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The map label for this gene is argF

Identifier: 33862652

GI number: 33862652

Start: 428851

End: 429807

Strand: Direct

Name: argF

Synonym: PMT0379

Alternate gene names: 33862652

Gene position: 428851-429807 (Clockwise)

Preceding gene: 33862651

Following gene: 33862653

Centisome position: 17.79

GC content: 54.75

Gene sequence:

>957_bases
ATGGCTGTCAATCCCCAAGGTGTTGCAGCCGTCCTTGCAGACCTCAAGGGTCGAGACTTCCTCTCCTGTGCTGATTTCAC
TGCGGAGCAGACCGTTGCCTTGCTTGAGCTTTCCCGTCAGCTCAAGAGCGGGGATCGCCGCATTGATTTGGGAAATCGAG
TTCTCGGATTGATTTTTACCAAGGCCTCGACGCGCACACGAGTGAGCTTTCAGGTCGCGATGGCACGCCTTGGCGGGCAA
ACGGTGGATCTCAATCCTCAGGTGACACAATTGGGCCGGGGCGAACCCCTTGAAGACACGGCGAGAGTGTTGAGTCGTTT
CTGTGATGTGATGGCGGTGCGGACCTTTGCTCAGCAGGAACTGCTGGATTACGCCCATTGGGCTTCGATTCCGGTGCTCA
ATGCTTTGACTGATTTGGAGCATCCCTGTCAGGCAATGGCTGACTTCCTAACGATTCAAGAGGCTCTCGGGTCATTAACC
GGCCAGACCTTGGCCTATGTGGGCGATGGAAATAACGTCTCACATTCTTTGATGCTCTGCGGCGCTCTCTTGGGGGTCAA
CGTTCGGATTGGCTGCCCGCAGGGATTTGAACCTCTACCTGAGGTGATTGATCAGGCCCGCAACTTGGCAGTGGCTGATG
CTCGTATTGAAGTGATGACAGATCCAGTTGATGCAGTGCGAGGTGCGCAGGCTTTGTACACCGATGTTTGGGCCTCGATG
GGACAGGAACAGGAACAGTCGCAGCGGGAAGAGGCCTTTCGTGGTTTCTGTCTCAATGAGGATTTGCTTGCTCATGCAGA
TCCCAATGCGATCGTGTTGCACTGCCTACCGGCTCATCGAGGGGAGGAGATCAGTTCAGGCGTGATGGAAGGAGAGGCCA
GTCGAATCTTTGATCAAGCTGAAAATCGTTTGCATGTTCAGCAAGCTTTGCTTGCGGCCGTGCTTGGTGGTCTCTAG

Upstream 100 bases:

>100_bases
GATGCTTGATTCCAGTTCTCTCCCTAGAGGTGTTGTTATTGCCTGAAGGCTTGACGGCAGGGGGGCTGGTCTCCGATAAA
GACTCTTTGAAGCTTCCCTA

Downstream 100 bases:

>100_bases
TTCCAGGCTGGATTGCTGCTTTCGGTTTTGAGCACTCCGGTTAACTCGGAATCGTCTTGCGGCTGCACTGTTTGGTGTTT
AAACCCTTGCCAGATTCAGT

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MAVNPQGVAAVLADLKGRDFLSCADFTAEQTVALLELSRQLKSGDRRIDLGNRVLGLIFTKASTRTRVSFQVAMARLGGQ
TVDLNPQVTQLGRGEPLEDTARVLSRFCDVMAVRTFAQQELLDYAHWASIPVLNALTDLEHPCQAMADFLTIQEALGSLT
GQTLAYVGDGNNVSHSLMLCGALLGVNVRIGCPQGFEPLPEVIDQARNLAVADARIEVMTDPVDAVRGAQALYTDVWASM
GQEQEQSQREEAFRGFCLNEDLLAHADPNAIVLHCLPAHRGEEISSGVMEGEASRIFDQAENRLHVQQALLAAVLGGL

Sequences:

>Translated_318_residues
MAVNPQGVAAVLADLKGRDFLSCADFTAEQTVALLELSRQLKSGDRRIDLGNRVLGLIFTKASTRTRVSFQVAMARLGGQ
TVDLNPQVTQLGRGEPLEDTARVLSRFCDVMAVRTFAQQELLDYAHWASIPVLNALTDLEHPCQAMADFLTIQEALGSLT
GQTLAYVGDGNNVSHSLMLCGALLGVNVRIGCPQGFEPLPEVIDQARNLAVADARIEVMTDPVDAVRGAQALYTDVWASM
GQEQEQSQREEAFRGFCLNEDLLAHADPNAIVLHCLPAHRGEEISSGVMEGEASRIFDQAENRLHVQQALLAAVLGGL
>Mature_317_residues
AVNPQGVAAVLADLKGRDFLSCADFTAEQTVALLELSRQLKSGDRRIDLGNRVLGLIFTKASTRTRVSFQVAMARLGGQT
VDLNPQVTQLGRGEPLEDTARVLSRFCDVMAVRTFAQQELLDYAHWASIPVLNALTDLEHPCQAMADFLTIQEALGSLTG
QTLAYVGDGNNVSHSLMLCGALLGVNVRIGCPQGFEPLPEVIDQARNLAVADARIEVMTDPVDAVRGAQALYTDVWASMG
QEQEQSQREEAFRGFCLNEDLLAHADPNAIVLHCLPAHRGEEISSGVMEGEASRIFDQAENRLHVQQALLAAVLGGL

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=307, Percent_Identity=40.0651465798046, Blast_Score=224, Evalue=6e-59,
Organism=Homo sapiens, GI18105007, Length=324, Percent_Identity=31.4814814814815, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1786469, Length=333, Percent_Identity=37.2372372372372, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1790703, Length=326, Percent_Identity=36.8098159509202, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI2367364, Length=315, Percent_Identity=30.4761904761905, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI48994908, Length=363, Percent_Identity=23.1404958677686, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193204318, Length=295, Percent_Identity=28.4745762711864, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322373, Length=308, Percent_Identity=33.1168831168831, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6322331, Length=319, Percent_Identity=31.3479623824451, Blast_Score=122, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24642586, Length=324, Percent_Identity=29.9382716049383, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTC_PROMM (Q7V8G9)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894212.1
- ProteinModelPortal:   Q7V8G9
- SMR:   Q7V8G9
- STRING:   Q7V8G9
- GeneID:   1728571
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT0379
- NMPDR:   fig|74547.1.peg.379
- eggNOG:   COG0078
- HOGENOM:   HBG579429
- OMA:   CVVTDTW
- ProtClustDB:   PRK00779
- BioCyc:   PMAR74547:PMT0379-MONOMER
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 34391; Mature: 34259

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 114-114 BINDING 141-141

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVNPQGVAAVLADLKGRDFLSCADFTAEQTVALLELSRQLKSGDRRIDLGNRVLGLIFT
CCCCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCEECCCCCEEEHEEE
KASTRTRVSFQVAMARLGGQTVDLNPQVTQLGRGEPLEDTARVLSRFCDVMAVRTFAQQE
CCCCCHHHHHHHHHHHHCCCEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLDYAHWASIPVLNALTDLEHPCQAMADFLTIQEALGSLTGQTLAYVGDGNNVSHSLMLC
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
GALLGVNVRIGCPQGFEPLPEVIDQARNLAVADARIEVMTDPVDAVRGAQALYTDVWASM
HHHHCCEEEECCCCCCCHHHHHHHHHHCCEEECCEEEEECCCHHHHHHHHHHHHHHHHHC
GQEQEQSQREEAFRGFCLNEDLLAHADPNAIVLHCLPAHRGEEISSGVMEGEASRIFDQA
CCHHHHHHHHHHHHCCCCCCCHHHCCCCCEEEEEEECCCCCCHHHHHHHCCHHHHHHHHH
ENRLHVQQALLAAVLGGL
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVNPQGVAAVLADLKGRDFLSCADFTAEQTVALLELSRQLKSGDRRIDLGNRVLGLIFT
CCCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCEECCCCCEEEHEEE
KASTRTRVSFQVAMARLGGQTVDLNPQVTQLGRGEPLEDTARVLSRFCDVMAVRTFAQQE
CCCCCHHHHHHHHHHHHCCCEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLDYAHWASIPVLNALTDLEHPCQAMADFLTIQEALGSLTGQTLAYVGDGNNVSHSLMLC
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
GALLGVNVRIGCPQGFEPLPEVIDQARNLAVADARIEVMTDPVDAVRGAQALYTDVWASM
HHHHCCEEEECCCCCCCHHHHHHHHHHCCEEECCEEEEECCCHHHHHHHHHHHHHHHHHC
GQEQEQSQREEAFRGFCLNEDLLAHADPNAIVLHCLPAHRGEEISSGVMEGEASRIFDQA
CCHHHHHHHHHHHHCCCCCCCHHHCCCCCEEEEEEECCCCCCHHHHHHHCCHHHHHHHHH
ENRLHVQQALLAAVLGGL
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642