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The map label for this gene is hisD

Identifier: 32267220

GI number: 32267220

Start: 1647128

End: 1648438

Strand: Direct

Name: hisD

Synonym: HH1721

Alternate gene names: 32267220

Gene position: 1647128-1648438 (Clockwise)

Preceding gene: 32267219

Following gene: 32267221

Centisome position: 91.55

GC content: 39.51

Gene sequence:

>1311_bases
ATGAAATATCTTGATGTGCGTTTGCCAGAGTTTGCAAATGAATTTCAACAAGTCTTATCTCGTGGAAAAATGGATATGAA
AGAAGTTTCATCTCTTGTGCAAGAATTGCTTGATGAGATTCGCACAGAGGGCTTAGATGCTCTAAAGAAGCATATTGCTC
GTTTTGATAAATGGGAGGTAAAAAGTTTTGAAGATTTGCGTATCTCGCCAAAAGAGTGTCTTAATGCCTATAATCAGCTT
TCTTCAGAATTAAAATCTGCACTTCATCTTGCTTATGATAGAATCTATGCTTTTCATCGCAAACAAAAAATGCAAAGTTG
GATTGATTGTGAGGAAAATGGAAACATACTTGGCTCAAAATTTACTCCAATGGAGCGTGCAGGATTATACATTCCCGGTG
GTAAAGCAGCTTACCCAAGCTCACTTTTGATGAATGCTATTCCTGCGATTGTTGCAGGAGTTAAAGAGATTGTTGTGTGT
TCTCCTACACCGCATAATCAAGCTAATCCCCTTGTGCTTGCAGCATTACATTTGTGTGGTATTACTGAAGTATATAAGGT
TGGTGGTGCGAGTGCCATAGGGCTTATGGCTTATGGGTGCAAAGAGATTCCTAAAGTTGATGTTATTACTGGTCCGGGCA
ATATTTTTGTTGCTTGTGCCAAAAAACTTGTTTTTGGCGAGGTAAATATTGATATGGTTGCAGGTCCAAGCGAGATAGCA
ATTATTGCAGATTCTCAAGCTAATCCGCTTTACATTGCCTATGATTTGCTTTCCCAAGCTGAACACGATGAAATGGCAAG
TTCCATACTCATAAGCGATAGTGCCCCACTTATAGAATCTGTGCAAAAACATATTGAACAGATTTTACCCTCAATGCCTA
GAGCAGAGATTGCAGGAGCGAGTATTAAAAATCGTGCAGTTATGATATATACGCGCAATTTACAAGAAAGTATAGAGATT
GCTAATGCCATTGCTCCCGAACATTTAGAAGTTCTTACAACCACTCCATTTGATACGCTTCCTTATATTAAACACGCAGG
AGCCATTTTCTTAGGAGAGCATTCAAGTGAGCCCATTGGAGACTATCTTGCGGGTCCTAATCATACGCTTCCCACAGGCG
GAAGTGCGCGTTTCTTTTCACCGCTTGGAGTGGAGCATTTTATGAAAAAAAGTTCAATTATTGCTTTTTCAGCTACTGCA
TTAGAAGAAGTTGGGGAATCTTGCGCACTTTTGGCTCAAAGTGAATCTTTATCTGCTCACGCTCAAGCGGTTTTAACAAG
ATTAGATTCTATTAAATCAAAGAGGGAGTAG

Upstream 100 bases:

>100_bases
TTAGAAGCTTAAAAAACCCTAAAAGGGTATTATAAATGTAATTTGTTTGTTTAGAGTTAATGTATATAATTCTCATTTAT
TTTTGATTATGGGGAAAATA

Downstream 100 bases:

>100_bases
TTTATGGACGCATTTTTTGAGGGCACGCCATTGCAAAAGTGGCAAGAGATTATCCTTAATGCTTCGCCTACTTTAGTAGG
ATTGGAGCTTGAGGCTTTGT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKYLDVRLPEFANEFQQVLSRGKMDMKEVSSLVQELLDEIRTEGLDALKKHIARFDKWEVKSFEDLRISPKECLNAYNQL
SSELKSALHLAYDRIYAFHRKQKMQSWIDCEENGNILGSKFTPMERAGLYIPGGKAAYPSSLLMNAIPAIVAGVKEIVVC
SPTPHNQANPLVLAALHLCGITEVYKVGGASAIGLMAYGCKEIPKVDVITGPGNIFVACAKKLVFGEVNIDMVAGPSEIA
IIADSQANPLYIAYDLLSQAEHDEMASSILISDSAPLIESVQKHIEQILPSMPRAEIAGASIKNRAVMIYTRNLQESIEI
ANAIAPEHLEVLTTTPFDTLPYIKHAGAIFLGEHSSEPIGDYLAGPNHTLPTGGSARFFSPLGVEHFMKKSSIIAFSATA
LEEVGESCALLAQSESLSAHAQAVLTRLDSIKSKRE

Sequences:

>Translated_436_residues
MKYLDVRLPEFANEFQQVLSRGKMDMKEVSSLVQELLDEIRTEGLDALKKHIARFDKWEVKSFEDLRISPKECLNAYNQL
SSELKSALHLAYDRIYAFHRKQKMQSWIDCEENGNILGSKFTPMERAGLYIPGGKAAYPSSLLMNAIPAIVAGVKEIVVC
SPTPHNQANPLVLAALHLCGITEVYKVGGASAIGLMAYGCKEIPKVDVITGPGNIFVACAKKLVFGEVNIDMVAGPSEIA
IIADSQANPLYIAYDLLSQAEHDEMASSILISDSAPLIESVQKHIEQILPSMPRAEIAGASIKNRAVMIYTRNLQESIEI
ANAIAPEHLEVLTTTPFDTLPYIKHAGAIFLGEHSSEPIGDYLAGPNHTLPTGGSARFFSPLGVEHFMKKSSIIAFSATA
LEEVGESCALLAQSESLSAHAQAVLTRLDSIKSKRE
>Mature_436_residues
MKYLDVRLPEFANEFQQVLSRGKMDMKEVSSLVQELLDEIRTEGLDALKKHIARFDKWEVKSFEDLRISPKECLNAYNQL
SSELKSALHLAYDRIYAFHRKQKMQSWIDCEENGNILGSKFTPMERAGLYIPGGKAAYPSSLLMNAIPAIVAGVKEIVVC
SPTPHNQANPLVLAALHLCGITEVYKVGGASAIGLMAYGCKEIPKVDVITGPGNIFVACAKKLVFGEVNIDMVAGPSEIA
IIADSQANPLYIAYDLLSQAEHDEMASSILISDSAPLIESVQKHIEQILPSMPRAEIAGASIKNRAVMIYTRNLQESIEI
ANAIAPEHLEVLTTTPFDTLPYIKHAGAIFLGEHSSEPIGDYLAGPNHTLPTGGSARFFSPLGVEHFMKKSSIIAFSATA
LEEVGESCALLAQSESLSAHAQAVLTRLDSIKSKRE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=428, Percent_Identity=38.785046728972, Blast_Score=287, Evalue=8e-79,
Organism=Saccharomyces cerevisiae, GI6319819, Length=431, Percent_Identity=34.338747099768, Blast_Score=234, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_HELHP (Q7VFF5)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_861252.1
- ProteinModelPortal:   Q7VFF5
- SMR:   Q7VFF5
- GeneID:   1492268
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1721
- NMPDR:   fig|235279.1.peg.1721
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   HHEP235279:HH_1721-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47550; Mature: 47550

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 327-327 ACT_SITE 328-328 BINDING 237-237 BINDING 259-259 BINDING 262-262 BINDING 328-328 BINDING 361-361 BINDING 415-415 BINDING 420-420

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYLDVRLPEFANEFQQVLSRGKMDMKEVSSLVQELLDEIRTEGLDALKKHIARFDKWEV
CCCEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
KSFEDLRISPKECLNAYNQLSSELKSALHLAYDRIYAFHRKQKMQSWIDCEENGNILGSK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCC
FTPMERAGLYIPGGKAAYPSSLLMNAIPAIVAGVKEIVVCSPTPHNQANPLVLAALHLCG
CCCHHHCCEECCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHH
ITEVYKVGGASAIGLMAYGCKEIPKVDVITGPGNIFVACAKKLVFGEVNIDMVAGPSEIA
HHHHHHCCCCHHHHHHHHCHHCCCCEEEEECCCHHHHHHHHHHHEECCCEEEEECCCEEE
IIADSQANPLYIAYDLLSQAEHDEMASSILISDSAPLIESVQKHIEQILPSMPRAEIAGA
EEECCCCCCEEEEHHHHHHCHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCCHHHCCC
SIKNRAVMIYTRNLQESIEIANAIAPEHLEVLTTTPFDTLPYIKHAGAIFLGEHSSEPIG
CCCCCEEEEEECCHHHHHHHHHHCCCCHHEEEECCCCCHHHHHHHCCEEEEECCCCCCCH
DYLAGPNHTLPTGGSARFFSPLGVEHFMKKSSIIAFSATALEEVGESCALLAQSESLSAH
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEHHHHHHHHCHHHHHHHCCCCHHHH
AQAVLTRLDSIKSKRE
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKYLDVRLPEFANEFQQVLSRGKMDMKEVSSLVQELLDEIRTEGLDALKKHIARFDKWEV
CCCEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
KSFEDLRISPKECLNAYNQLSSELKSALHLAYDRIYAFHRKQKMQSWIDCEENGNILGSK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCC
FTPMERAGLYIPGGKAAYPSSLLMNAIPAIVAGVKEIVVCSPTPHNQANPLVLAALHLCG
CCCHHHCCEECCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHH
ITEVYKVGGASAIGLMAYGCKEIPKVDVITGPGNIFVACAKKLVFGEVNIDMVAGPSEIA
HHHHHHCCCCHHHHHHHHCHHCCCCEEEEECCCHHHHHHHHHHHEECCCEEEEECCCEEE
IIADSQANPLYIAYDLLSQAEHDEMASSILISDSAPLIESVQKHIEQILPSMPRAEIAGA
EEECCCCCCEEEEHHHHHHCHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCCHHHCCC
SIKNRAVMIYTRNLQESIEIANAIAPEHLEVLTTTPFDTLPYIKHAGAIFLGEHSSEPIG
CCCCCEEEEEECCHHHHHHHHHHCCCCHHEEEECCCCCHHHHHHHCCEEEEECCCCCCCH
DYLAGPNHTLPTGGSARFFSPLGVEHFMKKSSIIAFSATALEEVGESCALLAQSESLSAH
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEHHHHHHHHCHHHHHHHCCCCHHHH
AQAVLTRLDSIKSKRE
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12810954