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The map label for this gene is groEL

Identifier: 33863601

GI number: 33863601

Start: 1419631

End: 1421331

Strand: Direct

Name: groEL

Synonym: PMT1334

Alternate gene names: 33863601

Gene position: 1419631-1421331 (Clockwise)

Preceding gene: 33863600

Following gene: 33863608

Centisome position: 58.88

GC content: 55.85

Gene sequence:

>1701_bases
ATGGCCAAACTCCTCAGTTTTTCGGATGACTCCCGCAGTGCGCTTGAGCGCGGTGTTAATTCCCTAGCCGATGCCGTGCG
CGTCACCATCGGCCCCCGTGGCCGCAACGTGGTGCTTGAGAAAAAATTTGGCGCCCCAGACATCGTTAATGACGGCGTCA
CCATCGCCAAAGAGATCGAACTTGACGATCCATTTGAAAACCTTGGTGCCAAGCTGATTCAACAGGTCGCATCCAAGACA
AAAGACAAGGCAGGGGATGGCACCACAACCGCCACCGTGCTTGCCCAAGCGATGGTGCATGAAGGCTTACGCAATGTGGC
CGCTGGCGCGAGTCCAATCGAACTACGGCGTGGCATGGAAAAGGCCGTGGCCCAATTGGTAGAAGAGCTTGCCCAGCTCA
GTCAATCTGTTGGAGGTAATGCCATCCATCAGGTCGCCACTGTTAGCTCAGGGGGAGACCAGGAAGTGGGCCGGATGGTG
TCTGAAGCCATGGACAAAGTAAGCGCCGATGGTGTGATCACAGTTGAGGAATCCAAATCTCTCGCCACCGAGCTAGAAGT
CACTGAAGGCATGGCCTTCGACCGCGGTTACAGCTCCCCTTACTTTGTTACCGATGCAGACCGTCAGATCTGCGAATTTG
AGAATGCCCTGCTGTTGCTCACAGACCGCAAGATCAGTTCAGTTTCCGATCTTGTGCCCATCTTGGAAAGCCTGCAGAAA
AGTGGCTCCCCTCTCGTCATCATTGCGGAGGAGGTAGAGGGTGAGGCCCTTGCCACCCTGGTCGTCAACAAAAACCGAGG
TGTCTTGCAGGTAGCCGCTGTTCGAGCACCATCCTTCGGAGATCGCCGCAAAGCTGCCCTGGCCGACATCGCAGTTCTAA
CTGGGGGAACTGTCATTAGTGAAGACCGCGCCATGACCCTTGAGAAAGTCAGCCAAGACGATCTAGGGCAGGTCCGACGA
ATCACAATCAGCAAAGACAACACAACCATTGTCGCCAAGGATGAGAACCGCGATGCCGTTAACGCCCGCGTGGCCTCTAT
CAAAAGAGAATTAGATGAAACTGACTCCGAATACGACCGCGAGAAACTCAATGAACGCATTGCCAAGCTGGCCGGTGGTG
TAGCCGTCATCAAGGTTGGGGCACCTACCGAAACGGAACTCAAAAACCGCAAGCTGCGCATTGAGGATGCGCTCAACGCG
ACCCGTGCTGCAGTTGAAGAGGGGATTGTGGCCGGTGGTGGCACCACGCTCCTGCACTTAAGCAAAGGGCTGAGCAAATT
GGCCGAACAGCTCAACGACGATCAACGCACCGGCGTAGAAATTGTGCAGCGAGCACTCTCAGCACCTGCACGCCAGATTG
CCATCAATGCTGGCGAGAATGGTGATGTAGTGATCTCTGAGATACAACGCCTTAACAAGGGCTTTAACGCGATCTCCAGC
ACCTACGAAGACCTTTTGGAAGCAGGCATTCTCGATGCCACCAAGGTGGTGCGCTTGGCACTTCAGGACGCAGTCTCAAT
CGCTTCGATGATGGTCACCACAGAGCTTGTGATTGCAGACAAACCCGAGCCTCCTGCCCCCGCAGGCGATGGCGGTGGAG
ACCCGATGGGTGGCATGGGTGGCATGGGTGGCATGGGTGGCATGGGTGGCATGGGTGGCATGGGTGGCATGGGTGGCATG
GGAATGCCAGGCATGATGTAG

Upstream 100 bases:

>100_bases
AAGCACACCCATAACAGCAAGGATTCGGCTTTCCCCACTTATTCCCCCTCGCCCGCAGTGAACGTCCTATGGGACATTGA
CGAACGGGTACCAGCAGACC

Downstream 100 bases:

>100_bases
TCCGGCCCCAAAGCGTTCCCTAGGGCTAGAAAAAGAACACCGGCACAACGCATGGACAAGTCTCATGCGTTGTGGCTCTG
CCTCGACAAGTCACGTCCCA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MAKLLSFSDDSRSALERGVNSLADAVRVTIGPRGRNVVLEKKFGAPDIVNDGVTIAKEIELDDPFENLGAKLIQQVASKT
KDKAGDGTTTATVLAQAMVHEGLRNVAAGASPIELRRGMEKAVAQLVEELAQLSQSVGGNAIHQVATVSSGGDQEVGRMV
SEAMDKVSADGVITVEESKSLATELEVTEGMAFDRGYSSPYFVTDADRQICEFENALLLLTDRKISSVSDLVPILESLQK
SGSPLVIIAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGDRRKAALADIAVLTGGTVISEDRAMTLEKVSQDDLGQVRR
ITISKDNTTIVAKDENRDAVNARVASIKRELDETDSEYDREKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNA
TRAAVEEGIVAGGGTTLLHLSKGLSKLAEQLNDDQRTGVEIVQRALSAPARQIAINAGENGDVVISEIQRLNKGFNAISS
TYEDLLEAGILDATKVVRLALQDAVSIASMMVTTELVIADKPEPPAPAGDGGGDPMGGMGGMGGMGGMGGMGGMGGMGGM
GMPGMM

Sequences:

>Translated_566_residues
MAKLLSFSDDSRSALERGVNSLADAVRVTIGPRGRNVVLEKKFGAPDIVNDGVTIAKEIELDDPFENLGAKLIQQVASKT
KDKAGDGTTTATVLAQAMVHEGLRNVAAGASPIELRRGMEKAVAQLVEELAQLSQSVGGNAIHQVATVSSGGDQEVGRMV
SEAMDKVSADGVITVEESKSLATELEVTEGMAFDRGYSSPYFVTDADRQICEFENALLLLTDRKISSVSDLVPILESLQK
SGSPLVIIAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGDRRKAALADIAVLTGGTVISEDRAMTLEKVSQDDLGQVRR
ITISKDNTTIVAKDENRDAVNARVASIKRELDETDSEYDREKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNA
TRAAVEEGIVAGGGTTLLHLSKGLSKLAEQLNDDQRTGVEIVQRALSAPARQIAINAGENGDVVISEIQRLNKGFNAISS
TYEDLLEAGILDATKVVRLALQDAVSIASMMVTTELVIADKPEPPAPAGDGGGDPMGGMGGMGGMGGMGGMGGMGGMGGM
GMPGMM
>Mature_565_residues
AKLLSFSDDSRSALERGVNSLADAVRVTIGPRGRNVVLEKKFGAPDIVNDGVTIAKEIELDDPFENLGAKLIQQVASKTK
DKAGDGTTTATVLAQAMVHEGLRNVAAGASPIELRRGMEKAVAQLVEELAQLSQSVGGNAIHQVATVSSGGDQEVGRMVS
EAMDKVSADGVITVEESKSLATELEVTEGMAFDRGYSSPYFVTDADRQICEFENALLLLTDRKISSVSDLVPILESLQKS
GSPLVIIAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGDRRKAALADIAVLTGGTVISEDRAMTLEKVSQDDLGQVRRI
TISKDNTTIVAKDENRDAVNARVASIKRELDETDSEYDREKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNAT
RAAVEEGIVAGGGTTLLHLSKGLSKLAEQLNDDQRTGVEIVQRALSAPARQIAINAGENGDVVISEIQRLNKGFNAISST
YEDLLEAGILDATKVVRLALQDAVSIASMMVTTELVIADKPEPPAPAGDGGGDPMGGMGGMGGMGGMGGMGGMGGMGGMG
MPGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=47.6280834914611, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=47.6280834914611, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI24307939, Length=551, Percent_Identity=21.4156079854809, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=55.4924242424242, Blast_Score=575, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=48.210922787194, Blast_Score=476, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=43.6018957345972, Blast_Score=168, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=49.7142857142857, Blast_Score=494, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6322524, Length=120, Percent_Identity=32.5, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=50.0948766603416, Blast_Score=497, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=50.0948766603416, Blast_Score=497, Evalue=1e-140,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=47.5285171102662, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=47.5285171102662, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=47.5285171102662, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=43.9163498098859, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=35.0943396226415, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=35.0943396226415, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_PROMM (Q7V643)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895161.1
- ProteinModelPortal:   Q7V643
- SMR:   Q7V643
- STRING:   Q7V643
- GeneID:   1728952
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT1334
- NMPDR:   fig|74547.1.peg.1328
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   GASPIEL
- ProtClustDB:   PRK12849
- BioCyc:   PMAR74547:PMT1334-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 59390; Mature: 59259

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLLSFSDDSRSALERGVNSLADAVRVTIGPRGRNVVLEKKFGAPDIVNDGVTIAKEIE
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCEEEEECC
LDDPFENLGAKLIQQVASKTKDKAGDGTTTATVLAQAMVHEGLRNVAAGASPIELRRGME
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVAQLVEELAQLSQSVGGNAIHQVATVSSGGDQEVGRMVSEAMDKVSADGVITVEESKS
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCH
LATELEVTEGMAFDRGYSSPYFVTDADRQICEFENALLLLTDRKISSVSDLVPILESLQK
HHHHHHHHCCCEECCCCCCCEEEECCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
SGSPLVIIAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGDRRKAALADIAVLTGGTVIS
CCCCEEEEEECCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEC
EDRAMTLEKVSQDDLGQVRRITISKDNTTIVAKDENRDAVNARVASIKRELDETDSEYDR
CCHHHHHHHCCCCHHCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHH
EKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNATRAAVEEGIVAGGGTTLLHL
HHHHHHHHHHHCCEEEEEECCCCHHHHHCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHH
SKGLSKLAEQLNDDQRTGVEIVQRALSAPARQIAINAGENGDVVISEIQRLNKGFNAISS
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
TYEDLLEAGILDATKVVRLALQDAVSIASMMVTTELVIADKPEPPAPAGDGGGDPMGGMG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCC
GMGGMGGMGGMGGMGGMGGMGMPGMM
CCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKLLSFSDDSRSALERGVNSLADAVRVTIGPRGRNVVLEKKFGAPDIVNDGVTIAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCEEEEECC
LDDPFENLGAKLIQQVASKTKDKAGDGTTTATVLAQAMVHEGLRNVAAGASPIELRRGME
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVAQLVEELAQLSQSVGGNAIHQVATVSSGGDQEVGRMVSEAMDKVSADGVITVEESKS
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCH
LATELEVTEGMAFDRGYSSPYFVTDADRQICEFENALLLLTDRKISSVSDLVPILESLQK
HHHHHHHHCCCEECCCCCCCEEEECCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
SGSPLVIIAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGDRRKAALADIAVLTGGTVIS
CCCCEEEEEECCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEC
EDRAMTLEKVSQDDLGQVRRITISKDNTTIVAKDENRDAVNARVASIKRELDETDSEYDR
CCHHHHHHHCCCCHHCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHH
EKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNATRAAVEEGIVAGGGTTLLHL
HHHHHHHHHHHCCEEEEEECCCCHHHHHCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHH
SKGLSKLAEQLNDDQRTGVEIVQRALSAPARQIAINAGENGDVVISEIQRLNKGFNAISS
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
TYEDLLEAGILDATKVVRLALQDAVSIASMMVTTELVIADKPEPPAPAGDGGGDPMGGMG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCC
GMGGMGGMGGMGGMGGMGGMGMPGMM
CCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642