Click here to switch to the map view.

The map label for this gene is trpC [H]

Identifier: 33862609

GI number: 33862609

Start: 383694

End: 384599

Strand: Direct

Name: trpC [H]

Synonym: PMT0336

Alternate gene names: 33862609

Gene position: 383694-384599 (Clockwise)

Preceding gene: 33862608

Following gene: 33862610

Centisome position: 15.92

GC content: 52.65

Gene sequence:

>906_bases
ATGGAGATCCGCAGACGTCCGCCCAATCCAAGTGTCAAGGTGGCGCATTTGCAGTACGCCATTCCTCACGCCGATGCTGA
GCCGCGCCACATTCTTGAGAAGATTGTTTGGGAGAAGGACCGTGAAGTTGAGACGGCAAGACAGCGTGTACCCCTAGAGA
CGCTTAAATCTCAGATCGCAGACTTGCCCATCCCTCGAGATTTCATTGCAGCCTTGCGTCAGGCTTCGCGAGCTCCGGCA
GTGATTGCTGAAGTGAAGAAGGCCAGCCCAAGTCAAGGTGTGATCCGTGCGGACTTTGACCCTGTTTTGATCGCCAATGC
CTATGCGGAAGGTGGTGCTAGTTGCTTGTCTGTGCTGACCGATAAGAGCTTCTTCCAGGGTGGATTTGAGGTGCTTGTTG
AGGTGCGGCAGACGGTTGGGCTACCACTGCTATGTAAGGACTTCATCCTGACGCCATATCAGCTTTATCAGGCGCGTGCT
GCAGGTGCAGATGCTGCCTTGTTGATTGTGGCGATCCTCTCTGATCAGGACCTGACGTATTTGAGCAAGGTGGCCAACAG
TCTTGGACTCAATGTCTTAGTGGAAGTGCATGATGCTGAGGAACTTGAACGGGTTCTCAACCTTGGTGGTTTCCCACTGA
TTGGTATCAATAATCGTGATCTCACCACCTTTGAGACAGACCTTGAAACCACTGAAACACTGAGCCAGCAATTCGCTACT
CGATTGCAGCAGCAGGGTGTCTTGTTGGTGAGTGAATCGGGCTTGTTTAACCGCGCTGATTTGGACAGGGTTCAGGCAGT
AGGCGCTGAAGCTGTGTTGGTAGGAGAAGCCCTGATGCGTCAGTCGGATGTTTGTGCTGGCTTACAGCAGCTGATGATTG
GAGACGAAGGAACGAGCAACAGCTGA

Upstream 100 bases:

>100_bases
GGCTAAGGCGGTTGTTGCATCGGCCAGTGCTTCCTAGGCCGCTGTTCTTCAAGCAGGTCTTAGCCCTGCGGTTCACTGTT
TTTAATTGCACTATCACCCG

Downstream 100 bases:

>100_bases
TCACTTTTTTTCTTTTATTTGAGGAATCGTTGCGATGCATTACCACAGCAAGAGGTTGATCTGAGCTTGCTGTGAGTTAA
GGATGAGCCGTTGCTCTTTG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MEIRRRPPNPSVKVAHLQYAIPHADAEPRHILEKIVWEKDREVETARQRVPLETLKSQIADLPIPRDFIAALRQASRAPA
VIAEVKKASPSQGVIRADFDPVLIANAYAEGGASCLSVLTDKSFFQGGFEVLVEVRQTVGLPLLCKDFILTPYQLYQARA
AGADAALLIVAILSDQDLTYLSKVANSLGLNVLVEVHDAEELERVLNLGGFPLIGINNRDLTTFETDLETTETLSQQFAT
RLQQQGVLLVSESGLFNRADLDRVQAVGAEAVLVGEALMRQSDVCAGLQQLMIGDEGTSNS

Sequences:

>Translated_301_residues
MEIRRRPPNPSVKVAHLQYAIPHADAEPRHILEKIVWEKDREVETARQRVPLETLKSQIADLPIPRDFIAALRQASRAPA
VIAEVKKASPSQGVIRADFDPVLIANAYAEGGASCLSVLTDKSFFQGGFEVLVEVRQTVGLPLLCKDFILTPYQLYQARA
AGADAALLIVAILSDQDLTYLSKVANSLGLNVLVEVHDAEELERVLNLGGFPLIGINNRDLTTFETDLETTETLSQQFAT
RLQQQGVLLVSESGLFNRADLDRVQAVGAEAVLVGEALMRQSDVCAGLQQLMIGDEGTSNS
>Mature_301_residues
MEIRRRPPNPSVKVAHLQYAIPHADAEPRHILEKIVWEKDREVETARQRVPLETLKSQIADLPIPRDFIAALRQASRAPA
VIAEVKKASPSQGVIRADFDPVLIANAYAEGGASCLSVLTDKSFFQGGFEVLVEVRQTVGLPLLCKDFILTPYQLYQARA
AGADAALLIVAILSDQDLTYLSKVANSLGLNVLVEVHDAEELERVLNLGGFPLIGINNRDLTTFETDLETTETLSQQFAT
RLQQQGVLLVSESGLFNRADLDRVQAVGAEAVLVGEALMRQSDVCAGLQQLMIGDEGTSNS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=266, Percent_Identity=41.7293233082707, Blast_Score=179, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322638, Length=237, Percent_Identity=39.662447257384, Blast_Score=151, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 32838; Mature: 32838

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRRRPPNPSVKVAHLQYAIPHADAEPRHILEKIVWEKDREVETARQRVPLETLKSQIA
CCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHH
DLPIPRDFIAALRQASRAPAVIAEVKKASPSQGVIRADFDPVLIANAYAEGGASCLSVLT
CCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHH
DKSFFQGGFEVLVEVRQTVGLPLLCKDFILTPYQLYQARAAGADAALLIVAILSDQDLTY
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHH
LSKVANSLGLNVLVEVHDAEELERVLNLGGFPLIGINNRDLTTFETDLETTETLSQQFAT
HHHHHHHCCCEEEEEECCHHHHHHHHCCCCCCEEECCCCCCEEEECCHHHHHHHHHHHHH
RLQQQGVLLVSESGLFNRADLDRVQAVGAEAVLVGEALMRQSDVCAGLQQLMIGDEGTSN
HHHHCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
S
C
>Mature Secondary Structure
MEIRRRPPNPSVKVAHLQYAIPHADAEPRHILEKIVWEKDREVETARQRVPLETLKSQIA
CCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHH
DLPIPRDFIAALRQASRAPAVIAEVKKASPSQGVIRADFDPVLIANAYAEGGASCLSVLT
CCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHH
DKSFFQGGFEVLVEVRQTVGLPLLCKDFILTPYQLYQARAAGADAALLIVAILSDQDLTY
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHH
LSKVANSLGLNVLVEVHDAEELERVLNLGGFPLIGINNRDLTTFETDLETTETLSQQFAT
HHHHHHHCCCEEEEEECCHHHHHHHHCCCCCCEEECCCCCCEEEECCHHHHHHHHHHHHH
RLQQQGVLLVSESGLFNRADLDRVQAVGAEAVLVGEALMRQSDVCAGLQQLMIGDEGTSN
HHHHCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA