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The map label for this gene is panB [H]

Identifier: 33862591

GI number: 33862591

Start: 364419

End: 365237

Strand: Reverse

Name: panB [H]

Synonym: PMT0318

Alternate gene names: 33862591

Gene position: 365237-364419 (Counterclockwise)

Preceding gene: 33862592

Following gene: 33862589

Centisome position: 15.15

GC content: 58.61

Gene sequence:

>819_bases
ATGCGCCCCAGCGAATTAACTCAACTCAAGCAGGACGGGCGAGCGATCAGCATCCTCACAGCCTGGGATGGCATAAGTGC
GGCCTTGGTTGAGGCCGCTGGAGCCGATGTGGTTCTAGTAGGAGACTCCCTAGCGATGGTGGCACTGTGCCATGCAACCA
CCCTGCCTGTGACAGTGGAGCAGATGCTCCACCACACCAAAGCGGTGGGGAGGGGTTTCACTCGCCCTCTGCCACAACAG
CCCCTCGTCGTCTGCGACCTCCCATTCCTGAGCTACCAATGCGGAGAAGACAAGGCTGTAGCTGCAGCTGGAAGCCTGCT
CAAGCACTCCTGTGCAGCCGCCGTGAAGCTAGAAGGAGCAGAGCCAGAGGTCCTAGCAGTCATTGAGCGTCTGGTGCGCA
TGGGGATCCCAGTCATGGGGCATTTGGGCCTCACTCCACAAGCAGTACATCAGCTCGGCTACCGCCGTCAGGCGGAGGAC
CCTCGCAGCCAAGCGCAAATGCTGCAACAAGCAAAACAACTTGAGCAAGCGGGCTGTTTCGCCCTGGTGGTCGAACATGT
GCCGAGTTCCATCGCTCGTTGCCTGAGTCAACAACTCACCATCCCCGTGATCGGTATCGGCGCTGGCGAAGATTGCGATG
GACAGGTAAGGGTCACCGCTGACCTGTTGGGACTGACTCCCAGCCAACCCCCCTTCAGTCAACCATTGATCCAAGGTCGC
CAGCTGTGCGTAGAAGCCCTTCAAGGTTGGGTGAAGCAACTGCATCAGCAGGCAAAGACTGCCACCACAACAACATCTCC
ACCAGAACCTGATTGCTGA

Upstream 100 bases:

>100_bases
GCTGCTCCCTTCCGGTCCTGACCAGATTTAGGCGTCGCGGCCGCATGGGTCCGAGTCAACACGATGCTAGCAATGGACCC
TCGAGGGCCTGGAGAAGCAG

Downstream 100 bases:

>100_bases
TGGCCATCCCCTCGGGGTCACTGAGCTGCCAACGTCGTCCATGCAGCTCTAACCAGCCCCGATCCAACGCCGCCTGCCAG
CGCACCTGCAACGACGGCAA

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MRPSELTQLKQDGRAISILTAWDGISAALVEAAGADVVLVGDSLAMVALCHATTLPVTVEQMLHHTKAVGRGFTRPLPQQ
PLVVCDLPFLSYQCGEDKAVAAAGSLLKHSCAAAVKLEGAEPEVLAVIERLVRMGIPVMGHLGLTPQAVHQLGYRRQAED
PRSQAQMLQQAKQLEQAGCFALVVEHVPSSIARCLSQQLTIPVIGIGAGEDCDGQVRVTADLLGLTPSQPPFSQPLIQGR
QLCVEALQGWVKQLHQQAKTATTTTSPPEPDC

Sequences:

>Translated_272_residues
MRPSELTQLKQDGRAISILTAWDGISAALVEAAGADVVLVGDSLAMVALCHATTLPVTVEQMLHHTKAVGRGFTRPLPQQ
PLVVCDLPFLSYQCGEDKAVAAAGSLLKHSCAAAVKLEGAEPEVLAVIERLVRMGIPVMGHLGLTPQAVHQLGYRRQAED
PRSQAQMLQQAKQLEQAGCFALVVEHVPSSIARCLSQQLTIPVIGIGAGEDCDGQVRVTADLLGLTPSQPPFSQPLIQGR
QLCVEALQGWVKQLHQQAKTATTTTSPPEPDC
>Mature_272_residues
MRPSELTQLKQDGRAISILTAWDGISAALVEAAGADVVLVGDSLAMVALCHATTLPVTVEQMLHHTKAVGRGFTRPLPQQ
PLVVCDLPFLSYQCGEDKAVAAAGSLLKHSCAAAVKLEGAEPEVLAVIERLVRMGIPVMGHLGLTPQAVHQLGYRRQAED
PRSQAQMLQQAKQLEQAGCFALVVEHVPSSIARCLSQQLTIPVIGIGAGEDCDGQVRVTADLLGLTPSQPPFSQPLIQGR
QLCVEALQGWVKQLHQQAKTATTTTSPPEPDC

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=242, Percent_Identity=38.8429752066116, Blast_Score=147, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6319653, Length=247, Percent_Identity=35.2226720647773, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28922; Mature: 28922

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPSELTQLKQDGRAISILTAWDGISAALVEAAGADVVLVGDSLAMVALCHATTLPVTVE
CCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCHHHH
QMLHHTKAVGRGFTRPLPQQPLVVCDLPFLSYQCGEDKAVAAAGSLLKHSCAAAVKLEGA
HHHHHHHHHHCCCCCCCCCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHEEECCC
EPEVLAVIERLVRMGIPVMGHLGLTPQAVHQLGYRRQAEDPRSQAQMLQQAKQLEQAGCF
CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHH
ALVVEHVPSSIARCLSQQLTIPVIGIGAGEDCDGQVRVTADLLGLTPSQPPFSQPLIQGR
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEHHCCCCCCCCCCCHHHHHH
QLCVEALQGWVKQLHQQAKTATTTTSPPEPDC
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRPSELTQLKQDGRAISILTAWDGISAALVEAAGADVVLVGDSLAMVALCHATTLPVTVE
CCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCHHHH
QMLHHTKAVGRGFTRPLPQQPLVVCDLPFLSYQCGEDKAVAAAGSLLKHSCAAAVKLEGA
HHHHHHHHHHCCCCCCCCCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHEEECCC
EPEVLAVIERLVRMGIPVMGHLGLTPQAVHQLGYRRQAEDPRSQAQMLQQAKQLEQAGCF
CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHH
ALVVEHVPSSIARCLSQQLTIPVIGIGAGEDCDGQVRVTADLLGLTPSQPPFSQPLIQGR
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEHHCCCCCCCCCCCHHHHHH
QLCVEALQGWVKQLHQQAKTATTTTSPPEPDC
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA