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The map label for this gene is pkn1 [H]

Identifier: 33863783

GI number: 33863783

Start: 1606859

End: 1607734

Strand: Direct

Name: pkn1 [H]

Synonym: PMT1516

Alternate gene names: 33863783

Gene position: 1606859-1607734 (Clockwise)

Preceding gene: 33863782

Following gene: 33863784

Centisome position: 66.65

GC content: 57.31

Gene sequence:

>876_bases
GTGACCACATCTTTGCCAGTAGAGATGGTAACCATCCCCGCAGGGCTCTATCGAGTTGGCTGTGATCGCTGCTATCCGGA
TGGTTCAGTTCGCTGCTATCCGGAGGAAACACCCGCGCGAGAAGTGCAGCTTGACTCATTCCAGATCGACGTAGGGCCAG
TCACCAATGCCCAGTTCCGAGCTTTCGTTAGCGCCACGCAGCATCTCACAGTCTCGGAGCTACCACCTGATCCAACGCTC
TATCCCGATCTAGCGCCCGAGGAACGCATCCCTGAATCAGTTGTCTTTCAACCGCCTCCAGCAACGGTGGATCGCAGCAA
ACCCTTGAGCTGGTGGACCCTCATGGCTGGGGCTGATTGGCGTCATCCCCAAGGACCCGAAAGCACGATCGATGGCCTTG
ATGATCACCCTGTCGTGCATGTCGCCTATGCCGACGCCATCGCCTATGCCCATTGGGCTGGCAAGCGTCTCCCCTCTGCT
GAAGAGTGGGAAGTAGCCGCCCGCGGGGGTCTTGTCGATGCCCAATACGCCTGGGGGAATGAACTCACTCCCAATAACCG
CTGGATGGCGAACATCTGGCAAGGTCCTTTCCCTTGGCACAACGAGGAGCTAGACGGCTGGTTCTGGACCTCGCCCGTTG
GCAGCTTTCCTGCCAACGGCTATGGACTCTTGGATGTTTGCGGCAATGTGTGGGAATGGACCAACTCTGTTTATCCCGTG
GCGTCAGGCCACCAGGAACGGCGAACTATCAAAGGCGGATCGTTTCTCTGCGCAGATAATTACTGCGTACGTTATCGACC
CTCTGCACTACAAGGCCAGACAGTAGACACTGCCACCTGTCACATGGGCTTTCGCTGTGCAAAAGGAGGGCCTTGA

Upstream 100 bases:

>100_bases
CAGTGACATTGGTTGGGCACTCTGAATGTGCTCTTACTTAGCCATCTTGGCTTTTAGGCAACAATAAAGATGGACACATT
TCCACCTGCAGACTTTAATT

Downstream 100 bases:

>100_bases
TTGCTGACTCACTTAGAGAGCATCAACCCCATCGCTAGGTCAAATTTCAACTGCAATCGTAGGCAGTTCGCAACAAAAGA
TGAATCCAGGTCAGTCAGTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTTSLPVEMVTIPAGLYRVGCDRCYPDGSVRCYPEETPAREVQLDSFQIDVGPVTNAQFRAFVSATQHLTVSELPPDPTL
YPDLAPEERIPESVVFQPPPATVDRSKPLSWWTLMAGADWRHPQGPESTIDGLDDHPVVHVAYADAIAYAHWAGKRLPSA
EEWEVAARGGLVDAQYAWGNELTPNNRWMANIWQGPFPWHNEELDGWFWTSPVGSFPANGYGLLDVCGNVWEWTNSVYPV
ASGHQERRTIKGGSFLCADNYCVRYRPSALQGQTVDTATCHMGFRCAKGGP

Sequences:

>Translated_291_residues
MTTSLPVEMVTIPAGLYRVGCDRCYPDGSVRCYPEETPAREVQLDSFQIDVGPVTNAQFRAFVSATQHLTVSELPPDPTL
YPDLAPEERIPESVVFQPPPATVDRSKPLSWWTLMAGADWRHPQGPESTIDGLDDHPVVHVAYADAIAYAHWAGKRLPSA
EEWEVAARGGLVDAQYAWGNELTPNNRWMANIWQGPFPWHNEELDGWFWTSPVGSFPANGYGLLDVCGNVWEWTNSVYPV
ASGHQERRTIKGGSFLCADNYCVRYRPSALQGQTVDTATCHMGFRCAKGGP
>Mature_290_residues
TTSLPVEMVTIPAGLYRVGCDRCYPDGSVRCYPEETPAREVQLDSFQIDVGPVTNAQFRAFVSATQHLTVSELPPDPTLY
PDLAPEERIPESVVFQPPPATVDRSKPLSWWTLMAGADWRHPQGPESTIDGLDDHPVVHVAYADAIAYAHWAGKRLPSAE
EWEVAARGGLVDAQYAWGNELTPNNRWMANIWQGPFPWHNEELDGWFWTSPVGSFPANGYGLLDVCGNVWEWTNSVYPVA
SGHQERRTIKGGSFLCADNYCVRYRPSALQGQTVDTATCHMGFRCAKGGP

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI38202250, Length=296, Percent_Identity=41.2162162162162, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI257470975, Length=293, Percent_Identity=39.9317406143345, Blast_Score=207, Evalue=9e-54,
Organism=Homo sapiens, GI257470977, Length=285, Percent_Identity=41.0526315789474, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI194248088, Length=284, Percent_Identity=40.4929577464789, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI194248087, Length=284, Percent_Identity=38.0281690140845, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI226437577, Length=184, Percent_Identity=47.8260869565217, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI194248090, Length=217, Percent_Identity=39.63133640553, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI194248084, Length=97, Percent_Identity=44.3298969072165, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130397, Length=286, Percent_Identity=40.9090909090909, Blast_Score=206, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 32279; Mature: 32148

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSLPVEMVTIPAGLYRVGCDRCYPDGSVRCYPEETPAREVQLDSFQIDVGPVTNAQFR
CCCCCCEEEEEECCCHHHHCCCCCCCCCCEEECCCCCCCCEEEEEEEEEECCCCCCHHHH
AFVSATQHLTVSELPPDPTLYPDLAPEERIPESVVFQPPPATVDRSKPLSWWTLMAGADW
HEEHHHHCEEEECCCCCCCCCCCCCCHHHCCCCEEECCCCCCCCCCCCCEEEEEECCCCC
RHPQGPESTIDGLDDHPVVHVAYADAIAYAHWAGKRLPSAEEWEVAARGGLVDAQYAWGN
CCCCCCCHHHCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEEECCCC
ELTPNNRWMANIWQGPFPWHNEELDGWFWTSPVGSFPANGYGLLDVCGNVWEWTNSVYPV
CCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCEEHHHHHCCHHHHCCCCCCC
ASGHQERRTIKGGSFLCADNYCVRYRPSALQGQTVDTATCHMGFRCAKGGP
CCCCHHHHEECCCCEEEECCEEEEECCCCCCCCCCCEEEHCCCEEECCCCC
>Mature Secondary Structure 
TTSLPVEMVTIPAGLYRVGCDRCYPDGSVRCYPEETPAREVQLDSFQIDVGPVTNAQFR
CCCCCEEEEEECCCHHHHCCCCCCCCCCEEECCCCCCCCEEEEEEEEEECCCCCCHHHH
AFVSATQHLTVSELPPDPTLYPDLAPEERIPESVVFQPPPATVDRSKPLSWWTLMAGADW
HEEHHHHCEEEECCCCCCCCCCCCCCHHHCCCCEEECCCCCCCCCCCCCEEEEEECCCCC
RHPQGPESTIDGLDDHPVVHVAYADAIAYAHWAGKRLPSAEEWEVAARGGLVDAQYAWGN
CCCCCCCHHHCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEEECCCC
ELTPNNRWMANIWQGPFPWHNEELDGWFWTSPVGSFPANGYGLLDVCGNVWEWTNSVYPV
CCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCEEHHHHHCCHHHHCCCCCCC
ASGHQERRTIKGGSFLCADNYCVRYRPSALQGQTVDTATCHMGFRCAKGGP
CCCCHHHHEECCCCEEEECCEEEEECCCCCCCCCCCEEEHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]