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The map label for this gene is atpB

Identifier: 32266996

GI number: 32266996

Start: 1434494

End: 1435174

Strand: Direct

Name: atpB

Synonym: HH1497

Alternate gene names: 32266996

Gene position: 1434494-1435174 (Clockwise)

Preceding gene: 32266995

Following gene: 32266997

Centisome position: 79.73

GC content: 36.86

Gene sequence:

>681_bases
ATGGACGAGAGGCTTTTTACTTTTGCAGGGTTGATTAATCCCAATCACGACTTTATCATTGGCTTTCATACACTGCTTGT
AGCAGTAATTTTACTTATTCTTGCACGATATGCAACACATAAAATGCAAGTTGTTCCAAGTGGCATACAAAATGTATTTG
AGTTTATTATTTCTGGCATTATCTCATTTGCTAAAGATATTGTAGGTGAGCAAGTTGCTCGCAAATATTTTCCGCTTGCT
GCAACCATTGCATTTTTAGTATTTTTTGGCAATGCCATAGGGATTATACCGGGATTTGAGGCTCCTACTTCAAGCTGGAG
TTTTACGCTTGTGTTAGCATTGGTTGTATTTTTTTATTATCATTTTGAGGGTATCCGTGCTCAAGGTGTATTGAAATATT
TTAAGCATTTTATGGGTCCTGTATGGTGGCTTGCTCCGCTTATGTTTCCCGTAGAAATTATTTCACATTTTTCGCGCATT
ATTTCGCTTTCTTTTCGTCTTTTTGGTAATATTAAAGGCGATGATATGTTTTTACTTGTAATGCTAATGCTTGCACCTTG
GATTGTGCCTGTTGCTCCTTTTGCAATTCTTACTTTTATGGCATTACTTCAGGCTTTTGTGTTTATGATACTTACTTATG
TGTATATTCACGGCGCAGTGGTCGTGGATGAAGAACACTGA

Upstream 100 bases:

>100_bases
GGTATTTAAATCAAAAGTTTTCATAAAAATTTTAAAGTTTAAAGTAAAACTAACCAAAAACTGGGCACAATCAATACATC
ATAAATAAAGGGGTATTGCT

Downstream 100 bases:

>100_bases
TTTTATTACACTTCTTATTACGCCTCATATTAATGGGGCATATCTTGAGAATCTTCAGCTTAAAATACAATCTTTGTCTG
TTGATTGGATTATGTATCGT

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MDERLFTFAGLINPNHDFIIGFHTLLVAVILLILARYATHKMQVVPSGIQNVFEFIISGIISFAKDIVGEQVARKYFPLA
ATIAFLVFFGNAIGIIPGFEAPTSSWSFTLVLALVVFFYYHFEGIRAQGVLKYFKHFMGPVWWLAPLMFPVEIISHFSRI
ISLSFRLFGNIKGDDMFLLVMLMLAPWIVPVAPFAILTFMALLQAFVFMILTYVYIHGAVVVDEEH

Sequences:

>Translated_226_residues
MDERLFTFAGLINPNHDFIIGFHTLLVAVILLILARYATHKMQVVPSGIQNVFEFIISGIISFAKDIVGEQVARKYFPLA
ATIAFLVFFGNAIGIIPGFEAPTSSWSFTLVLALVVFFYYHFEGIRAQGVLKYFKHFMGPVWWLAPLMFPVEIISHFSRI
ISLSFRLFGNIKGDDMFLLVMLMLAPWIVPVAPFAILTFMALLQAFVFMILTYVYIHGAVVVDEEH
>Mature_226_residues
MDERLFTFAGLINPNHDFIIGFHTLLVAVILLILARYATHKMQVVPSGIQNVFEFIISGIISFAKDIVGEQVARKYFPLA
ATIAFLVFFGNAIGIIPGFEAPTSSWSFTLVLALVVFFYYHFEGIRAQGVLKYFKHFMGPVWWLAPLMFPVEIISHFSRI
ISLSFRLFGNIKGDDMFLLVMLMLAPWIVPVAPFAILTFMALLQAFVFMILTYVYIHGAVVVDEEH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=218, Percent_Identity=31.1926605504587, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_HELHP (Q7VG27)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_861028.1
- ProteinModelPortal:   Q7VG27
- SMR:   Q7VG27
- GeneID:   1492044
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1497
- NMPDR:   fig|235279.1.peg.1497
- HOGENOM:   HBG734175
- OMA:   VTPIEFV
- ProtClustDB:   PRK05815
- BioCyc:   HHEP235279:HH_1497-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 25605; Mature: 25605

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe1ae3d4)-; HASH(0xf1e5fa8)-; HASH(0xfeb3cac)-; HASH(0xf043328)-; HASH(0xe6cdfb4)-; HASH(0xfeb3c28)-; HASH(0xda90bfc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDERLFTFAGLINPNHDFIIGFHTLLVAVILLILARYATHKMQVVPSGIQNVFEFIISGI
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISFAKDIVGEQVARKYFPLAATIAFLVFFGNAIGIIPGFEAPTSSWSFTLVLALVVFFYY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
HFEGIRAQGVLKYFKHFMGPVWWLAPLMFPVEIISHFSRIISLSFRLFGNIKGDDMFLLV
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
MLMLAPWIVPVAPFAILTFMALLQAFVFMILTYVYIHGAVVVDEEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCH
>Mature Secondary Structure
MDERLFTFAGLINPNHDFIIGFHTLLVAVILLILARYATHKMQVVPSGIQNVFEFIISGI
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISFAKDIVGEQVARKYFPLAATIAFLVFFGNAIGIIPGFEAPTSSWSFTLVLALVVFFYY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
HFEGIRAQGVLKYFKHFMGPVWWLAPLMFPVEIISHFSRIISLSFRLFGNIKGDDMFLLV
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
MLMLAPWIVPVAPFAILTFMALLQAFVFMILTYVYIHGAVVVDEEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12810954