| Definition | Helicobacter hepaticus ATCC 51449 chromosome, complete genome. |
|---|---|
| Accession | NC_004917 |
| Length | 1,799,146 |
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The map label for this gene is gyrA
Identifier: 32267132
GI number: 32267132
Start: 1557237
End: 1559711
Strand: Direct
Name: gyrA
Synonym: HH1633
Alternate gene names: 32267132
Gene position: 1557237-1559711 (Clockwise)
Preceding gene: 32267129
Following gene: 32267133
Centisome position: 86.55
GC content: 37.62
Gene sequence:
>2475_bases ATGGATAGCCTAATAGAAGATAATAATATAGATGTGAAAATTGATGATTCTATCAAAGAGAGTTATCTTGATTATTCAAT GAGCGTTATTGTGGGGAGAGCCTTGCCTGACGCAAAAGATGGACTAAAGCCTGTGCATAGAAGAATCTTATATGCAATGA ATGAGCTTAATCTCTCACCACGTCGTCCATATAAGAAAAGTGCGAGAATCGTAGGCGATGTAATTGGTAAATATCACCCA CACGGAGATACTGCGGTATATGATGCACTTGTGCGTATGGCACAGGATTTTTCTATGCGACTTGAACTTGTTGATGGGCA AGGGAATTTTGGTTCTATTGATGGCGATGGCGCAGCGGCTATGCGTTATACAGAGGCACGTATGACAAGTGCAAGTGAGG AGATGCTCCGTGATATTGATAAAGACACGGTTGAATTTGTGCCAAATTATGATAATACGCTTTATGAACCAGATGTTTTG CCTACGAGATTCCCAAATTTGCTTGTAAATGGTTCAAGCGGTATTGCGGTAGGTATGGCGACTTCTATTCCTCCGCATCG CATTGATGAGATTATAGATGCGCTTATTATGGTGATTGATAAAAATACGCAAGATGTGGAAGACTTGCTTGATATTGTGC AGGGACCGGATTTTCCAACAGGTGGAATTATCTATGGCAAAGCAGGAATTTTAGAAGCTTATCGGACAGGGCGGGGACGC ATTCGTGTGCGTGCAAAGGTGCATATTGAAAAAACAAAAACCAAAGATGTGATTGTCATTGATGAAGTGCCTTATCAAGT GAATAAAGCAAAGCTTGTTGAGCAAATTTCGGAATTAGCAAAAGAAAAGGTTATTGATGGTATTTCAGAAGTGCGTGATG AAAGCGATAGAGAGGGTATACGAGTTGTTATTGAGCTTAAACGTGATGCGATGAGTGAAATTGTGCTTAATCATCTTTTT AAATCCACAACAATGGAAAGCACTTTTGGGATTATCCTGCTTGCAATTAATAACAAAGAGCCCAAAATTTTCAATCTCCT TGAACTCTTACAGATTTTCATTGCTCATCGTAAAACAATTATTATCCGCAGGAGTATTTTTGAGCTTGAGAAAGCTAAAG CGCGAGCGCATATTTTAGAGGGTTTAATTATTGCCTTAGATAATATTGACGAAGTCATTAAAACTATCCGTGCTTCAAAG GATACTGATGAGGCAAAAAATGCACTTGTGTCTAAATTTAAATTAAGCGAATTGCAAGCTAAGGCTATACTTGAAATGCG TTTGCAGAGACTTACAGGCTTAGAGAGAGATAAGATTAATGAGGAATATGCCCAGCTTCAAGCTCAAATTGCATATTTAG AATCTATCCTTAAAAGTGAAGATAAGCTTAAGTCCATTGTAAAAGAAGAGCTTTTAGAAATAAAAGAGAAATTTAGCACG AAAAGGCGCACACAAATTGAAGAGGATTATGATGCCATTGATGTGGAGGATTTAATCCCTAATGAAAAAGTAGTTGTTAC AATGAGCCATAGAGGTTATGTCAAGCGTGTATTGCTTAAGACTTATGAAAAACAAAATCGTGGTGGTAAGGGTAAAATTA GTGGTAATACGCACGATGATGATTTTATAGAATCTTTCTTTGTGGCAAATACGCACGATACGATTATGTTTGTTACCAAT AAAGGGCAGCTTTATTGGCTTAAGGTGTATAAGATTCCAGAAGCAGGACGCACAGCTATTGGAAAGGCGGTAGTAAATCT CATTAATCTTCAAGCTGATGAAAAAATTATGGCAACTATTACTACCACAGATTTTAATGAAGATAAATCACTCGTATTTT TTACTAAAAATGGTGTTGTTAAACGCACAAATCTTAAAGAATATGGCAATATTCGTAGCATAGGTGTTAGAGCGATTAAT CTTGATGAAAATGATGAGCTTGTAACCGCACATATTGTTGATTCTCATATCAAAGAACTTTTTATAGCCACTTATCAAGG TATGTGTATTCGTTTTGGTGTTGAAGAATTGCGTGAGATTGGGCGTGTAAGTCGTGGGGTAACAGGTATTAAATTTAAAG CAAGCGAAGATTGTGTTATTGCAGCTACGACTATCGCTAATGATACAGATAAGCTTTTAACAGTGAGTGAGCGTGGTATT GGTAAGCAAACTTTGGCTGGAGAATATCGTTTGCAAAGCCGTGCTGGTAAAGGAGTCATTGTAATGAAGCTTACGCCTAG AACAGGAAAGCTTGTAAGTGTCGTAAATATTAATGATGAAAATATGGATCTTATGGTGCTGACAAGTTCAGGTAAAATGA TTCGTGTAGATACAGAGGCTATACGTAAAGCTGGGCGCAATACAAGTGGGGTAAAAATTGTAAATGTTGGTGATGATAAA GTGGCTTATGCTAATGTTTGCCCAAAAGAGCCAAAAGAAGAAGACATAAATGATGAAGAAGGAAGCGAGGGTTAA
Upstream 100 bases:
>100_bases TATGCCAAAGAAGAATTATATAACGCTTTTACTTAAGAAGTAAGCCTATTTTTAGTGAATTTGGGCTAAAATAGCGCTAA AACCTAGATTGGGAGAGACA
Downstream 100 bases:
>100_bases TTAAAAGTAAGGATTGTAAGAATAGAGTGAGGAGGTTTATATGCGTGGGCAACTCTTAATATTCCTTTTGTGTATAGGCA TACTCAATGGAGCAAATGAG
Product: DNA gyrase subunit A
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 824; Mature: 824
Protein sequence:
>824_residues MDSLIEDNNIDVKIDDSIKESYLDYSMSVIVGRALPDAKDGLKPVHRRILYAMNELNLSPRRPYKKSARIVGDVIGKYHP HGDTAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDGAAAMRYTEARMTSASEEMLRDIDKDTVEFVPNYDNTLYEPDVL PTRFPNLLVNGSSGIAVGMATSIPPHRIDEIIDALIMVIDKNTQDVEDLLDIVQGPDFPTGGIIYGKAGILEAYRTGRGR IRVRAKVHIEKTKTKDVIVIDEVPYQVNKAKLVEQISELAKEKVIDGISEVRDESDREGIRVVIELKRDAMSEIVLNHLF KSTTMESTFGIILLAINNKEPKIFNLLELLQIFIAHRKTIIIRRSIFELEKAKARAHILEGLIIALDNIDEVIKTIRASK DTDEAKNALVSKFKLSELQAKAILEMRLQRLTGLERDKINEEYAQLQAQIAYLESILKSEDKLKSIVKEELLEIKEKFST KRRTQIEEDYDAIDVEDLIPNEKVVVTMSHRGYVKRVLLKTYEKQNRGGKGKISGNTHDDDFIESFFVANTHDTIMFVTN KGQLYWLKVYKIPEAGRTAIGKAVVNLINLQADEKIMATITTTDFNEDKSLVFFTKNGVVKRTNLKEYGNIRSIGVRAIN LDENDELVTAHIVDSHIKELFIATYQGMCIRFGVEELREIGRVSRGVTGIKFKASEDCVIAATTIANDTDKLLTVSERGI GKQTLAGEYRLQSRAGKGVIVMKLTPRTGKLVSVVNINDENMDLMVLTSSGKMIRVDTEAIRKAGRNTSGVKIVNVGDDK VAYANVCPKEPKEEDINDEEGSEG
Sequences:
>Translated_824_residues MDSLIEDNNIDVKIDDSIKESYLDYSMSVIVGRALPDAKDGLKPVHRRILYAMNELNLSPRRPYKKSARIVGDVIGKYHP HGDTAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDGAAAMRYTEARMTSASEEMLRDIDKDTVEFVPNYDNTLYEPDVL PTRFPNLLVNGSSGIAVGMATSIPPHRIDEIIDALIMVIDKNTQDVEDLLDIVQGPDFPTGGIIYGKAGILEAYRTGRGR IRVRAKVHIEKTKTKDVIVIDEVPYQVNKAKLVEQISELAKEKVIDGISEVRDESDREGIRVVIELKRDAMSEIVLNHLF KSTTMESTFGIILLAINNKEPKIFNLLELLQIFIAHRKTIIIRRSIFELEKAKARAHILEGLIIALDNIDEVIKTIRASK DTDEAKNALVSKFKLSELQAKAILEMRLQRLTGLERDKINEEYAQLQAQIAYLESILKSEDKLKSIVKEELLEIKEKFST KRRTQIEEDYDAIDVEDLIPNEKVVVTMSHRGYVKRVLLKTYEKQNRGGKGKISGNTHDDDFIESFFVANTHDTIMFVTN KGQLYWLKVYKIPEAGRTAIGKAVVNLINLQADEKIMATITTTDFNEDKSLVFFTKNGVVKRTNLKEYGNIRSIGVRAIN LDENDELVTAHIVDSHIKELFIATYQGMCIRFGVEELREIGRVSRGVTGIKFKASEDCVIAATTIANDTDKLLTVSERGI GKQTLAGEYRLQSRAGKGVIVMKLTPRTGKLVSVVNINDENMDLMVLTSSGKMIRVDTEAIRKAGRNTSGVKIVNVGDDK VAYANVCPKEPKEEDINDEEGSEG >Mature_824_residues MDSLIEDNNIDVKIDDSIKESYLDYSMSVIVGRALPDAKDGLKPVHRRILYAMNELNLSPRRPYKKSARIVGDVIGKYHP HGDTAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDGAAAMRYTEARMTSASEEMLRDIDKDTVEFVPNYDNTLYEPDVL PTRFPNLLVNGSSGIAVGMATSIPPHRIDEIIDALIMVIDKNTQDVEDLLDIVQGPDFPTGGIIYGKAGILEAYRTGRGR IRVRAKVHIEKTKTKDVIVIDEVPYQVNKAKLVEQISELAKEKVIDGISEVRDESDREGIRVVIELKRDAMSEIVLNHLF KSTTMESTFGIILLAINNKEPKIFNLLELLQIFIAHRKTIIIRRSIFELEKAKARAHILEGLIIALDNIDEVIKTIRASK DTDEAKNALVSKFKLSELQAKAILEMRLQRLTGLERDKINEEYAQLQAQIAYLESILKSEDKLKSIVKEELLEIKEKFST KRRTQIEEDYDAIDVEDLIPNEKVVVTMSHRGYVKRVLLKTYEKQNRGGKGKISGNTHDDDFIESFFVANTHDTIMFVTN KGQLYWLKVYKIPEAGRTAIGKAVVNLINLQADEKIMATITTTDFNEDKSLVFFTKNGVVKRTNLKEYGNIRSIGVRAIN LDENDELVTAHIVDSHIKELFIATYQGMCIRFGVEELREIGRVSRGVTGIKFKASEDCVIAATTIANDTDKLLTVSERGI GKQTLAGEYRLQSRAGKGVIVMKLTPRTGKLVSVVNINDENMDLMVLTSSGKMIRVDTEAIRKAGRNTSGVKIVNVGDDK VAYANVCPKEPKEEDINDEEGSEG
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913406, Length=322, Percent_Identity=24.223602484472, Blast_Score=75, Evalue=2e-13, Organism=Homo sapiens, GI19913408, Length=174, Percent_Identity=28.735632183908, Blast_Score=73, Evalue=1e-12, Organism=Escherichia coli, GI1788562, Length=848, Percent_Identity=47.1698113207547, Blast_Score=775, Evalue=0.0, Organism=Escherichia coli, GI1789396, Length=681, Percent_Identity=38.7665198237885, Blast_Score=434, Evalue=1e-123, Organism=Caenorhabditis elegans, GI212645845, Length=515, Percent_Identity=22.7184466019417, Blast_Score=79, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17535065, Length=271, Percent_Identity=24.7232472324723, Blast_Score=73, Evalue=7e-13, Organism=Saccharomyces cerevisiae, GI6324241, Length=389, Percent_Identity=24.1645244215938, Blast_Score=81, Evalue=6e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR005743 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 92372; Mature: 92372
Theoretical pI: Translated: 5.79; Mature: 5.79
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDSLIEDNNIDVKIDDSIKESYLDYSMSVIVGRALPDAKDGLKPVHRRILYAMNELNLSP CCCCCCCCCCEEEECCHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHCCCCC RRPYKKSARIVGDVIGKYHPHGDTAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDGAAA CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCHH MRYTEARMTSASEEMLRDIDKDTVEFVPNYDNTLYEPDVLPTRFPNLLVNGSSGIAVGMA EEEHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEE TSIPPHRIDEIIDALIMVIDKNTQDVEDLLDIVQGPDFPTGGIIYGKAGILEAYRTGRGR CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCCCE IRVRAKVHIEKTKTKDVIVIDEVPYQVNKAKLVEQISELAKEKVIDGISEVRDESDREGI EEEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE RVVIELKRDAMSEIVLNHLFKSTTMESTFGIILLAINNKEPKIFNLLELLQIFIAHRKTI EEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEE IIRRSIFELEKAKARAHILEGLIIALDNIDEVIKTIRASKDTDEAKNALVSKFKLSELQA EEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH KAILEMRLQRLTGLERDKINEEYAQLQAQIAYLESILKSEDKLKSIVKEELLEIKEKFST HHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH KRRTQIEEDYDAIDVEDLIPNEKVVVTMSHRGYVKRVLLKTYEKQNRGGKGKISGNTHDD HHHHHHHCCCCCCCHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCEECCCCCCH DFIESFFVANTHDTIMFVTNKGQLYWLKVYKIPEAGRTAIGKAVVNLINLQADEKIMATI HHHHHHHEECCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEE TTTDFNEDKSLVFFTKNGVVKRTNLKEYGNIRSIGVRAINLDENDELVTAHIVDSHIKEL EECCCCCCCCEEEEECCCEEEECCHHHHCCEEEEEEEEEECCCCCCEEEEHHHHHHHHHH FIATYQGMCIRFGVEELREIGRVSRGVTGIKFKASEDCVIAATTIANDTDKLLTVSERGI HHHHHCCHHEECCHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEECCCCCCEEEECCCCC GKQTLAGEYRLQSRAGKGVIVMKLTPRTGKLVSVVNINDENMDLMVLTSSGKMIRVDTEA CCHHHCCHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCEEEEEHHH IRKAGRNTSGVKIVNVGDDKVAYANVCPKEPKEEDINDEEGSEG HHHCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure MDSLIEDNNIDVKIDDSIKESYLDYSMSVIVGRALPDAKDGLKPVHRRILYAMNELNLSP CCCCCCCCCCEEEECCHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHCCCCC RRPYKKSARIVGDVIGKYHPHGDTAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDGAAA CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCHH MRYTEARMTSASEEMLRDIDKDTVEFVPNYDNTLYEPDVLPTRFPNLLVNGSSGIAVGMA EEEHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEE TSIPPHRIDEIIDALIMVIDKNTQDVEDLLDIVQGPDFPTGGIIYGKAGILEAYRTGRGR CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCCCE IRVRAKVHIEKTKTKDVIVIDEVPYQVNKAKLVEQISELAKEKVIDGISEVRDESDREGI EEEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE RVVIELKRDAMSEIVLNHLFKSTTMESTFGIILLAINNKEPKIFNLLELLQIFIAHRKTI EEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEE IIRRSIFELEKAKARAHILEGLIIALDNIDEVIKTIRASKDTDEAKNALVSKFKLSELQA EEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH KAILEMRLQRLTGLERDKINEEYAQLQAQIAYLESILKSEDKLKSIVKEELLEIKEKFST HHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH KRRTQIEEDYDAIDVEDLIPNEKVVVTMSHRGYVKRVLLKTYEKQNRGGKGKISGNTHDD HHHHHHHCCCCCCCHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCEECCCCCCH DFIESFFVANTHDTIMFVTNKGQLYWLKVYKIPEAGRTAIGKAVVNLINLQADEKIMATI HHHHHHHEECCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEE TTTDFNEDKSLVFFTKNGVVKRTNLKEYGNIRSIGVRAINLDENDELVTAHIVDSHIKEL EECCCCCCCCEEEEECCCEEEECCHHHHCCEEEEEEEEEECCCCCCEEEEHHHHHHHHHH FIATYQGMCIRFGVEELREIGRVSRGVTGIKFKASEDCVIAATTIANDTDKLLTVSERGI HHHHHCCHHEECCHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEECCCCCCEEEECCCCC GKQTLAGEYRLQSRAGKGVIVMKLTPRTGKLVSVVNINDENMDLMVLTSSGKMIRVDTEA CCHHHCCHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCEEEEEHHH IRKAGRNTSGVKIVNVGDDKVAYANVCPKEPKEEDINDEEGSEG HHHCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9923682 [H]