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The map label for this gene is serRS [H]

Identifier: 161350042

GI number: 161350042

Start: 1458172

End: 1459449

Strand: Direct

Name: serRS [H]

Synonym: PMT1374

Alternate gene names: 161350042

Gene position: 1458172-1459449 (Clockwise)

Preceding gene: 33863640

Following gene: 33863642

Centisome position: 60.48

GC content: 55.4

Gene sequence:

>1278_bases
GTGCTTGACCAGCGCCTGGTGCGGGACAACCCCGACCTGATTGCCAACGAACTGGGCCGAAGGGGCATTACGTTAGATCT
AACGGGCCTACAACTGATCGCCCAGCAACAAAGAAATCTCGAGGAACAGCGCAGCAGCCTCCAGGCAGAAGGGAATCGGA
TCGGCAAGGAAGTCGGTCAACGGATCCAGCAGGGAAGCGACCCAAAAGCCAGCGACGTGGCAGAACTAAGACAGCAAGGC
AACCTAATCAAGCAAAAGGTGGCCGTTTTAGAAGACGAGGAGAAACAACTATCAGCGCGATTGCGAGAGCAACTGCTGAG
CTTGCCAAACCTGCCCTCCCCTGATTGTCCTGAAGGACGCGATGAGAACGACAACCAAGAAAGACACCGTTGGGGCAAGC
CACGTGAAGGGAAAGACCTTCTGGAGCACTGGTCAATTGCCGAGCGGCTCAAACTTTTCGAAACAGAACGCTCTGTACGA
ATTGCCCAAAGTCGCTTCGTCACCCTGATGGGTCAGGGTGCGCGACTGGAACGAGCACTCATCAACTTCATGCTCGACCT
TCACACCTCAAAGGGATATCGAGAAGTGATGCCTCCGGTACTGGTGAATACCGCCAGCCTTACGGGCTCTGGTCAGCTGC
CAAAATTCGCCGAAGAAAGCTTCCGCTGCGCTGAAGACGACCTCTGGCTAACACCAACTGCAGAGGTGCCGGTGACATCT
CTGCACCGCGATGAAATCATCCCCGCTGAGCAACTTCCACTGCGATACGCCGCTTACAGTCCATGTTTTCGCCGCGAAGC
TGGCAGCTATGGAAGAGACACCCGTGGCCTGATCCGGCTGCATCAATTCAACAAGGTGGAGCTCTATTGGTTCGTCCATC
CAGACCATTCGCAGGCTGCCCACGCTCAGATCACAGCCGATGCCGAAGCCGTGCTGCAGGCCTTGGAATTGCCCTACCGC
GTGATTGAACTTTGCACAGGTGATCTAGGGTTTTCTTCCTCACGCACCTACGACCTCGAAGTCTGGCTACCAGGAGCAGG
CGCCTTCAGGGAAATTTCAAGTTGCAGTATCTGTGGAGACTTCCAAGCACGGCGATCTGCTATTCGCACCAAAGACGAAA
AAGGTACCCGACTCATCCACACCCTCAATGGCAGTGGCCTAGCGGTAGGACGCACCATGGCTGCCCTTCTCGAAACAGGC
CAGCAATCTGATGGGAGTGTCCTCCTCCCCAAGGCACTTGTGCCTTATTTCGGCAACGATCGACTAGAGCCAGAATGA

Upstream 100 bases:

>100_bases
CTGTTGCTTCCAATCTCGCAGGCTGAATAGGCGAAACCAAACAGGATTCATTTGCAGAGCCAACAACACTTAGGCTGCCC
GCGCTGACTTGAAAACCCTC

Downstream 100 bases:

>100_bases
ACCCATTGCTAGAAGCTGAATGAACGTTTTTGCGGCGCTGACGGTTCTAGCCCTGCTAATCATCATTCATGAAGCTGGGC
ACTTTCTGGCTGCCACTGCT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDQRLVRDNPDLIANELGRRGITLDLTGLQLIAQQQRNLEEQRSSLQAEGNRIGKEVGQRIQQGSDPKASDVAELRQQG
NLIKQKVAVLEDEEKQLSARLREQLLSLPNLPSPDCPEGRDENDNQERHRWGKPREGKDLLEHWSIAERLKLFETERSVR
IAQSRFVTLMGQGARLERALINFMLDLHTSKGYREVMPPVLVNTASLTGSGQLPKFAEESFRCAEDDLWLTPTAEVPVTS
LHRDEIIPAEQLPLRYAAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFVHPDHSQAAHAQITADAEAVLQALELPYR
VIELCTGDLGFSSSRTYDLEVWLPGAGAFREISSCSICGDFQARRSAIRTKDEKGTRLIHTLNGSGLAVGRTMAALLETG
QQSDGSVLLPKALVPYFGNDRLEPE

Sequences:

>Translated_425_residues
MLDQRLVRDNPDLIANELGRRGITLDLTGLQLIAQQQRNLEEQRSSLQAEGNRIGKEVGQRIQQGSDPKASDVAELRQQG
NLIKQKVAVLEDEEKQLSARLREQLLSLPNLPSPDCPEGRDENDNQERHRWGKPREGKDLLEHWSIAERLKLFETERSVR
IAQSRFVTLMGQGARLERALINFMLDLHTSKGYREVMPPVLVNTASLTGSGQLPKFAEESFRCAEDDLWLTPTAEVPVTS
LHRDEIIPAEQLPLRYAAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFVHPDHSQAAHAQITADAEAVLQALELPYR
VIELCTGDLGFSSSRTYDLEVWLPGAGAFREISSCSICGDFQARRSAIRTKDEKGTRLIHTLNGSGLAVGRTMAALLETG
QQSDGSVLLPKALVPYFGNDRLEPE
>Mature_425_residues
MLDQRLVRDNPDLIANELGRRGITLDLTGLQLIAQQQRNLEEQRSSLQAEGNRIGKEVGQRIQQGSDPKASDVAELRQQG
NLIKQKVAVLEDEEKQLSARLREQLLSLPNLPSPDCPEGRDENDNQERHRWGKPREGKDLLEHWSIAERLKLFETERSVR
IAQSRFVTLMGQGARLERALINFMLDLHTSKGYREVMPPVLVNTASLTGSGQLPKFAEESFRCAEDDLWLTPTAEVPVTS
LHRDEIIPAEQLPLRYAAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFVHPDHSQAAHAQITADAEAVLQALELPYR
VIELCTGDLGFSSSRTYDLEVWLPGAGAFREISSCSICGDFQARRSAIRTKDEKGTRLIHTLNGSGLAVGRTMAALLETG
QQSDGSVLLPKALVPYFGNDRLEPE

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=363, Percent_Identity=34.1597796143251, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI8923421, Length=413, Percent_Identity=33.6561743341404, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI225579074, Length=410, Percent_Identity=31.9512195121951, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=47.4299065420561, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17539260, Length=406, Percent_Identity=30.7881773399015, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17542084, Length=322, Percent_Identity=30.4347826086957, Blast_Score=144, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=445, Percent_Identity=29.6629213483146, Blast_Score=212, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6321799, Length=412, Percent_Identity=28.6407766990291, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24581334, Length=463, Percent_Identity=30.4535637149028, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17737985, Length=336, Percent_Identity=28.8690476190476, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24649556, Length=421, Percent_Identity=23.2779097387173, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47726; Mature: 47726

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDQRLVRDNPDLIANELGRRGITLDLTGLQLIAQQQRNLEEQRSSLQAEGNRIGKEVGQ
CCCCCCCCCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIQQGSDPKASDVAELRQQGNLIKQKVAVLEDEEKQLSARLREQLLSLPNLPSPDCPEGR
HHHCCCCCCHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DENDNQERHRWGKPREGKDLLEHWSIAERLKLFETERSVRIAQSRFVTLMGQGARLERAL
CCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
INFMLDLHTSKGYREVMPPVLVNTASLTGSGQLPKFAEESFRCAEDDLWLTPTAEVPVTS
HHHHHHHHCCCCHHHHCCHHHEECCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCCCCHH
LHRDEIIPAEQLPLRYAAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFVHPDHSQAA
CCHHCCCCHHHCCCHHHHCCCHHHHHCCCCCCCCHHHHEEEECCEEEEEEEECCCCCCCC
HAQITADAEAVLQALELPYRVIELCTGDLGFSSSRTYDLEVWLPGAGAFREISSCSICGD
CEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHCCCCCCCC
FQARRSAIRTKDEKGTRLIHTLNGSGLAVGRTMAALLETGQQSDGSVLLPKALVPYFGND
HHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEECHHHHCCCCCCC
RLEPE
CCCCC
>Mature Secondary Structure
MLDQRLVRDNPDLIANELGRRGITLDLTGLQLIAQQQRNLEEQRSSLQAEGNRIGKEVGQ
CCCCCCCCCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIQQGSDPKASDVAELRQQGNLIKQKVAVLEDEEKQLSARLREQLLSLPNLPSPDCPEGR
HHHCCCCCCHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DENDNQERHRWGKPREGKDLLEHWSIAERLKLFETERSVRIAQSRFVTLMGQGARLERAL
CCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
INFMLDLHTSKGYREVMPPVLVNTASLTGSGQLPKFAEESFRCAEDDLWLTPTAEVPVTS
HHHHHHHHCCCCHHHHCCHHHEECCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCCCCHH
LHRDEIIPAEQLPLRYAAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFVHPDHSQAA
CCHHCCCCHHHCCCHHHHCCCHHHHHCCCCCCCCHHHHEEEECCEEEEEEEECCCCCCCC
HAQITADAEAVLQALELPYRVIELCTGDLGFSSSRTYDLEVWLPGAGAFREISSCSICGD
CEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHCCCCCCCC
FQARRSAIRTKDEKGTRLIHTLNGSGLAVGRTMAALLETGQQSDGSVLLPKALVPYFGND
HHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEECHHHHCCCCCCC
RLEPE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA