| Definition | Helicobacter hepaticus ATCC 51449 chromosome, complete genome. |
|---|---|
| Accession | NC_004917 |
| Length | 1,799,146 |
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The map label for this gene is nrdA
Identifier: 32267273
GI number: 32267273
Start: 1696801
End: 1699176
Strand: Direct
Name: nrdA
Synonym: HH1774
Alternate gene names: 32267273
Gene position: 1696801-1699176 (Clockwise)
Preceding gene: 32267272
Following gene: 32267274
Centisome position: 94.31
GC content: 36.36
Gene sequence:
>2376_bases ATGTTAGATACAATCACGGTTACAAAGAGAAATGGTCGGATTGAACCACTTGATATTGCAAAGATTCAAAAACATACTTA CGCGGCAGTAGAGGGGTTAGAAGGAGTTAGTCAAAGTGAGTTAGAAGTTGATGCAAAGATTCTATTTAAAGATAAAATTA CAACTGAAGAAATTCAGCAAACACTCATAAAAACAGCAGTAGATAAAATTGATGTAAATACGCCAAATTGGAGTTTTGTA GCAGCACGATTATTTTTGTATGATTTGTATCATAAAGTTACAGGTTGGACAGGTTATAAAAAGCTTGAAGAGTATTTTGA ACAGGGGGAAAGAGAGGGTAAGCTTATCTCTGGTATTAAAGAAAAATATGATTTAGCATTTTTAGATTCTCATATTAAGC CTGAACGTGATTTGCAATTTAATTATTTGGGCATTAAGACACTTTATGATAGATATTTATTAAAAGATAGTAATAATCGT CCCATTGAATTGCCTCAACATATGTTTATGGCAATTGCTATGTTTTTGGCACAAAATGAAAAAGATTGCAACGCTTGGGC AGTGAAATTTTATAATATGATTTCCTTATTTGAGGTTATTTGCGCGACACCTACCCTTGCAAATGCTCGCACTACGCGTC ATCAGTTAAGCTCGTGTTTTGTAGGAAGCACGCCTGATAATATTGAGGGAATCTTTGATGCTTATAAAGAAATGGCACTT TTAAGCAAATATGGAGGCGGTATAGGCTGGGATTTTAGCCGAGTGCGTGGGCTTGGAAGCTTTATTGATGGACATAAAAA TGCAGCAGGTGGTGTCGTGCCATTTTTAAAAATCGCTAATGATGTGGCAATAGCAGTTGATCAGCTTGGCACACGAAAGG GTGCAATTGCTACTTATTTAGAGATTTGGCATAATGATATTCACGATTTTATTGATTTGCGCAAAAATAGCGGTGAGGAG CGAAGACGCACACACGACTTATTCCCTGCTATTTGGATTTGTGATTTATTTATGAAGCGCGTAGAATCAAATGAGTTTTG GACACTTTTTGACCCTTATGAATGTCCTGAACTCACTGAACTCTATGGTGAAGCATTTGAAGCAAAATATATTGAATATG AGCAATCTGATAAGGTATTAAAATCTCGTATATTAGCCAAAGATTTATGGAAAAAGATTTTGACAAATTATTTTGAATCT GGCTTGCCTTTTTTATGCTTTAAAGACAATGCTAATCGGGTAAATCCTAATGCTCACGCAGGAATTATTAGAAGCTCAAA TCTCTGCACAGAGATTTTTCAAAATACTAATCCTAACCATTATGTGGTGGAAGTGGAGTTTGAAGATGGCTCAAAAGTAG TGTATGAAGAAAAAGAAGAGGTAAAGCTTGATAATGGTATGTGCAAGAGGGCAAATAAAATTACAAGTGTAGATTCTATA AATGGTAGGAAAGTGTTTATTACTTCGCGTATAGCACAAGGTGGGGCAACAGCGGTATGTAATCTCGCAAGTGTGAATCT AAGCAAAATAAACACCAAGGAAGATATTGAGCGTGTCTTGCCTATTGCTATTAGAATGCTTGATAATGTCATTGATTTAA ATTTTTATCCTAATCGTAAAGTTAAAGTTACAAATATGCAAAATCGTGCTATTGGGCTTGGAGTTATGGGTGAAGCAGAA ATGCTTGCGCGTTCCCACATTGATTGGGGGAGTGAAGAGCATTTGATAAAAATTGATGAGATTATGGAACTTGTGAGTTT TTATGCGATTGAATCAAGTGCAAATCTTGCCCAAGAAAAGGGTAAATATCCTCAATTTGAAGGCAGTAATTGGAGCAAAG GCATATTTCCTATTGATATGGCAAACAAAGAGGCACTTAAGATTGTTGATAGAGGGGGGCTTTTCTCACAGCAATGTGAT TGGGAATCTTTGAGAGCAAAAGTAAAAACACAAGGTATGCGCAATGGCTATTTAATGGCGATTGCTCCTACAAGTTCAAT TAGTATTTTAGTAGGCACAACACAAACCATTGAGCCTGTGTATAGAAAAAAATGGTATGAAGAGAATCTAAGCGGACTTA TTCCTGTGGTTGTGCCTCACTTGAACCTTGACACTTGGAATTATTATGTTTCAGCGTATGATATTGAGCAAACTCATATC ATTAAAGCGGCGGCTGTCCGACAAAAATGGATAGATCAAGGGCAAAGCACAAATATTTTTGTGCGTCTTGATAAAGCAAG TGGTAAAATGCTCAATGACATTTATACACTTGCGTGGAAATTAGGATTGAAAAGCACATATTATTTACGCTCTCAAAGCC CAGAGGCAGAAGAGCAGGTGATGGATAGAAGTGTAGAATGTGTGAATTGTCAATAA
Upstream 100 bases:
>100_bases AGTAAGTTTGATTGTATGTTTTGGTTATCGCGGTAAAGCACAGCAGGCACGTTATAGAATCACGCTTGATGAATTGGTTG AATATAAATAAGGGGGATAA
Downstream 100 bases:
>100_bases TGTCAATACTAAGATCAATAGGAGTAAAATACTAGGAGTTCAATTTTAGCTATAAAGGGGGGATATTATGGCACTGCAAG AAGAATTGAAACAACAAGGT
Product: ribonucleotide-diphosphate reductase subunit alpha
Products: NA
Alternate protein names: Ribonucleotide reductase [H]
Number of amino acids: Translated: 791; Mature: 791
Protein sequence:
>791_residues MLDTITVTKRNGRIEPLDIAKIQKHTYAAVEGLEGVSQSELEVDAKILFKDKITTEEIQQTLIKTAVDKIDVNTPNWSFV AARLFLYDLYHKVTGWTGYKKLEEYFEQGEREGKLISGIKEKYDLAFLDSHIKPERDLQFNYLGIKTLYDRYLLKDSNNR PIELPQHMFMAIAMFLAQNEKDCNAWAVKFYNMISLFEVICATPTLANARTTRHQLSSCFVGSTPDNIEGIFDAYKEMAL LSKYGGGIGWDFSRVRGLGSFIDGHKNAAGGVVPFLKIANDVAIAVDQLGTRKGAIATYLEIWHNDIHDFIDLRKNSGEE RRRTHDLFPAIWICDLFMKRVESNEFWTLFDPYECPELTELYGEAFEAKYIEYEQSDKVLKSRILAKDLWKKILTNYFES GLPFLCFKDNANRVNPNAHAGIIRSSNLCTEIFQNTNPNHYVVEVEFEDGSKVVYEEKEEVKLDNGMCKRANKITSVDSI NGRKVFITSRIAQGGATAVCNLASVNLSKINTKEDIERVLPIAIRMLDNVIDLNFYPNRKVKVTNMQNRAIGLGVMGEAE MLARSHIDWGSEEHLIKIDEIMELVSFYAIESSANLAQEKGKYPQFEGSNWSKGIFPIDMANKEALKIVDRGGLFSQQCD WESLRAKVKTQGMRNGYLMAIAPTSSISILVGTTQTIEPVYRKKWYEENLSGLIPVVVPHLNLDTWNYYVSAYDIEQTHI IKAAAVRQKWIDQGQSTNIFVRLDKASGKMLNDIYTLAWKLGLKSTYYLRSQSPEAEEQVMDRSVECVNCQ
Sequences:
>Translated_791_residues MLDTITVTKRNGRIEPLDIAKIQKHTYAAVEGLEGVSQSELEVDAKILFKDKITTEEIQQTLIKTAVDKIDVNTPNWSFV AARLFLYDLYHKVTGWTGYKKLEEYFEQGEREGKLISGIKEKYDLAFLDSHIKPERDLQFNYLGIKTLYDRYLLKDSNNR PIELPQHMFMAIAMFLAQNEKDCNAWAVKFYNMISLFEVICATPTLANARTTRHQLSSCFVGSTPDNIEGIFDAYKEMAL LSKYGGGIGWDFSRVRGLGSFIDGHKNAAGGVVPFLKIANDVAIAVDQLGTRKGAIATYLEIWHNDIHDFIDLRKNSGEE RRRTHDLFPAIWICDLFMKRVESNEFWTLFDPYECPELTELYGEAFEAKYIEYEQSDKVLKSRILAKDLWKKILTNYFES GLPFLCFKDNANRVNPNAHAGIIRSSNLCTEIFQNTNPNHYVVEVEFEDGSKVVYEEKEEVKLDNGMCKRANKITSVDSI NGRKVFITSRIAQGGATAVCNLASVNLSKINTKEDIERVLPIAIRMLDNVIDLNFYPNRKVKVTNMQNRAIGLGVMGEAE MLARSHIDWGSEEHLIKIDEIMELVSFYAIESSANLAQEKGKYPQFEGSNWSKGIFPIDMANKEALKIVDRGGLFSQQCD WESLRAKVKTQGMRNGYLMAIAPTSSISILVGTTQTIEPVYRKKWYEENLSGLIPVVVPHLNLDTWNYYVSAYDIEQTHI IKAAAVRQKWIDQGQSTNIFVRLDKASGKMLNDIYTLAWKLGLKSTYYLRSQSPEAEEQVMDRSVECVNCQ >Mature_791_residues MLDTITVTKRNGRIEPLDIAKIQKHTYAAVEGLEGVSQSELEVDAKILFKDKITTEEIQQTLIKTAVDKIDVNTPNWSFV AARLFLYDLYHKVTGWTGYKKLEEYFEQGEREGKLISGIKEKYDLAFLDSHIKPERDLQFNYLGIKTLYDRYLLKDSNNR PIELPQHMFMAIAMFLAQNEKDCNAWAVKFYNMISLFEVICATPTLANARTTRHQLSSCFVGSTPDNIEGIFDAYKEMAL LSKYGGGIGWDFSRVRGLGSFIDGHKNAAGGVVPFLKIANDVAIAVDQLGTRKGAIATYLEIWHNDIHDFIDLRKNSGEE RRRTHDLFPAIWICDLFMKRVESNEFWTLFDPYECPELTELYGEAFEAKYIEYEQSDKVLKSRILAKDLWKKILTNYFES GLPFLCFKDNANRVNPNAHAGIIRSSNLCTEIFQNTNPNHYVVEVEFEDGSKVVYEEKEEVKLDNGMCKRANKITSVDSI NGRKVFITSRIAQGGATAVCNLASVNLSKINTKEDIERVLPIAIRMLDNVIDLNFYPNRKVKVTNMQNRAIGLGVMGEAE MLARSHIDWGSEEHLIKIDEIMELVSFYAIESSANLAQEKGKYPQFEGSNWSKGIFPIDMANKEALKIVDRGGLFSQQCD WESLRAKVKTQGMRNGYLMAIAPTSSISILVGTTQTIEPVYRKKWYEENLSGLIPVVVPHLNLDTWNYYVSAYDIEQTHI IKAAAVRQKWIDQGQSTNIFVRLDKASGKMLNDIYTLAWKLGLKSTYYLRSQSPEAEEQVMDRSVECVNCQ
Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]
COG id: COG0209
COG function: function code F; Ribonucleotide reductase, alpha subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ATP-cone domain [H]
Homologues:
Organism=Homo sapiens, GI4506749, Length=815, Percent_Identity=33.9877300613497, Blast_Score=386, Evalue=1e-107, Organism=Escherichia coli, GI2367133, Length=821, Percent_Identity=27.6492082825822, Blast_Score=296, Evalue=5e-81, Organism=Escherichia coli, GI1789030, Length=665, Percent_Identity=27.6691729323308, Blast_Score=228, Evalue=2e-60, Organism=Caenorhabditis elegans, GI17555242, Length=810, Percent_Identity=33.4567901234568, Blast_Score=384, Evalue=1e-106, Organism=Saccharomyces cerevisiae, GI6320914, Length=831, Percent_Identity=33.9350180505415, Blast_Score=402, Evalue=1e-113, Organism=Saccharomyces cerevisiae, GI6322123, Length=818, Percent_Identity=33.0073349633252, Blast_Score=388, Evalue=1e-108, Organism=Drosophila melanogaster, GI17352481, Length=809, Percent_Identity=32.1384425216316, Blast_Score=366, Evalue=1e-101,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005144 - InterPro: IPR013346 - InterPro: IPR013509 - InterPro: IPR000788 - InterPro: IPR008926 [H]
Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]
EC number: =1.17.4.1 [H]
Molecular weight: Translated: 90136; Mature: 90136
Theoretical pI: Translated: 6.16; Mature: 6.16
Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 3.8 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLDTITVTKRNGRIEPLDIAKIQKHTYAAVEGLEGVSQSELEVDAKILFKDKITTEEIQQ CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEECEEEEEECCCCHHHHHH TLIKTAVDKIDVNTPNWSFVAARLFLYDLYHKVTGWTGYKKLEEYFEQGEREGKLISGIK HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHH EKYDLAFLDSHIKPERDLQFNYLGIKTLYDRYLLKDSNNRPIELPQHMFMAIAMFLAQNE HHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC KDCNAWAVKFYNMISLFEVICATPTLANARTTRHQLSSCFVGSTPDNIEGIFDAYKEMAL CCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH LSKYGGGIGWDFSRVRGLGSFIDGHKNAAGGVVPFLKIANDVAIAVDQLGTRKGAIATYL HHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH EIWHNDIHDFIDLRKNSGEERRRTHDLFPAIWICDLFMKRVESNEFWTLFDPYECPELTE HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHH LYGEAFEAKYIEYEQSDKVLKSRILAKDLWKKILTNYFESGLPFLCFKDNANRVNPNAHA HHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC GIIRSSNLCTEIFQNTNPNHYVVEVEFEDGSKVVYEEKEEVKLDNGMCKRANKITSVDSI CEEECCHHHHHHHHCCCCCEEEEEEEECCCCEEEECCHHHHHHCCCHHHHCCCCCCCCCC NGRKVFITSRIAQGGATAVCNLASVNLSKINTKEDIERVLPIAIRMLDNVIDLNFYPNRK CCCEEEEEECCCCCCCCEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCE VKVTNMQNRAIGLGVMGEAEMLARSHIDWGSEEHLIKIDEIMELVSFYAIESSANLAQEK EEEEECCCCEEEEEECCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCCCCHHHHHC GKYPQFEGSNWSKGIFPIDMANKEALKIVDRGGLFSQQCDWESLRAKVKTQGMRNGYLMA CCCCCCCCCCCCCCEEEEECCCCHHHHEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEE IAPTSSISILVGTTQTIEPVYRKKWYEENLSGLIPVVVPHLNLDTWNYYVSAYDIEQTHI EECCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEEECCHHHH IKAAAVRQKWIDQGQSTNIFVRLDKASGKMLNDIYTLAWKLGLKSTYYLRSQSPEAEEQV HHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHH MDRSVECVNCQ HCCCCCEECCC >Mature Secondary Structure MLDTITVTKRNGRIEPLDIAKIQKHTYAAVEGLEGVSQSELEVDAKILFKDKITTEEIQQ CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEECEEEEEECCCCHHHHHH TLIKTAVDKIDVNTPNWSFVAARLFLYDLYHKVTGWTGYKKLEEYFEQGEREGKLISGIK HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHH EKYDLAFLDSHIKPERDLQFNYLGIKTLYDRYLLKDSNNRPIELPQHMFMAIAMFLAQNE HHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC KDCNAWAVKFYNMISLFEVICATPTLANARTTRHQLSSCFVGSTPDNIEGIFDAYKEMAL CCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH LSKYGGGIGWDFSRVRGLGSFIDGHKNAAGGVVPFLKIANDVAIAVDQLGTRKGAIATYL HHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH EIWHNDIHDFIDLRKNSGEERRRTHDLFPAIWICDLFMKRVESNEFWTLFDPYECPELTE HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHH LYGEAFEAKYIEYEQSDKVLKSRILAKDLWKKILTNYFESGLPFLCFKDNANRVNPNAHA HHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC GIIRSSNLCTEIFQNTNPNHYVVEVEFEDGSKVVYEEKEEVKLDNGMCKRANKITSVDSI CEEECCHHHHHHHHCCCCCEEEEEEEECCCCEEEECCHHHHHHCCCHHHHCCCCCCCCCC NGRKVFITSRIAQGGATAVCNLASVNLSKINTKEDIERVLPIAIRMLDNVIDLNFYPNRK CCCEEEEEECCCCCCCCEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCE VKVTNMQNRAIGLGVMGEAEMLARSHIDWGSEEHLIKIDEIMELVSFYAIESSANLAQEK EEEEECCCCEEEEEECCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCCCCHHHHHC GKYPQFEGSNWSKGIFPIDMANKEALKIVDRGGLFSQQCDWESLRAKVKTQGMRNGYLMA CCCCCCCCCCCCCCEEEEECCCCHHHHEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEE IAPTSSISILVGTTQTIEPVYRKKWYEENLSGLIPVVVPHLNLDTWNYYVSAYDIEQTHI EECCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEEECCHHHH IKAAAVRQKWIDQGQSTNIFVRLDKASGKMLNDIYTLAWKLGLKSTYYLRSQSPEAEEQV HHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHH MDRSVECVNCQ HCCCCCEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9923682 [H]