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The map label for this gene is hemA [H]

Identifier: 33862840

GI number: 33862840

Start: 621119

End: 622429

Strand: Reverse

Name: hemA [H]

Synonym: PMT0567

Alternate gene names: 33862840

Gene position: 622429-621119 (Counterclockwise)

Preceding gene: 33862841

Following gene: 33862839

Centisome position: 25.82

GC content: 52.48

Gene sequence:

>1311_bases
ATGCACATTGCCGTCGTCGGCTTAAGTCATCGCACGGCGCCGGTGGAAATCCGTGAAAAGCTCAGCATCCCTGAGCAAAC
CATGGAGACCTCCCTGCAAACTCTTCGCGGCAACGATCAAATCCTTGAGGTTTCGATCCTTAGCACCTGCAATCGGCTTG
AGATTTACACCTTGGTTCGTCACCCTGAACGAGGTATCTCCGCCATCAGTGATTTTCTAGGCCAACATTCAGGTTTGGCA
ACGGAAGATCTTTCCCCCCATCTGTTCAACTTTCATCACGATGAAGCAGTAGCCCACTTGATGAGGGTGGCTGCGGGTCT
GGACAGTCTGGTTTTAGGAGAAGGGCAGATCCTTTCCCAGGTGAAGAAGATGGTGCGATTGGGGCAGGAGCACAAATCCA
TGGGCCCGATTCTTAACCGTCTGCTCACTCAGGCAGTCAGTACTGGCAAACGAGTTCGCAGTGAAACCAATCTGGGTACG
GGGGCTGTCTCAATTAGTTCTGCGGCTGTGGAGTTAGCCCAACTGAAACTTGGCCAGGCGCAAGGGGAAGATCAGTTGAT
GACTCTGGAATCTGAGTTGGTCGCAGTAGTGGGTGCGGGGCGGATGAGCCGACTACTGCTTCAACATCTTCAGGCGAAAG
GTTGTTCTGGGGTGATGTTGCTGAACCGCACGCGGCAACGAGCTGAGGATCTATCGGCTGATTTCCCTGAGCTCCCCGTT
GAGTGTCGCCCCCTTGATGATTTGAACCATTGTCTAAGTACCTGTTCATTGGTATTTACCAGTACGGCTGCTGACGATCC
GATTGTTGATGCATCTCTGCTCAAGCAGCTCAAGCGCCGCAGTTTTCTTCGTCTGATTGACATCGGCGTGCCGCGCAACA
TCGCCTCAGATGTGGTCGATGTACCCGGTGTTGAGTCCCATGATGTGGATGATTTGCATGAGGTAGTGTCTCGTAATCAG
GAGGCCCGCCAACAGATGGCCAAAGAAGCAGAGGTTGTGCTCCAAGAAGAGACGCGTCTGTTTTTAGAGTGGTGGGACAG
TCTTGAAGCTGTGCCAACCATTAATCGCTTAAGGGCGACCCTTGAGGCTATTCGTGCAGAGGAATTACAAAAAGCGCTCA
GTCGTATGGGGCCTGATTTCTCTGCTCGAGAGCGCAAAGTCGTTGAGGCTTTAAGCAAAGGAATCATTAACAAAATTCTC
CATACCCCAGTCACTCAGCTACGGGCTCCTCAGGCTCGTCCAGAGCGGCAACAGGCTCTGCGTGTGGTGGCGAGTTTGTT
TGAGTTAGATCCACCACTAGAGAATGGGTAG

Upstream 100 bases:

>100_bases
GACAACACAGCTCGGTTTACCAATACCGTGCATATCAAGGATGGAGCTAAGAGCATCGCTCTGAGCTAACCATCCAAGAC
AAGATCTAAGGGACGTCTCC

Downstream 100 bases:

>100_bases
TTCTATGCCAAATTCTGGTTGCGTCTTGATTTGCAGAAGTCTTGTTGGATCTTCGCAGCAGACAGCTTTAGATGGCCAAC
CGTCCGGTAAGTTTGCTGCG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MHIAVVGLSHRTAPVEIREKLSIPEQTMETSLQTLRGNDQILEVSILSTCNRLEIYTLVRHPERGISAISDFLGQHSGLA
TEDLSPHLFNFHHDEAVAHLMRVAAGLDSLVLGEGQILSQVKKMVRLGQEHKSMGPILNRLLTQAVSTGKRVRSETNLGT
GAVSISSAAVELAQLKLGQAQGEDQLMTLESELVAVVGAGRMSRLLLQHLQAKGCSGVMLLNRTRQRAEDLSADFPELPV
ECRPLDDLNHCLSTCSLVFTSTAADDPIVDASLLKQLKRRSFLRLIDIGVPRNIASDVVDVPGVESHDVDDLHEVVSRNQ
EARQQMAKEAEVVLQEETRLFLEWWDSLEAVPTINRLRATLEAIRAEELQKALSRMGPDFSARERKVVEALSKGIINKIL
HTPVTQLRAPQARPERQQALRVVASLFELDPPLENG

Sequences:

>Translated_436_residues
MHIAVVGLSHRTAPVEIREKLSIPEQTMETSLQTLRGNDQILEVSILSTCNRLEIYTLVRHPERGISAISDFLGQHSGLA
TEDLSPHLFNFHHDEAVAHLMRVAAGLDSLVLGEGQILSQVKKMVRLGQEHKSMGPILNRLLTQAVSTGKRVRSETNLGT
GAVSISSAAVELAQLKLGQAQGEDQLMTLESELVAVVGAGRMSRLLLQHLQAKGCSGVMLLNRTRQRAEDLSADFPELPV
ECRPLDDLNHCLSTCSLVFTSTAADDPIVDASLLKQLKRRSFLRLIDIGVPRNIASDVVDVPGVESHDVDDLHEVVSRNQ
EARQQMAKEAEVVLQEETRLFLEWWDSLEAVPTINRLRATLEAIRAEELQKALSRMGPDFSARERKVVEALSKGIINKIL
HTPVTQLRAPQARPERQQALRVVASLFELDPPLENG
>Mature_436_residues
MHIAVVGLSHRTAPVEIREKLSIPEQTMETSLQTLRGNDQILEVSILSTCNRLEIYTLVRHPERGISAISDFLGQHSGLA
TEDLSPHLFNFHHDEAVAHLMRVAAGLDSLVLGEGQILSQVKKMVRLGQEHKSMGPILNRLLTQAVSTGKRVRSETNLGT
GAVSISSAAVELAQLKLGQAQGEDQLMTLESELVAVVGAGRMSRLLLQHLQAKGCSGVMLLNRTRQRAEDLSADFPELPV
ECRPLDDLNHCLSTCSLVFTSTAADDPIVDASLLKQLKRRSFLRLIDIGVPRNIASDVVDVPGVESHDVDDLHEVVSRNQ
EARQQMAKEAEVVLQEETRLFLEWWDSLEAVPTINRLRATLEAIRAEELQKALSRMGPDFSARERKVVEALSKGIINKIL
HTPVTQLRAPQARPERQQALRVVASLFELDPPLENG

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=414, Percent_Identity=33.3333333333333, Blast_Score=202, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 48149; Mature: 48149

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIAVVGLSHRTAPVEIREKLSIPEQTMETSLQTLRGNDQILEVSILSTCNRLEIYTLVR
CEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHH
HPERGISAISDFLGQHSGLATEDLSPHLFNFHHDEAVAHLMRVAAGLDSLVLGEGQILSQ
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHH
VKKMVRLGQEHKSMGPILNRLLTQAVSTGKRVRSETNLGTGAVSISSAAVELAQLKLGQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
QGEDQLMTLESELVAVVGAGRMSRLLLQHLQAKGCSGVMLLNRTRQRAEDLSADFPELPV
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC
ECRPLDDLNHCLSTCSLVFTSTAADDPIVDASLLKQLKRRSFLRLIDIGVPRNIASDVVD
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
VPGVESHDVDDLHEVVSRNQEARQQMAKEAEVVLQEETRLFLEWWDSLEAVPTINRLRAT
CCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LEAIRAEELQKALSRMGPDFSARERKVVEALSKGIINKILHTPVTQLRAPQARPERQQAL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHH
RVVASLFELDPPLENG
HHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHIAVVGLSHRTAPVEIREKLSIPEQTMETSLQTLRGNDQILEVSILSTCNRLEIYTLVR
CEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHH
HPERGISAISDFLGQHSGLATEDLSPHLFNFHHDEAVAHLMRVAAGLDSLVLGEGQILSQ
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHH
VKKMVRLGQEHKSMGPILNRLLTQAVSTGKRVRSETNLGTGAVSISSAAVELAQLKLGQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
QGEDQLMTLESELVAVVGAGRMSRLLLQHLQAKGCSGVMLLNRTRQRAEDLSADFPELPV
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC
ECRPLDDLNHCLSTCSLVFTSTAADDPIVDASLLKQLKRRSFLRLIDIGVPRNIASDVVD
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
VPGVESHDVDDLHEVVSRNQEARQQMAKEAEVVLQEETRLFLEWWDSLEAVPTINRLRAT
CCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LEAIRAEELQKALSRMGPDFSARERKVVEALSKGIINKILHTPVTQLRAPQARPERQQAL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHH
RVVASLFELDPPLENG
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA