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The map label for this gene is folP [H]

Identifier: 33863088

GI number: 33863088

Start: 893637

End: 894503

Strand: Reverse

Name: folP [H]

Synonym: PMT0816

Alternate gene names: 33863088

Gene position: 894503-893637 (Counterclockwise)

Preceding gene: 33863089

Following gene: 33863086

Centisome position: 37.1

GC content: 51.67

Gene sequence:

>867_bases
TTGACCCAGAGAGTTTTGCGCGCATTGCCAATTATCAAACCAGTTAAATCTCCTTGGCCTCAGGAATGGGGACAGCGAAC
GAACGTGATGGGTGTGATTAATATCACGCCCGATTCTTTTAGCGATGGTGGCAATTATCTAGAGCCTGCTAGTGCCCTAG
CACAGGCAACTCTTCTTATACAGGAAGGGGCTGATGTACTAGATCTTGGTGCTCAGAGCACGAGGCCTAAGGCCGAGGAG
GTTGGCTGGCAAGAGGAGCTGAACAGAATGATGCCTGCTCTTCATGCAATACGTGCAGCTCACCCGCAGGCGTTGATCTC
TGTGGATACATTCCTTTTGGAGGTGGCGGAGGCGGCTCTGCAAGCAGGTGCAGATTGGATTAATGATGTCAGCGGCGGCA
GGCGTGACCCTGAGTTGCTGAGGGTTGTTGCCGAAGCAGGATGTCCCTATGTGTTGATGCATAGCCGTGGCAACAGTCAA
TCCATGGATCAACTTGCCACTTATAGCAATGTGATTGAAGAGGTTCGCCTTGGCCTACTTCGTCGAACGGATCAAGCTTT
GGCTGCTGGTATTCGATCTGATCAGTTGATTTGGGACCCAGGCTTGGGTTTTGCTAAAACCACTGAACAAAATCTGATGT
TGTTGAAGCATCTAGAGAGGATTTGCTCTGAAGGCTTCCCTGTTTTGGTTGGGCCCTCAAGGAAACGCTTCATCGGAGAT
GTTTTGCACCAACCTGACCCAGAGGCTCGTATATGGGGTACTGCCGCCGTGGCCTGCCGTTGTGTGCAGGCGAAGGCGGC
AATGGTGAGAGTGCATGATGTGGGCCCAATCCATCAGACCCTTCAAATGGGTAGCAGACTCTGGTAA

Upstream 100 bases:

>100_bases
GAACTAATCATTCAGTACGGCGGTTCGGTCAAACCAGGAAATATTGATGAGTTGATGGCAATGAGTGATATCGACGGAGT
GTTGGTGGGTGGTGCCTCCC

Downstream 100 bases:

>100_bases
TTAGGGTTTGAGTTACTTTTTAATCATTCGCCAGACGATTGGTTGTCTGGCGTTGTTACTCCTTCAATTCGATCTTCAAT
TTCCTGGTAAAGCTCTTGCA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MTQRVLRALPIIKPVKSPWPQEWGQRTNVMGVINITPDSFSDGGNYLEPASALAQATLLIQEGADVLDLGAQSTRPKAEE
VGWQEELNRMMPALHAIRAAHPQALISVDTFLLEVAEAALQAGADWINDVSGGRRDPELLRVVAEAGCPYVLMHSRGNSQ
SMDQLATYSNVIEEVRLGLLRRTDQALAAGIRSDQLIWDPGLGFAKTTEQNLMLLKHLERICSEGFPVLVGPSRKRFIGD
VLHQPDPEARIWGTAAVACRCVQAKAAMVRVHDVGPIHQTLQMGSRLW

Sequences:

>Translated_288_residues
MTQRVLRALPIIKPVKSPWPQEWGQRTNVMGVINITPDSFSDGGNYLEPASALAQATLLIQEGADVLDLGAQSTRPKAEE
VGWQEELNRMMPALHAIRAAHPQALISVDTFLLEVAEAALQAGADWINDVSGGRRDPELLRVVAEAGCPYVLMHSRGNSQ
SMDQLATYSNVIEEVRLGLLRRTDQALAAGIRSDQLIWDPGLGFAKTTEQNLMLLKHLERICSEGFPVLVGPSRKRFIGD
VLHQPDPEARIWGTAAVACRCVQAKAAMVRVHDVGPIHQTLQMGSRLW
>Mature_287_residues
TQRVLRALPIIKPVKSPWPQEWGQRTNVMGVINITPDSFSDGGNYLEPASALAQATLLIQEGADVLDLGAQSTRPKAEEV
GWQEELNRMMPALHAIRAAHPQALISVDTFLLEVAEAALQAGADWINDVSGGRRDPELLRVVAEAGCPYVLMHSRGNSQS
MDQLATYSNVIEEVRLGLLRRTDQALAAGIRSDQLIWDPGLGFAKTTEQNLMLLKHLERICSEGFPVLVGPSRKRFIGDV
LHQPDPEARIWGTAAVACRCVQAKAAMVRVHDVGPIHQTLQMGSRLW

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=247, Percent_Identity=40.080971659919, Blast_Score=172, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=31.4465408805031, Blast_Score=169, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31618; Mature: 31487

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRVLRALPIIKPVKSPWPQEWGQRTNVMGVINITPDSFSDGGNYLEPASALAQATLLI
CCHHHHHHHCCHHCCCCCCCHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
QEGADVLDLGAQSTRPKAEEVGWQEELNRMMPALHAIRAAHPQALISVDTFLLEVAEAAL
HCCCCHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QAGADWINDVSGGRRDPELLRVVAEAGCPYVLMHSRGNSQSMDQLATYSNVIEEVRLGLL
HHCHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
RRTDQALAAGIRSDQLIWDPGLGFAKTTEQNLMLLKHLERICSEGFPVLVGPSRKRFIGD
HHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHH
VLHQPDPEARIWGTAAVACRCVQAKAAMVRVHDVGPIHQTLQMGSRLW
HHCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TQRVLRALPIIKPVKSPWPQEWGQRTNVMGVINITPDSFSDGGNYLEPASALAQATLLI
CHHHHHHHCCHHCCCCCCCHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
QEGADVLDLGAQSTRPKAEEVGWQEELNRMMPALHAIRAAHPQALISVDTFLLEVAEAAL
HCCCCHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QAGADWINDVSGGRRDPELLRVVAEAGCPYVLMHSRGNSQSMDQLATYSNVIEEVRLGLL
HHCHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
RRTDQALAAGIRSDQLIWDPGLGFAKTTEQNLMLLKHLERICSEGFPVLVGPSRKRFIGD
HHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHH
VLHQPDPEARIWGTAAVACRCVQAKAAMVRVHDVGPIHQTLQMGSRLW
HHCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]