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The map label for this gene is lysA

Identifier: 32267006

GI number: 32267006

Start: 1445971

End: 1447245

Strand: Direct

Name: lysA

Synonym: HH1507

Alternate gene names: 32267006

Gene position: 1445971-1447245 (Clockwise)

Preceding gene: 32267004

Following gene: 32267007

Centisome position: 80.37

GC content: 36.31

Gene sequence:

>1275_bases
ATGGAGCAAACACATTATTTTGCCCTTGCAGATACTTATCAAACACCACTTTATGTATATGATTTGGAGCGCATTACTCA
AGCATTTTGTGCGATAAAAGACGCTTTTAAAGCGCGTAAATCGCTCATTTGTTATGCACTTAAGGCAAATTCTAATCTCT
CTATTATTCATCACCTAGCTCAACTTGGGAGCGGAGCGGATTGTGTATCTATCGGTGAAGTAAGACGCGCTTTAAGAGCC
GGGATTCCTAAATATAAAATTATTTTTAGTGGTGTAGGAAAACAAGATAATGAAATTGAAGAAGCACTTCAAAGTGATAT
TCTATTTTTAAATGTGGAGAGCGAAGAGGAATTATTGCGTATAGAATCTATTGCAAAAAAACTTGATAAAATAGCAAGAA
TATCAGTGCGTGTTAATCCAAATATTGATGCTAAAACTCACCCTTATATCTCAACAGGATTGAATGAAAATAAATTCGGC
GTAGATATAGAGCAGGCAAAATCTATGTATATTTTTGCTAAAAATGCTCAATTTCTTGAGCCTATCGGGATTCATTTTCA
TATTGGCTCACAAATTACAGATTTAGAGCCAATTAAACAATCTGCACAAAAAATAGCACAACTTACACATTCTCTTCTTG
CCCTTAAAATTGATTTGAAATTTTTTGATATTGGTGGGGGTATAGGGATTCGCTATACTGATGAATCCCTTATTAATCCA
TATGATTATGCTCAAGCTATTTTGGAAGCATTGTATGGGCTTGATTTAACAATTATATGTGAGCCCGGACGATTTCTTGT
AGGGGAGAGTGGCGTTTTGCTTACGCGTGTGCTCTATGAAAAGCATAATGGACATAAACGTTTTGTAATTGTAGATGCAG
CGATGAATGATTTAATGCGCCCTGCACTTTATCGTGCTACGCATCAAGTGGAATATTTTTTAAAAGATAAAAGAGTAGAT
TCTTCTTTAGAGTCTAGCCTATGCGATATTGTAGGACCTATTTGTGAGAGCAGCGATTATTTGGCGAAAAATATTAAACT
TCCACCACTTCAGGCAGGAGATGTGCTCGTGCTTAAAAATGCTGGAGCGTATGGTTATAGTATGGCAAGTAATTATAATA
CGCGTCCTCGTCCTGCAGAAGTAGCTCTTATGCAAGGCAATGCACGGCTTATTAAACATAGAGAATCTTTTGAGAAAATG
ATAGAAGATGAGGAGAGATTGCTTGAAGATACTTTAGAAATGCCTCTTCAATCAGAAGATGGAGAGAATCCCTAA

Upstream 100 bases:

>100_bases
GAAAATTGTTATTACATATTAGATTTTAACATAATATTATGCTATTGTGGCTAAAATTATCATTTATAAAAGTAATTGAA
ATGATAAATTCGGAGTAATT

Downstream 100 bases:

>100_bases
AACAAGATAAGGACATATTATGCCTCAAATACCACAAGATACGATACTCCAAACTCTCCGTAATGAGATTGATAGCATTG
ATTCGGAGATTTTTGATGCT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MEQTHYFALADTYQTPLYVYDLERITQAFCAIKDAFKARKSLICYALKANSNLSIIHHLAQLGSGADCVSIGEVRRALRA
GIPKYKIIFSGVGKQDNEIEEALQSDILFLNVESEEELLRIESIAKKLDKIARISVRVNPNIDAKTHPYISTGLNENKFG
VDIEQAKSMYIFAKNAQFLEPIGIHFHIGSQITDLEPIKQSAQKIAQLTHSLLALKIDLKFFDIGGGIGIRYTDESLINP
YDYAQAILEALYGLDLTIICEPGRFLVGESGVLLTRVLYEKHNGHKRFVIVDAAMNDLMRPALYRATHQVEYFLKDKRVD
SSLESSLCDIVGPICESSDYLAKNIKLPPLQAGDVLVLKNAGAYGYSMASNYNTRPRPAEVALMQGNARLIKHRESFEKM
IEDEERLLEDTLEMPLQSEDGENP

Sequences:

>Translated_424_residues
MEQTHYFALADTYQTPLYVYDLERITQAFCAIKDAFKARKSLICYALKANSNLSIIHHLAQLGSGADCVSIGEVRRALRA
GIPKYKIIFSGVGKQDNEIEEALQSDILFLNVESEEELLRIESIAKKLDKIARISVRVNPNIDAKTHPYISTGLNENKFG
VDIEQAKSMYIFAKNAQFLEPIGIHFHIGSQITDLEPIKQSAQKIAQLTHSLLALKIDLKFFDIGGGIGIRYTDESLINP
YDYAQAILEALYGLDLTIICEPGRFLVGESGVLLTRVLYEKHNGHKRFVIVDAAMNDLMRPALYRATHQVEYFLKDKRVD
SSLESSLCDIVGPICESSDYLAKNIKLPPLQAGDVLVLKNAGAYGYSMASNYNTRPRPAEVALMQGNARLIKHRESFEKM
IEDEERLLEDTLEMPLQSEDGENP
>Mature_424_residues
MEQTHYFALADTYQTPLYVYDLERITQAFCAIKDAFKARKSLICYALKANSNLSIIHHLAQLGSGADCVSIGEVRRALRA
GIPKYKIIFSGVGKQDNEIEEALQSDILFLNVESEEELLRIESIAKKLDKIARISVRVNPNIDAKTHPYISTGLNENKFG
VDIEQAKSMYIFAKNAQFLEPIGIHFHIGSQITDLEPIKQSAQKIAQLTHSLLALKIDLKFFDIGGGIGIRYTDESLINP
YDYAQAILEALYGLDLTIICEPGRFLVGESGVLLTRVLYEKHNGHKRFVIVDAAMNDLMRPALYRATHQVEYFLKDKRVD
SSLESSLCDIVGPICESSDYLAKNIKLPPLQAGDVLVLKNAGAYGYSMASNYNTRPRPAEVALMQGNARLIKHRESFEKM
IEDEERLLEDTLEMPLQSEDGENP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=367, Percent_Identity=25.6130790190736, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI16506287, Length=382, Percent_Identity=27.2251308900524, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI22538418, Length=398, Percent_Identity=23.8693467336683, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI21361583, Length=398, Percent_Identity=23.8693467336683, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789203, Length=410, Percent_Identity=30.9756097560976, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789307, Length=301, Percent_Identity=25.5813953488372, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562780, Length=383, Percent_Identity=24.2819843342037, Blast_Score=108, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6322664, Length=365, Percent_Identity=23.8356164383562, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24586472, Length=345, Percent_Identity=26.9565217391304, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24586474, Length=339, Percent_Identity=25.3687315634218, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47563; Mature: 47563

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTHYFALADTYQTPLYVYDLERITQAFCAIKDAFKARKSLICYALKANSNLSIIHHLA
CCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHH
QLGSGADCVSIGEVRRALRAGIPKYKIIFSGVGKQDNEIEEALQSDILFLNVESEEELLR
HHCCCCCEEEHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCEEEEEECCHHHHHH
IESIAKKLDKIARISVRVNPNIDAKTHPYISTGLNENKFGVDIEQAKSMYIFAKNAQFLE
HHHHHHHHHHHHEEEEEECCCCCCCCCCCEECCCCCCCCCCCHHHCCEEEEEECCCCCCC
PIGIHFHIGSQITDLEPIKQSAQKIAQLTHSLLALKIDLKFFDIGGGIGIRYTDESLINP
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCEEEEECCHHHCCH
YDYAQAILEALYGLDLTIICEPGRFLVGESGVLLTRVLYEKHNGHKRFVIVDAAMNDLMR
HHHHHHHHHHHHCCCEEEEECCCCEEECCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHH
PALYRATHQVEYFLKDKRVDSSLESSLCDIVGPICESSDYLAKNIKLPPLQAGDVLVLKN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEC
AGAYGYSMASNYNTRPRPAEVALMQGNARLIKHRESFEKMIEDEERLLEDTLEMPLQSED
CCCCCEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GENP
CCCC
>Mature Secondary Structure
MEQTHYFALADTYQTPLYVYDLERITQAFCAIKDAFKARKSLICYALKANSNLSIIHHLA
CCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHH
QLGSGADCVSIGEVRRALRAGIPKYKIIFSGVGKQDNEIEEALQSDILFLNVESEEELLR
HHCCCCCEEEHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCEEEEEECCHHHHHH
IESIAKKLDKIARISVRVNPNIDAKTHPYISTGLNENKFGVDIEQAKSMYIFAKNAQFLE
HHHHHHHHHHHHEEEEEECCCCCCCCCCCEECCCCCCCCCCCHHHCCEEEEEECCCCCCC
PIGIHFHIGSQITDLEPIKQSAQKIAQLTHSLLALKIDLKFFDIGGGIGIRYTDESLINP
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCEEEEECCHHHCCH
YDYAQAILEALYGLDLTIICEPGRFLVGESGVLLTRVLYEKHNGHKRFVIVDAAMNDLMR
HHHHHHHHHHHHCCCEEEEECCCCEEECCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHH
PALYRATHQVEYFLKDKRVDSSLESSLCDIVGPICESSDYLAKNIKLPPLQAGDVLVLKN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEC
AGAYGYSMASNYNTRPRPAEVALMQGNARLIKHRESFEKMIEDEERLLEDTLEMPLQSED
CCCCCEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GENP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]