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The map label for this gene is fbp [H]

Identifier: 33862614

GI number: 33862614

Start: 386881

End: 387513

Strand: Reverse

Name: fbp [H]

Synonym: PMT0341

Alternate gene names: 33862614

Gene position: 387513-386881 (Counterclockwise)

Preceding gene: 161350046

Following gene: 33862613

Centisome position: 16.07

GC content: 58.77

Gene sequence:

>633_bases
GTGCGCGACATCTTCATCAGTGCAGCAGTCTTTGTGGTGTGCGTGGTTGTGGCCTTTGTCAGCCAGATCGTGTCACCCTC
AGTTGTGGTCGCCGACAGCAATCTGAATGCCGTGCAGGCAGAGGTGCGAACTGTCGAGCCAGCTGCTTTGAGCATGGCAG
TGCTTGAACTCGACCCCGACGATCCCAACCCAACACTATTCAAGATGGCGGTCAACGGCTCCAAAGCAGATGCTGCTGAA
ATCGATGCCGCGCAAGCCAATGCCTCAGCCCTTGGCGGCCCAATCGAAGCAGAACCATCCCAACTAACAGCCAGTGGTCT
GAGCATCACTGACCTCAAGATCGGCGATGGCCCGGAGGCCACAGCAGGCCAAACCGTTTCCGTGAACTACCGCGGCACAC
TGGAAAACGGCCAGGAATTCGACAGCAGCTACAAACGTGGGCCGTTCGAGTTCCCCCTCGGTGCAGGGCGAGTGATCAAA
GGCTGGGATGAAGGCGTTGCTGGCATGAAGGTGGGCGGCAAGCGCAAGCTGGTCATCCCCCCAGAGCTTGGCTACGGAAG
CCGCGGCGCAGGCCGTGTCATCCCTGGCAACGCCACGTTGATTTTCGAAGTCGAACTCCTGGGCATCAAATGA

Upstream 100 bases:

>100_bases
TGGAGCAGCAGCAAAGGCAACTGAAACAGCAGAAATCAACCAAGCACAGTCGAAAGCTGCATCTCCTGCCAGAATCATGT
TGATTGATTATTGAGATTCA

Downstream 100 bases:

>100_bases
TCTAAAGACTGAAAAGCAAATCAAATCAAAAGCAAACCCAATTAGCAATCAGCCTGGGTAGGCTCAGTTTGGCTTTCTCT
ATCTGCCAGATGTTGCGCTC

Product: FKBP-type peptidyl-prolyl cis-trans isomerase (PPIase)

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MRDIFISAAVFVVCVVVAFVSQIVSPSVVVADSNLNAVQAEVRTVEPAALSMAVLELDPDDPNPTLFKMAVNGSKADAAE
IDAAQANASALGGPIEAEPSQLTASGLSITDLKIGDGPEATAGQTVSVNYRGTLENGQEFDSSYKRGPFEFPLGAGRVIK
GWDEGVAGMKVGGKRKLVIPPELGYGSRGAGRVIPGNATLIFEVELLGIK

Sequences:

>Translated_210_residues
MRDIFISAAVFVVCVVVAFVSQIVSPSVVVADSNLNAVQAEVRTVEPAALSMAVLELDPDDPNPTLFKMAVNGSKADAAE
IDAAQANASALGGPIEAEPSQLTASGLSITDLKIGDGPEATAGQTVSVNYRGTLENGQEFDSSYKRGPFEFPLGAGRVIK
GWDEGVAGMKVGGKRKLVIPPELGYGSRGAGRVIPGNATLIFEVELLGIK
>Mature_210_residues
MRDIFISAAVFVVCVVVAFVSQIVSPSVVVADSNLNAVQAEVRTVEPAALSMAVLELDPDDPNPTLFKMAVNGSKADAAE
IDAAQANASALGGPIEAEPSQLTASGLSITDLKIGDGPEATAGQTVSVNYRGTLENGQEFDSSYKRGPFEFPLGAGRVIK
GWDEGVAGMKVGGKRKLVIPPELGYGSRGAGRVIPGNATLIFEVELLGIK

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=93, Percent_Identity=59.1397849462366, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI17149844, Length=93, Percent_Identity=59.1397849462366, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI17149842, Length=93, Percent_Identity=59.1397849462366, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI224809329, Length=100, Percent_Identity=52, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI224809327, Length=100, Percent_Identity=52, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4758384, Length=100, Percent_Identity=52, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=47.6635514018692, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=47.6635514018692, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI224809331, Length=100, Percent_Identity=52, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=47.6635514018692, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI8923659, Length=96, Percent_Identity=46.875, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI192448443, Length=92, Percent_Identity=46.7391304347826, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI4503729, Length=89, Percent_Identity=50.561797752809, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI33469985, Length=89, Percent_Identity=44.9438202247191, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI150010552, Length=106, Percent_Identity=42.4528301886792, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4503727, Length=108, Percent_Identity=40.7407407407407, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7706131, Length=90, Percent_Identity=36.6666666666667, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI206725547, Length=94, Percent_Identity=41.4893617021277, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI87082390, Length=108, Percent_Identity=49.0740740740741, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789745, Length=111, Percent_Identity=49.5495495495495, Blast_Score=85, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71993519, Length=88, Percent_Identity=62.5, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17540882, Length=92, Percent_Identity=53.2608695652174, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17561782, Length=88, Percent_Identity=57.9545454545455, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561778, Length=101, Percent_Identity=46.5346534653465, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17506169, Length=89, Percent_Identity=41.5730337078652, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17506167, Length=89, Percent_Identity=41.5730337078652, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561780, Length=89, Percent_Identity=44.9438202247191, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=59.5744680851064, Blast_Score=104, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323566, Length=111, Percent_Identity=47.7477477477478, Blast_Score=101, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6323482, Length=111, Percent_Identity=47.7477477477478, Blast_Score=98, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324194, Length=113, Percent_Identity=46.0176991150442, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281363946, Length=93, Percent_Identity=56.989247311828, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17352457, Length=93, Percent_Identity=56.989247311828, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24647110, Length=126, Percent_Identity=50, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=49.5327102803738, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21356629, Length=94, Percent_Identity=59.5744680851064, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24583150, Length=101, Percent_Identity=52.4752475247525, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21743; Mature: 21743

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS50059 FKBP_PPIASE ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDIFISAAVFVVCVVVAFVSQIVSPSVVVADSNLNAVQAEVRTVEPAALSMAVLELDPD
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEHEECCCHHEEEEEEEECCC
DPNPTLFKMAVNGSKADAAEIDAAQANASALGGPIEAEPSQLTASGLSITDLKIGDGPEA
CCCCEEEEEEECCCCCCHHHCCHHHCCHHHCCCCCCCCCCCEEECCCEEEEEEECCCCCC
TAGQTVSVNYRGTLENGQEFDSSYKRGPFEFPLGAGRVIKGWDEGVAGMKVGGKRKLVIP
CCCCEEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCEEECCCEEEEEC
PELGYGSRGAGRVIPGNATLIFEVELLGIK
CCCCCCCCCCCEEECCCEEEEEEEEEEECC
>Mature Secondary Structure
MRDIFISAAVFVVCVVVAFVSQIVSPSVVVADSNLNAVQAEVRTVEPAALSMAVLELDPD
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEHEECCCHHEEEEEEEECCC
DPNPTLFKMAVNGSKADAAEIDAAQANASALGGPIEAEPSQLTASGLSITDLKIGDGPEA
CCCCEEEEEEECCCCCCHHHCCHHHCCHHHCCCCCCCCCCCEEECCCEEEEEEECCCCCC
TAGQTVSVNYRGTLENGQEFDSSYKRGPFEFPLGAGRVIKGWDEGVAGMKVGGKRKLVIP
CCCCEEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCEEECCCEEEEEC
PELGYGSRGAGRVIPGNATLIFEVELLGIK
CCCCCCCCCCCEEECCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]