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The map label for this gene is lpxB [H]

Identifier: 33863676

GI number: 33863676

Start: 1495398

End: 1496576

Strand: Reverse

Name: lpxB [H]

Synonym: PMT1409

Alternate gene names: 33863676

Gene position: 1496576-1495398 (Counterclockwise)

Preceding gene: 33863677

Following gene: 33863675

Centisome position: 62.08

GC content: 55.22

Gene sequence:

>1179_bases
ATGGTGCGCCTGCTGATCAGCACTGGCGAGGTCTCTGGTGATTTGCAGGGAAGTCTCTTGATTCAAGCTCTCCAAAGGGA
GGTTGAACGGCGTTCCTTACCGCTTGAGTTGATGGCCCTTGGAGGTCCCCGCATGCAGGCTTCTGGTGCAGAACTGCTTG
CTGATACGGCTCCGATGGGTGCGATTGGACTTTGGGAGGCCCTGCCTCTGGTGCTCCCCACTTTGCGACTTCAGTCTCGG
GTGGATCACGTGCTCAAGCAGCGACCACCCGATGCCGTGGTGCTGATCGATTACATGGGGGCCAACGTGCGTTTGGGGCA
CAAGTTGCGGCGCTGGTTTCCCAGGGTGCCGATTATTTATTACATCGCTCCTCAGGAATGGGCTTGGCGTTTTGGCGATG
GCGGCACCACTCAGTTGCTGAGTTTCACCGACAGAATTTTGGCGATCTTTCCCGTTGAAGCTGAGTTCTATTCCCAGCGG
GGGGCCAAGGTGACTTGGGTCGGTCATCCATTACTCGATACGGTGAGTGTGCTGCCTGATCGTCAGCAGGCGCGTGAGCG
GCTTGGCTTGAAGCCTGGCCAAAGATTGTTGTTGCTTTTACCTGCTTCCCGGCAACAGGAACTTCGTTACTTGATGCCCA
CTCTCGCCAAGGCAGCAGCGTTGCTTCAGCAGCGTGACCAATCCCTTGAGGTGATTGTTCCTGCAGGATTAGCAAGTTTT
GAGAAGTCTTTGCAGGAGGCTCTTGAGGCAGCGGCAGTTCGAGGGCGAGTCCTTTCTGCTCAGCAGGCCGATGAACTCAA
ACCAATGCTTTATGCGGCGGCTGATCTTGCCCTCGGCAAATCAGGCACCGTCAATATGGAGATGGCCTTGCGTGGCGTTC
CCCAGGTGGTGGGCTACAAGGTGAGTCGGATCACAGCATTTGTGGCTCGACACTTTTTGCGCTTTCGAGTGGAACATATC
TCGCCGGTGAATCTGTTGCTGAAGGAACGGCTTGTGCCGGAATTACTACAGGATGAGTTGACTGCAGAAGCACTTGTGCA
GGCAGCTATCCCTTTATTGGAGGATCCTGCCCAGCGTAATGAGATGCTCGAGGGCTATCGGCGATTGCGGCAGACGCTTG
GCGTTCCAGGTGTTACCGATAGGGCAGCAAAGGAAATCCTTGATTTAACCAAGACATGA

Upstream 100 bases:

>100_bases
AGCAGTTGATGCCAGCGGGTGCACACCTCTGTGCCTTTCTGGAGGCCTCGATTGAGAAGGGACGTCGTGGTCCTATGCCT
GCGATGTCTTTGAGTCGCTG

Downstream 100 bases:

>100_bases
AGACAACGTTTCGACCTTTGAGGAGATGGTGGATTGCCATCTTTCTCTGTGTTGCCTTACTTGGCTTGCCGCTTCAAGTT
TTGGCGTCAGTTGAGGAAGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MVRLLISTGEVSGDLQGSLLIQALQREVERRSLPLELMALGGPRMQASGAELLADTAPMGAIGLWEALPLVLPTLRLQSR
VDHVLKQRPPDAVVLIDYMGANVRLGHKLRRWFPRVPIIYYIAPQEWAWRFGDGGTTQLLSFTDRILAIFPVEAEFYSQR
GAKVTWVGHPLLDTVSVLPDRQQARERLGLKPGQRLLLLLPASRQQELRYLMPTLAKAAALLQQRDQSLEVIVPAGLASF
EKSLQEALEAAAVRGRVLSAQQADELKPMLYAAADLALGKSGTVNMEMALRGVPQVVGYKVSRITAFVARHFLRFRVEHI
SPVNLLLKERLVPELLQDELTAEALVQAAIPLLEDPAQRNEMLEGYRRLRQTLGVPGVTDRAAKEILDLTKT

Sequences:

>Translated_392_residues
MVRLLISTGEVSGDLQGSLLIQALQREVERRSLPLELMALGGPRMQASGAELLADTAPMGAIGLWEALPLVLPTLRLQSR
VDHVLKQRPPDAVVLIDYMGANVRLGHKLRRWFPRVPIIYYIAPQEWAWRFGDGGTTQLLSFTDRILAIFPVEAEFYSQR
GAKVTWVGHPLLDTVSVLPDRQQARERLGLKPGQRLLLLLPASRQQELRYLMPTLAKAAALLQQRDQSLEVIVPAGLASF
EKSLQEALEAAAVRGRVLSAQQADELKPMLYAAADLALGKSGTVNMEMALRGVPQVVGYKVSRITAFVARHFLRFRVEHI
SPVNLLLKERLVPELLQDELTAEALVQAAIPLLEDPAQRNEMLEGYRRLRQTLGVPGVTDRAAKEILDLTKT
>Mature_392_residues
MVRLLISTGEVSGDLQGSLLIQALQREVERRSLPLELMALGGPRMQASGAELLADTAPMGAIGLWEALPLVLPTLRLQSR
VDHVLKQRPPDAVVLIDYMGANVRLGHKLRRWFPRVPIIYYIAPQEWAWRFGDGGTTQLLSFTDRILAIFPVEAEFYSQR
GAKVTWVGHPLLDTVSVLPDRQQARERLGLKPGQRLLLLLPASRQQELRYLMPTLAKAAALLQQRDQSLEVIVPAGLASF
EKSLQEALEAAAVRGRVLSAQQADELKPMLYAAADLALGKSGTVNMEMALRGVPQVVGYKVSRITAFVARHFLRFRVEHI
SPVNLLLKERLVPELLQDELTAEALVQAAIPLLEDPAQRNEMLEGYRRLRQTLGVPGVTDRAAKEILDLTKT

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=386, Percent_Identity=30.3108808290155, Blast_Score=151, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43535; Mature: 43535

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRLLISTGEVSGDLQGSLLIQALQREVERRSLPLELMALGGPRMQASGAELLADTAPMG
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCCCC
AIGLWEALPLVLPTLRLQSRVDHVLKQRPPDAVVLIDYMGANVRLGHKLRRWFPRVPIIY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHCCCCCEEE
YIAPQEWAWRFGDGGTTQLLSFTDRILAIFPVEAEFYSQRGAKVTWVGHPLLDTVSVLPD
EECCCCCCEEECCCCHHHHHHHHHHHHEEECCCHHHHHCCCCEEEEECCHHHHHHHHCCC
RQQARERLGLKPGQRLLLLLPASRQQELRYLMPTLAKAAALLQQRDQSLEVIVPAGLASF
HHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
EKSLQEALEAAAVRGRVLSAQQADELKPMLYAAADLALGKSGTVNMEMALRGVPQVVGYK
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCHHHHHHH
VSRITAFVARHFLRFRVEHISPVNLLLKERLVPELLQDELTAEALVQAAIPLLEDPAQRN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
EMLEGYRRLRQTLGVPGVTDRAAKEILDLTKT
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MVRLLISTGEVSGDLQGSLLIQALQREVERRSLPLELMALGGPRMQASGAELLADTAPMG
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCCCC
AIGLWEALPLVLPTLRLQSRVDHVLKQRPPDAVVLIDYMGANVRLGHKLRRWFPRVPIIY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHCCCCCEEE
YIAPQEWAWRFGDGGTTQLLSFTDRILAIFPVEAEFYSQRGAKVTWVGHPLLDTVSVLPD
EECCCCCCEEECCCCHHHHHHHHHHHHEEECCCHHHHHCCCCEEEEECCHHHHHHHHCCC
RQQARERLGLKPGQRLLLLLPASRQQELRYLMPTLAKAAALLQQRDQSLEVIVPAGLASF
HHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
EKSLQEALEAAAVRGRVLSAQQADELKPMLYAAADLALGKSGTVNMEMALRGVPQVVGYK
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCHHHHHHH
VSRITAFVARHFLRFRVEHISPVNLLLKERLVPELLQDELTAEALVQAAIPLLEDPAQRN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
EMLEGYRRLRQTLGVPGVTDRAAKEILDLTKT
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA