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The map label for this gene is purL

Identifier: 32267324

GI number: 32267324

Start: 1745942

End: 1748179

Strand: Direct

Name: purL

Synonym: HH1825

Alternate gene names: 32267324

Gene position: 1745942-1748179 (Clockwise)

Preceding gene: 32267322

Following gene: 32267325

Centisome position: 97.04

GC content: 39.54

Gene sequence:

>2238_bases
ATGACAAATATTACACATCTTTTGGGTGAGATTAAAGACATTGATGAGACTCTAAAGGTTCATAAGCTTTCAAAGCAGGA
TTATGAGGAGATTCTTAAGATTTTAAAGCGTCCTCCAAACCTTATAGAATTAGGGATTTTTGCGGCAATGTGGAGTGAAC
ATTGTAGTTACAAATCAAGCAAAAAATATCTTAATGGATTCCCTACCAAAGCTCCTTGGGTTGTACAAGGACCAGGTGAA
AATGCGGGCATAATTGATATTGGGGAAAATCTTTGTGCGGTCTTTAAGATAGAATCTCATAATCACCCAAGTTTCATTGA
GCCTCACGCAGGGGCTGCTACTGGCGTAGGTGGGATTATGCGAGATATTTTTACAATGGGAGCACGTCCTGTGGCAAGCC
TTAATTCTATTCGTTTTGGCGATATAAGCGATAATGGCACACTTGGCAAAAAACATCGTTACTTATTACGAGGCGTGGTA
GAAGGCATAGGGAGTTATGGAAATTGTATGGGAGTGCCTACAATTGGCGGAGAAATGAGTTTTGAATCTTGCTATAATGG
CAATATCTTAGTAAATGCATTTTGTTTAGGATTAGTCAAAAAAGATGAGATTTTTTATGGAAAAGCTGAAGGGATAGGGA
ATCCTGTTATTTATGTAGGGAGTAAGACAGGACGTGATGGGTTAGGTGGAGCAGTGATGAGCAGTGATAGTTTCAGCTCT
ACTTCAAAGGCTGTGCGTTCCGCGGTGCAAGTAGGCGACCCGTTTGCAGAAAAACTTTTGCTTGAAGCGTGTTTAGAGCT
TTTCAAGCAAGATTTAATTGTTGGGATTCAAGATATGGGTGCAGCTGGGCTCACAAGCTCAAGTTTTGAAATGGCAGGTC
GTAGTGGCAGCGGTATGACACTGTATCTTGATAAAGTGCCTATGCGCGAAGAAGGAATGAATCCTTATGAATTAATGCTA
AGTGAATCTCAAGAGAGAATGCTTATTTGCGCTAAAAAAGGTTGTGAGCAACAGGTATTAGATATTTTTGCCAAATGGGA
AGTAGATGCAGCAATTATTGGAGAAGTTACAAAAAGTGGCATTATGGAACTTTTTTGGTATGGAGAGAAATGTGCGGAGA
TTCCAATCGCGCAATTAAGTGAAAATGCTCCTATGCTTGATATGCCCTTACGCCCTGTTGCAGTGCAAACTCATAAAGCT
AATCAACTTAAAACATCTCAAAGCGCACAAGAAATTTTTATAACTCTGCTTGGAAGTGTAGAGGTTGCAAATAAAAGATG
GGTTTATAGCCAATATGATAGTAGTGTGCAAAGCAATACGATTACTCCTGCAGGAAGCGGTGATGCGAGTATGATACGTA
TAAAAGGCACAAATAGTGCATTGAGTATGAGCGTGGATTGCAATATGCGCTATTGTTACCTTGACCCCAAAAATGGCGCA
AAGATTGCGGTAGCAACTTCAGGACGTAACTCCATAGTCAATGGTGCAAAGCCTTTGGCAATTAGTGATTGTCTGAATTT
TGGCTCACCTCATAATCCTGAAGTGATGTGGGCGTTCAAGGAAGTATGTCAAGGCATTAAAGAATCTTGTAAAGTATTAA
ATACTCCAGTAGTAAGCGGTAATGTTTCTTTGCATAATCAAAGCGATGGCGTGGATATTTACCCTACACCCTCTATTGTA
AGTGTGGGTTTGATAGATGATGTAAGTAAGGTAGTGTCTTCAACATTCCAAACACAGGGGAATATGCTCGTATTACTTGG
CGAAATTAAAGCCGAGTTTGGTGGCTCTTTGGCACAAAAGATTTTGGAAGGACATATTTATGGGCAAATTCCAAGCATTG
ATTTAACACAAGAGTTTGCTTTATGGAATTTAATGCTTGAGGCGAGTGATGAATGTATGTTGAGTGCTGCAAAAGATATT
GGTGAGGGGGGATTAGCTATTACTCTTGCAAAAATGGCATTAGGCAATGGCGAATGCCAACCCATAGGTTGTAATGTCCA
TACGCATTTACCCTCACAGCTACTTTTTGCACCTTCCCAAAGCTGTATCATTGTAGAAGTAGCAGGAGAGCATCTCAATA
CGCTAAAGCAAAAAGCAAAACAACATAAGATTGCTTTTACAGAAATTGGTTGTGTAGGAGGTGATATTTTTTGTGTTGAT
GAGATTAATATAAGCCTTGAAGAGATGAAAAAGCTTTATTTTGAGAGTTTTGAAAAGTTAATTGCTCAAGATTTGTGA

Upstream 100 bases:

>100_bases
CCAAACTTAAAAAGTGTAACTCTTAAACAAAAGCGAAAAAAAGCATAAGTTGTGATAGAATCTACACTTTTTATTTATTT
TTGCAATGATTGAGGTGGCA

Downstream 100 bases:

>100_bases
TTTTAAGGGGAATTGAGTAAAGTAAAAATGCAAACTTTTGTTTTAAAAACTGCATTCATTTATACATTTATATGCTTTGC
TCTTGATATAGCCATTGCGG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MTNITHLLGEIKDIDETLKVHKLSKQDYEEILKILKRPPNLIELGIFAAMWSEHCSYKSSKKYLNGFPTKAPWVVQGPGE
NAGIIDIGENLCAVFKIESHNHPSFIEPHAGAATGVGGIMRDIFTMGARPVASLNSIRFGDISDNGTLGKKHRYLLRGVV
EGIGSYGNCMGVPTIGGEMSFESCYNGNILVNAFCLGLVKKDEIFYGKAEGIGNPVIYVGSKTGRDGLGGAVMSSDSFSS
TSKAVRSAVQVGDPFAEKLLLEACLELFKQDLIVGIQDMGAAGLTSSSFEMAGRSGSGMTLYLDKVPMREEGMNPYELML
SESQERMLICAKKGCEQQVLDIFAKWEVDAAIIGEVTKSGIMELFWYGEKCAEIPIAQLSENAPMLDMPLRPVAVQTHKA
NQLKTSQSAQEIFITLLGSVEVANKRWVYSQYDSSVQSNTITPAGSGDASMIRIKGTNSALSMSVDCNMRYCYLDPKNGA
KIAVATSGRNSIVNGAKPLAISDCLNFGSPHNPEVMWAFKEVCQGIKESCKVLNTPVVSGNVSLHNQSDGVDIYPTPSIV
SVGLIDDVSKVVSSTFQTQGNMLVLLGEIKAEFGGSLAQKILEGHIYGQIPSIDLTQEFALWNLMLEASDECMLSAAKDI
GEGGLAITLAKMALGNGECQPIGCNVHTHLPSQLLFAPSQSCIIVEVAGEHLNTLKQKAKQHKIAFTEIGCVGGDIFCVD
EINISLEEMKKLYFESFEKLIAQDL

Sequences:

>Translated_745_residues
MTNITHLLGEIKDIDETLKVHKLSKQDYEEILKILKRPPNLIELGIFAAMWSEHCSYKSSKKYLNGFPTKAPWVVQGPGE
NAGIIDIGENLCAVFKIESHNHPSFIEPHAGAATGVGGIMRDIFTMGARPVASLNSIRFGDISDNGTLGKKHRYLLRGVV
EGIGSYGNCMGVPTIGGEMSFESCYNGNILVNAFCLGLVKKDEIFYGKAEGIGNPVIYVGSKTGRDGLGGAVMSSDSFSS
TSKAVRSAVQVGDPFAEKLLLEACLELFKQDLIVGIQDMGAAGLTSSSFEMAGRSGSGMTLYLDKVPMREEGMNPYELML
SESQERMLICAKKGCEQQVLDIFAKWEVDAAIIGEVTKSGIMELFWYGEKCAEIPIAQLSENAPMLDMPLRPVAVQTHKA
NQLKTSQSAQEIFITLLGSVEVANKRWVYSQYDSSVQSNTITPAGSGDASMIRIKGTNSALSMSVDCNMRYCYLDPKNGA
KIAVATSGRNSIVNGAKPLAISDCLNFGSPHNPEVMWAFKEVCQGIKESCKVLNTPVVSGNVSLHNQSDGVDIYPTPSIV
SVGLIDDVSKVVSSTFQTQGNMLVLLGEIKAEFGGSLAQKILEGHIYGQIPSIDLTQEFALWNLMLEASDECMLSAAKDI
GEGGLAITLAKMALGNGECQPIGCNVHTHLPSQLLFAPSQSCIIVEVAGEHLNTLKQKAKQHKIAFTEIGCVGGDIFCVD
EINISLEEMKKLYFESFEKLIAQDL
>Mature_744_residues
TNITHLLGEIKDIDETLKVHKLSKQDYEEILKILKRPPNLIELGIFAAMWSEHCSYKSSKKYLNGFPTKAPWVVQGPGEN
AGIIDIGENLCAVFKIESHNHPSFIEPHAGAATGVGGIMRDIFTMGARPVASLNSIRFGDISDNGTLGKKHRYLLRGVVE
GIGSYGNCMGVPTIGGEMSFESCYNGNILVNAFCLGLVKKDEIFYGKAEGIGNPVIYVGSKTGRDGLGGAVMSSDSFSST
SKAVRSAVQVGDPFAEKLLLEACLELFKQDLIVGIQDMGAAGLTSSSFEMAGRSGSGMTLYLDKVPMREEGMNPYELMLS
ESQERMLICAKKGCEQQVLDIFAKWEVDAAIIGEVTKSGIMELFWYGEKCAEIPIAQLSENAPMLDMPLRPVAVQTHKAN
QLKTSQSAQEIFITLLGSVEVANKRWVYSQYDSSVQSNTITPAGSGDASMIRIKGTNSALSMSVDCNMRYCYLDPKNGAK
IAVATSGRNSIVNGAKPLAISDCLNFGSPHNPEVMWAFKEVCQGIKESCKVLNTPVVSGNVSLHNQSDGVDIYPTPSIVS
VGLIDDVSKVVSSTFQTQGNMLVLLGEIKAEFGGSLAQKILEGHIYGQIPSIDLTQEFALWNLMLEASDECMLSAAKDIG
EGGLAITLAKMALGNGECQPIGCNVHTHLPSQLLFAPSQSCIIVEVAGEHLNTLKQKAKQHKIAFTEIGCVGGDIFCVDE
INISLEEMKKLYFESFEKLIAQDL

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=652, Percent_Identity=22.8527607361963, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI48994899, Length=734, Percent_Identity=25.3405994550409, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17553022, Length=684, Percent_Identity=22.6608187134503, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_HELHP (Q7VF52)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_861356.1
- ProteinModelPortal:   Q7VF52
- SMR:   Q7VF52
- GeneID:   1492372
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1825
- NMPDR:   fig|235279.1.peg.1825
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   HHEP235279:HH_1825-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 80516; Mature: 80384

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNITHLLGEIKDIDETLKVHKLSKQDYEEILKILKRPPNLIELGIFAAMWSEHCSYKSS
CCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHH
KKYLNGFPTKAPWVVQGPGENAGIIDIGENLCAVFKIESHNHPSFIEPHAGAATGVGGIM
HHHHCCCCCCCCEEEECCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDIFTMGARPVASLNSIRFGDISDNGTLGKKHRYLLRGVVEGIGSYGNCMGVPTIGGEMS
HHHHHCCCCCCHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCC
FESCYNGNILVNAFCLGLVKKDEIFYGKAEGIGNPVIYVGSKTGRDGLGGAVMSSDSFSS
HHHHCCCCEEEEEHHHHHEECCCEEEECCCCCCCCEEEECCCCCCCCCCCEEECCCCCCH
TSKAVRSAVQVGDPFAEKLLLEACLELFKQDLIVGIQDMGAAGLTSSSFEMAGRSGSGMT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCCCCHHHCCCCCCCCE
LYLDKVPMREEGMNPYELMLSESQERMLICAKKGCEQQVLDIFAKWEVDAAIIGEVTKSG
EEEECCCCHHCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHH
IMELFWYGEKCAEIPIAQLSENAPMLDMPLRPVAVQTHKANQLKTSQSAQEIFITLLGSV
HHHHHHCCCHHHCCCHHHHCCCCCEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCE
EVANKRWVYSQYDSSVQSNTITPAGSGDASMIRIKGTNSALSMSVDCNMRYCYLDPKNGA
EECCCCEEHHHHCCCHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCEEEEEEECCCCC
KIAVATSGRNSIVNGAKPLAISDCLNFGSPHNPEVMWAFKEVCQGIKESCKVLNTPVVSG
EEEEEECCCCCCCCCCCCEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEC
NVSLHNQSDGVDIYPTPSIVSVGLIDDVSKVVSSTFQTQGNMLVLLGEIKAEFGGSLAQK
CEEECCCCCCEEECCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHCHHHHHH
ILEGHIYGQIPSIDLTQEFALWNLMLEASDECMLSAAKDIGEGGLAITLAKMALGNGECQ
HHHCCCEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEHHCCCCCCC
PIGCNVHTHLPSQLLFAPSQSCIIVEVAGEHLNTLKQKAKQHKIAFTEIGCVGGDIFCVD
EECCCEECCCCCHHEECCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCEEEEE
EINISLEEMKKLYFESFEKLIAQDL
ECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNITHLLGEIKDIDETLKVHKLSKQDYEEILKILKRPPNLIELGIFAAMWSEHCSYKSS
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHH
KKYLNGFPTKAPWVVQGPGENAGIIDIGENLCAVFKIESHNHPSFIEPHAGAATGVGGIM
HHHHCCCCCCCCEEEECCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDIFTMGARPVASLNSIRFGDISDNGTLGKKHRYLLRGVVEGIGSYGNCMGVPTIGGEMS
HHHHHCCCCCCHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCC
FESCYNGNILVNAFCLGLVKKDEIFYGKAEGIGNPVIYVGSKTGRDGLGGAVMSSDSFSS
HHHHCCCCEEEEEHHHHHEECCCEEEECCCCCCCCEEEECCCCCCCCCCCEEECCCCCCH
TSKAVRSAVQVGDPFAEKLLLEACLELFKQDLIVGIQDMGAAGLTSSSFEMAGRSGSGMT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCCCCHHHCCCCCCCCE
LYLDKVPMREEGMNPYELMLSESQERMLICAKKGCEQQVLDIFAKWEVDAAIIGEVTKSG
EEEECCCCHHCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHH
IMELFWYGEKCAEIPIAQLSENAPMLDMPLRPVAVQTHKANQLKTSQSAQEIFITLLGSV
HHHHHHCCCHHHCCCHHHHCCCCCEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCE
EVANKRWVYSQYDSSVQSNTITPAGSGDASMIRIKGTNSALSMSVDCNMRYCYLDPKNGA
EECCCCEEHHHHCCCHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCEEEEEEECCCCC
KIAVATSGRNSIVNGAKPLAISDCLNFGSPHNPEVMWAFKEVCQGIKESCKVLNTPVVSG
EEEEEECCCCCCCCCCCCEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEC
NVSLHNQSDGVDIYPTPSIVSVGLIDDVSKVVSSTFQTQGNMLVLLGEIKAEFGGSLAQK
CEEECCCCCCEEECCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHCHHHHHH
ILEGHIYGQIPSIDLTQEFALWNLMLEASDECMLSAAKDIGEGGLAITLAKMALGNGECQ
HHHCCCEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEHHCCCCCCC
PIGCNVHTHLPSQLLFAPSQSCIIVEVAGEHLNTLKQKAKQHKIAFTEIGCVGGDIFCVD
EECCCEECCCCCHHEECCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCEEEEE
EINISLEEMKKLYFESFEKLIAQDL
ECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12810954