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The map label for this gene is vanRB [H]

Identifier: 32267155

GI number: 32267155

Start: 1583821

End: 1584492

Strand: Direct

Name: vanRB [H]

Synonym: HH1656

Alternate gene names: 32267155

Gene position: 1583821-1584492 (Clockwise)

Preceding gene: 32267154

Following gene: 32267156

Centisome position: 88.03

GC content: 34.23

Gene sequence:

>672_bases
ATGTCGGCAAAAATTTTGTTACTTGAAGATGATTTTGTTCTTTCAGAGATTCTATTGGAGTTTTTGCAAGAACAAGGCTA
TAATGTGCGATTGTGTGATAATGCTAAAGATGCTCTAGATTGCGCTTATGAACAATATTTTGATTTGTGGATTTTAGATG
TGAAAGTGCCTCAAGGTAATGGATTTGATGTGCTCAAAGAATTACGGGAGTGCGGGAAAGATACTCCTGCTATTTTTATT
ACTTCACTTGATAGAATTGATGATTTGCACAACGGATATAAAGTAGGTTGTGATGATTATATTAAAAAGCCCTTTGAACT
CTTAGAACTTCAATGTCGTATCAATACATTACTCAAGCGTCCGTTTTTGCACACTCATAAGGATTTTATTATTTTGCCTA
ATGGCTTTAAATTTGGAATTCTTACGCAATTACTTTATGATAAAAGTGGCATAGTCATTCCTCTTACACAAAAAGAAAGC
TTGCTTTTATCACTTTTGCTCCAACATAAAGGAAGTTATGTCTCTCAAGAGATAATTTTTGATACACTTTGGGAATATGA
ACAAGAGCCAAGCGAAATGAGTTTGCGTGTATATGTGAAGAATCTACGTAAAATTTTGGGTAAAGATAGTATTCTTAACC
AGCGTGGGCGAGGGTATTGTTATAATGCGTGA

Upstream 100 bases:

>100_bases
AGATTCTAAAGGCAAAAAAGCTTTGTGTCATTGCAAAGATAAAAAATAGGTAAATGCTCCCTTTAAATGGGGGCAAAATG
AAGATTAAGAGAGAAATAAA

Downstream 100 bases:

>100_bases
TTGGGAGGAGTGATGTCTGATAATTCAAAACGTGCAATTATTAAAGTGTTGTGTTTATATCTTGGCACAACAGGAGTTTT
TTTATGTGTATTTTTTTGGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MSAKILLLEDDFVLSEILLEFLQEQGYNVRLCDNAKDALDCAYEQYFDLWILDVKVPQGNGFDVLKELRECGKDTPAIFI
TSLDRIDDLHNGYKVGCDDYIKKPFELLELQCRINTLLKRPFLHTHKDFIILPNGFKFGILTQLLYDKSGIVIPLTQKES
LLLSLLLQHKGSYVSQEIIFDTLWEYEQEPSEMSLRVYVKNLRKILGKDSILNQRGRGYCYNA

Sequences:

>Translated_223_residues
MSAKILLLEDDFVLSEILLEFLQEQGYNVRLCDNAKDALDCAYEQYFDLWILDVKVPQGNGFDVLKELRECGKDTPAIFI
TSLDRIDDLHNGYKVGCDDYIKKPFELLELQCRINTLLKRPFLHTHKDFIILPNGFKFGILTQLLYDKSGIVIPLTQKES
LLLSLLLQHKGSYVSQEIIFDTLWEYEQEPSEMSLRVYVKNLRKILGKDSILNQRGRGYCYNA
>Mature_222_residues
SAKILLLEDDFVLSEILLEFLQEQGYNVRLCDNAKDALDCAYEQYFDLWILDVKVPQGNGFDVLKELRECGKDTPAIFIT
SLDRIDDLHNGYKVGCDDYIKKPFELLELQCRINTLLKRPFLHTHKDFIILPNGFKFGILTQLLYDKSGIVIPLTQKESL
LLSLLLQHKGSYVSQEIIFDTLWEYEQEPSEMSLRVYVKNLRKILGKDSILNQRGRGYCYNA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=29.4117647058824, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=32.8888888888889, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=33.1818181818182, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1789809, Length=211, Percent_Identity=29.3838862559242, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=29.2792792792793, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=29.4642857142857, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=28.695652173913, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI2367329, Length=237, Percent_Identity=32.9113924050633, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=25.6756756756757, Blast_Score=81, Evalue=4e-17,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=24.8908296943231, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790437, Length=123, Percent_Identity=31.7073170731707, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788394, Length=208, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=24.4444444444444, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790863, Length=214, Percent_Identity=25.7009345794392, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788550, Length=145, Percent_Identity=26.8965517241379, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25879; Mature: 25748

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKILLLEDDFVLSEILLEFLQEQGYNVRLCDNAKDALDCAYEQYFDLWILDVKVPQGN
CCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHEEEEEEEECCCCC
GFDVLKELRECGKDTPAIFITSLDRIDDLHNGYKVGCDDYIKKPFELLELQCRINTLLKR
CHHHHHHHHHHCCCCCEEEEEEHHHHHHHCCCEEECCHHHHHCHHHHHHHHHHHHHHHHC
PFLHTHKDFIILPNGFKFGILTQLLYDKSGIVIPLTQKESLLLSLLLQHKGSYVSQEIIF
CCCCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHH
DTLWEYEQEPSEMSLRVYVKNLRKILGKDSILNQRGRGYCYNA
HHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECC
>Mature Secondary Structure 
SAKILLLEDDFVLSEILLEFLQEQGYNVRLCDNAKDALDCAYEQYFDLWILDVKVPQGN
CCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHEEEEEEEECCCCC
GFDVLKELRECGKDTPAIFITSLDRIDDLHNGYKVGCDDYIKKPFELLELQCRINTLLKR
CHHHHHHHHHHCCCCCEEEEEEHHHHHHHCCCEEECCHHHHHCHHHHHHHHHHHHHHHHC
PFLHTHKDFIILPNGFKFGILTQLLYDKSGIVIPLTQKESLLLSLLLQHKGSYVSQEIIF
CCCCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHH
DTLWEYEQEPSEMSLRVYVKNLRKILGKDSILNQRGRGYCYNA
HHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]