The gene/protein map for NC_005071 is currently unavailable.
Definition Prochlorococcus marinus str. MIT 9313 chromosome, complete genome.
Accession NC_005071
Length 2,410,873

Click here to switch to the map view.

The map label for this gene is pnp

Identifier: 33863644

GI number: 33863644

Start: 1461150

End: 1463321

Strand: Direct

Name: pnp

Synonym: PMT1377

Alternate gene names: 33863644

Gene position: 1461150-1463321 (Clockwise)

Preceding gene: 33863643

Following gene: 33863646

Centisome position: 60.61

GC content: 55.71

Gene sequence:

>2172_bases
GTGCAAGGTCAGACACAGTCGATCTCCTTTGATGGTCGGGAGATTCGGCTGACCACAGGGCGATATGCCCCCCAGGCCGG
TGGTTCCGTGATGATGGAATGCGGCGACACCGCCGTCCTGGTAACCGCCACCAGATCAACAGGCCGCGAAGGCATCGATT
TTCTTCCCCTGATTTGCGACTACGAGGAGCGGCTCTATGCAGCTGGCCGCATTCCTGGCAGTTTCATGCGACGTGAAGGA
CGCCCGCCAGAAAGAGCCACACTGATCGCTCGTCTAATCGACCGCCCCATGAGGCCCTTATTCCCTAGCTGGATGAGGGA
CGACCTTCAGATCGTGGCAACATGCCTCTCTCTCGATGAACGGGTTCCAGCAGATGTGCTTGCCGTTACGGGAGCTTCCA
TGGCCACCTTGCTAGCAAGCATCCCCTTCCAGGGGCCAATGGCTGCAGTAAGGGTAGGGCTTCTCGGTGACGATTTCGTT
CTGAATCCCAGCTATCGAGAAATCGAACGTGGCGATCTCGATCTCGTGGTAGCTGGTACTCCAGATGGGGTTGTCATGGT
TGAAGCCGGTGCAAACCAGCTGCCACAAGGGGATGTCATCGAAGCCATCGACTTTGGCTATGAAGCCGTATGCGAATTAA
TCAAGGCACAGCAAACCATCCTCAAGGATGCAGGGATTAAGCAGGTACAGCCCGAACCCCCCACTCAAGACCAAGACACC
AAGCTGTCGACTTATCTAGAAAAAAATTGCAGCAAGAGCATCGGGGAAGTGCTTAAGCAATTTGAACAGACCAAAGCTGA
ACGCGATAGCAAGTTGGATGCCATCAAAGCGAAAACTGCTGAAGCCATTGACAGCCTCAAAGAAGACGATGCCGTTCGCA
AGTCAGTGAATGCCAACAGCAAAGTCTTGAGCAACAACTTCAAGGCGCTCACCAAAAAATTGATGCGTGAGCAGATCATC
AAACAAGGCAAACGAGTCGATGGTCGCAAGCTCGATGAGGTGCGCCCGATCAGTTCCGCCGCAGGCGTGCTGCCAAAACG
CGTGCACGGATCCGGACTCTTCCAACGCGGACTAACCCAGGTGCTGTCCACCGCCACCCTAGGCACACCCAGCGATGCCC
AGGAGATGGATGACCTCAACCCTGGACCTGAGAAGACCTATCTACACCACTACAACTTCCCGCCCTATTCCGTTGGCGAG
ACACGTCCAATGCGATCGCCCGGGCGCCGTGAGGTAGGCCATGGTTCCCTCGCTGAACGCGCCATCATTCCAGTACTGCC
TCCCAAGGACAGCTTCCCTTATGTGCTCAGGGTGGTGAGCGAAGTCCTCAGCTCCAATGGGTCCACCTCGATGGGCTCGG
TCTGCGGCAGCACCCTGGCCCTCATGGATGCTGGTGTTCCACTGAAGGCTCCAGTCAGCGGAGCCGCCATGGGCTTGATC
AAGGAAGATGCTGAGATTCGCATCCTCACTGACATCCAGGGAATCGAGGACTTCCTCGGTGATATGGACTTCAAGGTGGC
TGGAACAAAAGATGGCATCACGGCCCTGCAGATGGACATGAAGATCACCGGCCTTCCGGTCAAAACCATTGCAGAAGCTG
TCAATCAGGCCCGCCCTGCCAGGATCCACATCCTCGAGAAGATGCTGGAAGCCATCGACGCTCCCAGAACTACCCTCTCT
CCCCATGCCCCGCGCCTGCTGAGCTTCAGAATCGATCCAGAACTGATCGGCACAGTGATTGGACCAGGTGGTCGCACAAT
CAAGGGCATCACAGAACGCACGAACACCAAGATCGACATTGAAGACGGTGGCATCGTCACGATTGCTTCTCATGACGGGG
CTGCTGCAGAGGCAGCCCAACGCATCATCGAAGGACTTACCCGCAAAGTAAACGAGGGGGAGGTGTTCACCGGAACCATC
ACAAGGATCATTCCGATCGGGGCTTTCGTAGAGATCCTGCCCGGCAAAGAGGGCATGATCCACATCTCCCAGCTGTCAGA
GGCTCGCGTGGAGAAGGTCGACGACGTCGTAAAAGTAGGTGATCAAGTAACAGTACGAATACGAGAGATTGACAATCGTG
GCCGTATCAACCTCACACTCAGAGGCGTGCCTCAAAACGGCGAAGAGACTCAATCAGAGCCAGCTCCAACTCCTGTAGCC
CCTCTCAACTAA

Upstream 100 bases:

>100_bases
TGCTTAGCAACTGAACCAACAGGAATCAATTCCAAAATTCCACGAAAGTTGACTCGGCAAAGTGCCAGTATGGTGCTTGA
CAAAAAAAACATAAGAGAAC

Downstream 100 bases:

>100_bases
TCGGCTGCTTCAGGTCAATTCAAACCTGAAAGCCTGGGTCGATCTCTTTCATAGCCCGCGCCGCTGCTTCACAAAGCTGG
GCGTGGGCGAGCCCATGGCT

Product: polynucleotide phosphorylase/polyadenylase

Products: NA

Alternate protein names: Polynucleotide phosphorylase; PNPase

Number of amino acids: Translated: 723; Mature: 723

Protein sequence:

>723_residues
MQGQTQSISFDGREIRLTTGRYAPQAGGSVMMECGDTAVLVTATRSTGREGIDFLPLICDYEERLYAAGRIPGSFMRREG
RPPERATLIARLIDRPMRPLFPSWMRDDLQIVATCLSLDERVPADVLAVTGASMATLLASIPFQGPMAAVRVGLLGDDFV
LNPSYREIERGDLDLVVAGTPDGVVMVEAGANQLPQGDVIEAIDFGYEAVCELIKAQQTILKDAGIKQVQPEPPTQDQDT
KLSTYLEKNCSKSIGEVLKQFEQTKAERDSKLDAIKAKTAEAIDSLKEDDAVRKSVNANSKVLSNNFKALTKKLMREQII
KQGKRVDGRKLDEVRPISSAAGVLPKRVHGSGLFQRGLTQVLSTATLGTPSDAQEMDDLNPGPEKTYLHHYNFPPYSVGE
TRPMRSPGRREVGHGSLAERAIIPVLPPKDSFPYVLRVVSEVLSSNGSTSMGSVCGSTLALMDAGVPLKAPVSGAAMGLI
KEDAEIRILTDIQGIEDFLGDMDFKVAGTKDGITALQMDMKITGLPVKTIAEAVNQARPARIHILEKMLEAIDAPRTTLS
PHAPRLLSFRIDPELIGTVIGPGGRTIKGITERTNTKIDIEDGGIVTIASHDGAAAEAAQRIIEGLTRKVNEGEVFTGTI
TRIIPIGAFVEILPGKEGMIHISQLSEARVEKVDDVVKVGDQVTVRIREIDNRGRINLTLRGVPQNGEETQSEPAPTPVA
PLN

Sequences:

>Translated_723_residues
MQGQTQSISFDGREIRLTTGRYAPQAGGSVMMECGDTAVLVTATRSTGREGIDFLPLICDYEERLYAAGRIPGSFMRREG
RPPERATLIARLIDRPMRPLFPSWMRDDLQIVATCLSLDERVPADVLAVTGASMATLLASIPFQGPMAAVRVGLLGDDFV
LNPSYREIERGDLDLVVAGTPDGVVMVEAGANQLPQGDVIEAIDFGYEAVCELIKAQQTILKDAGIKQVQPEPPTQDQDT
KLSTYLEKNCSKSIGEVLKQFEQTKAERDSKLDAIKAKTAEAIDSLKEDDAVRKSVNANSKVLSNNFKALTKKLMREQII
KQGKRVDGRKLDEVRPISSAAGVLPKRVHGSGLFQRGLTQVLSTATLGTPSDAQEMDDLNPGPEKTYLHHYNFPPYSVGE
TRPMRSPGRREVGHGSLAERAIIPVLPPKDSFPYVLRVVSEVLSSNGSTSMGSVCGSTLALMDAGVPLKAPVSGAAMGLI
KEDAEIRILTDIQGIEDFLGDMDFKVAGTKDGITALQMDMKITGLPVKTIAEAVNQARPARIHILEKMLEAIDAPRTTLS
PHAPRLLSFRIDPELIGTVIGPGGRTIKGITERTNTKIDIEDGGIVTIASHDGAAAEAAQRIIEGLTRKVNEGEVFTGTI
TRIIPIGAFVEILPGKEGMIHISQLSEARVEKVDDVVKVGDQVTVRIREIDNRGRINLTLRGVPQNGEETQSEPAPTPVA
PLN
>Mature_723_residues
MQGQTQSISFDGREIRLTTGRYAPQAGGSVMMECGDTAVLVTATRSTGREGIDFLPLICDYEERLYAAGRIPGSFMRREG
RPPERATLIARLIDRPMRPLFPSWMRDDLQIVATCLSLDERVPADVLAVTGASMATLLASIPFQGPMAAVRVGLLGDDFV
LNPSYREIERGDLDLVVAGTPDGVVMVEAGANQLPQGDVIEAIDFGYEAVCELIKAQQTILKDAGIKQVQPEPPTQDQDT
KLSTYLEKNCSKSIGEVLKQFEQTKAERDSKLDAIKAKTAEAIDSLKEDDAVRKSVNANSKVLSNNFKALTKKLMREQII
KQGKRVDGRKLDEVRPISSAAGVLPKRVHGSGLFQRGLTQVLSTATLGTPSDAQEMDDLNPGPEKTYLHHYNFPPYSVGE
TRPMRSPGRREVGHGSLAERAIIPVLPPKDSFPYVLRVVSEVLSSNGSTSMGSVCGSTLALMDAGVPLKAPVSGAAMGLI
KEDAEIRILTDIQGIEDFLGDMDFKVAGTKDGITALQMDMKITGLPVKTIAEAVNQARPARIHILEKMLEAIDAPRTTLS
PHAPRLLSFRIDPELIGTVIGPGGRTIKGITERTNTKIDIEDGGIVTIASHDGAAAEAAQRIIEGLTRKVNEGEVFTGTI
TRIIPIGAFVEILPGKEGMIHISQLSEARVEKVDDVVKVGDQVTVRIREIDNRGRINLTLRGVPQNGEETQSEPAPTPVA
PLN

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction

COG id: COG1185

COG function: function code J; Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain

Homologues:

Organism=Homo sapiens, GI188528628, Length=741, Percent_Identity=36.302294197031, Blast_Score=431, Evalue=1e-120,
Organism=Escherichia coli, GI145693187, Length=699, Percent_Identity=47.3533619456366, Blast_Score=619, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI115534063, Length=707, Percent_Identity=34.6534653465347, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI281362905, Length=698, Percent_Identity=37.1060171919771, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24651641, Length=698, Percent_Identity=37.1060171919771, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24651643, Length=698, Percent_Identity=37.1060171919771, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI161079377, Length=642, Percent_Identity=36.9158878504673, Blast_Score=397, Evalue=1e-110,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1000 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 3328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media

Swissprot (AC and ID): PNP_PROMM (Q7V606)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895204.1
- HSSP:   P05055
- ProteinModelPortal:   Q7V606
- STRING:   Q7V606
- GeneID:   1728211
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT1377
- NMPDR:   fig|74547.1.peg.1371
- eggNOG:   COG1185
- HOGENOM:   HBG382411
- OMA:   LHISEIR
- ProtClustDB:   PRK11824
- BioCyc:   PMAR74547:PMT1377-MONOMER
- GO:   GO:0005739
- HAMAP:   MF_01595
- InterPro:   IPR001247
- InterPro:   IPR015847
- InterPro:   IPR004087
- InterPro:   IPR004088
- InterPro:   IPR018111
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR012162
- InterPro:   IPR015848
- InterPro:   IPR003029
- InterPro:   IPR020568
- InterPro:   IPR022967
- Gene3D:   G3DSA:2.40.50.140
- Gene3D:   G3DSA:1.10.10.400
- PANTHER:   PTHR11252
- PIRSF:   PIRSF005499
- SMART:   SM00322
- SMART:   SM00316
- TIGRFAMs:   TIGR03591

Pfam domain/function: PF00013 KH_1; PF03726 PNPase; PF01138 RNase_PH; PF03725 RNase_PH_C; PF00575 S1; SSF46915 3_ExoRNase; SSF55666 3_ExoRNase; SSF50249 Nucleic_acid_OB; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.7.8

Molecular weight: Translated: 78165; Mature: 78165

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50084 KH_TYPE_1; PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MQGQTQSISFDGREIRLTTGRYAPQAGGSVMMECGDTAVLVTATRSTGREGIDFLPLICD
CCCCCCEEECCCCEEEEECCCCCCCCCCCEEEECCCEEEEEEEECCCCCCCCCHHHHEEC
YEERLYAAGRIPGSFMRREGRPPERATLIARLIDRPMRPLFPSWMRDDLQIVATCLSLDE
HHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC
RVPADVLAVTGASMATLLASIPFQGPMAAVRVGLLGDDFVLNPSYREIERGDLDLVVAGT
CCCHHHHHHCCHHHHHHHHHCCCCCCHHHHEEEECCCCEEECCCHHHHCCCCEEEEEECC
PDGVVMVEAGANQLPQGDVIEAIDFGYEAVCELIKAQQTILKDAGIKQVQPEPPTQDQDT
CCCEEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KLSTYLEKNCSKSIGEVLKQFEQTKAERDSKLDAIKAKTAEAIDSLKEDDAVRKSVNANS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
KVLSNNFKALTKKLMREQIIKQGKRVDGRKLDEVRPISSAAGVLPKRVHGSGLFQRGLTQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHCCCCHHHCCCHHHHHHHHH
VLSTATLGTPSDAQEMDDLNPGPEKTYLHHYNFPPYSVGETRPMRSPGRREVGHGSLAER
HHHHHCCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHC
AIIPVLPPKDSFPYVLRVVSEVLSSNGSTSMGSVCGSTLALMDAGVPLKAPVSGAAMGLI
CEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHE
KEDAEIRILTDIQGIEDFLGDMDFKVAGTKDGITALQMDMKITGLPVKTIAEAVNQARPA
ECCCCEEEEECHHHHHHHHCCCCEEEECCCCCCEEEEECCEEECCCHHHHHHHHHHCCCH
RIHILEKMLEAIDAPRTTLSPHAPRLLSFRIDPELIGTVIGPGGRTIKGITERTNTKIDI
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECHHHHHEEECCCCCEEECHHHCCCCEEEE
EDGGIVTIASHDGAAAEAAQRIIEGLTRKVNEGEVFTGTITRIIPIGAFVEILPGKEGMI
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHEECCCCCCEE
HISQLSEARVEKVDDVVKVGDQVTVRIREIDNRGRINLTLRGVPQNGEETQSEPAPTPVA
EHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCC
PLN
CCC
>Mature Secondary Structure
MQGQTQSISFDGREIRLTTGRYAPQAGGSVMMECGDTAVLVTATRSTGREGIDFLPLICD
CCCCCCEEECCCCEEEEECCCCCCCCCCCEEEECCCEEEEEEEECCCCCCCCCHHHHEEC
YEERLYAAGRIPGSFMRREGRPPERATLIARLIDRPMRPLFPSWMRDDLQIVATCLSLDE
HHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC
RVPADVLAVTGASMATLLASIPFQGPMAAVRVGLLGDDFVLNPSYREIERGDLDLVVAGT
CCCHHHHHHCCHHHHHHHHHCCCCCCHHHHEEEECCCCEEECCCHHHHCCCCEEEEEECC
PDGVVMVEAGANQLPQGDVIEAIDFGYEAVCELIKAQQTILKDAGIKQVQPEPPTQDQDT
CCCEEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KLSTYLEKNCSKSIGEVLKQFEQTKAERDSKLDAIKAKTAEAIDSLKEDDAVRKSVNANS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
KVLSNNFKALTKKLMREQIIKQGKRVDGRKLDEVRPISSAAGVLPKRVHGSGLFQRGLTQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHCCCCHHHCCCHHHHHHHHH
VLSTATLGTPSDAQEMDDLNPGPEKTYLHHYNFPPYSVGETRPMRSPGRREVGHGSLAER
HHHHHCCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHC
AIIPVLPPKDSFPYVLRVVSEVLSSNGSTSMGSVCGSTLALMDAGVPLKAPVSGAAMGLI
CEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHE
KEDAEIRILTDIQGIEDFLGDMDFKVAGTKDGITALQMDMKITGLPVKTIAEAVNQARPA
ECCCCEEEEECHHHHHHHHCCCCEEEECCCCCCEEEEECCEEECCCHHHHHHHHHHCCCH
RIHILEKMLEAIDAPRTTLSPHAPRLLSFRIDPELIGTVIGPGGRTIKGITERTNTKIDI
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECHHHHHEEECCCCCEEECHHHCCCCEEEE
EDGGIVTIASHDGAAAEAAQRIIEGLTRKVNEGEVFTGTITRIIPIGAFVEILPGKEGMI
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHEECCCCCCEE
HISQLSEARVEKVDDVVKVGDQVTVRIREIDNRGRINLTLRGVPQNGEETQSEPAPTPVA
EHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCC
PLN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642