Click here to switch to the map view.

The map label for this gene is ribD [H]

Identifier: 33862648

GI number: 33862648

Start: 422321

End: 423427

Strand: Direct

Name: ribD [H]

Synonym: PMT0375

Alternate gene names: 33862648

Gene position: 422321-423427 (Clockwise)

Preceding gene: 33862647

Following gene: 33862651

Centisome position: 17.52

GC content: 58.72

Gene sequence:

>1107_bases
ATGAAGGTCAACCCCTCTGCAAGTGCTGTTTGGCTGCCATGGATGCGGCGGGCGTTGCAGTTAGCTGCTCTCGCAGATGG
TCGCACCAGTCCCAATCCTCTTGTTGGGGCAGTTGTTCTAGACAAGGCTGGAAAGCTTGTGGGAGAGGGTTTTCATGCAT
GTGCTGGTGAGCCCCATGCGGAGGTAGGCGCTCTCGCACAAGCTGGTAAACAGGCCAGCGGTGGGACCCTGCTGGTCACC
CTGGAACCCTGTTGTCATCAAGGCCGCACGCCTCCCTGCACGGAGGCCGTCATCGCTGCCGGACTTCGCCGAGTTGTGGT
GGCAATGCAGGACCCAGACCCTCGTGTTGCTGGAGCCGGCATCACTCGTTTGCGTGATGCCGGGCTGGAGGTGATCACTG
CTGTGTTGGAGCTCGAAGCAGCACATCAGAACCGGGCTTTTGTGCATCGGGTTTCTACTGGGCGCCCCTGGGGGATTCTC
AAATGGGCGATGAGCCTCGATGGACGCACGGCTCTTCCCAATGGCGCCAGTCAGTGGATCAGTGGTGGTGAAGCGCGTCG
CTGGGTGCATCGCTTACGTGGCCAATGTGATGCTGTGATCGTTGGAGGCGGCACTGTGCGTGCGGACGATCCGTTGTTGA
CCAGTCGTGGGCACTCTGACCCCGAACCAAAGCGGGTGGTGCTGAGTCGCAGCCTTGACTTGCCTCAACAAGCTCAGCTT
TGGAACACTGCAGTGGCTCAGACCCTCGTTGCACATGGCCTAGAGCCTGGCCATGAACAGTTGGCTCATTTGCCTGAGGG
GCCTGAGCTACTTGCTTTGCCTGTCTCTGAACCGCTTGAGTTGCTGCAGGCCTTAGCTCAACAAGACTGCAATCGTGTGC
TGTGGGAATGCGGGCCAGGCTTAGCAGCCGCAGCATTGCAGCAAGGCTGTGTTCAAGAATTGGCGGTGGTGGTGGCTCCC
AAGCTGTTGGGTGGCTTGCCGGCGAGAACACCACTTGATGATCTTGGCCTCACAAGCATGAAAGAGGTTGTTGGGCTCGC
GTCTGGCTCATTGCAGTCGTTGGGGGCTGACTGGCTCTTGCAATATGAGCTTTCTAAGCATTGCTGA

Upstream 100 bases:

>100_bases
CCCACTGCGCTTGCAGCTCGCCGGTGTGTTTACTGAACTGCCTGTGCCTCCTTATGTCGTCGGCGAGTGGCGTTCATTGC
CGCAGGCTTCTCAATAGTTG

Downstream 100 bases:

>100_bases
GGTATATAATATTTATCGTTTGAATATTGTTGGAGTAAGTTGTATCTATGAATTGTATTGGTAACTATTTTTATAGGCTG
ACTACAGAAAGTTATCGCAA

Product: diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino)uracil reductase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKVNPSASAVWLPWMRRALQLAALADGRTSPNPLVGAVVLDKAGKLVGEGFHACAGEPHAEVGALAQAGKQASGGTLLVT
LEPCCHQGRTPPCTEAVIAAGLRRVVVAMQDPDPRVAGAGITRLRDAGLEVITAVLELEAAHQNRAFVHRVSTGRPWGIL
KWAMSLDGRTALPNGASQWISGGEARRWVHRLRGQCDAVIVGGGTVRADDPLLTSRGHSDPEPKRVVLSRSLDLPQQAQL
WNTAVAQTLVAHGLEPGHEQLAHLPEGPELLALPVSEPLELLQALAQQDCNRVLWECGPGLAAAALQQGCVQELAVVVAP
KLLGGLPARTPLDDLGLTSMKEVVGLASGSLQSLGADWLLQYELSKHC

Sequences:

>Translated_368_residues
MKVNPSASAVWLPWMRRALQLAALADGRTSPNPLVGAVVLDKAGKLVGEGFHACAGEPHAEVGALAQAGKQASGGTLLVT
LEPCCHQGRTPPCTEAVIAAGLRRVVVAMQDPDPRVAGAGITRLRDAGLEVITAVLELEAAHQNRAFVHRVSTGRPWGIL
KWAMSLDGRTALPNGASQWISGGEARRWVHRLRGQCDAVIVGGGTVRADDPLLTSRGHSDPEPKRVVLSRSLDLPQQAQL
WNTAVAQTLVAHGLEPGHEQLAHLPEGPELLALPVSEPLELLQALAQQDCNRVLWECGPGLAAAALQQGCVQELAVVVAP
KLLGGLPARTPLDDLGLTSMKEVVGLASGSLQSLGADWLLQYELSKHC
>Mature_368_residues
MKVNPSASAVWLPWMRRALQLAALADGRTSPNPLVGAVVLDKAGKLVGEGFHACAGEPHAEVGALAQAGKQASGGTLLVT
LEPCCHQGRTPPCTEAVIAAGLRRVVVAMQDPDPRVAGAGITRLRDAGLEVITAVLELEAAHQNRAFVHRVSTGRPWGIL
KWAMSLDGRTALPNGASQWISGGEARRWVHRLRGQCDAVIVGGGTVRADDPLLTSRGHSDPEPKRVVLSRSLDLPQQAQL
WNTAVAQTLVAHGLEPGHEQLAHLPEGPELLALPVSEPLELLQALAQQDCNRVLWECGPGLAAAALQQGCVQELAVVVAP
KLLGGLPARTPLDDLGLTSMKEVVGLASGSLQSLGADWLLQYELSKHC

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=350, Percent_Identity=42.8571428571429, Blast_Score=236, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 38785; Mature: 38785

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVNPSASAVWLPWMRRALQLAALADGRTSPNPLVGAVVLDKAGKLVGEGFHACAGEPHA
CCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHCCHHHCCCCCHH
EVGALAQAGKQASGGTLLVTLEPCCHQGRTPPCTEAVIAAGLRRVVVAMQDPDPRVAGAG
HHHHHHHCCCCCCCCEEEEEECHHHCCCCCCCHHHHHHHHHHHHEEEEECCCCCCCCCCC
ITRLRDAGLEVITAVLELEAAHQNRAFVHRVSTGRPWGILKWAMSLDGRTALPNGASQWI
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHH
SGGEARRWVHRLRGQCDAVIVGGGTVRADDPLLTSRGHSDPEPKRVVLSRSLDLPQQAQL
CCCHHHHHHHHHCCCCCEEEECCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHH
WNTAVAQTLVAHGLEPGHEQLAHLPEGPELLALPVSEPLELLQALAQQDCNRVLWECGPG
HHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
LAAAALQQGCVQELAVVVAPKLLGGLPARTPLDDLGLTSMKEVVGLASGSLQSLGADWLL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHCCCCHHHCCHHHEE
QYELSKHC
EEHHHCCC
>Mature Secondary Structure
MKVNPSASAVWLPWMRRALQLAALADGRTSPNPLVGAVVLDKAGKLVGEGFHACAGEPHA
CCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHCCHHHCCCCCHH
EVGALAQAGKQASGGTLLVTLEPCCHQGRTPPCTEAVIAAGLRRVVVAMQDPDPRVAGAG
HHHHHHHCCCCCCCCEEEEEECHHHCCCCCCCHHHHHHHHHHHHEEEEECCCCCCCCCCC
ITRLRDAGLEVITAVLELEAAHQNRAFVHRVSTGRPWGILKWAMSLDGRTALPNGASQWI
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHH
SGGEARRWVHRLRGQCDAVIVGGGTVRADDPLLTSRGHSDPEPKRVVLSRSLDLPQQAQL
CCCHHHHHHHHHCCCCCEEEECCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHH
WNTAVAQTLVAHGLEPGHEQLAHLPEGPELLALPVSEPLELLQALAQQDCNRVLWECGPG
HHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
LAAAALQQGCVQELAVVVAPKLLGGLPARTPLDDLGLTSMKEVVGLASGSLQSLGADWLL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHCCCCHHHCCHHHEE
QYELSKHC
EEHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]