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The map label for this gene is hom

Identifier: 32267249

GI number: 32267249

Start: 1675725

End: 1677020

Strand: Direct

Name: hom

Synonym: HH1750

Alternate gene names: 32267249

Gene position: 1675725-1677020 (Clockwise)

Preceding gene: 32267248

Following gene: 32267250

Centisome position: 93.14

GC content: 39.51

Gene sequence:

>1296_bases
ATGTCAAAACTTGTAGTGGGTATGGTTGGCTTTGGTGTTGTAGGAAGTAGCGTATTAAAGGCACTTTTGGCAAATCGGAA
TATTATTAGCGCAAGGGCTGGAAAAGAAATTGAGCTTAAGCGCATTGTAGTGCGTGATGAGGCAAAAGCTCACGCAAAGC
TTAAGAATCTAAACGCCACTGATGTAAAGGTAAGCACAAATATAGATGATATTTTGCAAGATTGCGAAATTGAAGTTGTT
ATTGAACTTATGGGCGGTGTGGAAGTTGCTTATGAGATTGCTAAGAGGGCGTTAGAAGTAAAAAAAGCTTTTATTACTGC
AAATAAAGCAATGCTTGCTTATCACCGTTATGATATAGCACCGCTTGCAAATGGTATGCCTGTGGGTTTTGAGGCAAGTG
TGTGTGGTGGCATACCCATTATTCGTGCTTTGAAAGATGGTTTGAGTGCAAATCATATTCTTGCTATTCGTGGGATACTC
AATGGCACGAGTAATTATATTCTCACACAAATGCAGCAATACAATCAAGATTTTCACACAGCACTTAATCAAGCACAGAA
TCTTGGCTACGCAGAAGCTGACCCAACACTTGATATAAGCGGTGGCGATGCAGGACATAAGCTACTTATACTTGCTTCTT
TAGCGTATGGCATTAATGCGATGCCAGAGGAGATTCTCATTGAGGGTATTGAGAGTATTATGCCTGATGATATAGAGTTT
GCAAATGAATTTGGCTATGCGATTAAACTTCTTGGTATTGCTAAAAAGCAAGGAAACGAAGTAGAGCTGCGTGTGCATCC
GAGTATGATTAAGAAAGGTGCGATGTTAAGCAAGGTAGATAATGTAATGAATGGCATTAGTGTCATTGGGGATTATGTGG
GGGAGAGTATGTATTATGGAGCAGGAGCAGGAGGTGATGCAACTGCAAGCTCTGTAGTAAGTGATATTATTGCTATTGCA
CGAGGGGAGAGTGCAGCAATGCTTGGATTTAGCCAACCGCTTGAAGGCAATGAGCATTTAAAGCTTAAAAGTATTGATGA
GATTTACTCACAATACTACATACGACTCTATGTATGTGATAAACCCGGTGTATTGGGGCAAGTATCGCAGATTCTAGGGC
AGCATAATATTTCTATTGGTGCATTTTTACAAAAAGAGACAAATGATAAAAATATCGCCAAAATGTTACTTTCCACACAT
CATTGCTATGAAAGGGATATTAATGCTGCACTCTTGGAGCTAGAAAGATTAGATTCTATTTCACAAAAGCCCTATAAAAT
GCGCATTGAATGTTGA

Upstream 100 bases:

>100_bases
GGGCTATGTGAGGATCGCACTGATTGAAAATGAAAAACGCATTCGCCAAGCTGCACGGAATCTCAAATCATTTCTTAAAC
AATTTCAATAAGAGGTTTGT

Downstream 100 bases:

>100_bases
AATAGGAGAAAAAAGGCATATAAATGAATAGCAGACACAAAGGCACACAAGCAGAAGATTTTGCCTGTGTATTCTTGCGT
GAATGTGGTTTTGAGATTTT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSKLVVGMVGFGVVGSSVLKALLANRNIISARAGKEIELKRIVVRDEAKAHAKLKNLNATDVKVSTNIDDILQDCEIEVV
IELMGGVEVAYEIAKRALEVKKAFITANKAMLAYHRYDIAPLANGMPVGFEASVCGGIPIIRALKDGLSANHILAIRGIL
NGTSNYILTQMQQYNQDFHTALNQAQNLGYAEADPTLDISGGDAGHKLLILASLAYGINAMPEEILIEGIESIMPDDIEF
ANEFGYAIKLLGIAKKQGNEVELRVHPSMIKKGAMLSKVDNVMNGISVIGDYVGESMYYGAGAGGDATASSVVSDIIAIA
RGESAAMLGFSQPLEGNEHLKLKSIDEIYSQYYIRLYVCDKPGVLGQVSQILGQHNISIGAFLQKETNDKNIAKMLLSTH
HCYERDINAALLELERLDSISQKPYKMRIEC

Sequences:

>Translated_431_residues
MSKLVVGMVGFGVVGSSVLKALLANRNIISARAGKEIELKRIVVRDEAKAHAKLKNLNATDVKVSTNIDDILQDCEIEVV
IELMGGVEVAYEIAKRALEVKKAFITANKAMLAYHRYDIAPLANGMPVGFEASVCGGIPIIRALKDGLSANHILAIRGIL
NGTSNYILTQMQQYNQDFHTALNQAQNLGYAEADPTLDISGGDAGHKLLILASLAYGINAMPEEILIEGIESIMPDDIEF
ANEFGYAIKLLGIAKKQGNEVELRVHPSMIKKGAMLSKVDNVMNGISVIGDYVGESMYYGAGAGGDATASSVVSDIIAIA
RGESAAMLGFSQPLEGNEHLKLKSIDEIYSQYYIRLYVCDKPGVLGQVSQILGQHNISIGAFLQKETNDKNIAKMLLSTH
HCYERDINAALLELERLDSISQKPYKMRIEC
>Mature_430_residues
SKLVVGMVGFGVVGSSVLKALLANRNIISARAGKEIELKRIVVRDEAKAHAKLKNLNATDVKVSTNIDDILQDCEIEVVI
ELMGGVEVAYEIAKRALEVKKAFITANKAMLAYHRYDIAPLANGMPVGFEASVCGGIPIIRALKDGLSANHILAIRGILN
GTSNYILTQMQQYNQDFHTALNQAQNLGYAEADPTLDISGGDAGHKLLILASLAYGINAMPEEILIEGIESIMPDDIEFA
NEFGYAIKLLGIAKKQGNEVELRVHPSMIKKGAMLSKVDNVMNGISVIGDYVGESMYYGAGAGGDATASSVVSDIIAIAR
GESAAMLGFSQPLEGNEHLKLKSIDEIYSQYYIRLYVCDKPGVLGQVSQILGQHNISIGAFLQKETNDKNIAKMLLSTHH
CYERDINAALLELERLDSISQKPYKMRIEC

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=370, Percent_Identity=26.2162162162162, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786183, Length=242, Percent_Identity=26.4462809917355, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46744; Mature: 46612

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLVVGMVGFGVVGSSVLKALLANRNIISARAGKEIELKRIVVRDEAKAHAKLKNLNAT
CCCEEEHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEECCCHHHHHHHHCCCCC
DVKVSTNIDDILQDCEIEVVIELMGGVEVAYEIAKRALEVKKAFITANKAMLAYHRYDIA
CEEEECCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCC
PLANGMPVGFEASVCGGIPIIRALKDGLSANHILAIRGILNGTSNYILTQMQQYNQDFHT
CCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCEEEEEEEHHCCCCHHHHHHHHHHCHHHHH
ALNQAQNLGYAEADPTLDISGGDAGHKLLILASLAYGINAMPEEILIEGIESIMPDDIEF
HHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
ANEFGYAIKLLGIAKKQGNEVELRVHPSMIKKGAMLSKVDNVMNGISVIGDYVGESMYYG
HHHHCHHEEEEEHHCCCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEC
AGAGGDATASSVVSDIIAIARGESAAMLGFSQPLEGNEHLKLKSIDEIYSQYYIRLYVCD
CCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEECCHHHHHHCEEEEEEEEC
KPGVLGQVSQILGQHNISIGAFLQKETNDKNIAKMLLSTHHCYERDINAALLELERLDSI
CCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SQKPYKMRIEC
CCCCCEEEECC
>Mature Secondary Structure 
SKLVVGMVGFGVVGSSVLKALLANRNIISARAGKEIELKRIVVRDEAKAHAKLKNLNAT
CCEEEHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEECCCHHHHHHHHCCCCC
DVKVSTNIDDILQDCEIEVVIELMGGVEVAYEIAKRALEVKKAFITANKAMLAYHRYDIA
CEEEECCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCC
PLANGMPVGFEASVCGGIPIIRALKDGLSANHILAIRGILNGTSNYILTQMQQYNQDFHT
CCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCEEEEEEEHHCCCCHHHHHHHHHHCHHHHH
ALNQAQNLGYAEADPTLDISGGDAGHKLLILASLAYGINAMPEEILIEGIESIMPDDIEF
HHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
ANEFGYAIKLLGIAKKQGNEVELRVHPSMIKKGAMLSKVDNVMNGISVIGDYVGESMYYG
HHHHCHHEEEEEHHCCCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEC
AGAGGDATASSVVSDIIAIARGESAAMLGFSQPLEGNEHLKLKSIDEIYSQYYIRLYVCD
CCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEECCHHHHHHCEEEEEEEEC
KPGVLGQVSQILGQHNISIGAFLQKETNDKNIAKMLLSTHHCYERDINAALLELERLDSI
CCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SQKPYKMRIEC
CCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]