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The map label for this gene is penA [H]

Identifier: 32266909

GI number: 32266909

Start: 1348129

End: 1349922

Strand: Direct

Name: penA [H]

Synonym: HH1410

Alternate gene names: 32266909

Gene position: 1348129-1349922 (Clockwise)

Preceding gene: 32266908

Following gene: 32266910

Centisome position: 74.93

GC content: 36.68

Gene sequence:

>1794_bases
GTGGCGTATTATGCGAAAAAAACAGGTGTGATTATATCTGTTTTTTTCTTGATTTTATTATGTTTTATTATTTTTCTTAG
CATTGTGTATGTCAAAATAGTAACTCCACGCAAACTTCCTGCAGTAACGGCAACTAAGAGTGATACTTCGGTAAGAGGCA
GTCTTTATACAAGTGATGGTTTTGAAGTCGCCTATAGTGATAAACTTTATAAAGCAAGTGTGAATACTCAAAGTATTGAC
CCAGATAAAAAAGAGCTATTTATCACACTTTTTTCCATATATAGCGGTATTCCTAAAGATGAGATTAGCAAAAAATTAGC
CCAAAAGGGTTATGTGGTGCTTTCTTATACTCTTAATTCCGCTGTGGCGACAAATTTAAAGAATCTCAATCTTATCCTTA
TCCGTTATGACGTATTTCGTGAGTATGAAGATAAAAGAGGACGCGTGATACAAAAAATGGGACTTAGCATTGAAGTGAGC
GGCAATAATAGAAATTATGTATATAAAAATATCCTTGAGCCGCTCATAGGCTATACGCGTAAATTTGAGAGCCAAAATAT
CACACGTGTTGATGGTGTCAAGGGAGTAGAAAAATATTATAATGATATACTTTCTCCTAAGCAAGATGGCAATATCACGG
GCAAACGCGATGTGGGCTTTAACGTCATTGCCAATAAATCAGCGCATATTCAAAGTAGGCAAGATGGTTTTGATGTTACG
CTAAGTATTCCTTTAAGTTTGCAGCGTAAAATAGAGTTTGAACTTGATGAGGCAAAAAAACGTTATAAGGTGCGTGAGAT
TATTGCTGGAGTAATGGATTCTAAAACAGGTAAGATTCTTGCTCTTGCGACTTCAAATCGCTTTGACCCAAAGAATATTC
AACAAAAAGATTATCCACATCTTAATCTCAATGCCATTGAATATTCTTATGAACCAGGCAGCACGATTAAACCTATCATC
TATGCCATTTTGTTGCAAAAGGGTATGGTAAGCCCAAATGATATGATTGAGCTTGATAATGGTTACTACAAGTTAAAAAG
TTATACTATACGCGATACTCATCCTCTCAAAAGCGCAAGTGCTGAAGATGTTATAGTGCGTTCTAGCAATATAGGTATGG
TAAAAATCTCTAAAGATTTAAAGCCCAATGAATATCATATCGCACTCCACGCTTTTGGATTCGGGGAATTAAGCGGGATT
GACTTGCCTTATGAAAAAACGGGTTTAGTGCCAAGCCCTAAAACTTTTAACAATGAAGTGTATCGTGCGAGTGTGAGCTA
TGGATATGGAATGAGAGCGACTTTTATACAGCTTTTGCGCTCTTATGCAATTTTTAGCAATGGTGGATACTTGATAACAC
CTCGTGTAAGCGAATATGTAACTTCTCCGAGTGGAGAAAAGTATATCCCTAAGCGACTTGAACCAATCGCTATTATTTCT
CCACAAACAACGCAGCAAGTCTATCATACGCTTATTCAAGTTGTGCAAAAGGTTATTAAAATAGCCCAAGTAGAAGGTAT
TATTACTGGGGGTAAAACAGGCACGGCTAAAATCGCTCTTAATGGGAAATATGATAGTAAGTATAATGGCTCATTTTTTG
GCTTTGCACAAGATGAAAGTAATGCTTATACCATTGGTGTTGTGGCTTTTGAATCTGATATAAAAGATGATTATTATGGC
GCACGCACAGCTGCTCCGATTTTTAAACGCATTGTAGAAATTATGCTTGAAGATGGTTATCTCAAACGTATAGAATCTGC
TCCTGTGCAGCCTAATGAAGCCCAAGCAATGTAA

Upstream 100 bases:

>100_bases
TTAATCGTGCAGAAAATAGTATGAAAGTAATGCTTGAAGTGAGAAACAAAGCAATTAATGCTTATAAAGAGATTTTAAGA
ACTCAAATTTAAGGGCATTT

Downstream 100 bases:

>100_bases
GTAAAATATTGATAATGACAAAAGATTCTAAAAAGATTACTCATAAAGACTATAATCGCATATTTTTAAAAATAAGGAGC
ACAAATGAACATTGTAAAAG

Product: hypothetical protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MAYYAKKTGVIISVFFLILLCFIIFLSIVYVKIVTPRKLPAVTATKSDTSVRGSLYTSDGFEVAYSDKLYKASVNTQSID
PDKKELFITLFSIYSGIPKDEISKKLAQKGYVVLSYTLNSAVATNLKNLNLILIRYDVFREYEDKRGRVIQKMGLSIEVS
GNNRNYVYKNILEPLIGYTRKFESQNITRVDGVKGVEKYYNDILSPKQDGNITGKRDVGFNVIANKSAHIQSRQDGFDVT
LSIPLSLQRKIEFELDEAKKRYKVREIIAGVMDSKTGKILALATSNRFDPKNIQQKDYPHLNLNAIEYSYEPGSTIKPII
YAILLQKGMVSPNDMIELDNGYYKLKSYTIRDTHPLKSASAEDVIVRSSNIGMVKISKDLKPNEYHIALHAFGFGELSGI
DLPYEKTGLVPSPKTFNNEVYRASVSYGYGMRATFIQLLRSYAIFSNGGYLITPRVSEYVTSPSGEKYIPKRLEPIAIIS
PQTTQQVYHTLIQVVQKVIKIAQVEGIITGGKTGTAKIALNGKYDSKYNGSFFGFAQDESNAYTIGVVAFESDIKDDYYG
ARTAAPIFKRIVEIMLEDGYLKRIESAPVQPNEAQAM

Sequences:

>Translated_597_residues
MAYYAKKTGVIISVFFLILLCFIIFLSIVYVKIVTPRKLPAVTATKSDTSVRGSLYTSDGFEVAYSDKLYKASVNTQSID
PDKKELFITLFSIYSGIPKDEISKKLAQKGYVVLSYTLNSAVATNLKNLNLILIRYDVFREYEDKRGRVIQKMGLSIEVS
GNNRNYVYKNILEPLIGYTRKFESQNITRVDGVKGVEKYYNDILSPKQDGNITGKRDVGFNVIANKSAHIQSRQDGFDVT
LSIPLSLQRKIEFELDEAKKRYKVREIIAGVMDSKTGKILALATSNRFDPKNIQQKDYPHLNLNAIEYSYEPGSTIKPII
YAILLQKGMVSPNDMIELDNGYYKLKSYTIRDTHPLKSASAEDVIVRSSNIGMVKISKDLKPNEYHIALHAFGFGELSGI
DLPYEKTGLVPSPKTFNNEVYRASVSYGYGMRATFIQLLRSYAIFSNGGYLITPRVSEYVTSPSGEKYIPKRLEPIAIIS
PQTTQQVYHTLIQVVQKVIKIAQVEGIITGGKTGTAKIALNGKYDSKYNGSFFGFAQDESNAYTIGVVAFESDIKDDYYG
ARTAAPIFKRIVEIMLEDGYLKRIESAPVQPNEAQAM
>Mature_596_residues
AYYAKKTGVIISVFFLILLCFIIFLSIVYVKIVTPRKLPAVTATKSDTSVRGSLYTSDGFEVAYSDKLYKASVNTQSIDP
DKKELFITLFSIYSGIPKDEISKKLAQKGYVVLSYTLNSAVATNLKNLNLILIRYDVFREYEDKRGRVIQKMGLSIEVSG
NNRNYVYKNILEPLIGYTRKFESQNITRVDGVKGVEKYYNDILSPKQDGNITGKRDVGFNVIANKSAHIQSRQDGFDVTL
SIPLSLQRKIEFELDEAKKRYKVREIIAGVMDSKTGKILALATSNRFDPKNIQQKDYPHLNLNAIEYSYEPGSTIKPIIY
AILLQKGMVSPNDMIELDNGYYKLKSYTIRDTHPLKSASAEDVIVRSSNIGMVKISKDLKPNEYHIALHAFGFGELSGID
LPYEKTGLVPSPKTFNNEVYRASVSYGYGMRATFIQLLRSYAIFSNGGYLITPRVSEYVTSPSGEKYIPKRLEPIAIISP
QTTQQVYHTLIQVVQKVIKIAQVEGIITGGKTGTAKIALNGKYDSKYNGSFFGFAQDESNAYTIGVVAFESDIKDDYYGA
RTAAPIFKRIVEIMLEDGYLKRIESAPVQPNEAQAM

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=586, Percent_Identity=25.2559726962457, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1786854, Length=451, Percent_Identity=25.9423503325942, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 66976; Mature: 66845

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYYAKKTGVIISVFFLILLCFIIFLSIVYVKIVTPRKLPAVTATKSDTSVRGSLYTSDG
CCEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCCCCCCEEEECCC
FEVAYSDKLYKASVNTQSIDPDKKELFITLFSIYSGIPKDEISKKLAQKGYVVLSYTLNS
CEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEEECH
AVATNLKNLNLILIRYDVFREYEDKRGRVIQKMGLSIEVSGNNRNYVYKNILEPLIGYTR
HHHCCCCCCEEEEEEEHHHHHHHHHHCHHHHHCCCEEEECCCCCCEEHHHHHHHHHHHHH
KFESQNITRVDGVKGVEKYYNDILSPKQDGNITGKRDVGFNVIANKSAHIQSRQDGFDVT
HHCCCCCEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEE
LSIPLSLQRKIEFELDEAKKRYKVREIIAGVMDSKTGKILALATSNRFDPKNIQQKDYPH
EECCCEEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCC
LNLNAIEYSYEPGSTIKPIIYAILLQKGMVSPNDMIELDNGYYKLKSYTIRDTHPLKSAS
CEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEEEEECCCCCCCCCC
AEDVIVRSSNIGMVKISKDLKPNEYHIALHAFGFGELSGIDLPYEKTGLVPSPKTFNNEV
CCCEEEECCCCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCHHCCCCCCCCCCCCCE
YRASVSYGYGMRATFIQLLRSYAIFSNGGYLITPRVSEYVTSPSGEKYIPKRLEPIAIIS
EEEEECCCCCHHHHHHHHHHHHHEECCCCEEECCCHHHHHCCCCCCCCCCCCCCCEEEEC
PQTTQQVYHTLIQVVQKVIKIAQVEGIITGGKTGTAKIALNGKYDSKYNGSFFGFAQDES
CCHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCEEEEEEECCCCCCCCCCEEEEECCCC
NAYTIGVVAFESDIKDDYYGARTAAPIFKRIVEIMLEDGYLKRIESAPVQPNEAQAM
CEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AYYAKKTGVIISVFFLILLCFIIFLSIVYVKIVTPRKLPAVTATKSDTSVRGSLYTSDG
CEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCCCCCCEEEECCC
FEVAYSDKLYKASVNTQSIDPDKKELFITLFSIYSGIPKDEISKKLAQKGYVVLSYTLNS
CEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEEECH
AVATNLKNLNLILIRYDVFREYEDKRGRVIQKMGLSIEVSGNNRNYVYKNILEPLIGYTR
HHHCCCCCCEEEEEEEHHHHHHHHHHCHHHHHCCCEEEECCCCCCEEHHHHHHHHHHHHH
KFESQNITRVDGVKGVEKYYNDILSPKQDGNITGKRDVGFNVIANKSAHIQSRQDGFDVT
HHCCCCCEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEE
LSIPLSLQRKIEFELDEAKKRYKVREIIAGVMDSKTGKILALATSNRFDPKNIQQKDYPH
EECCCEEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCC
LNLNAIEYSYEPGSTIKPIIYAILLQKGMVSPNDMIELDNGYYKLKSYTIRDTHPLKSAS
CEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEEEEECCCCCCCCCC
AEDVIVRSSNIGMVKISKDLKPNEYHIALHAFGFGELSGIDLPYEKTGLVPSPKTFNNEV
CCCEEEECCCCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCHHCCCCCCCCCCCCCE
YRASVSYGYGMRATFIQLLRSYAIFSNGGYLITPRVSEYVTSPSGEKYIPKRLEPIAIIS
EEEEECCCCCHHHHHHHHHHHHHEECCCCEEECCCHHHHHCCCCCCCCCCCCCCCEEEEC
PQTTQQVYHTLIQVVQKVIKIAQVEGIITGGKTGTAKIALNGKYDSKYNGSFFGFAQDES
CCHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCEEEEEEECCCCCCCCCCEEEEECCCC
NAYTIGVVAFESDIKDDYYGARTAAPIFKRIVEIMLEDGYLKRIESAPVQPNEAQAM
CEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]