGCAGGCGGCATCAG
CCGCGACAGCCTTATCCAAGCAGTCGTTTGTAGCGGATGCCGTGGCTCGCAGCGGCCCTGCTGTGGTGACTCTTGAGACG
AGTCGGACGGTCCGTTCTATGGGCATGGCTGGTCTGCCTCAGGGGCTATTAGCCGACCCGCTGTTCCAACATTTCTTTGG
TTTGCCTGGCAGAGTCGCTCCCCGCTCGCGGATAGAACGAGGGCAGGGAAGTGGTGTGATTTTTTCGGCGGAAGGATTGG
TTCTCACCAATGCTCATGTCGTGGAGAAGACCGATCAGCTGATGGTGGGATTGCCAGATGGTCGAAGGGTGCCTGGGCGA
CTGGTTGGTCAGGACAAGATTACGGATCTGGCTGTAGTGCAGTTGGATGGCTCGGGGCCTTGGCCCACAGCCCCATTGGG
AGACTCGGACCAGCTTCGGGTCGGGGATTGGGCCATAGCTGTTGGCAACCCCTTTGGCCTTGAAAATACGGTGACGTTGG
GAATCGTCAGCAACCTCAACCGCAACGTCTCTCAGCTAGGGATCTCTGGCAAGCGGTTGGATTTAATTCAGACCGATGCT
GCTATCAATCCAGGTAACTCAGGAGGACCGCTGTTGAATTCTGAGGGCAATGTGGTGGGTATCAATACACTCGTTCGCTC
TGGACCAGGAGCTGGGCTGGGTTTTGCTATTCCTATTAATCGGGCTAGGACCATCGCCCAGCAGCTGGTGGAGCGAGGAC
GGGCCAGTCATCCGATGGTGGGTGTAGGTCTCTCGCCGGTGCCATCTGCTCGTTCTGGGGAAGCCAACTCTCCTGGTGCT
GTGATTCGTTCCGTGGTGCCGGATGGGCCTGCAGCGCGTGCCGGGTTGAAGGTTGATGATGTGATCATTTCGGTGGAAGG
GTTACCGATTGATGGGCCTGCTGAGGTCGTGAGCGCGATTGATCGTCATGGAGTTGGGCGACCAATCACTTTTGGATTAA
TCCGGGGCGACAGTCGGATTGAGTTGGCGGTTACACCAGTGGAGCTGACGGCGATGCAGGCGCCTTGA

Upstream 100 bases:

>100_bases
AGCTCAGGCGTATTTGGTCACAGCTCTGTCAAGGATTGACACTGTTGTTTGAGAGAGCTCTGTCTACGGTCAAAGTCATG
AATTGATTGTCGTTTGGCCA

Downstream 100 bases:

>100_bases
CCCTGTTGTTATGTGCACTACTCCCGACTAGTCCAGTCTCAGGCTCTACAAAAGGATCTAAGACATGTTCAGCCCATGAG
CGGGTAGTGATGCAATCTCA

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSALVEESSAELRLSSQSSGLSRVFRGGLLLGTGLVCLPVLSGLSPQPLQAASAATALSKQSFVADAVARSGPAVVTLET
SRTVRSMGMAGLPQGLLADPLFQHFFGLPGRVAPRSRIERGQGSGVIFSAEGLVLTNAHVVEKTDQLMVGLPDGRRVPGR
LVGQDKITDLAVVQLDGSGPWPTAPLGDSDQLRVGDWAIAVGNPFGLENTVTLGIVSNLNRNVSQLGISGKRLDLIQTDA
AINPGNSGGPLLNSEGNVVGINTLVRSGPGAGLGFAIPINRARTIAQQLVERGRASHPMVGVGLSPVPSARSGEANSPGA
VIRSVVPDGPAARAGLKVDDVIISVEGLPIDGPAEVVSAIDRHGVGRPITFGLIRGDSRIELAVTPVELTAMQAP

Sequences:

>Translated_395_residues
MSALVEESSAELRLSSQSSGLSRVFRGGLLLGTGLVCLPVLSGLSPQPLQAASAATALSKQSFVADAVARSGPAVVTLET
SRTVRSMGMAGLPQGLLADPLFQHFFGLPGRVAPRSRIERGQGSGVIFSAEGLVLTNAHVVEKTDQLMVGLPDGRRVPGR
LVGQDKITDLAVVQLDGSGPWPTAPLGDSDQLRVGDWAIAVGNPFGLENTVTLGIVSNLNRNVSQLGISGKRLDLIQTDA
AINPGNSGGPLLNSEGNVVGINTLVRSGPGAGLGFAIPINRARTIAQQLVERGRASHPMVGVGLSPVPSARSGEANSPGA
VIRSVVPDGPAARAGLKVDDVIISVEGLPIDGPAEVVSAIDRHGVGRPITFGLIRGDSRIELAVTPVELTAMQAP
>Mature_394_residues
SALVEESSAELRLSSQSSGLSRVFRGGLLLGTGLVCLPVLSGLSPQPLQAASAATALSKQSFVADAVARSGPAVVTLETS
RTVRSMGMAGLPQGLLADPLFQHFFGLPGRVAPRSRIERGQGSGVIFSAEGLVLTNAHVVEKTDQLMVGLPDGRRVPGRL
VGQDKITDLAVVQLDGSGPWPTAPLGDSDQLRVGDWAIAVGNPFGLENTVTLGIVSNLNRNVSQLGISGKRLDLIQTDAA
INPGNSGGPLLNSEGNVVGINTLVRSGPGAGLGFAIPINRARTIAQQLVERGRASHPMVGVGLSPVPSARSGEANSPGAV
IRSVVPDGPAARAGLKVDDVIISVEGLPIDGPAEVVSAIDRHGVGRPITFGLIRGDSRIELAVTPVELTAMQAP

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoB and HtrA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=344, Percent_Identity=34.593023255814, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI22129776, Length=369, Percent_Identity=33.0623306233062, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI24308541, Length=278, Percent_Identity=35.6115107913669, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI7019477, Length=346, Percent_Identity=32.9479768786127, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1789629, Length=321, Percent_Identity=41.1214953271028, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1786356, Length=267, Percent_Identity=40.4494382022472, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1789630, Length=281, Percent_Identity=39.5017793594306, Blast_Score=176, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24646839, Length=361, Percent_Identity=29.9168975069252, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40510; Mature: 40379

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALVEESSAELRLSSQSSGLSRVFRGGLLLGTGLVCLPVLSGLSPQPLQAASAATALSK
CCCCCCCCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
QSFVADAVARSGPAVVTLETSRTVRSMGMAGLPQGLLADPLFQHFFGLPGRVAPRSRIER
HHHHHHHHHCCCCEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHC
GQGSGVIFSAEGLVLTNAHVVEKTDQLMVGLPDGRRVPGRLVGQDKITDLAVVQLDGSGP
CCCCEEEEECCCEEEECCHHEECCCCEEEECCCCCCCCCEECCCCCCCEEEEEEECCCCC
WPTAPLGDSDQLRVGDWAIAVGNPFGLENTVTLGIVSNLNRNVSQLGISGKRLDLIQTDA
CCCCCCCCCCCEEECCEEEEECCCCCCCCEEEEEEHHHCCCCHHHHCCCCCEEEEEEECC
AINPGNSGGPLLNSEGNVVGINTLVRSGPGAGLGFAIPINRARTIAQQLVERGRASHPMV
CCCCCCCCCCEECCCCCEEEEHHHHHCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCEE
GVGLSPVPSARSGEANSPGAVIRSVVPDGPAARAGLKVDDVIISVEGLPIDGPAEVVSAI
ECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHCCCEEEEEEEEEECCCCCCHHHHHHHH
DRHGVGRPITFGLIRGDSRIELAVTPVELTAMQAP
HHCCCCCCEEEEEEECCCEEEEEEECEEEEEECCC
>Mature Secondary Structure 
SALVEESSAELRLSSQSSGLSRVFRGGLLLGTGLVCLPVLSGLSPQPLQAASAATALSK
CCCCCCCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
QSFVADAVARSGPAVVTLETSRTVRSMGMAGLPQGLLADPLFQHFFGLPGRVAPRSRIER
HHHHHHHHHCCCCEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHC
GQGSGVIFSAEGLVLTNAHVVEKTDQLMVGLPDGRRVPGRLVGQDKITDLAVVQLDGSGP
CCCCEEEEECCCEEEECCHHEECCCCEEEECCCCCCCCCEECCCCCCCEEEEEEECCCCC
WPTAPLGDSDQLRVGDWAIAVGNPFGLENTVTLGIVSNLNRNVSQLGISGKRLDLIQTDA
CCCCCCCCCCCEEECCEEEEECCCCCCCCEEEEEEHHHCCCCHHHHCCCCCEEEEEEECC
AINPGNSGGPLLNSEGNVVGINTLVRSGPGAGLGFAIPINRARTIAQQLVERGRASHPMV
CCCCCCCCCCEECCCCCEEEEHHHHHCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCEE
GVGLSPVPSARSGEANSPGAVIRSVVPDGPAARAGLKVDDVIISVEGLPIDGPAEVVSAI
ECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHCCCEEEEEEEEEECCCCCCHHHHHHHH
DRHGVGRPITFGLIRGDSRIELAVTPVELTAMQAP
HHCCCCCCEEEEEEECCCEEEEEEECEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]