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The map label for this gene is flgR

Identifier: 32267134

GI number: 32267134

Start: 1560222

End: 1561532

Strand: Direct

Name: flgR

Synonym: HH1635

Alternate gene names: 32267134

Gene position: 1560222-1561532 (Clockwise)

Preceding gene: 32267133

Following gene: 32267135

Centisome position: 86.72

GC content: 37.22

Gene sequence:

>1311_bases
ATGAAAATCGCAATCGTAGAAGATGATATTAATTATCGTAAATCATTAGAAACCGCGTTTGAAGATTATCCACAATATGA
GATTGTCAGTTTTAAGAATCCAAAAGATGCCCTAAAAAAGCTTGATGAGAGTTTTGAGCTTGTTATTACAGATATTAATA
TGCCTCAAATGGATGGTTTAGCTTTTTTACAAGAGCTTAATGGGCGATATGAGGCAATTGTCATTACAGGGAATGCTTCT
GTGCAAAATGCGATAAAATCCATTCGTTTGGGTGTTAAAGATTTTCTTATTAAAGGTTGTGAGATAGAAACATTTATTGA
AGCCATAGAGCGTAGTCATAAAGTCCGCCAAATAGCACAAAAATCCCCTGCTAAGTTATCAGATTCTATTAAGGATTTTA
TTGCTTCTTCTCCAAAATTAGAGGAGATTAAAGCTATTGCACTCAAAGTTGCAAAAACTGATGCAAGTGTGCTACTTTTA
GGGCAGAGTGGTGTAGGTAAAGATGTGTTTGCACAATTTATTCATCGTAATTCTCATAGGGCAGATGCGCCTTTCATAGC
TATTAATATGGCAGCAATCCCTGAGCATTTATTAGAATCTGAACTCTTTGGGTATGAAAAAGGTGCTTTTACAGATGCTA
CAACTGCTAAACCGGGTATTTTAGAAGATGCTAATGGAGGCAGTGTATTTTTAGATGAAATCGGAGAAATGCCTCTAGCT
CTTCAAGCTAAACTTTTGCGAGTATTGCAAGAAAAGGCTCTGACACGACTTGGTAGTTCAAAGCCTATCAAAATTGATGT
GCGTTTTATATCTGCTACAAATGCCGATATACAAGCAAAAATTGCCAAAAATGAATTTAGAGAGGATTTGTTTTTTAGAT
TGCAGACAATTCCCCTATCTATCCCACCGCTTAAAGAGCGCAAAGAGGAGATTTTGCCCTTGAGCGAGTGGAAATTAGAA
TCTGTATGTATGCAGTATGGTTTAGAACAAAAGCGGTTTTCATCTCAGGCTAAAGAAGCTCTTATGTCTTATGAGTGGCC
CGGTAATGTGCGCGAATTGCTTTCTGTTATTGAACGAGCTGGTATTTTAAGTGAGGGAGATGAAATAAGCGTAAAAGATT
TATTTTTAGAGAGCCGAAGTGGTGTATTTGGGTTTGTCCCTCAAGCGCAAGGAAGCAAGATTGCCGAGCTTGAAAAGCAG
CTTATCGCTCAAACACTTATAGAATCTGCTAATGATGTGCAAAAAGCAAGTGATATATTAGGTATGAATTTAGAGGTATT
ACGGCATAAAATTGCCCGCTATGGGCTTTAA

Upstream 100 bases:

>100_bases
CTCTAAGTTCGCGAGTGAGCTTTGAAATTGCACCCACAAGGATTAAAGCAAAGCTTGTTGATAAAAGCATTATGTTACAA
ATCTTATCAAAGGGGAGAGT

Downstream 100 bases:

>100_bases
TAGCATAATGAGGAGAAAAAATGTTTAGGTTTATTTTGATTTTGGTATTTTTGGGAATAAATATTTATGCAGATGATAAG
GCTAAGATCAAAGAGTTATA

Product: transcriptional activator FlgR

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKIAIVEDDINYRKSLETAFEDYPQYEIVSFKNPKDALKKLDESFELVITDINMPQMDGLAFLQELNGRYEAIVITGNAS
VQNAIKSIRLGVKDFLIKGCEIETFIEAIERSHKVRQIAQKSPAKLSDSIKDFIASSPKLEEIKAIALKVAKTDASVLLL
GQSGVGKDVFAQFIHRNSHRADAPFIAINMAAIPEHLLESELFGYEKGAFTDATTAKPGILEDANGGSVFLDEIGEMPLA
LQAKLLRVLQEKALTRLGSSKPIKIDVRFISATNADIQAKIAKNEFREDLFFRLQTIPLSIPPLKERKEEILPLSEWKLE
SVCMQYGLEQKRFSSQAKEALMSYEWPGNVRELLSVIERAGILSEGDEISVKDLFLESRSGVFGFVPQAQGSKIAELEKQ
LIAQTLIESANDVQKASDILGMNLEVLRHKIARYGL

Sequences:

>Translated_436_residues
MKIAIVEDDINYRKSLETAFEDYPQYEIVSFKNPKDALKKLDESFELVITDINMPQMDGLAFLQELNGRYEAIVITGNAS
VQNAIKSIRLGVKDFLIKGCEIETFIEAIERSHKVRQIAQKSPAKLSDSIKDFIASSPKLEEIKAIALKVAKTDASVLLL
GQSGVGKDVFAQFIHRNSHRADAPFIAINMAAIPEHLLESELFGYEKGAFTDATTAKPGILEDANGGSVFLDEIGEMPLA
LQAKLLRVLQEKALTRLGSSKPIKIDVRFISATNADIQAKIAKNEFREDLFFRLQTIPLSIPPLKERKEEILPLSEWKLE
SVCMQYGLEQKRFSSQAKEALMSYEWPGNVRELLSVIERAGILSEGDEISVKDLFLESRSGVFGFVPQAQGSKIAELEKQ
LIAQTLIESANDVQKASDILGMNLEVLRHKIARYGL
>Mature_436_residues
MKIAIVEDDINYRKSLETAFEDYPQYEIVSFKNPKDALKKLDESFELVITDINMPQMDGLAFLQELNGRYEAIVITGNAS
VQNAIKSIRLGVKDFLIKGCEIETFIEAIERSHKVRQIAQKSPAKLSDSIKDFIASSPKLEEIKAIALKVAKTDASVLLL
GQSGVGKDVFAQFIHRNSHRADAPFIAINMAAIPEHLLESELFGYEKGAFTDATTAKPGILEDANGGSVFLDEIGEMPLA
LQAKLLRVLQEKALTRLGSSKPIKIDVRFISATNADIQAKIAKNEFREDLFFRLQTIPLSIPPLKERKEEILPLSEWKLE
SVCMQYGLEQKRFSSQAKEALMSYEWPGNVRELLSVIERAGILSEGDEISVKDLFLESRSGVFGFVPQAQGSKIAELEKQ
LIAQTLIESANDVQKASDILGMNLEVLRHKIARYGL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=38.1578947368421, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=34.9680170575693, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1790437, Length=441, Percent_Identity=34.4671201814059, Blast_Score=264, Evalue=9e-72,
Organism=Escherichia coli, GI1788905, Length=349, Percent_Identity=41.2607449856734, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI1789233, Length=357, Percent_Identity=37.2549019607843, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI87082117, Length=321, Percent_Identity=41.4330218068536, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1789087, Length=293, Percent_Identity=41.9795221843003, Blast_Score=215, Evalue=6e-57,
Organism=Escherichia coli, GI1786524, Length=254, Percent_Identity=44.0944881889764, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI87082152, Length=241, Percent_Identity=43.9834024896266, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1787583, Length=326, Percent_Identity=35.2760736196319, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI87081872, Length=299, Percent_Identity=34.4481605351171, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI87081858, Length=343, Percent_Identity=30.6122448979592, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1789828, Length=241, Percent_Identity=32.7800829875519, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48588; Mature: 48588

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIVEDDINYRKSLETAFEDYPQYEIVSFKNPKDALKKLDESFELVITDINMPQMDGL
CEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCEEEEEEECCCCCHHHH
AFLQELNGRYEAIVITGNASVQNAIKSIRLGVKDFLIKGCEIETFIEAIERSHKVRQIAQ
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KSPAKLSDSIKDFIASSPKLEEIKAIALKVAKTDASVLLLGQSGVGKDVFAQFIHRNSHR
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCEEEEEECCCCCHHHHHHHHHCCCCC
ADAPFIAINMAAIPEHLLESELFGYEKGAFTDATTAKPGILEDANGGSVFLDEIGEMPLA
CCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCHH
LQAKLLRVLQEKALTRLGSSKPIKIDVRFISATNADIQAKIAKNEFREDLFFRLQTIPLS
HHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCC
IPPLKERKEEILPLSEWKLESVCMQYGLEQKRFSSQAKEALMSYEWPGNVRELLSVIERA
CCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
GILSEGDEISVKDLFLESRSGVFGFVPQAQGSKIAELEKQLIAQTLIESANDVQKASDIL
CCCCCCCCCCHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMNLEVLRHKIARYGL
CCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAIVEDDINYRKSLETAFEDYPQYEIVSFKNPKDALKKLDESFELVITDINMPQMDGL
CEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCEEEEEEECCCCCHHHH
AFLQELNGRYEAIVITGNASVQNAIKSIRLGVKDFLIKGCEIETFIEAIERSHKVRQIAQ
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KSPAKLSDSIKDFIASSPKLEEIKAIALKVAKTDASVLLLGQSGVGKDVFAQFIHRNSHR
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCEEEEEECCCCCHHHHHHHHHCCCCC
ADAPFIAINMAAIPEHLLESELFGYEKGAFTDATTAKPGILEDANGGSVFLDEIGEMPLA
CCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCHH
LQAKLLRVLQEKALTRLGSSKPIKIDVRFISATNADIQAKIAKNEFREDLFFRLQTIPLS
HHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCC
IPPLKERKEEILPLSEWKLESVCMQYGLEQKRFSSQAKEALMSYEWPGNVRELLSVIERA
CCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
GILSEGDEISVKDLFLESRSGVFGFVPQAQGSKIAELEKQLIAQTLIESANDVQKASDIL
CCCCCCCCCCHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMNLEVLRHKIARYGL
CCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]