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The map label for this gene is nhaA1

Identifier: 32267143

GI number: 32267143

Start: 1571029

End: 1572411

Strand: Direct

Name: nhaA1

Synonym: HH1644

Alternate gene names: 32267143

Gene position: 1571029-1572411 (Clockwise)

Preceding gene: 32267142

Following gene: 32267144

Centisome position: 87.32

GC content: 34.35

Gene sequence:

>1383_bases
ATGCTTGTAGCGAACTCATCGTATGCAGATATGTATTTTACTTTTTTTCATAGCGAATTTGGTGCATTTTTTAGTGATTC
GCATTTTAAGGTAAGTTTGCAGGATTTTATCAATGATGTATTAATGTCATTTTTCTTTTTGCTCGTGGGTTTGGAAATGA
AACGCGAAATGCTCTATGGGGAGCTGGCTGGGTTTAAAAAAGTAAGTTTTTCTTTTCTCGCAGCATTTGGAGGCATTATA
TGTCCAGTAATGATTTATTCATATTTTAACTCTGGCACAGCATATGAAAGTGGTTTTGGTGTCGCAATGAGCACAGATAC
AGCCTTTGCACTTGGGCTTATAATGCTTCTTGGAGATAGAGTGCCTAAGATTTTGAAGATTTTTCTTGTAACACTTGCTG
TAGCTGATGATTTAGGGGCTATTTCTGTAATTGCAATTTTTTATTCTGATAATATTAATATGCAATGGATTTATGCTTCT
TTAATCCTTGTTGCAGTACTTATTTATCTTAATTATCGTGATACTAAATATCTTTCACTATATTTTTTGGCGGGTATTTT
GTTGTGGTTTTGTGTGCACCATAGCGGGATTCACGTAACAATTGCAGCAGTTATTTTGGCAATGGCGATTCCCGGGCGCA
CACGCGTAAATAAAAAATATTTTATCAATATGCTTAAAGAATTTGAAAGAATGAAAGTAGCCACGAATGATTGGAATGAT
GTAGTCTATGCACGTGAATCGGAGAAGGTGGGTTTTTGGAGAGGAAGCTTTAAGAATATTAGAAGTTTTATATTTGGAAA
TCAAGATGTGGAAAAAAAGATTGATATGGCAAAAACTTCCCAACTCGTGCATATGTTGGATACTATAGGCACATATTCTC
GTTATGCACAAAATCCGCTTATACGTCTTGAAATTGCTCTGCAACCCATTTGCGCTTATTTTTTTGTTCCTCTTTTTGCT
TTTGCTAATGCAGGTGTAACACTTGAAGGCAATATTGATATAAGTTTAAATAGTGTTATGCTTGGGACAATTTTAGGCTT
AGTAGTGGGCAAACCTGTAGGTGTATTACTTTTTTGTTTTTTAGGAGAGAAGTTAAATCTTGCTACTCGTCCAAAAGATT
TAAATTATTTGCATATTTTATCTGTGGGTATGATTTCAGGCATTGGCTTTACAATGTCTATGTTTGTGGCAAATCTTGCC
TATAAAGATGATATAATGAGTATTGATATGTCTAAAATTTCTATTCTTGTAGCATCTTCAATAGCAGCTGTTCTTGGGCT
TTTGGTGGTTTATCTTAGCACAATTAAGCAGGATAATCAGCTTGAGAATATAAATGAAGAAGATGAGATTCAAAAGCTTA
AGGAAACACAAAGTATCATTTGA

Upstream 100 bases:

>100_bases
ACATTCATATGTAAAAGATAGACTTCAAGACAGCCTCAATCGTTTTATCAAGCACGAATCTTTCGGGGGAGTTTTGCTTG
CATTTTGCGTTGGAGCAGCT

Downstream 100 bases:

>100_bases
TTTAAGAGTAAGGAGTAAAAATGGCAGCAAAGCAAAATAGAATTTCGGAAGCATTAAGTAGTTTTATCCGCGCAGAATCT
TTTAGTGGTATTTTTTTATT

Product: hypothetical protein

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MLVANSSYADMYFTFFHSEFGAFFSDSHFKVSLQDFINDVLMSFFFLLVGLEMKREMLYGELAGFKKVSFSFLAAFGGII
CPVMIYSYFNSGTAYESGFGVAMSTDTAFALGLIMLLGDRVPKILKIFLVTLAVADDLGAISVIAIFYSDNINMQWIYAS
LILVAVLIYLNYRDTKYLSLYFLAGILLWFCVHHSGIHVTIAAVILAMAIPGRTRVNKKYFINMLKEFERMKVATNDWND
VVYARESEKVGFWRGSFKNIRSFIFGNQDVEKKIDMAKTSQLVHMLDTIGTYSRYAQNPLIRLEIALQPICAYFFVPLFA
FANAGVTLEGNIDISLNSVMLGTILGLVVGKPVGVLLFCFLGEKLNLATRPKDLNYLHILSVGMISGIGFTMSMFVANLA
YKDDIMSIDMSKISILVASSIAAVLGLLVVYLSTIKQDNQLENINEEDEIQKLKETQSII

Sequences:

>Translated_460_residues
MLVANSSYADMYFTFFHSEFGAFFSDSHFKVSLQDFINDVLMSFFFLLVGLEMKREMLYGELAGFKKVSFSFLAAFGGII
CPVMIYSYFNSGTAYESGFGVAMSTDTAFALGLIMLLGDRVPKILKIFLVTLAVADDLGAISVIAIFYSDNINMQWIYAS
LILVAVLIYLNYRDTKYLSLYFLAGILLWFCVHHSGIHVTIAAVILAMAIPGRTRVNKKYFINMLKEFERMKVATNDWND
VVYARESEKVGFWRGSFKNIRSFIFGNQDVEKKIDMAKTSQLVHMLDTIGTYSRYAQNPLIRLEIALQPICAYFFVPLFA
FANAGVTLEGNIDISLNSVMLGTILGLVVGKPVGVLLFCFLGEKLNLATRPKDLNYLHILSVGMISGIGFTMSMFVANLA
YKDDIMSIDMSKISILVASSIAAVLGLLVVYLSTIKQDNQLENINEEDEIQKLKETQSII
>Mature_460_residues
MLVANSSYADMYFTFFHSEFGAFFSDSHFKVSLQDFINDVLMSFFFLLVGLEMKREMLYGELAGFKKVSFSFLAAFGGII
CPVMIYSYFNSGTAYESGFGVAMSTDTAFALGLIMLLGDRVPKILKIFLVTLAVADDLGAISVIAIFYSDNINMQWIYAS
LILVAVLIYLNYRDTKYLSLYFLAGILLWFCVHHSGIHVTIAAVILAMAIPGRTRVNKKYFINMLKEFERMKVATNDWND
VVYARESEKVGFWRGSFKNIRSFIFGNQDVEKKIDMAKTSQLVHMLDTIGTYSRYAQNPLIRLEIALQPICAYFFVPLFA
FANAGVTLEGNIDISLNSVMLGTILGLVVGKPVGVLLFCFLGEKLNLATRPKDLNYLHILSVGMISGIGFTMSMFVANLA
YKDDIMSIDMSKISILVASSIAAVLGLLVVYLSTIKQDNQLENINEEDEIQKLKETQSII

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=189, Percent_Identity=43.9153439153439, Blast_Score=150, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA1_HELHP (Q7VFN1)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_861175.1
- HSSP:   P13738
- ProteinModelPortal:   Q7VFN1
- SMR:   Q7VFN1
- GeneID:   1492191
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1644
- NMPDR:   fig|235279.1.peg.1644
- HOGENOM:   HBG665619
- OMA:   FLHIEAA
- BioCyc:   HHEP235279:HH_1644-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 51493; Mature: 51493

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xff00204)-; HASH(0xffc61fc)-; HASH(0x10376104)-; HASH(0xfe98bf0)-; HASH(0x10339898)-; HASH(0xfeb7314)-; HASH(0x1033caf4)-; HASH(0xfac6970)-; HASH(0xb0df8cc)-; HASH(0xe27f318)-; HASH(0xff2f0e8)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVANSSYADMYFTFFHSEFGAFFSDSHFKVSLQDFINDVLMSFFFLLVGLEMKREMLYG
CEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELAGFKKVSFSFLAAFGGIICPVMIYSYFNSGTAYESGFGVAMSTDTAFALGLIMLLGDR
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHCC
VPKILKIFLVTLAVADDLGAISVIAIFYSDNINMQWIYASLILVAVLIYLNYRDTKYLSL
HHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
YFLAGILLWFCVHHSGIHVTIAAVILAMAIPGRTRVNKKYFINMLKEFERMKVATNDWND
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
VVYARESEKVGFWRGSFKNIRSFIFGNQDVEKKIDMAKTSQLVHMLDTIGTYSRYAQNPL
EEEEECCCCCCEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IRLEIALQPICAYFFVPLFAFANAGVTLEGNIDISLNSVMLGTILGLVVGKPVGVLLFCF
EEEEEHHHHHHHHHHHHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHHHCCHHHHHHHHH
LGEKLNLATRPKDLNYLHILSVGMISGIGFTMSMFVANLAYKDDIMSIDMSKISILVASS
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHH
IAAVLGLLVVYLSTIKQDNQLENINEEDEIQKLKETQSII
HHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHCCH
>Mature Secondary Structure
MLVANSSYADMYFTFFHSEFGAFFSDSHFKVSLQDFINDVLMSFFFLLVGLEMKREMLYG
CEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELAGFKKVSFSFLAAFGGIICPVMIYSYFNSGTAYESGFGVAMSTDTAFALGLIMLLGDR
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHCC
VPKILKIFLVTLAVADDLGAISVIAIFYSDNINMQWIYASLILVAVLIYLNYRDTKYLSL
HHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
YFLAGILLWFCVHHSGIHVTIAAVILAMAIPGRTRVNKKYFINMLKEFERMKVATNDWND
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
VVYARESEKVGFWRGSFKNIRSFIFGNQDVEKKIDMAKTSQLVHMLDTIGTYSRYAQNPL
EEEEECCCCCCEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IRLEIALQPICAYFFVPLFAFANAGVTLEGNIDISLNSVMLGTILGLVVGKPVGVLLFCF
EEEEEHHHHHHHHHHHHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHHHCCHHHHHHHHH
LGEKLNLATRPKDLNYLHILSVGMISGIGFTMSMFVANLAYKDDIMSIDMSKISILVASS
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHH
IAAVLGLLVVYLSTIKQDNQLENINEEDEIQKLKETQSII
HHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12810954