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The map label for this gene is 33863804

Identifier: 33863804

GI number: 33863804

Start: 1628608

End: 1629522

Strand: Reverse

Name: 33863804

Synonym: PMT1537

Alternate gene names: NA

Gene position: 1629522-1628608 (Counterclockwise)

Preceding gene: 33863810

Following gene: 33863800

Centisome position: 67.59

GC content: 54.75

Gene sequence:

>915_bases
ATGTCTGGCCTTCAGGTGCTTCTGGTGGCGGGTACTCATGGCAATGAAATCAACGGTCCCTGGCTTCTCGATCAATGGTC
TCAGACCCCTGAGCTGATCAACACCCATGGTGTTGGTGTGGTGCCGGTGATCGGTAATCCAGAGGCTCTTGCGTTGGGCC
GGCGTTATTTGGATTGCGATCTCAACCGCAGCTTTCGGCTCGACTTGCTCAGATCTCCCAGCATCTTGGATCGAGAGGTT
GTTCGTGCCAAGCAGTTGCTTAGTTTTTTTGGTCCAGAGGGATCAACCCCTTGCCAGATCGTTATTGATTTGCACAGCAC
CACTTCAGCAATGGGAAGCACTCTTGTGGTTTATGGCCGACGGTCGGTTGACTTGGCTTTAGCAGCATTGATTCAGGCTC
GCTTGGGTTTGCCTATCTATCTGCATGATGGGGATGATGACCAGCAGGGGTTTTTGGTGGAGCGCTGGCCCTGTGGCTTA
GTGATTGAAATCGGTCCTGTTCCCCAGGGCCTGTTAAAGGCCCGCATTATTGAACAGACACGACTTGCTGTTCAGGCCTG
TCTCGAGGCTCTGAGCAGCGTTGCATCTGGATCGCCGACCTACCCAGATGAGTTTGTGGTGCACTCTCATCTGGGTAGTC
TGGACCTGCCCCGTGATGCCTTGGGCCAGCCTGCTGCATGTGTGCATCCATCTCTTCAGGGCCGTGATTGGCAGCCTCTG
CAGATGGGCGCCCCCTTGTTTCTCTGGCCAGATGGAGAGGTGTTCAGATTTGAAGGTCGAGATTCTCCCATCCCCGTTTT
TATCAACGAGGCGGCCTACGTTGAAAAGCACATCGCCATGAGCCTGACCTGTCGAGAGGTCTGCCCCCTGCCTGAGCAAT
GGCAAGGGGCCCTGCAGCAGTTAGTCGACTGTTAA

Upstream 100 bases:

>100_bases
CCAGCCCATGCGTGCTGCGGCAACGATTGCGGGGGGGATCGACATGGTTGTTCCCTTTGCAGCCATTTTCGGTCAGGCTG
AGGATTGCGATCGAATCTTG

Downstream 100 bases:

>100_bases
CGAGGGGGACCGTTGTAGATGATCTGATTGACAGACCTTCCGTCGGGGGCAATCTGAATGACGGTTTCTGTGGTCGGTTC
ATTGCCATATTCCGACCAGC

Product: aspartoacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSGLQVLLVAGTHGNEINGPWLLDQWSQTPELINTHGVGVVPVIGNPEALALGRRYLDCDLNRSFRLDLLRSPSILDREV
VRAKQLLSFFGPEGSTPCQIVIDLHSTTSAMGSTLVVYGRRSVDLALAALIQARLGLPIYLHDGDDDQQGFLVERWPCGL
VIEIGPVPQGLLKARIIEQTRLAVQACLEALSSVASGSPTYPDEFVVHSHLGSLDLPRDALGQPAACVHPSLQGRDWQPL
QMGAPLFLWPDGEVFRFEGRDSPIPVFINEAAYVEKHIAMSLTCREVCPLPEQWQGALQQLVDC

Sequences:

>Translated_304_residues
MSGLQVLLVAGTHGNEINGPWLLDQWSQTPELINTHGVGVVPVIGNPEALALGRRYLDCDLNRSFRLDLLRSPSILDREV
VRAKQLLSFFGPEGSTPCQIVIDLHSTTSAMGSTLVVYGRRSVDLALAALIQARLGLPIYLHDGDDDQQGFLVERWPCGL
VIEIGPVPQGLLKARIIEQTRLAVQACLEALSSVASGSPTYPDEFVVHSHLGSLDLPRDALGQPAACVHPSLQGRDWQPL
QMGAPLFLWPDGEVFRFEGRDSPIPVFINEAAYVEKHIAMSLTCREVCPLPEQWQGALQQLVDC
>Mature_303_residues
SGLQVLLVAGTHGNEINGPWLLDQWSQTPELINTHGVGVVPVIGNPEALALGRRYLDCDLNRSFRLDLLRSPSILDREVV
RAKQLLSFFGPEGSTPCQIVIDLHSTTSAMGSTLVVYGRRSVDLALAALIQARLGLPIYLHDGDDDQQGFLVERWPCGLV
IEIGPVPQGLLKARIIEQTRLAVQACLEALSSVASGSPTYPDEFVVHSHLGSLDLPRDALGQPAACVHPSLQGRDWQPLQ
MGAPLFLWPDGEVFRFEGRDSPIPVFINEAAYVEKHIAMSLTCREVCPLPEQWQGALQQLVDC

Specific function: Unknown

COG id: COG2988

COG function: function code E; Succinylglutamate desuccinylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AspA/AstE family. Aspartoacylase subfamily

Homologues:

Organism=Homo sapiens, GI4557335, Length=290, Percent_Identity=37.2413793103448, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI189339202, Length=290, Percent_Identity=37.2413793103448, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI18087825, Length=295, Percent_Identity=36.271186440678, Blast_Score=174, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ASPA_PROMM (Q7V5L6)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895364.1
- ProteinModelPortal:   Q7V5L6
- SMR:   Q7V5L6
- STRING:   Q7V5L6
- GeneID:   1728413
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT1537
- NMPDR:   fig|74547.1.peg.1531
- eggNOG:   COG2988
- HOGENOM:   HBG635125
- OMA:   DFLIQMF
- ProtClustDB:   PRK02259
- BioCyc:   PMAR74547:PMT1537-MONOMER
- HAMAP:   MF_00704
- InterPro:   IPR016708
- InterPro:   IPR007036
- PIRSF:   PIRSF018001

Pfam domain/function: PF04952 AstE_AspA

EC number: =3.5.1.15

Molecular weight: Translated: 33251; Mature: 33119

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: BINDING 55-55 BINDING 163-163 BINDING 273-273

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLQVLLVAGTHGNEINGPWLLDQWSQTPELINTHGVGVVPVIGNPEALALGRRYLDCD
CCCEEEEEEECCCCCCCCCCEEECCCCCCCHHHHCCCCEEEEEECCCCHHHHCCEEEECC
LNRSFRLDLLRSPSILDREVVRAKQLLSFFGPEGSTPCQIVIDLHSTTSAMGSTLVVYGR
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHCCCEEEEECC
RSVDLALAALIQARLGLPIYLHDGDDDQQGFLVERWPCGLVIEIGPVPQGLLKARIIEQT
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHH
RLAVQACLEALSSVASGSPTYPDEFVVHSHLGSLDLPRDALGQPAACVHPSLQGRDWQPL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHCCCCEEECCCCCCCCCCCH
QMGAPLFLWPDGEVFRFEGRDSPIPVFINEAAYVEKHIAMSLTCREVCPLPEQWQGALQQ
HCCCCEEECCCCCEEEECCCCCCCCEEECCHHHHHHHHHHEEEHHHHCCCCHHHHHHHHH
LVDC
HHCC
>Mature Secondary Structure 
SGLQVLLVAGTHGNEINGPWLLDQWSQTPELINTHGVGVVPVIGNPEALALGRRYLDCD
CCEEEEEEECCCCCCCCCCEEECCCCCCCHHHHCCCCEEEEEECCCCHHHHCCEEEECC
LNRSFRLDLLRSPSILDREVVRAKQLLSFFGPEGSTPCQIVIDLHSTTSAMGSTLVVYGR
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHCCCEEEEECC
RSVDLALAALIQARLGLPIYLHDGDDDQQGFLVERWPCGLVIEIGPVPQGLLKARIIEQT
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHH
RLAVQACLEALSSVASGSPTYPDEFVVHSHLGSLDLPRDALGQPAACVHPSLQGRDWQPL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHCCCCEEECCCCCCCCCCCH
QMGAPLFLWPDGEVFRFEGRDSPIPVFINEAAYVEKHIAMSLTCREVCPLPEQWQGALQQ
HCCCCEEECCCCCEEEECCCCCCCCEEECCHHHHHHHHHHEEEHHHHCCCCHHHHHHHHH
LVDC
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642