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The map label for this gene is pheA

Identifier: 32267007

GI number: 32267007

Start: 1447265

End: 1448362

Strand: Direct

Name: pheA

Synonym: HH1508

Alternate gene names: 32267007

Gene position: 1447265-1448362 (Clockwise)

Preceding gene: 32267006

Following gene: 32267008

Centisome position: 80.44

GC content: 35.88

Gene sequence:

>1098_bases
ATGCCTCAAATACCACAAGATACGATACTCCAAACTCTCCGTAATGAGATTGATAGCATTGATTCGGAGATTTTTGATGC
TTTGCAAAAGCGTATGGCGCTTGTAGCACAAGTAGGAGCACATAAGACCAAGCAAGGCGGAGCAATTTATCGCCCAGAGC
GAGAGAGGGAAATTATTGAACGTTTGAGTCAAAGAGAAAGTAAATATTTAAATGAACGTGCCATTGAGGCAATTTATCAA
GAAATTTTTGCTATTTCGCGCAATTTGGAGTTACCTGAAAAAGTGGCATTTTTAGGACCTGTAGGGAGTTATACGCATCA
GGCGGCAGAAGAACGATTTGGCGCAATGAGCAAGTATATACCACTTAATACTATCAGTGCAGTTTTTGAATCTCTTGCTT
ATAAACGTGTAAAATATGGCGTAATACCACTTGAGAATAATACAAATGGTATGGTAGGTGAGAGTATTGACTTTTTAGCA
TATTATGATTTTAAAATTATTGCAGAAATCATTTTGCCTATTCATCATAGTTTTTTGAGTAGCTGTGAGCATTTGAGCGA
AGTGAAAAAGATTTTTTCTAAAGATATTGCATTTGGGCAATGTCAAAAATTTCTTCACGCACATAATCTTCATCATATTG
AACAGATTCCTACAGATTCAACAGCACGTGCTGTGCAACTTGCTGCTAGTAACCCGCAAAGTGCGGCTATTGGCTCTAAA
ATTGCAGGAAAGCTTTATAATTTGCCATTGATGTTTGAACATATTGAGGATTCCCAAAATAATAAAACTCGTTTTGTGAT
AGTGAGTGATTTTGCGAATGCACCTAGTGGAAAGGATAAAACCTCTCTTTTTGTGAATCTCAAAAATGATGACCAAGTAG
GCACTTTATTTCGTTTATTGGGTGATTTTGAAAAAGAGGGTATTAATCTTACAAAAATAGATTCGCGTCCGATTCGCTCA
AATGAGAGCTTTAAAACAGGATTTTTTATTGATTGTGAGGGGCATTACCTTGATAAACCATTGCAGCGACTTTTTGCTAA
GAGAAGTGATGAAATAAAATGGCTTGGAAGTTATATTTTTACTGATATTAAAAAATAA

Upstream 100 bases:

>100_bases
AAAATGATAGAAGATGAGGAGAGATTGCTTGAAGATACTTTAGAAATGCCTCTTCAATCAGAAGATGGAGAGAATCCCTA
AAACAAGATAAGGACATATT

Downstream 100 bases:

>100_bases
ATGCAATATAGGCAACTAAGGAGAAATAATGGAGTTTAAAAAAATAGAACTTGAAGATAGAACACTTCTAGAACCATTTA
CAAATCAGAAAGGACGATGG

Product: chorismate mutase/prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MPQIPQDTILQTLRNEIDSIDSEIFDALQKRMALVAQVGAHKTKQGGAIYRPEREREIIERLSQRESKYLNERAIEAIYQ
EIFAISRNLELPEKVAFLGPVGSYTHQAAEERFGAMSKYIPLNTISAVFESLAYKRVKYGVIPLENNTNGMVGESIDFLA
YYDFKIIAEIILPIHHSFLSSCEHLSEVKKIFSKDIAFGQCQKFLHAHNLHHIEQIPTDSTARAVQLAASNPQSAAIGSK
IAGKLYNLPLMFEHIEDSQNNKTRFVIVSDFANAPSGKDKTSLFVNLKNDDQVGTLFRLLGDFEKEGINLTKIDSRPIRS
NESFKTGFFIDCEGHYLDKPLQRLFAKRSDEIKWLGSYIFTDIKK

Sequences:

>Translated_365_residues
MPQIPQDTILQTLRNEIDSIDSEIFDALQKRMALVAQVGAHKTKQGGAIYRPEREREIIERLSQRESKYLNERAIEAIYQ
EIFAISRNLELPEKVAFLGPVGSYTHQAAEERFGAMSKYIPLNTISAVFESLAYKRVKYGVIPLENNTNGMVGESIDFLA
YYDFKIIAEIILPIHHSFLSSCEHLSEVKKIFSKDIAFGQCQKFLHAHNLHHIEQIPTDSTARAVQLAASNPQSAAIGSK
IAGKLYNLPLMFEHIEDSQNNKTRFVIVSDFANAPSGKDKTSLFVNLKNDDQVGTLFRLLGDFEKEGINLTKIDSRPIRS
NESFKTGFFIDCEGHYLDKPLQRLFAKRSDEIKWLGSYIFTDIKK
>Mature_364_residues
PQIPQDTILQTLRNEIDSIDSEIFDALQKRMALVAQVGAHKTKQGGAIYRPEREREIIERLSQRESKYLNERAIEAIYQE
IFAISRNLELPEKVAFLGPVGSYTHQAAEERFGAMSKYIPLNTISAVFESLAYKRVKYGVIPLENNTNGMVGESIDFLAY
YDFKIIAEIILPIHHSFLSSCEHLSEVKKIFSKDIAFGQCQKFLHAHNLHHIEQIPTDSTARAVQLAASNPQSAAIGSKI
AGKLYNLPLMFEHIEDSQNNKTRFVIVSDFANAPSGKDKTSLFVNLKNDDQVGTLFRLLGDFEKEGINLTKIDSRPIRSN
ESFKTGFFIDCEGHYLDKPLQRLFAKRSDEIKWLGSYIFTDIKK

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=372, Percent_Identity=27.4193548387097, Blast_Score=131, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6324013, Length=289, Percent_Identity=28.719723183391, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 41437; Mature: 41306

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00857 PREPHENATE_DEHYDR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQIPQDTILQTLRNEIDSIDSEIFDALQKRMALVAQVGAHKTKQGGAIYRPEREREIIE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
RLSQRESKYLNERAIEAIYQEIFAISRNLELPEKVAFLGPVGSYTHQAAEERFGAMSKYI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
PLNTISAVFESLAYKRVKYGVIPLENNTNGMVGESIDFLAYYDFKIIAEIILPIHHSFLS
CHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SCEHLSEVKKIFSKDIAFGQCQKFLHAHNLHHIEQIPTDSTARAVQLAASNPQSAAIGSK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHCCCCCHHHHEEEECCCCCHHHHHHH
IAGKLYNLPLMFEHIEDSQNNKTRFVIVSDFANAPSGKDKTSLFVNLKNDDQVGTLFRLL
HHHHHHCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHH
GDFEKEGINLTKIDSRPIRSNESFKTGFFIDCEGHYLDKPLQRLFAKRSDEIKWLGSYIF
HHHHHCCCCEEECCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHH
TDIKK
HHCCC
>Mature Secondary Structure 
PQIPQDTILQTLRNEIDSIDSEIFDALQKRMALVAQVGAHKTKQGGAIYRPEREREIIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
RLSQRESKYLNERAIEAIYQEIFAISRNLELPEKVAFLGPVGSYTHQAAEERFGAMSKYI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
PLNTISAVFESLAYKRVKYGVIPLENNTNGMVGESIDFLAYYDFKIIAEIILPIHHSFLS
CHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SCEHLSEVKKIFSKDIAFGQCQKFLHAHNLHHIEQIPTDSTARAVQLAASNPQSAAIGSK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHCCCCCHHHHEEEECCCCCHHHHHHH
IAGKLYNLPLMFEHIEDSQNNKTRFVIVSDFANAPSGKDKTSLFVNLKNDDQVGTLFRLL
HHHHHHCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHH
GDFEKEGINLTKIDSRPIRSNESFKTGFFIDCEGHYLDKPLQRLFAKRSDEIKWLGSYIF
HHHHHCCCCEEECCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHH
TDIKK
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]